HK1000206A1 - (Substituted aralkyl) heterocyclic compounds - Google Patents

(Substituted aralkyl) heterocyclic compounds

Info

Publication number
HK1000206A1
HK1000206A1 HK97101733A HK97101733A HK1000206A1 HK 1000206 A1 HK1000206 A1 HK 1000206A1 HK 97101733 A HK97101733 A HK 97101733A HK 97101733 A HK97101733 A HK 97101733A HK 1000206 A1 HK1000206 A1 HK 1000206A1
Authority
HK
Hong Kong
Prior art keywords
radical
cyano
hydroxy
alkyl
alkoxy
Prior art date
Application number
HK97101733A
Other languages
English (en)
Inventor
Edwards Philip Neil
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10618970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1000206(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of HK1000206A1 publication Critical patent/HK1000206A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HK97101733A 1987-06-16 1997-09-05 (Substituted aralkyl) heterocyclic compounds HK1000206A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878714013A GB8714013D0 (en) 1987-06-16 1987-06-16 (substituted-aralkyl)heterocyclic compounds

Publications (1)

Publication Number Publication Date
HK1000206A1 true HK1000206A1 (en) 1998-02-06

Family

ID=10618970

Family Applications (1)

Application Number Title Priority Date Filing Date
HK97101733A HK1000206A1 (en) 1987-06-16 1997-09-05 (Substituted aralkyl) heterocyclic compounds

Country Status (22)

Country Link
US (2) US4935437A (fr)
EP (1) EP0296749B1 (fr)
JP (1) JP2609290B2 (fr)
AT (1) ATE113277T1 (fr)
AU (1) AU605872B2 (fr)
CA (1) CA1337420C (fr)
DE (1) DE3851914T2 (fr)
DK (1) DK174573B1 (fr)
ES (1) ES2063036T3 (fr)
FI (1) FI97804C (fr)
GB (1) GB8714013D0 (fr)
HK (1) HK1000206A1 (fr)
HU (1) HU211142A9 (fr)
IE (1) IE65570B1 (fr)
IL (1) IL86499A (fr)
LU (1) LU88778I2 (fr)
MX (1) MX9202876A (fr)
NL (1) NL970012I2 (fr)
NO (2) NO170080C (fr)
NZ (1) NZ225037A (fr)
PT (1) PT87720B (fr)
ZA (1) ZA883691B (fr)

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KR100219760B1 (ko) * 1996-03-13 1999-09-01 김성환 보온 단열재
GB0012293D0 (en) * 2000-05-23 2000-07-12 Astrazeneca Ab Pharmaceutical combination
GB0129457D0 (en) * 2001-12-10 2002-01-30 Astrazeneca Ab Method of treatment
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GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
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WO2006077428A1 (fr) 2005-01-21 2006-07-27 Astex Therapeutics Limited Composes pharmaceutiques
US20060189670A1 (en) * 2005-02-22 2006-08-24 Glenmark Pharmaceuticals Limited Process for the preparation of anastrozole and intermediates thereof
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WO2006108155A2 (fr) * 2005-04-06 2006-10-12 Sicor, Inc. Procede de preparation de medicaments anticancereux
US20070032660A1 (en) * 2005-06-27 2007-02-08 Alessandro Pontiroli Purification process for Anastrozole intermediate
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WO2007039919A1 (fr) * 2005-10-06 2007-04-12 Natco Pharma Limited Formes cristallines d'anastrozole
US20070100148A1 (en) * 2005-10-31 2007-05-03 Veerender Murki Process for preparing anastrozole
EP1994014A4 (fr) * 2006-03-10 2010-01-20 Shilpa Medicare Ltd Procédé amélioré permettant de préparer un anastrozole a haut degré de pureté
US7655806B2 (en) * 2006-05-19 2010-02-02 Synthon Bv Process for purification of anastrozole
WO2007141799A1 (fr) * 2006-06-05 2007-12-13 Cadila Healthcare Limited Procédé de préparation d'anastrozole pur
WO2008034644A2 (fr) * 2006-09-22 2008-03-27 Synthon B.V. Procédé de fabrication d'anastrozole
WO2008044041A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
EP2073807A1 (fr) 2006-10-12 2009-07-01 Astex Therapeutics Limited Combinaisons pharmaceutiques
KR101502322B1 (ko) * 2006-10-17 2015-03-13 시플라 리미티드 순수한 아나스트로졸의 제조방법
US20080177081A1 (en) * 2007-01-19 2008-07-24 Formosa Laboratories, Inc. Process for Preparation of Anastrozole
CN101307027B (zh) * 2007-05-17 2011-09-07 杜焕达 一种阿那曲唑的新的制备方法
WO2009018811A1 (fr) * 2007-08-06 2009-02-12 Schebo Biotech Ag Nouveaux médicaments, procédé pour leur production et leur utilisation thérapeutique médicale
NZ585389A (en) 2007-10-16 2011-10-28 Repros Therapeutics Inc Trans-clomiphene for metabolic syndrome
WO2009128919A1 (fr) * 2008-04-15 2009-10-22 Concert Pharmaceuticals, Inc. Analogues d'anastrozole portant du deutérium en tant qu'inhibiteurs d'aromatase pour le traitement du cancer du sein
US20100111901A1 (en) * 2008-11-03 2010-05-06 Auspex Pharmaceuticals, Inc. Triazole inhibitors of aromatase
DE102010046464A1 (de) 2009-03-19 2011-04-21 Amw Gmbh Transdermales System mit Aromatasehemmer
EP2343278A1 (fr) 2010-01-07 2011-07-13 Hexal AG Procédé de préparation de dérivés de phényle trisubstitué comprenant un groupe (1H-1,2,4-triazol-1-yl)alkyle
DE102010026883A1 (de) 2010-03-11 2011-12-15 Amw Gmbh Transdermales System mit Aromatasehemmer
CA2865234A1 (fr) 2012-02-29 2013-09-06 Repros Therapeutics Inc. Polytherapie pour le traitement d'une carence en androgene
CN103172580B (zh) * 2013-03-29 2015-04-22 凯莱英医药集团（天津）股份有限公司 一种阿那曲唑的制备方法
ITRM20130285A1 (it) 2013-05-14 2014-11-15 Corden Pharma Latina S P A Con Uni Co Socio Metodo per la preparazione di anastrozolo di grado farmaceutico
CN103342663B (zh) * 2013-07-15 2015-07-29 凯莱英医药集团（天津）股份有限公司 一种阿那曲唑关键中间体的制备方法
CN104387332B (zh) * 2014-11-27 2016-04-13 江苏正大清江制药有限公司 一种合成芳香化酶抑制剂的方法
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CN106083748B (zh) * 2016-06-21 2019-08-16 扬子江药业集团江苏海慈生物药业有限公司 一种阿那曲唑的制备方法

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Also Published As

Publication number Publication date
FI882882A (fi) 1988-12-17
IL86499A (en) 1997-09-30
NO170080B (no) 1992-06-01
DE3851914D1 (de) 1994-12-01
NO882628L (no) 1988-12-19
USRE36617E (en) 2000-03-14
JP2609290B2 (ja) 1997-05-14
NL970012I1 (nl) 1997-05-01
FI97804B (fi) 1996-11-15
NZ225037A (en) 1991-10-25
PT87720A (pt) 1988-07-01
EP0296749A1 (fr) 1988-12-28
DK330488D0 (da) 1988-06-16
US4935437A (en) 1990-06-19
GB8714013D0 (en) 1987-07-22
PT87720B (pt) 1992-10-30
DK330488A (da) 1988-12-17
IE881505L (en) 1988-12-16
AU605872B2 (en) 1991-01-24
NO1997006I1 (no) 1997-05-16
IE65570B1 (en) 1995-11-01
ZA883691B (en) 1989-02-22
AU1691188A (en) 1988-12-22
LU88778I2 (fr) 1996-11-05
IL86499A0 (en) 1988-11-15
ATE113277T1 (de) 1994-11-15
MX9202876A (es) 1992-06-30
JPS6419067A (en) 1989-01-23
DK174573B1 (da) 2003-06-23
FI882882A0 (fi) 1988-06-16
NO882628D0 (no) 1988-06-15
ES2063036T3 (es) 1995-01-01
NL970012I2 (nl) 1997-07-01
FI97804C (fi) 1997-02-25
HU211142A9 (en) 1995-10-30
NO170080C (no) 1992-09-09
DE3851914T2 (de) 1995-03-23
EP0296749B1 (fr) 1994-10-26
CA1337420C (fr) 1995-10-24

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Effective date: 20080613