DK330488D0 - (substitueret aralkyl)-heterocykliske forbindelser, fremgangsmaader til fremstilling heraf samt farmaceutiske og veterinaere midler indeholdende disse - Google Patents

(substitueret aralkyl)-heterocykliske forbindelser, fremgangsmaader til fremstilling heraf samt farmaceutiske og veterinaere midler indeholdende disse

Info

Publication number
DK330488D0
DK330488D0 DK330488A DK330488A DK330488D0 DK 330488 D0 DK330488 D0 DK 330488D0 DK 330488 A DK330488 A DK 330488A DK 330488 A DK330488 A DK 330488A DK 330488 D0 DK330488 D0 DK 330488D0
Authority
DK
Denmark
Prior art keywords
radical
cyano
hydroxy
alkyl
alkoxy
Prior art date
Application number
DK330488A
Other languages
English (en)
Other versions
DK330488A (da
DK174573B1 (da
Inventor
Philips Neil Edwards
Michael Stewart Large
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10618970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK330488(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ici Plc filed Critical Ici Plc
Publication of DK330488D0 publication Critical patent/DK330488D0/da
Publication of DK330488A publication Critical patent/DK330488A/da
Application granted granted Critical
Publication of DK174573B1 publication Critical patent/DK174573B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
DK198803304A 1987-06-16 1988-06-16 (Substitueret aralkyl)-triazolyl-,imidazolyl-, -pyridinyl- eller -pyrimidinyl- forbindelser, fremgangsmåder til fremstilling heraf samt farmaceutiske og veterinære midler indeholdende disse DK174573B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8714013 1987-06-16
GB878714013A GB8714013D0 (en) 1987-06-16 1987-06-16 (substituted-aralkyl)heterocyclic compounds

Publications (3)

Publication Number Publication Date
DK330488D0 true DK330488D0 (da) 1988-06-16
DK330488A DK330488A (da) 1988-12-17
DK174573B1 DK174573B1 (da) 2003-06-23

Family

ID=10618970

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198803304A DK174573B1 (da) 1987-06-16 1988-06-16 (Substitueret aralkyl)-triazolyl-,imidazolyl-, -pyridinyl- eller -pyrimidinyl- forbindelser, fremgangsmåder til fremstilling heraf samt farmaceutiske og veterinære midler indeholdende disse

Country Status (22)

Country Link
US (2) US4935437A (da)
EP (1) EP0296749B1 (da)
JP (1) JP2609290B2 (da)
AT (1) ATE113277T1 (da)
AU (1) AU605872B2 (da)
CA (1) CA1337420C (da)
DE (1) DE3851914T2 (da)
DK (1) DK174573B1 (da)
ES (1) ES2063036T3 (da)
FI (1) FI97804C (da)
GB (1) GB8714013D0 (da)
HK (1) HK1000206A1 (da)
HU (1) HU211142A9 (da)
IE (1) IE65570B1 (da)
IL (1) IL86499A (da)
LU (1) LU88778I2 (da)
MX (1) MX9202876A (da)
NL (1) NL970012I2 (da)
NO (2) NO170080C (da)
NZ (1) NZ225037A (da)
PT (1) PT87720B (da)
ZA (1) ZA883691B (da)

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US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
KR100219760B1 (ko) * 1996-03-13 1999-09-01 김성환 보온 단열재
GB0012293D0 (en) * 2000-05-23 2000-07-12 Astrazeneca Ab Pharmaceutical combination
GB0129457D0 (en) * 2001-12-10 2002-01-30 Astrazeneca Ab Method of treatment
WO2005105762A1 (en) * 2004-05-05 2005-11-10 Natco Pharma Limited Improved process for the preparation of high purity anastrozole
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
GB0414120D0 (en) * 2004-06-24 2004-07-28 Generics Uk Ltd Novel processes and intermediates
US20060035950A1 (en) * 2004-08-09 2006-02-16 Mohammed Alnabari Novel processes for preparing substantially pure anastrozole
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US20060189670A1 (en) * 2005-02-22 2006-08-24 Glenmark Pharmaceuticals Limited Process for the preparation of anastrozole and intermediates thereof
EP1705168A1 (en) * 2005-03-21 2006-09-27 Helm AG Improved process for side-chain bromination of alkyl-benzenes
US7692025B2 (en) * 2005-04-06 2010-04-06 Sicor, Inc. Process for the preparation of anticancer drugs
KR20080015438A (ko) * 2005-06-27 2008-02-19 시코르, 인크. 아나스트로졸 중간체의 불순물, 및 이의 용도
WO2007002720A2 (en) * 2005-06-27 2007-01-04 Sicor, Inc. An impurity of anastrozole intermediate, and uses thereof
EP2397472A1 (en) 2005-09-30 2011-12-21 Cadila Healthcare Limited A process for the preparation of a benzylbromide intermediates
WO2007039913A1 (en) * 2005-10-05 2007-04-12 Usv Limited Process for the preparation of 2,2’-[5-(1,2,4-triazole-1-ylmethyl) -1,3-phenylene] di (2-methylpropionitrile).
WO2007039919A1 (en) * 2005-10-06 2007-04-12 Natco Pharma Limited Crystalline forms of anastrozole
US20070100148A1 (en) * 2005-10-31 2007-05-03 Veerender Murki Process for preparing anastrozole
WO2007105231A1 (en) * 2006-03-10 2007-09-20 Shilpa Medicare Ltd. Improved process for high purity anastrozole
CN101568526B (zh) * 2006-05-19 2013-03-06 斯索恩有限公司 阿那曲唑的纯化方法
EP2029557A1 (en) * 2006-06-05 2009-03-04 Cadila Healthcare Ltd. A process for preparing pure anastrozole
WO2008034644A2 (en) * 2006-09-22 2008-03-27 Synthon B.V. Process for making anastrozole
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
WO2008047104A1 (en) * 2006-10-17 2008-04-24 Cipla Limited Process for the preparation of pure anastrozole
US20080177081A1 (en) * 2007-01-19 2008-07-24 Formosa Laboratories, Inc. Process for Preparation of Anastrozole
CN101307027B (zh) * 2007-05-17 2011-09-07 杜焕达 一种阿那曲唑的新的制备方法
WO2009018811A1 (de) * 2007-08-06 2009-02-12 Schebo Biotech Ag Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie
CA2702710C (en) 2007-10-16 2013-05-07 Repros Therapeutics, Inc. Trans-clomiphene for metabolic syndrome
US20110104158A1 (en) * 2008-04-15 2011-05-05 Harbeson Scott L Deuterium bearing analogs of anastrozole as aromatase inhibitors for the treatment of breast cancer
US20100111901A1 (en) * 2008-11-03 2010-05-06 Auspex Pharmaceuticals, Inc. Triazole inhibitors of aromatase
DE102010046464A1 (de) 2009-03-19 2011-04-21 Amw Gmbh Transdermales System mit Aromatasehemmer
EP2343278A1 (en) 2010-01-07 2011-07-13 Hexal AG A process for preparing trisubstituted phenyl derivatives comprising a (1H-1,2,4-triazol-1-yl)alkyl group
DE102010026883A1 (de) 2010-03-11 2011-12-15 Amw Gmbh Transdermales System mit Aromatasehemmer
ES2681023T3 (es) 2012-02-29 2018-09-11 Repros Therapeutics Inc. Terapia de combinación para tratar el déficit de andrógenos
CN103172580B (zh) * 2013-03-29 2015-04-22 凯莱英医药集团（天津）股份有限公司 一种阿那曲唑的制备方法
ITRM20130285A1 (it) 2013-05-14 2014-11-15 Corden Pharma Latina S P A Con Uni Co Socio Metodo per la preparazione di anastrozolo di grado farmaceutico
CN103342663B (zh) * 2013-07-15 2015-07-29 凯莱英医药集团（天津）股份有限公司 一种阿那曲唑关键中间体的制备方法
CN104387332B (zh) * 2014-11-27 2016-04-13 江苏正大清江制药有限公司 一种合成芳香化酶抑制剂的方法
CN108348605B (zh) 2015-11-10 2023-06-09 帕拉卡林治疗公司 用pdgf-cc抑制剂和抗雌激素治疗er阴性乳癌
CN106083748B (zh) * 2016-06-21 2019-08-16 扬子江药业集团江苏海慈生物药业有限公司 一种阿那曲唑的制备方法

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Also Published As

Publication number Publication date
FI97804B (fi) 1996-11-15
DK330488A (da) 1988-12-17
PT87720B (pt) 1992-10-30
US4935437A (en) 1990-06-19
CA1337420C (en) 1995-10-24
ZA883691B (en) 1989-02-22
NO170080C (no) 1992-09-09
NL970012I1 (nl) 1997-05-01
IE65570B1 (en) 1995-11-01
MX9202876A (es) 1992-06-30
FI882882A0 (fi) 1988-06-16
EP0296749A1 (en) 1988-12-28
GB8714013D0 (en) 1987-07-22
NL970012I2 (nl) 1997-07-01
AU605872B2 (en) 1991-01-24
HK1000206A1 (en) 1998-02-06
IL86499A (en) 1997-09-30
JPS6419067A (en) 1989-01-23
ATE113277T1 (de) 1994-11-15
PT87720A (pt) 1988-07-01
NO170080B (no) 1992-06-01
LU88778I2 (fr) 1996-11-05
EP0296749B1 (en) 1994-10-26
NO882628L (no) 1988-12-19
HU211142A9 (en) 1995-10-30
AU1691188A (en) 1988-12-22
NO882628D0 (no) 1988-06-15
DE3851914T2 (de) 1995-03-23
USRE36617E (en) 2000-03-14
FI882882A (fi) 1988-12-17
ES2063036T3 (es) 1995-01-01
NO1997006I1 (no) 1997-05-16
DE3851914D1 (de) 1994-12-01
DK174573B1 (da) 2003-06-23
JP2609290B2 (ja) 1997-05-14
FI97804C (fi) 1997-02-25
IE881505L (en) 1988-12-16
IL86499A0 (en) 1988-11-15
NZ225037A (en) 1991-10-25

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Legal Events

Date Code Title Description
CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2003 00028

Filing date: 20031219

Expiry date: 20100811

CTFG Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: ANASTROZOL ELLER FARMACEUTISK ACCEPTABELT SYREADDITIONSSALT DERAF

Spc suppl protection certif: CA 2003 00028

Filing date: 20031219

PUP Patent expired