NO328363B1 - Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat - Google Patents
Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat Download PDFInfo
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- NO328363B1 NO328363B1 NO20014128A NO20014128A NO328363B1 NO 328363 B1 NO328363 B1 NO 328363B1 NO 20014128 A NO20014128 A NO 20014128A NO 20014128 A NO20014128 A NO 20014128A NO 328363 B1 NO328363 B1 NO 328363B1
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- iminomethylcamptothecin
- cpt
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- C—CHEMISTRY; METALLURGY
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- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99830124A EP1044977B1 (fr) | 1999-03-09 | 1999-03-09 | Dérivés de camptothécine à activité anti-tumorale |
| PCT/EP2000/001570 WO2000053607A1 (fr) | 1999-03-09 | 2000-03-08 | Derives de camptothecine ayant une action antitumorale |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20014128L NO20014128L (no) | 2001-08-24 |
| NO20014128D0 NO20014128D0 (no) | 2001-08-24 |
| NO328363B1 true NO328363B1 (no) | 2010-02-01 |
Family
ID=8243303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014128A NO328363B1 (no) | 1999-03-09 | 2001-08-24 | Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US6242457B1 (fr) |
| EP (1) | EP1044977B1 (fr) |
| JP (1) | JP4610743B2 (fr) |
| KR (1) | KR100702085B1 (fr) |
| CN (1) | CN1139592C (fr) |
| AR (1) | AR022860A1 (fr) |
| AT (1) | ATE216998T1 (fr) |
| AU (1) | AU774174B2 (fr) |
| BG (1) | BG65032B1 (fr) |
| BR (1) | BR0008840B1 (fr) |
| CA (1) | CA2362760C (fr) |
| CO (1) | CO5180590A1 (fr) |
| CZ (1) | CZ304465B6 (fr) |
| DE (1) | DE69901379T2 (fr) |
| DK (1) | DK1044977T3 (fr) |
| EA (1) | EA003605B1 (fr) |
| EE (1) | EE04679B1 (fr) |
| EG (1) | EG23999A (fr) |
| ES (1) | ES2175919T3 (fr) |
| HK (1) | HK1031222A1 (fr) |
| HR (1) | HRP20010667B1 (fr) |
| HU (1) | HU229506B1 (fr) |
| IL (2) | IL144958A0 (fr) |
| IS (1) | IS2003B (fr) |
| ME (2) | MEP4008A (fr) |
| MX (1) | MXPA01009081A (fr) |
| NO (1) | NO328363B1 (fr) |
| NZ (1) | NZ513393A (fr) |
| PE (1) | PE20001485A1 (fr) |
| PL (1) | PL222208B1 (fr) |
| PT (1) | PT1044977E (fr) |
| RS (1) | RS50405B (fr) |
| SI (1) | SI1044977T1 (fr) |
| SK (1) | SK287561B6 (fr) |
| TN (1) | TNSN00045A1 (fr) |
| TR (1) | TR200102603T2 (fr) |
| TW (1) | TWI272272B (fr) |
| WO (1) | WO2000053607A1 (fr) |
| ZA (1) | ZA200107408B (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2370003C (fr) | 1999-01-13 | 2008-08-19 | Tracey Brown | Composition visant a accroitre l'efficacite de medicaments et methodes afferentes |
| US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| FR2794123B1 (fr) * | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
| US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| US20040029906A1 (en) * | 2001-07-31 | 2004-02-12 | Michael Christman | Inhibitors of dna polymerase sigma |
| CA2458856C (fr) * | 2001-08-27 | 2011-02-15 | Meditech Research Limited | Protocoles therapeutiques ameliores |
| WO2003033525A1 (fr) * | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Derives polymeres de camptothecine amino-substitues et utilisation de ceux-ci pour la fabrication d'un medicament |
| ITRM20020305A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Camptotecine con anello lattonico modificato. |
| ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
| ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| CN101480395A (zh) * | 2004-03-26 | 2009-07-15 | 诺瓦提斯公司 | 喜树碱衍生物以固定给药方案治疗增生性疾病的用途 |
| RU2408387C2 (ru) | 2004-04-27 | 2011-01-10 | Веллстат Байолоджикс Корпорейшн | Лечение злокачественного новообразования с применением вирусов и камптотецинов |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
| ITRM20040241A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 20 con antagonisti delle integrine. |
| ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
| CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9－硝基喜树碱的生产方法 |
| GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| EP1827437B1 (fr) * | 2004-12-15 | 2011-11-02 | Novartis AG | Combinaisons d'agents therapeutiques pour le traitement du cancer |
| DK1828196T3 (da) | 2004-12-21 | 2012-11-26 | Sigma Tau Ind Farmaceuti | Stereospecifik fremgangsmåde og krystallinske former af en camptothecin |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| EP1907015B1 (fr) | 2005-07-14 | 2012-01-11 | Wellstat Biologics Corporation | Traitement anticancéreux à l'aide de virus, fluoropyrimidines et camptothécines |
| CA2616607C (fr) * | 2005-07-27 | 2015-06-02 | Alchemia Oncology Pty Limited | Protocoles therapeutiques utilisant hyaluronan |
| ITRM20050418A1 (it) * | 2005-08-04 | 2007-02-05 | Sigma Tau Ind Farmaceuti | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
| EP1915134A2 (fr) * | 2005-08-10 | 2008-04-30 | Novartis AG | Formulations pour 7-(t-butoxy)iminomethyl camptothecine |
| JP5627181B2 (ja) * | 2005-09-07 | 2014-11-19 | アルケミア オンコロジー ピーティーワイ リミテッド | ヒアルロナンおよび治療用抗体を含む治療用組成物ならびに治療方法 |
| EA016487B1 (ru) | 2005-12-21 | 2012-05-30 | Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. | Лечение резистентных к лекарственным препаратам опухолей |
| JP5596924B2 (ja) | 2006-02-17 | 2014-09-24 | カスケード プロドラッグ インコーポレイテッド | ビンカアルカロイドｎ酸化物および類似体による過剰増殖疾患の処置 |
| US8410045B2 (en) | 2006-03-30 | 2013-04-02 | Drais Pharmaceuticals, Inc. | Camptothecin-peptide conjugates and pharmaceutical compositions containing the same |
| CA2676986A1 (fr) * | 2007-02-01 | 2008-08-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition pharmaceutique comprenant un derive de camptothecine |
| EP2120948A1 (fr) * | 2007-02-13 | 2009-11-25 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Traitement anti-cancéreux à large spectre à base de dérivés d'iminocamptothécine |
| SG183010A1 (en) * | 2007-08-01 | 2012-08-30 | Sigma Tau Ind Farmaceuti | Treatment of pediatric tumors |
| EP2096113A1 (fr) * | 2008-02-05 | 2009-09-02 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Dérivés de camptothécine substitués 9 en tant que composants antitumeurs |
| TWI482621B (zh) | 2009-12-23 | 2015-05-01 | Sigma Tau Ind Farmaceuti | 青蒿素基藥物與其他化學治療劑的抗癌組合物 |
| AU2016326747A1 (en) | 2015-09-25 | 2018-03-01 | Zy Therapeutics Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
| ATE247471T1 (de) * | 1991-11-15 | 2003-09-15 | Smithkline Beecham Corp | Cisplatin und topotecan enthaltende zusammensetzung als antitumor. |
| US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
| US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
| GB9512670D0 (en) * | 1995-06-21 | 1995-08-23 | Sod Conseils Rech Applic | Camptothecin analogues |
| IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
| AU718799C (en) * | 1996-08-19 | 2004-02-12 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
-
1999
- 1999-03-09 ES ES99830124T patent/ES2175919T3/es not_active Expired - Lifetime
- 1999-03-09 AT AT99830124T patent/ATE216998T1/de active
- 1999-03-09 SI SI9930010T patent/SI1044977T1/xx unknown
- 1999-03-09 EP EP99830124A patent/EP1044977B1/fr not_active Expired - Lifetime
- 1999-03-09 DK DK99830124T patent/DK1044977T3/da active
- 1999-03-09 PT PT99830124T patent/PT1044977E/pt unknown
- 1999-03-09 DE DE69901379T patent/DE69901379T2/de not_active Expired - Lifetime
-
2000
- 2000-02-22 US US09/507,928 patent/US6242457B1/en not_active Expired - Lifetime
- 2000-03-07 EG EG20000293A patent/EG23999A/xx active
- 2000-03-07 TW TW089104090A patent/TWI272272B/zh not_active IP Right Cessation
- 2000-03-08 IL IL14495800A patent/IL144958A0/xx unknown
- 2000-03-08 CO CO00016957A patent/CO5180590A1/es active IP Right Grant
- 2000-03-08 PL PL355094A patent/PL222208B1/pl unknown
- 2000-03-08 TR TR2001/02603T patent/TR200102603T2/xx unknown
- 2000-03-08 WO PCT/EP2000/001570 patent/WO2000053607A1/fr active IP Right Grant
- 2000-03-08 SK SK1164-2001A patent/SK287561B6/sk not_active IP Right Cessation
- 2000-03-08 EA EA200100954A patent/EA003605B1/ru not_active IP Right Cessation
- 2000-03-08 HU HU0200210A patent/HU229506B1/hu not_active IP Right Cessation
- 2000-03-08 CA CA002362760A patent/CA2362760C/fr not_active Expired - Fee Related
- 2000-03-08 BR BRPI0008840-4A patent/BR0008840B1/pt not_active IP Right Cessation
- 2000-03-08 JP JP2000604043A patent/JP4610743B2/ja not_active Expired - Fee Related
- 2000-03-08 TN TNTNSN00045A patent/TNSN00045A1/fr unknown
- 2000-03-08 RS YUP-643/01A patent/RS50405B/sr unknown
- 2000-03-08 AR ARP000101013A patent/AR022860A1/es not_active Application Discontinuation
- 2000-03-08 NZ NZ513393A patent/NZ513393A/xx not_active IP Right Cessation
- 2000-03-08 MX MXPA01009081A patent/MXPA01009081A/es unknown
- 2000-03-08 CN CNB008047804A patent/CN1139592C/zh not_active Expired - Fee Related
- 2000-03-08 PE PE2000000206A patent/PE20001485A1/es not_active Application Discontinuation
- 2000-03-08 AU AU31604/00A patent/AU774174B2/en not_active Ceased
- 2000-03-08 ME MEP-40/08A patent/MEP4008A/xx unknown
- 2000-03-08 KR KR1020017011336A patent/KR100702085B1/ko not_active IP Right Cessation
- 2000-03-08 EE EEP200100466A patent/EE04679B1/xx not_active IP Right Cessation
- 2000-03-08 CZ CZ2001-3077A patent/CZ304465B6/cs not_active IP Right Cessation
- 2000-03-08 ME MEP-2008-40A patent/ME00017B/fr unknown
- 2000-11-29 HK HK00107660A patent/HK1031222A1/xx not_active IP Right Cessation
- 2000-12-22 US US09/741,818 patent/US6589939B2/en not_active Expired - Lifetime
-
2001
- 2001-07-31 IS IS6031A patent/IS2003B/is unknown
- 2001-08-10 BG BG105810A patent/BG65032B1/bg unknown
- 2001-08-16 IL IL144958A patent/IL144958A/en not_active IP Right Cessation
- 2001-08-24 NO NO20014128A patent/NO328363B1/no not_active IP Right Cessation
- 2001-09-07 ZA ZA200107408A patent/ZA200107408B/xx unknown
- 2001-09-10 HR HR960321A patent/HRP20010667B1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO328363B1 (no) | Camptothecinderivater som har antitumoraktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk preparat | |
| EP2112154B1 (fr) | Esters en position 20 de camptothécines | |
| CA2643400C (fr) | Derives de la camptothecine et leurs utilisations | |
| US7105492B2 (en) | Camptothecin derivatives having antitumor activity | |
| US10640515B2 (en) | Hepatitis C virus inhibitor and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |