CA2305803C - Crystalline antifungal polymorph - Google Patents

Crystalline antifungal polymorph Download PDF

Info

Publication number
CA2305803C
CA2305803C CA002305803A CA2305803A CA2305803C CA 2305803 C CA2305803 C CA 2305803C CA 002305803 A CA002305803 A CA 002305803A CA 2305803 A CA2305803 A CA 2305803A CA 2305803 C CA2305803 C CA 2305803C
Authority
CA
Canada
Prior art keywords
vwd
crystalline polymorph
triazol
phenyl
polymorph form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002305803A
Other languages
English (en)
French (fr)
Other versions
CA2305803A1 (en
Inventor
David R. Andrews
William Leong
Anantha R. Sudhakar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2305803A1 publication Critical patent/CA2305803A1/en
Application granted granted Critical
Publication of CA2305803C publication Critical patent/CA2305803C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002305803A 1997-10-07 1998-10-05 Crystalline antifungal polymorph Expired - Lifetime CA2305803C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94618397A 1997-10-07 1997-10-07
US08/946,183 1997-10-07
PCT/US1998/020476 WO1999018097A1 (en) 1997-10-07 1998-10-05 Crystalline antifungal polymorph

Publications (2)

Publication Number Publication Date
CA2305803A1 CA2305803A1 (en) 1999-04-15
CA2305803C true CA2305803C (en) 2009-12-22

Family

ID=25484068

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002305803A Expired - Lifetime CA2305803C (en) 1997-10-07 1998-10-05 Crystalline antifungal polymorph

Country Status (30)

Country Link
EP (1) EP1021439B1 (enExample)
JP (4) JP2001519346A (enExample)
KR (1) KR100626109B1 (enExample)
CN (1) CN1125067C (enExample)
AR (1) AR015947A1 (enExample)
AT (1) ATE263163T1 (enExample)
AU (1) AU759982B2 (enExample)
BR (1) BR9812866A (enExample)
CA (1) CA2305803C (enExample)
CO (1) CO4970829A1 (enExample)
CZ (1) CZ299835B6 (enExample)
DE (1) DE69822859T2 (enExample)
DK (1) DK1021439T3 (enExample)
ES (1) ES2217594T3 (enExample)
HU (1) HU225233B1 (enExample)
ID (1) ID29290A (enExample)
IL (1) IL135331A (enExample)
IN (1) IN1998CH02232A (enExample)
MX (1) MX225999B (enExample)
MY (1) MY130126A (enExample)
NO (1) NO318827B1 (enExample)
NZ (1) NZ503662A (enExample)
PE (1) PE120499A1 (enExample)
PH (1) PH11998002606B1 (enExample)
PL (1) PL189317B1 (enExample)
PT (1) PT1021439E (enExample)
SK (1) SK285190B6 (enExample)
TW (1) TW589310B (enExample)
WO (1) WO1999018097A1 (enExample)
ZA (1) ZA989063B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2130540A1 (en) 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
EP2451805A1 (en) 2009-07-09 2012-05-16 Sandoz AG A crystalline form of posaconazole
US9199919B2 (en) 2010-05-19 2015-12-01 Sandoz Ag Process for the preparation of chiral hydrazides
RU2580318C2 (ru) 2010-05-19 2016-04-10 Сандоз Аг Получение промежуточных продуктов для синтеза позаконазола
US9206146B2 (en) 2010-05-19 2015-12-08 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
EP2571871B1 (en) * 2010-05-19 2017-06-21 Sandoz AG Process for the preparation of chiral triazolones
CN108329303A (zh) 2011-06-16 2018-07-27 桑多斯股份公司 制备手性化合物的方法
US9102664B2 (en) 2011-09-19 2015-08-11 Msn Laboratories Private Limited Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof
MX370849B (es) * 2013-07-25 2020-01-08 Sandoz Ag Proceso mejorado para preparar la forma cristalina iv del posaconazol.
ITMI20132117A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132118A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132115A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
KR102331856B1 (ko) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
CN104387374A (zh) * 2014-10-21 2015-03-04 江苏恒盛药业有限公司 泊沙康唑晶型i的制备工艺
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
WO2017025292A1 (en) 2015-08-08 2017-02-16 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant formulation containing posaconazole
EA039213B1 (ru) 2015-12-24 2021-12-17 Такеда Фармасьютикал Компани Лимитед Сокристалл, способ его получения и лекарственное средство, содержащее сокристалл
EP3925601B1 (en) 2016-02-26 2024-07-17 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
TR201722493A2 (tr) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon
WO2022034232A1 (en) 2020-08-13 2022-02-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant high-strength formulation containing posaconazole
AU2022324717A1 (en) 2021-11-25 2024-06-13 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
PL181193B1 (pl) * 1993-12-21 2001-06-29 Schering Corp Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków
NZ278882A (en) * 1994-01-24 1997-06-24 Janssen Pharmaceutica Nv Piperazine-containing azole antifungal compounds
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
SK27097A3 (en) * 1995-06-02 1997-09-10 Schering Corp Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
ES2217594T3 (es) 2004-11-01
HU225233B1 (en) 2006-08-28
ATE263163T1 (de) 2004-04-15
KR100626109B1 (ko) 2006-09-20
SK285190B6 (sk) 2006-08-03
NZ503662A (en) 2002-10-25
ZA989063B (en) 1999-04-06
HUP0004899A2 (hu) 2002-02-28
NO318827B1 (no) 2005-05-09
CZ20001264A3 (cs) 2000-08-16
PL339659A1 (en) 2001-01-02
IL135331A0 (en) 2001-05-20
CN1281449A (zh) 2001-01-24
PH11998002606B1 (en) 2006-08-10
PL189317B1 (pl) 2005-07-29
CN1125067C (zh) 2003-10-22
DE69822859T2 (de) 2005-01-27
KR20010030959A (ko) 2001-04-16
WO1999018097A1 (en) 1999-04-15
TW589310B (en) 2004-06-01
PE120499A1 (es) 1999-12-04
AR015947A1 (es) 2001-05-30
NO20001779L (no) 2000-06-06
HK1029588A1 (en) 2001-04-06
CA2305803A1 (en) 1999-04-15
SK5122000A3 (en) 2000-09-12
AU9780398A (en) 1999-04-27
MX225999B (es) 2005-02-02
HUP0004899A3 (en) 2002-03-28
DK1021439T3 (da) 2004-05-10
BR9812866A (pt) 2000-08-08
CZ299835B6 (cs) 2008-12-10
IN1998CH02232A (enExample) 2005-03-04
JP2001519346A (ja) 2001-10-23
EP1021439A1 (en) 2000-07-26
MY130126A (en) 2007-06-29
PT1021439E (pt) 2004-07-30
JP2008106075A (ja) 2008-05-08
JP2012153730A (ja) 2012-08-16
AU759982B2 (en) 2003-05-01
NO20001779D0 (no) 2000-04-06
EP1021439B1 (en) 2004-03-31
DE69822859D1 (de) 2004-05-06
MXPA00003404A (es) 2000-11-01
CO4970829A1 (es) 2000-11-07
JP2012153729A (ja) 2012-08-16
ID29290A (id) 2001-08-16
IL135331A (en) 2005-08-31

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Effective date: 20181005