NO325343B1 - DNA-basert vaksinering av fisk ved immersjon - Google Patents
DNA-basert vaksinering av fisk ved immersjon Download PDFInfo
- Publication number
- NO325343B1 NO325343B1 NO19964713A NO964713A NO325343B1 NO 325343 B1 NO325343 B1 NO 325343B1 NO 19964713 A NO19964713 A NO 19964713A NO 964713 A NO964713 A NO 964713A NO 325343 B1 NO325343 B1 NO 325343B1
- Authority
- NO
- Norway
- Prior art keywords
- protein
- dna
- polypeptide
- fish
- use according
- Prior art date
Links
- 241000251468 Actinopterygii Species 0.000 title claims description 83
- 238000007654 immersion Methods 0.000 title description 16
- 238000002255 vaccination Methods 0.000 title description 6
- 108020004414 DNA Proteins 0.000 claims description 97
- 108090000623 proteins and genes Proteins 0.000 claims description 70
- 102000004169 proteins and genes Human genes 0.000 claims description 56
- 239000013612 plasmid Substances 0.000 claims description 41
- 108091007433 antigens Proteins 0.000 claims description 40
- 102000036639 antigens Human genes 0.000 claims description 40
- 239000000427 antigen Substances 0.000 claims description 37
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 33
- 229920001184 polypeptide Polymers 0.000 claims description 32
- 244000052769 pathogen Species 0.000 claims description 31
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 26
- 239000002502 liposome Substances 0.000 claims description 26
- 230000001717 pathogenic effect Effects 0.000 claims description 17
- 229920006317 cationic polymer Polymers 0.000 claims description 16
- 241000710921 Infectious pancreatic necrosis virus Species 0.000 claims description 13
- 230000003612 virological effect Effects 0.000 claims description 12
- 241000711825 Viral hemorrhagic septicemia virus Species 0.000 claims description 10
- 230000000890 antigenic effect Effects 0.000 claims description 10
- 101001056675 Klebsiella pneumoniae Ferric aerobactin receptor Proteins 0.000 claims description 9
- 230000001580 bacterial effect Effects 0.000 claims description 8
- 101710116435 Outer membrane protein Proteins 0.000 claims description 7
- 101710172711 Structural protein Proteins 0.000 claims description 7
- 102000003886 Glycoproteins Human genes 0.000 claims description 6
- 108090000288 Glycoproteins Proteins 0.000 claims description 6
- 102000004127 Cytokines Human genes 0.000 claims description 5
- 108090000695 Cytokines Proteins 0.000 claims description 5
- 108091006027 G proteins Proteins 0.000 claims description 5
- 108091000058 GTP-Binding Proteins 0.000 claims description 5
- 241000711804 Infectious hematopoietic necrosis virus Species 0.000 claims description 5
- 208000035143 Bacterial infection Diseases 0.000 claims description 4
- 241000252233 Cyprinus carpio Species 0.000 claims description 4
- 108050001049 Extracellular proteins Proteins 0.000 claims description 4
- 208000030852 Parasitic disease Diseases 0.000 claims description 4
- 102000034356 gene-regulatory proteins Human genes 0.000 claims description 4
- 108091006104 gene-regulatory proteins Proteins 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 102000030782 GTP binding Human genes 0.000 claims description 3
- 101710141454 Nucleoprotein Proteins 0.000 claims description 3
- 102000011931 Nucleoproteins Human genes 0.000 claims description 3
- 108010061100 Nucleoproteins Proteins 0.000 claims description 3
- 206010058874 Viraemia Diseases 0.000 claims description 3
- 241001167018 Aroa Species 0.000 claims description 2
- 108090000565 Capsid Proteins Proteins 0.000 claims description 2
- 102100023321 Ceruloplasmin Human genes 0.000 claims description 2
- 102100028233 Coronin-1A Human genes 0.000 claims description 2
- 241000605056 Cytophaga Species 0.000 claims description 2
- 101710112752 Cytotoxin Proteins 0.000 claims description 2
- 241000607471 Edwardsiella tarda Species 0.000 claims description 2
- 101100491986 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) aromA gene Proteins 0.000 claims description 2
- 108010006464 Hemolysin Proteins Proteins 0.000 claims description 2
- 108010052285 Membrane Proteins Proteins 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 206010034107 Pasteurella infections Diseases 0.000 claims description 2
- 206010035148 Plague Diseases 0.000 claims description 2
- 241000606701 Rickettsia Species 0.000 claims description 2
- 241001135139 Vibrio ordalii Species 0.000 claims description 2
- 206010048249 Yersinia infections Diseases 0.000 claims description 2
- 208000025079 Yersinia infectious disease Diseases 0.000 claims description 2
- 101150037081 aroA gene Proteins 0.000 claims description 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 2
- 239000002619 cytotoxin Substances 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 239000000122 growth hormone Substances 0.000 claims description 2
- 239000003228 hemolysin Substances 0.000 claims description 2
- 201000005115 pasteurellosis Diseases 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 101150002764 purA gene Proteins 0.000 claims description 2
- 108091026890 Coding region Proteins 0.000 claims 3
- 241000700723 Ictalurid herpesvirus 1 Species 0.000 claims 2
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 235000019688 fish Nutrition 0.000 description 84
- 230000028993 immune response Effects 0.000 description 33
- 230000014509 gene expression Effects 0.000 description 26
- 239000013598 vector Substances 0.000 description 26
- 210000004027 cell Anatomy 0.000 description 24
- 239000007924 injection Substances 0.000 description 22
- 238000002347 injection Methods 0.000 description 22
- 230000003053 immunization Effects 0.000 description 19
- 238000002649 immunization Methods 0.000 description 19
- 229960005486 vaccine Drugs 0.000 description 18
- 239000002671 adjuvant Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 210000003205 muscle Anatomy 0.000 description 15
- 108060001084 Luciferase Proteins 0.000 description 14
- 239000005089 Luciferase Substances 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 13
- 241000699670 Mus sp. Species 0.000 description 13
- 238000000034 method Methods 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 241000277331 Salmonidae Species 0.000 description 12
- 208000015181 infectious disease Diseases 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 241000124008 Mammalia Species 0.000 description 9
- 241000700605 Viruses Species 0.000 description 9
- 239000013604 expression vector Substances 0.000 description 9
- 210000002816 gill Anatomy 0.000 description 9
- 230000006698 induction Effects 0.000 description 9
- 150000002632 lipids Chemical class 0.000 description 9
- 241000252212 Danio rerio Species 0.000 description 8
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 8
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 8
- -1 cationic lipid Chemical class 0.000 description 8
- MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 238000001890 transfection Methods 0.000 description 8
- 241000701022 Cytomegalovirus Species 0.000 description 7
- 108010041986 DNA Vaccines Proteins 0.000 description 7
- 229940021995 DNA vaccine Drugs 0.000 description 7
- 125000002091 cationic group Chemical group 0.000 description 7
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 7
- 239000013613 expression plasmid Substances 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- 230000036039 immunity Effects 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 239000007927 intramuscular injection Substances 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 239000012096 transfection reagent Substances 0.000 description 6
- 238000012286 ELISA Assay Methods 0.000 description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 5
- 230000003308 immunostimulating effect Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 238000010255 intramuscular injection Methods 0.000 description 5
- 239000013603 viral vector Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000024932 T cell mediated immunity Effects 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 4
- 210000003719 b-lymphocyte Anatomy 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 239000010931 gold Substances 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 239000004005 microsphere Substances 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 241000700721 Hepatitis B virus Species 0.000 description 3
- 241000248484 Ichthyophthirius Species 0.000 description 3
- 108091061960 Naked DNA Proteins 0.000 description 3
- 241000277275 Oncorhynchus mykiss Species 0.000 description 3
- 108700008625 Reporter Genes Proteins 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 210000000612 antigen-presenting cell Anatomy 0.000 description 3
- 229940031567 attenuated vaccine Drugs 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000012447 hatching Effects 0.000 description 3
- 230000028996 humoral immune response Effects 0.000 description 3
- 230000008348 humoral response Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 230000003071 parasitic effect Effects 0.000 description 3
- 235000015170 shellfish Nutrition 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- ZMCBYSBVJIMENC-UHFFFAOYSA-N tricaine Chemical compound CCOC(=O)C1=CC=CC(N)=C1 ZMCBYSBVJIMENC-UHFFFAOYSA-N 0.000 description 3
- 229960004854 viral vaccine Drugs 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 241000972773 Aulopiformes Species 0.000 description 2
- 230000003844 B-cell-activation Effects 0.000 description 2
- 108020000946 Bacterial DNA Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 102000009016 Cholera Toxin Human genes 0.000 description 2
- 108010049048 Cholera Toxin Proteins 0.000 description 2
- 201000003883 Cystic fibrosis Diseases 0.000 description 2
- 101100281682 Danio rerio fsta gene Proteins 0.000 description 2
- 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 102100027723 Endogenous retrovirus group K member 6 Rec protein Human genes 0.000 description 2
- 101710091045 Envelope protein Proteins 0.000 description 2
- 108700028146 Genetic Enhancer Elements Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 101710188315 Protein X Proteins 0.000 description 2
- 241000186812 Renibacterium salmoninarum Species 0.000 description 2
- 241000714474 Rous sarcoma virus Species 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 108010006025 bovine growth hormone Proteins 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 230000033687 granuloma formation Effects 0.000 description 2
- 210000004837 gut-associated lymphoid tissue Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000004727 humoral immunity Effects 0.000 description 2
- 210000003000 inclusion body Anatomy 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 229940031348 multivalent vaccine Drugs 0.000 description 2
- 210000000663 muscle cell Anatomy 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000013600 plasmid vector Substances 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 235000019515 salmon Nutrition 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229940031626 subunit vaccine Drugs 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 229940072040 tricaine Drugs 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
- FCVJYKICQNLXAX-XPTLAUCJSA-N (2S)-1-oleoyl-2-methylglycero-3-phosphothionate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](OC)COP(O)(O)=S FCVJYKICQNLXAX-XPTLAUCJSA-N 0.000 description 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 241000607525 Aeromonas salmonicida Species 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 241000237519 Bivalvia Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 206010008761 Choriomeningitis lymphocytic Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 241000607473 Edwardsiella <enterobacteria> Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000003792 Metallothionein Human genes 0.000 description 1
- 108090000157 Metallothionein Proteins 0.000 description 1
- 241000723741 Nodaviridae Species 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 241000606860 Pasteurella Species 0.000 description 1
- 241000269799 Perca fluviatilis Species 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 241001600434 Plectroglyphidodon lacrymatus Species 0.000 description 1
- 241000269980 Pleuronectidae Species 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 206010037742 Rabies Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000277293 Salvelinus alpinus Species 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine kinase Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 210000004712 air sac Anatomy 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229960001212 bacterial vaccine Drugs 0.000 description 1
- RIIWUGSYXOBDMC-UHFFFAOYSA-N benzene-1,2-diamine;hydron;dichloride Chemical compound Cl.Cl.NC1=CC=CC=C1N RIIWUGSYXOBDMC-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 241001233037 catfish Species 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000020639 clam Nutrition 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000006334 disulfide bridging Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006355 external stress Effects 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000003259 immunoinhibitory effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 229940065638 intron a Drugs 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000003670 luciferase enzyme activity assay Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 208000001419 lymphocytic choriomeningitis Diseases 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001937 non-anti-biotic effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229940126578 oral vaccine Drugs 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 229940126583 recombinant protein vaccine Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000012770 revaccination Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 108010089727 siderophore receptors Proteins 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/10011—Birnaviridae
- C12N2720/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/817—Viral vaccine for fish
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US629095P | 1995-11-07 | 1995-11-07 | |
US08/740,805 US5780448A (en) | 1995-11-07 | 1996-11-04 | DNA-based vaccination of fish |
Publications (3)
Publication Number | Publication Date |
---|---|
NO964713D0 NO964713D0 (no) | 1996-11-07 |
NO964713L NO964713L (no) | 1997-05-09 |
NO325343B1 true NO325343B1 (no) | 2008-04-07 |
Family
ID=26675437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19964713A NO325343B1 (no) | 1995-11-07 | 1996-11-07 | DNA-basert vaksinering av fisk ved immersjon |
Country Status (6)
Country | Link |
---|---|
US (2) | US5780448A (fr) |
EP (2) | EP0773295B1 (fr) |
JP (1) | JPH09285291A (fr) |
CA (1) | CA2189831C (fr) |
DK (1) | DK0773295T3 (fr) |
NO (1) | NO325343B1 (fr) |
Families Citing this family (294)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6605712B1 (en) * | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
US5849719A (en) * | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
FR2711670B1 (fr) | 1993-10-22 | 1996-01-12 | Pasteur Institut | Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite. |
US6727230B1 (en) | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
JP4111403B2 (ja) * | 1996-10-11 | 2008-07-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 免疫刺激ポリヌクレオチド/免疫調節分子複合体 |
ATE331030T1 (de) * | 1996-11-04 | 2006-07-15 | Ottawa Health Research Inst | Verfahren zur expression von polypeptide in fishen durch wässerung in dns enthaltende lösung |
AU738384B2 (en) * | 1996-11-04 | 2001-09-20 | Qiagen Gmbh | Cationic reagents for transfection |
EP0855184A1 (fr) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination |
WO1998040100A1 (fr) * | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | UTILISATION D'ACIDES NUCLEIQUES CONTENANT UN DINUCLEOTIDE CpG NON METHYLE EN TANT QU'ADJUVANT |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
TR199902522T2 (xx) * | 1997-04-11 | 2000-04-21 | B. Of S.Visors Of Louisiana State Uni. & Agricul.& | Bal�k patojenlerine kar�� zay�flat�lm�� invazif a��. |
US6010705A (en) * | 1997-04-11 | 2000-01-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Attenuated, invasive vaccines against fish pathogens |
US6339068B1 (en) | 1997-05-20 | 2002-01-15 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
US20040006034A1 (en) * | 1998-06-05 | 2004-01-08 | Eyal Raz | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
US6589940B1 (en) * | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
US6348450B1 (en) * | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
JP2002508386A (ja) | 1997-12-16 | 2002-03-19 | ザ・ユニバーシティー・オブ・サスカチワン・テクノロジーズ・インコーポレーテッド | 導電性金属含有核酸 |
US6153202A (en) * | 1998-03-06 | 2000-11-28 | The United States Of America As Represented By The Secretary Of Agriculture | In ovo methods for utilizing live Edwardsiella ictaluri against enteric septicemia in channel catfish |
CA2323929C (fr) * | 1998-04-03 | 2004-03-09 | University Of Iowa Research Foundation | Procedes et produits servant a stimuler le systeme immunitaire au moyen d'oligonucleotides et de cytokines immunotherapeutiques |
WO1999056755A1 (fr) * | 1998-05-06 | 1999-11-11 | University Of Iowa Research Foundation | Methodes de prevention et de traitement des parasitoses et maladies associees a l'aide d'oligonucleotides cpg |
CA2328406A1 (fr) * | 1998-05-14 | 1999-11-18 | Hermann Wagner | Procedes de regulation de l'hematopoiese au moyen d'oligonucleotides a cpg |
NZ508927A (en) | 1998-05-22 | 2003-12-19 | Ottawa Health Research Inst | Methods and products for inducing mucosal immunity |
US6881561B1 (en) * | 1998-05-27 | 2005-04-19 | Cheil Jedang Corporation | Endonuclease of immune cell, process for producing the same and immune adjuvant using the same |
US6562798B1 (en) * | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
US6462027B2 (en) | 1998-07-06 | 2002-10-08 | University Of Georgia Research Foundation, Inc. | Delivery of nucleic acid into aquatic animals |
US20070071776A1 (en) * | 1998-09-28 | 2007-03-29 | National University Of Singapore | Recombinant Vaccine Against Fish Infectious Diseases |
US7160869B2 (en) * | 1998-12-16 | 2007-01-09 | University Of Saskatchewan | Biologically active metal-containing nucleic acids |
US7326568B2 (en) * | 1999-02-04 | 2008-02-05 | University Of Georgia Research Foundation, Inc. | Recombinant expression of heterologous nucleic acids in protozoa |
US6846481B1 (en) | 1999-02-04 | 2005-01-25 | University Of Georgia Research Foundation, Inc. | Recombinant expression of heterologous nucleic acids in protozoa |
US7026156B1 (en) | 1999-02-04 | 2006-04-11 | The University Of Georgia Research Foundation, Inc. | Diagnostic and protective antigen gene sequences of ichthyophthirius |
EP1151118B1 (fr) * | 1999-02-04 | 2008-04-09 | The University Of Georgia Research Foundation, Inc. | Expression recombinante d'acides nucleiques heterologues dans un protozoaire |
JP5084984B2 (ja) | 1999-02-17 | 2012-11-28 | シーエスエル、リミテッド | 免疫原複合体およびそれに関する方法 |
US7683035B1 (en) | 1999-02-23 | 2010-03-23 | Qiagen, Gmbh | Method of stabilizing and/or isolating nucleic acids |
EP1177440A1 (fr) * | 1999-04-15 | 2002-02-06 | Genetics Institute, Inc. | Proteines secretees et polynucleotides codant ces dernieres |
US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
NO311648B1 (no) * | 1999-05-31 | 2001-12-27 | Genomar Asa | DNA-sekvenser som kan benyttes til vaksine, forebyggende helsearbeid på fisk og akvatiske organismer og ellers innenbiomedisin, vektor, vaksine mot ILA-virus samt diagnostisk sett |
WO2000074650A2 (fr) * | 1999-06-04 | 2000-12-14 | Alza Corporation | Compositions de gel implantables et procede de fabrication |
US6514948B1 (en) * | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
US20040109874A1 (en) * | 1999-11-10 | 2004-06-10 | Powderject Vaccines, Inc. | Induction of mucosal immunity by vaccination via the skin route |
AU2001229677A1 (en) * | 2000-01-28 | 2001-08-07 | Thomas Jefferson University | Recombinant rhabdoviruses as live-viral vaccines for immunodeficiency viruses |
AU2001251407A1 (en) * | 2000-04-07 | 2001-10-23 | The Regents Of The University Of California | Synergistic improvements to polynucleotide vaccines |
US20030022359A1 (en) | 2000-06-20 | 2003-01-30 | Sayre Richard T. | Transgenic algae for delivering antigens to an animal |
JP2003535907A (ja) | 2000-06-22 | 2003-12-02 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 抗体誘導性細胞溶解を促進し、そして癌を処置するための方法 |
US7083858B1 (en) | 2000-07-26 | 2006-08-01 | Worthen Industries, Inc. | Thermally activated adhesive films for the collation of wire staples |
WO2002036618A1 (fr) * | 2000-11-04 | 2002-05-10 | Rna Inc. | Nouveaux genes codant pour les proteines g et m1 d'un virus coreen isole de la necrose hematopoietique infectieuse-scs (nhi-scs) et vaccin permettant de lutter contre le virus de la necrose hematopoietique infectieuse chez un salmonide |
EP1350262B8 (fr) | 2000-12-08 | 2008-08-13 | Coley Pharmaceuticals GmbH | Acides nucleiques du type cpg et procedes d'utilisation correspondants |
US7906492B2 (en) * | 2001-01-16 | 2011-03-15 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
US8034791B2 (en) | 2001-04-06 | 2011-10-11 | The University Of Chicago | Activation of Egr-1 promoter by DNA damaging chemotherapeutics |
EP1390075B1 (fr) * | 2001-04-06 | 2012-01-18 | The University of Chicago | Induction chimiotherapeutique de l'activite du promoteur egr-1 dans la therapie genique |
US20040242523A1 (en) * | 2003-03-06 | 2004-12-02 | Ana-Farber Cancer Institue And The Univiersity Of Chicago | Chemo-inducible cancer gene therapy |
JP4338402B2 (ja) | 2001-05-22 | 2009-10-07 | ユニバーシティ オブ シカゴ | N4ウイルス一本鎖dna依存的rnaポリメラーゼ |
EP1389350A1 (fr) * | 2001-05-24 | 2004-02-18 | University of Saskatchewan Technologies Inc. | Procedes et elements pour circuit a acides nucleiques |
WO2003013597A1 (fr) * | 2001-08-10 | 2003-02-20 | University Of Maryland Biotechnology Institute | Vaccin sous-unite pour le virus de necrose pancreatique infectieux |
IL160157A0 (en) | 2001-08-17 | 2004-07-25 | Coley Pharm Group Inc | Combination motif immune stimulation oligonucleotides with improved activity |
JP4863341B2 (ja) * | 2001-09-06 | 2012-01-25 | Meiji Seikaファルマ株式会社 | ヒラメラブドウイルス感染魚類用dnaワクチン |
US20030091593A1 (en) * | 2001-09-14 | 2003-05-15 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
EP1450856B1 (fr) | 2001-09-14 | 2009-11-11 | Cytos Biotechnology AG | Emballage de cpg dans des particules de type virus : procede de preparation et utilisation correspondante |
AR037038A1 (es) | 2001-10-26 | 2004-10-20 | Baylor College Medicine | Una composicion y metodo para alterar la masa corporal magra y las propiedades oseas en un sujeto |
AU2002340662B2 (en) * | 2001-11-07 | 2008-07-03 | Tekmira Pharmaceuticals Corporation | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
CA2469310C (fr) | 2001-12-11 | 2013-01-29 | Advisys, Inc. | Supplementation administree par plasmides pour le traitement de patients a maladie chronique |
US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
EP2221377B2 (fr) | 2002-02-01 | 2017-05-17 | Life Technologies Corporation | Oligonucletides double brin |
WO2003064621A2 (fr) | 2002-02-01 | 2003-08-07 | Ambion, Inc. | Courts fragments d'arn interferant haute activite visant a reduire l'expression de genes cibles |
US20030158103A1 (en) * | 2002-02-19 | 2003-08-21 | Aqua Bounty Farms, Inc. | Prevention of viral and bacterial disease in shrimp |
US20040147467A1 (en) * | 2002-03-29 | 2004-07-29 | Clouthier Sharon C. | Nucleic acids encoding isav polypeptides |
US20040013649A1 (en) * | 2002-05-10 | 2004-01-22 | Inex Pharmaceuticals Corporation | Cancer vaccines and methods of using the same |
US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
KR100456681B1 (ko) * | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7576066B2 (en) * | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7569553B2 (en) | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US6916474B2 (en) | 2002-07-15 | 2005-07-12 | Board Of Regents, The University Of Texas System | Antibodies with increased affinities for anthrax antigens |
EP2044948B1 (fr) | 2002-08-12 | 2013-10-30 | Jennerex Biotherapeutics ULC | Virus de vaccinia pour utilisation dans une méthode de traitement du cancer |
US7501128B2 (en) * | 2002-09-17 | 2009-03-10 | Novartis Animal Health Us, Inc. | IHNV G protein for immune stimulation |
BR0315810A (pt) | 2002-10-29 | 2005-09-13 | Coley Pharmaceutical Group Ltd | Uso de oligonucleotìdeos cpg no tratamento de infecção por vìrus da hepatite c |
EP1578954A4 (fr) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | Acides nucleiques 5'cpg et leurs methodes d'utilisation |
TW201139672A (en) | 2002-12-13 | 2011-11-16 | Novartis Ag | Immunization of fish with plant-expressed recombinant proteins |
IL153775A0 (en) * | 2003-01-01 | 2003-07-31 | Yissum Res Dev Co | Immunizing fish against viral infection |
WO2004084940A1 (fr) * | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | Encapsulation d'oligonucleotides immunostimulateurs dans des particules pseudovirales, procedes de preparation et utilisations |
TW200424214A (en) * | 2003-04-21 | 2004-11-16 | Advisys Inc | Plasmid mediated GHRH supplementation for renal failures |
US7790189B2 (en) | 2003-05-15 | 2010-09-07 | Mitsui Sugar Co., Ltd. | Immunostimulating agents |
US20070224615A1 (en) * | 2003-07-09 | 2007-09-27 | Invitrogen Corporation | Methods for assaying protein-protein interactions |
CN1894581B (zh) | 2003-07-09 | 2012-02-01 | 生命技术公司 | 检测蛋白-蛋白相互作用的方法 |
GB0317733D0 (en) | 2003-07-29 | 2003-09-03 | Novartis Ag | Organic compounds |
AU2004275876B2 (en) * | 2003-09-25 | 2011-03-31 | Coley Pharmaceutical Gmbh | Nucleic acid-lipophilic conjugates |
US7204993B2 (en) * | 2004-03-18 | 2007-04-17 | The United States Of America As Represented By The Secretary Of Agriculture | Streptococcus agalactiae vaccine |
EP1735435A1 (fr) * | 2004-03-18 | 2006-12-27 | Fred Hutchinson Cancer Research Center | Procedes et compositions impliquant des regions de promoteur s-ship |
TWI235440B (en) * | 2004-03-31 | 2005-07-01 | Advanced Semiconductor Eng | Method for making leadless semiconductor package |
US20080286294A1 (en) * | 2004-05-19 | 2008-11-20 | Agence Francaise De Securite Sanitaire Des Aliment | Nodavirus-Vlp Immunization Composition |
WO2006017279A2 (fr) * | 2004-07-12 | 2006-02-16 | Board Of Regents, The University Of Texas System | Procédés et compositions concernant l'identification des interactions protéine-protéine |
KR100958505B1 (ko) | 2004-07-18 | 2010-05-17 | 씨에스엘 리미티드 | 면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기위한 올리고뉴클레오티드 제제 |
US7334538B1 (en) * | 2004-07-27 | 2008-02-26 | Aquascience Research Group, Inc. | Topical medicants for aquatic animals |
ES2247942B1 (es) * | 2004-08-27 | 2006-10-01 | Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria (Inia) | Construccion genica, vector y vacuna adn para la vacunacion de animales acuaticos. |
ES2534300T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
KR100701672B1 (ko) * | 2004-12-10 | 2007-04-03 | 대한민국 | 한국형 돌돔 이리도바이러스의 유전자 및 이를 이용한 백신 |
AU2006216671A1 (en) * | 2005-02-23 | 2006-08-31 | The Uab Research Foundation | Alkyl-glycoside enhanced vaccination |
EP1904530A2 (fr) * | 2005-07-07 | 2008-04-02 | Coley Pharmaceutical Group, Inc. | Polytherapie associant un anticorps anti-ctla-4 et un oligodesoxynucleotide synthetique a motif cpg destinee au traitement du cancer |
US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
CA2621982C (fr) * | 2005-09-07 | 2017-11-28 | Jennerex Biotherapeutics Ulc | Traitement systemique de cancers metastasiques et/ou systemiquement dissemines a l'aide de poxvirus exprimant le gm-csf |
CN100370023C (zh) * | 2005-11-17 | 2008-02-20 | 中国海洋大学 | 利用大菱鲆鳍细胞系繁殖大菱鲆出血性败血症病毒的方法 |
WO2007080203A1 (fr) * | 2006-01-11 | 2007-07-19 | Instituto Nacional De Investigación Y Tecnología Agraria Y Alimentaria (Inia) | Construction genique, vecteur et vaccin d'adn pour la vaccination d'animaux aquatiques |
US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
US8323644B2 (en) | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
EP2368570A3 (fr) | 2006-01-18 | 2012-05-02 | University Of Chicago | Compositions et procédés liés aux protéines des bactéries staphylocoques |
CN101495636B (zh) | 2006-04-13 | 2012-12-05 | 国立大学法人东京海洋大学 | 锦鲤疱疹病毒(khv)病用dna疫苗 |
WO2008014484A1 (fr) | 2006-07-27 | 2008-01-31 | University Of Maryland, Baltimore | Récepteur cellulaire du facteur antiprolifération |
CN102026645B (zh) * | 2006-09-15 | 2016-01-27 | 渥太华医院研究机构 | 溶瘤弹状病毒 |
BRPI0717474A2 (pt) * | 2006-10-20 | 2014-03-11 | Arizona Board Of Regentes For And On Behalf Of Arizona State University | Cianobactéria modificada |
CA2671264C (fr) | 2006-11-30 | 2015-11-24 | Research Development Foundation | Bibliotheques d'immunoglobulines ameliorees |
NZ578541A (en) * | 2006-12-22 | 2012-04-27 | Soluciones Biotecnologicas Innovacion Ltda | Dna vaccines for fish |
KR20080084528A (ko) | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
EP2155789B1 (fr) | 2007-05-01 | 2013-07-24 | Research Development Foundation | Banques d'immunoglobulines fc |
US20100317084A1 (en) * | 2007-05-10 | 2010-12-16 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens |
EP2150616A4 (fr) | 2007-05-10 | 2011-07-27 | Univ Arizona | Expression régulée d'antigène et/ou atténuation régulée pour accroître l'immunogénicité et/ou la sécurité de vaccins |
CA2697538C (fr) | 2007-08-31 | 2019-02-12 | University Of Chicago | Procedes et compositions associees pour immuniser contre des maladies et des etats staphylococciques des poumons |
GB0717911D0 (en) | 2007-09-14 | 2007-10-24 | Univ Stirling | Vaccine |
US8465755B2 (en) * | 2007-10-05 | 2013-06-18 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against enteric pathogens |
JP5677703B2 (ja) | 2008-01-10 | 2015-02-25 | リサーチ ディベロップメント ファウンデーション | Ehrlichiachaffeensisにのためのワクチンおよび診断 |
PL2245464T3 (pl) | 2008-01-25 | 2017-08-31 | Multivir Inc. | Biomarkery p53 |
RU2010139426A (ru) | 2008-03-17 | 2012-04-27 | Зе Скрипс Ресеч Инститьют (Us) | Комбинация химического и генетического подходов к получению индуцированных плюрипотентных стволовых клеток |
GB0808780D0 (en) * | 2008-05-15 | 2008-06-18 | Big Dna Ltd | Fish vaccines |
KR101648019B1 (ko) | 2008-06-04 | 2016-08-16 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 비-바이러스 접근법을 사용한 iPS 세포의 생산 방법 |
US9175268B2 (en) | 2008-08-12 | 2015-11-03 | Cellular Dynamics International, Inc. | Methods for the production of iPS cells |
US8912146B2 (en) | 2008-08-18 | 2014-12-16 | University Of Maryland, Baltimore | Derivatives of APF and methods of use |
JP2012504660A (ja) | 2008-10-06 | 2012-02-23 | ユニバーシティ オブ シカゴ | 細菌eap、empおよび/またはadsaタンパク質に関連する組成物および方法 |
WO2010045620A1 (fr) | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactérie recombinante pouvant éliciter une réponse immunitaire contre le streptococcus pneumoniae |
JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Mek阻害剤に対する耐性を付与するmek突然変異 |
EP3312269A1 (fr) | 2008-12-17 | 2018-04-25 | The Scripps Research Institute | Génération et entretien de cellules souches |
EP2379720B1 (fr) | 2009-01-20 | 2016-08-17 | Alona Zilberberg | Thérapie anticancéreuse ciblée entraînée par le promoteur de mir-21 |
US20100183523A1 (en) | 2009-01-22 | 2010-07-22 | Wagner Richard E | Dental composition and method |
KR20170102039A (ko) | 2009-04-03 | 2017-09-06 | 유니버시티 오브 시카고 | 단백질 A(SpA) 변이체와 관련된 조성물 및 방법 |
US9163219B2 (en) * | 2009-04-14 | 2015-10-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Single expression vector for generation of a virus with a segmented genome |
EP2424885B1 (fr) | 2009-04-28 | 2016-03-23 | Vanderbilt University | Compositions et procédés pour le traitement de troubles mettant en jeu une apoptose de cellules épithéliales |
GB2483595B (en) | 2009-05-22 | 2017-03-29 | The Arizona Board Of Regents For And On Behalf Of Arizona State Univ | Recombinant bacterium and methods of antigen and nucleic acid delivery |
US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
AU2010254811B2 (en) | 2009-06-05 | 2015-02-19 | FUJIFILM Cellular Dynamics, Inc. | Reprogramming T cells and hematopoietic cells |
US20110053803A1 (en) | 2009-08-26 | 2011-03-03 | Xin Ge | Methods for creating antibody libraries |
ES2848650T3 (es) | 2009-09-14 | 2021-08-11 | Sillajen Biotherapeutics Inc | Terapia combinada contra el cáncer con virus vaccinia oncolítico |
WO2011045573A2 (fr) | 2009-10-15 | 2011-04-21 | University Court Of The University Of Edinburgh | Antigènes staphylococciques |
JP5808331B2 (ja) | 2009-10-16 | 2015-11-10 | ザ スクリプス リサーチ インスティテュート | 多能性細胞の誘導法 |
CN102858959B (zh) | 2009-12-10 | 2016-02-24 | 渥太华医院研究院 | 溶瘤弹状病毒 |
US9062297B2 (en) | 2010-01-13 | 2015-06-23 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Yersinia pestis vaccine |
WO2011091291A1 (fr) | 2010-01-22 | 2011-07-28 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactérie renfermant un acide nucléique régulé par le rfah |
US10080799B2 (en) | 2010-02-12 | 2018-09-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions related to glycoprotein-immunoglobulin fusions |
ES2674682T3 (es) | 2010-02-25 | 2018-07-03 | Dana-Farber Cancer Institute, Inc. | Mutaciones de BRAF que confieren resistencia a inhibidores de BRAF |
WO2011108930A1 (fr) | 2010-03-04 | 2011-09-09 | Interna Technologies Bv | Molécule de miarn définie par sa source et ses utilisations thérapeutiques et en diagnostic pour maladies ou états associés à l'emt |
CN102959076B (zh) | 2010-03-31 | 2015-09-16 | 斯克里普斯研究所 | 重编程细胞 |
JP2013523818A (ja) | 2010-04-05 | 2013-06-17 | ザ・ユニバーシティー・オブ・シカゴ | 免疫反応のエンハンサーとしてのプロテインA(SpA)抗体に関連する組成物および方法 |
WO2011126976A1 (fr) | 2010-04-07 | 2011-10-13 | Vanderbilt University | Vaccins à réovirus et procédés d'utilisation associés |
DK2560672T3 (en) | 2010-04-19 | 2014-03-17 | Res Dev Foundation | RTEF-1 variants and their uses |
WO2011150421A2 (fr) | 2010-05-28 | 2011-12-01 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Bactérie recombinante permettant de diminuer la croissance tumorale |
ES2873933T3 (es) | 2010-06-09 | 2021-11-04 | Dana Farber Cancer Inst Inc | Una mutación de MEK1 que confiere resistencia a inhibidores de RAF y de MEK |
ES2685171T3 (es) | 2010-06-14 | 2018-10-05 | The Scripps Research Institute | Reprogramación de células a un nuevo destino |
CA2802087A1 (fr) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Compendium de modeles de cellules souches prefabriques pour l'interrogation d'une reponse biologique |
EP2582794B2 (fr) | 2010-06-15 | 2024-04-24 | FUJIFILM Cellular Dynamics, Inc. | Génération de cellules souches pluripotentes induites à partir de petits volumes de sang périphérique |
KR20130093084A (ko) | 2010-07-02 | 2013-08-21 | 더 유니버시티 오브 시카고 | 단백질 A(SpA) 변이체와 관련된 조성물 및 방법 |
NZ719520A (en) | 2010-07-06 | 2017-07-28 | Int Tech Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
CA2804595C (fr) | 2010-07-07 | 2018-11-13 | Cellular Dynamics International, Inc. | Production de cellules endotheliales par programmation |
CA2806858C (fr) | 2010-08-04 | 2021-06-15 | Cellular Dynamics International, Inc. | Reprogrammation des lymphocytes b immortalises |
JP5793194B2 (ja) | 2010-09-09 | 2015-10-14 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 感染防御ブドウ球菌抗原が関与する方法および組成物 |
FR2964569B1 (fr) | 2010-09-10 | 2012-10-19 | Ct De Cooperation Internationale En Rech Agronomique Pour Le Dev Cirad | Nouveaux liposomes de vaccination genique |
EP3536337A1 (fr) | 2010-09-22 | 2019-09-11 | The Regents of the University of Colorado, a body corporate | Applications thérapeutiques de smad7 |
EP2622065B1 (fr) | 2010-10-01 | 2016-09-07 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Manipulation de la fonction de cellules souches par des isoformes p53 |
US9732319B2 (en) | 2010-12-22 | 2017-08-15 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
JP6121910B2 (ja) | 2011-01-04 | 2017-04-26 | シラジェン バイオセラピューティクス インコーポレイテッド | 腫瘍溶解性ワクシニアウイルスの投与による腫瘍抗原に対する抗体の生成および腫瘍特異的補体依存性細胞傷害の生成 |
EP2474617A1 (fr) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | MIR pour traiter une nouvelle angiogenèse |
US8952132B2 (en) | 2011-02-07 | 2015-02-10 | Research Development Foundation | Engineered immunoglobulin FC polypeptides |
WO2012109208A2 (fr) | 2011-02-08 | 2012-08-16 | Cellular Dynamics International, Inc. | Production de précurseurs hématopoïétiques obtenus par programmation |
EP3406628A1 (fr) | 2011-04-08 | 2018-11-28 | Evaxion Biotech ApS | Protéines et acides nucléiques utiles dans des vaccins ciblant le staphylococcus aureus |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
WO2012156535A1 (fr) | 2011-05-19 | 2012-11-22 | Fundación Progreso Y Salud | Système tet-on lentiviral à double promoteur très inductible |
ES2627529T3 (es) | 2011-06-08 | 2017-07-28 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Composiciones para tratamiento de glioblastoma |
WO2013009825A1 (fr) | 2011-07-11 | 2013-01-17 | Cellular Dynamics International, Inc. | Procédés de reprogrammation cellulaire et d'ingénierie génomique |
CN103906535B (zh) | 2011-08-15 | 2017-07-14 | 芝加哥大学 | 与葡萄球菌蛋白a的抗体相关的组合物和方法 |
US20130101664A1 (en) | 2011-08-18 | 2013-04-25 | Donald W. Kufe | Muc1 ligand traps for use in treating cancers |
US9345760B2 (en) | 2011-09-09 | 2016-05-24 | Advanced Bionutrition Corporation | IPNV-ISAV bivalent vaccine using a virus-like particle-based platform and methods of using the same |
US9273102B2 (en) | 2011-10-12 | 2016-03-01 | Niels Iversen Møller | Peptides derived from Campylobacter jejuni and their use in vaccination |
DK2788110T3 (en) | 2011-12-08 | 2019-02-11 | Pentair Water Pool & Spa Inc | AQUACULTURE SYSTEM AND PROCEDURE TO OPERATE A PUMP IN SUCH A SYSTEM |
US10174314B2 (en) | 2011-12-22 | 2019-01-08 | Interna Technologies B.V. | MiRNA for treating head and neck cancer |
WO2013144579A1 (fr) | 2012-03-30 | 2013-10-03 | Heriot-Watt University | Utilisation de flagelline en tant que vaccin |
CA2910320A1 (fr) | 2012-04-26 | 2013-10-31 | University Of Chicago | Compositions et procedes associes a des anticorps qui neutralisent l'activite coagulase dans une maladie a staphylococcus aureus |
EP3805395A1 (fr) | 2012-04-26 | 2021-04-14 | University Of Chicago | Antigènes des staphylocoques coagulase et leurs méthodes d'utilisation |
US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
EP2870238A4 (fr) | 2012-07-05 | 2016-03-09 | Ohio State Innovation Foundation | Compositions et procédés associés à des vaccins viraux |
CN104736169B (zh) * | 2012-09-10 | 2018-04-17 | 国立大学法人东京海洋大学 | 海产鱼的类结节病用dna疫苗 |
WO2014046410A1 (fr) * | 2012-09-20 | 2014-03-27 | 중앙대학교 산학협력단 | Procédé de production de particules de type virus de nodavirus, lignée de cellules de levure exprimant celui-ci, et composition de vaccin contenant celui-ci |
WO2014065945A1 (fr) | 2012-10-23 | 2014-05-01 | The Board Of Regents Of The University Of Texas System | Anticorps avec des domaines fc d'igg modifiés |
US10201556B2 (en) | 2012-11-06 | 2019-02-12 | Interna Technologies B.V. | Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated B-raf pathway |
WO2014116721A1 (fr) | 2013-01-22 | 2014-07-31 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Vecteur geminiviral pour l'expression du rituximab |
EP2958990B1 (fr) | 2013-02-20 | 2019-10-16 | Regeneron Pharmaceuticals, Inc. | Modification génétique de rats |
US10363293B2 (en) | 2013-02-21 | 2019-07-30 | Turnstone Limited Partnership | Vaccine composition |
WO2014130770A1 (fr) | 2013-02-22 | 2014-08-28 | Cellular Dynamics International, Inc. | Production d'hépatocytes par programmation aller par génie génétique et chimique combiné |
EP2961386B1 (fr) | 2013-02-28 | 2019-07-10 | The General Hospital Corporation | Compositions de profilage de miarn et procédés d'utilisation |
US20160010094A1 (en) | 2013-03-01 | 2016-01-14 | University Of Pretoria | Transgenic cell selection |
CN105358704B (zh) | 2013-03-08 | 2020-01-03 | 科罗拉多大学董事会 | Ptd-smad7治疗剂 |
EP2969158A4 (fr) | 2013-03-14 | 2016-12-21 | Pentair Water Pool & Spa Inc | Système de régulation de dioxyde de carbone destiné à l'aquaculture |
WO2014145661A1 (fr) | 2013-03-15 | 2014-09-18 | Pentair Water Pool And Spa, Inc. | Système de régulation d'oxygène dissous pour une aquaculture |
US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
AU2014292926B2 (en) | 2013-07-25 | 2020-03-05 | Exicure Operating Company | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
CA2923857A1 (fr) | 2013-09-09 | 2015-03-12 | Figene, Llc | Therapie genique pour la regeneration de cellules de type chondrocytes ou cartilagineuses |
CA2929555A1 (fr) | 2013-11-08 | 2015-05-14 | Baylor Research Institute | La localisation nucleaire de glp-1 stimule la regeneration myocardique et entraine la regression d'une insuffisance cardiaque |
US20170002064A1 (en) | 2013-11-08 | 2017-01-05 | The Board Of Regents Of The University Of Texas System | Vh4 antibodies against gray matter neuron and astrocyte |
MX369329B (es) * | 2013-11-15 | 2019-11-05 | Univ Maryland | Metodo para la produccion de peces infertiles y animales acuaticos productores de huevos y para la administracion de compuestos en huevos y embriones. |
EP4227685A3 (fr) | 2013-12-03 | 2024-02-28 | Evaxion Biotech A/S | Proteines et acides nucleiques utiles dans des vaccins ciblant staphylococcus aureus |
KR102448454B1 (ko) | 2014-01-29 | 2022-09-28 | 다나-파버 캔서 인스티튜트 인크. | Muc1-c/세포외 도메인 (muc1-c/ecd)에 대한 항체 |
US10214741B2 (en) | 2014-02-14 | 2019-02-26 | University Of Utah Research Foundation | Methods and compositions for inhibiting retinopathy of prematurity |
WO2015130783A1 (fr) | 2014-02-25 | 2015-09-03 | Research Development Foundation | Peptides sty pour l'inhibition de l'angiogenèse |
EP3805369A1 (fr) | 2014-03-04 | 2021-04-14 | Fate Therapeutics, Inc. | Procédés améliorés de reprogrammation et plateformes de culture cellulaire |
US20170107486A1 (en) | 2014-04-21 | 2017-04-20 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
PL3164113T3 (pl) | 2014-06-04 | 2019-09-30 | Exicure, Inc. | Wielowartościowe dostarczanie modulatorów immunologicznych w liposomowych kolistych kwasach nukleinowych do zastosowań profilaktycznych lub terapeutycznych |
US20180363070A9 (en) | 2014-08-12 | 2018-12-20 | Univ Wayne State | Systems and methods to detect stem cell stress and uses thereof |
WO2016075305A2 (fr) | 2014-11-13 | 2016-05-19 | Evaxion Biotech Aps | Peptides dérivés d'acinetobacter baumannii et leur utilisation en vaccination |
CA2968531A1 (fr) | 2014-11-21 | 2016-05-26 | Northwestern University | Absorption cellulaire specifique a une sequence de conjugues nanoparticulaires d'acides nucleiques spheriques |
EP4279080A3 (fr) | 2015-01-12 | 2024-02-21 | Evaxion Biotech A/S | Traitement et prophylaxie d'une infection k. pneumoniae |
WO2016120697A1 (fr) | 2015-01-28 | 2016-08-04 | Sabic Global Technologies B.V. | Procédés et compositions pour une production à haut rendement de biocarburant et/ou de biomasse |
WO2016130516A1 (fr) | 2015-02-09 | 2016-08-18 | Research Development Foundation | Polypeptides ayant un domaine fc d'immunoglobuline modifié manifestant une activation du complément améliorée |
US11421229B2 (en) | 2015-02-20 | 2022-08-23 | Baylor College Of Medicine | p63 inactivation for the treatment of heart failure |
WO2016196366A1 (fr) | 2015-05-29 | 2016-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Extension de durée de vie réplicative dans des maladies de vieillissement prématuré à l'aide d'isoformes p53 |
EP3317295B1 (fr) | 2015-07-04 | 2022-05-18 | Evaxion Biotech A/S | Protéines et acides nucléiques utiles dans des vaccins ciblant pseudomonas aeruginosa |
DK3328423T3 (da) * | 2015-07-31 | 2021-07-26 | Bayer Animal Health Gmbh | Forbedret immunrespons hos fisk |
WO2017040380A2 (fr) | 2015-08-28 | 2017-03-09 | Research Development Foundation | Variants de fc d'anticorps modifiés |
AU2016338680B2 (en) | 2015-10-16 | 2022-11-17 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
WO2017070337A1 (fr) | 2015-10-20 | 2017-04-27 | Cellular Dynamics International, Inc. | Procédés de différenciation dirigée de cellules souches pluripotentes en cellules immunes |
JP6983771B2 (ja) | 2015-10-30 | 2021-12-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | 幹細胞からt細胞を作製する方法および該t細胞を用いた免疫療法的方法 |
WO2017079202A1 (fr) | 2015-11-02 | 2017-05-11 | Board Of Regents, The University Of Texas System | Méthodes d'activation de cd40 et blocage de points de contrôle immunitaires |
US20190038713A1 (en) | 2015-11-07 | 2019-02-07 | Multivir Inc. | Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
CA3004438A1 (fr) | 2015-11-09 | 2017-05-18 | The Children's Hospital Of Philadelphia | Glypicane 2 a utiliser en tant que marqueur cancereux et cible therapeutique |
US11064680B2 (en) * | 2015-11-13 | 2021-07-20 | Applied Lifesciences And Systems Llc | Automatic system and method for injecting a substance into an animal |
CA3011920A1 (fr) * | 2016-02-02 | 2017-08-10 | Benchmark Animal Health Limited | Methodes de production de virus |
WO2017144523A1 (fr) | 2016-02-22 | 2017-08-31 | Evaxion Biotech Aps | Protéines et acides nucléiques utiles dans des vaccins ciblant staphylococcus aureus |
US20190177391A1 (en) | 2016-03-31 | 2019-06-13 | Baylor Research Institute | Angiopoietin-like protein 8 (angptl8) |
WO2017216384A1 (fr) | 2016-06-17 | 2017-12-21 | Evaxion Biotech Aps | Vaccination ciblant ichthyophthirius multifiliis |
WO2017220787A1 (fr) | 2016-06-24 | 2017-12-28 | Evaxion Biotech Aps | Vaccin contre l'infection provoquée par aeromonas salmonicida |
US20180030478A1 (en) | 2016-07-01 | 2018-02-01 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
WO2018015575A1 (fr) | 2016-07-22 | 2018-01-25 | Evaxion Biotech Aps | Protéines chimériques pour induire une immunité vis-à-vis d'une infection à s. aureus |
US9963498B2 (en) | 2016-08-18 | 2018-05-08 | Wisconsin Alumni Research Foundation | Peptides that inhibit syndecan-1 activation of VLA-4 and IGF-1R |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
AU2017319702A1 (en) | 2016-09-02 | 2019-04-11 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
JP7212615B2 (ja) | 2016-10-05 | 2023-01-25 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | 多能性幹細胞からhlaホモ接合免疫細胞への指向分化方法 |
CN110050061A (zh) | 2016-10-05 | 2019-07-23 | 富士胶片细胞动力公司 | 从具有MeCP2破坏的诱导多能干细胞生成成熟谱系 |
EP3551226A1 (fr) | 2016-12-12 | 2019-10-16 | MultiVir Inc. | Méthodes et compositions comprenant une thérapie génique virale et un inhibiteur de point de contrôle immunitaire pour le traitement et la prévention du cancer et des maladies infectieuses |
WO2018127545A1 (fr) | 2017-01-05 | 2018-07-12 | Evaxion Biotech Aps | Vaccins ciblant pseudomonas aeruginosa |
JP7181219B2 (ja) | 2017-04-18 | 2022-11-30 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | 抗原特異的免疫エフェクター細胞 |
CN107099496B (zh) * | 2017-04-25 | 2021-04-13 | 中国农业科学院哈尔滨兽医研究所 | 融合表达鸡传染性法氏囊病毒vp2蛋白和沙门菌属外膜蛋白的重组乳酸菌菌株及其用途 |
US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
EP3704250A1 (fr) | 2017-11-03 | 2020-09-09 | InteRNA Technologies B.V. | Molécule de micro-arn, équivalent, antagomir, ou source de cette molécule pour le traitement et/ou le diagnostic d'une affection et/ou d'une maladie associée à une déficience neuronale ou pour la (ré)génération neuronale |
WO2019099493A1 (fr) | 2017-11-14 | 2019-05-23 | Henry Ford Health System | Compositions destinées à être utilisées dans le traitement et la prévention de troubles cardiovasculaires résultant d'une lésion cérébrovasculaire |
CA3083873A1 (fr) | 2017-12-06 | 2019-06-13 | Intervet International B.V. | Utilisation d'une proteine non structurale issue de prv pour proteger contre l'inflammation du cur et du muscle squelettique |
RU2020124404A (ru) | 2018-01-05 | 2022-01-24 | Оттава Хоспитл Рисерч Инститьют | Векторы на основе модифицированного вируса осповакцины |
WO2019145399A1 (fr) | 2018-01-24 | 2019-08-01 | Evaxion Biotech Aps | Vaccins pour la prophylaxie d'infections par s. aureus |
WO2020036635A2 (fr) | 2018-03-19 | 2020-02-20 | Multivir Inc. | Procédés et compositions comprenant une thérapie génique suppressive de tumeur et des agonistes de cd122/cd132 pour le traitement du cancer |
SG11202009697RA (en) | 2018-03-30 | 2020-10-29 | Univ Geneve | Micro rna expression constructs and uses thereof |
RU2702716C2 (ru) * | 2018-04-03 | 2019-10-09 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Рекомбинантная плазмида pHis6-flagG-protE, обеспечивающая синтез рекомбинантного химерного белка, включающего эпитопы гликопротеина Е вируса клещевого энцефалита и флагеллин G S.typhii и используемого в качестве основы для вакцины против вируса клещевого энцефалита |
SG11202102058UA (en) | 2018-08-30 | 2021-03-30 | Tenaya Therapeutics Inc | Cardiac cell reprogramming with myocardin and ascl1 |
US20220000932A1 (en) | 2018-09-28 | 2022-01-06 | Henry Ford Health System | Use of extracellular vesicles in combination with tissue plasminogen activator and/or thrombectomy to treat stroke |
WO2020083904A1 (fr) | 2018-10-22 | 2020-04-30 | Evaxion Biotech Aps | Vaccins ciblant m. catharrhalis |
WO2020171889A1 (fr) | 2019-02-19 | 2020-08-27 | University Of Rochester | Blocage de l'accumulation des lipides ou de l'inflammation dans la maladie oculaire thyroïdienne |
EP3931206A1 (fr) | 2019-02-27 | 2022-01-05 | Evaxion Biotech ApS | Vaccins ciblant h. influenzae |
US20230137971A1 (en) | 2019-07-11 | 2023-05-04 | Tenaya Therapeutics Inc. | Cardiac cell reprogramming with micrornas and other factors |
AU2020317009A1 (en) | 2019-07-19 | 2022-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric antigen receptors containing Glypican 2 binding domains |
US20210147525A1 (en) | 2019-10-18 | 2021-05-20 | The Regents Of The University Of California | Methods and compositions for treating pathogenic blood vessel disorders |
WO2021113644A1 (fr) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinaisons comprenant un activateur de lymphocytes t cd8+, un inhibiteur de point de contrôle immunitaire et une radiothérapie en vue d'obtenir des effets ciblés et abscopal pour le traitement du cancer |
EP4087593A1 (fr) | 2020-01-06 | 2022-11-16 | Evaxion Biotech A/S | Vaccins ciblant neisseria gonorrhoeae |
JP2023515672A (ja) | 2020-03-02 | 2023-04-13 | テナヤ セラピューティクス, インコーポレイテッド | 心筋細胞発現マイクロrnaによる遺伝子ベクター制御 |
JP2023520359A (ja) | 2020-03-25 | 2023-05-17 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | 放射性核種イメージングのためのレポーター系 |
WO2021240240A1 (fr) | 2020-05-27 | 2021-12-02 | Antion Biosciences Sa | Molécules d'adaptateurs pour rediriger des lymphocytes t à car vers un antigène d'intérêt |
KR20230019453A (ko) | 2020-05-29 | 2023-02-08 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 망막 색소 상피 세포 및 광수용체의 이중 세포 응집체 및 이의 사용 방법 |
CN116323677A (zh) | 2020-05-29 | 2023-06-23 | 富士胶片细胞动力公司 | 视网膜色素上皮和光感受器双层及其用途 |
WO2022053130A1 (fr) | 2020-09-09 | 2022-03-17 | Sid Alex Group, S.R.O. | Antago-mir-155 pour le traitement des cancers induits par v-src, c-src-tyrosine kinase |
JP2024508088A (ja) | 2021-02-09 | 2024-02-22 | ユニバーシティ オブ ヒューストン システム | 全身送達及び抗腫瘍活性の向上のための腫瘍溶解性ウイルス |
WO2022175815A1 (fr) | 2021-02-19 | 2022-08-25 | Pfizer Inc. | Procédés de protection de l'arn |
CN117242173A (zh) | 2021-05-03 | 2023-12-15 | 安斯泰来再生医药协会 | 产生成熟角膜内皮细胞的方法 |
AU2022270117A1 (en) | 2021-05-07 | 2023-11-02 | Astellas Institute For Regenerative Medicine | Methods of generating mature hepatocytes |
US20220389436A1 (en) | 2021-05-26 | 2022-12-08 | FUJIFILM Cellular Dynamics, Inc. | Methods to prevent rapid silencing of genes in pluripotent stem cells |
EP4366762A1 (fr) | 2021-07-05 | 2024-05-15 | Evaxion Biotech A/S | Vaccins ciblant neisseria gonorrhoeae |
WO2023089556A1 (fr) | 2021-11-22 | 2023-05-25 | Pfizer Inc. | Réduction du risque de mimétisme antigènique dans des médicaments immunogènes |
WO2023144779A1 (fr) | 2022-01-28 | 2023-08-03 | Pfizer Inc. | Variants d'antigène de coronavirus |
WO2023178191A1 (fr) | 2022-03-16 | 2023-09-21 | University Of Houston System | Système d'administration de gène hsv persistant |
GB202205265D0 (en) | 2022-04-11 | 2022-05-25 | Mogrify Ltd | Cell conversion |
WO2023213393A1 (fr) | 2022-05-04 | 2023-11-09 | Evaxion Biotech A/S | Variants de protéine staphylococcique et parties tronquées |
GB202206507D0 (en) | 2022-05-04 | 2022-06-15 | Antion Biosciences Sa | Expression construct |
WO2023239940A1 (fr) | 2022-06-10 | 2023-12-14 | Research Development Foundation | Variants de fc igg1 sélectifs de fcriib modifiés et leurs utilisations |
US20240003871A1 (en) | 2022-06-29 | 2024-01-04 | FUJIFILM Cellular Dynamics, Inc. | Ipsc-derived astrocytes and methods of use thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4009259A (en) * | 1975-10-03 | 1977-02-22 | Wildlife Vaccines, Inc. | Immersion method for treating aquatic animals |
IL74289A (en) * | 1985-02-10 | 1989-02-28 | Israel State | Vaccine system comprising a live-non-virulent vaccine and an adjuvant |
US5354555A (en) * | 1985-04-10 | 1994-10-11 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Vaccine to control the viral infection of fish |
US5165925A (en) * | 1989-05-02 | 1992-11-24 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Vaccine for immunizing fish against infectious pancreatic necrosis virus |
US5076208A (en) * | 1990-09-14 | 1991-12-31 | Massachusetts Institute Of Technology | Ultrasound-mediated administration of compounds into aquatic animals |
US5512421A (en) * | 1991-02-19 | 1996-04-30 | The Regents Of The University Of California | Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors |
DE69231947T2 (de) * | 1991-03-15 | 2002-05-29 | Hsc Res Dev Lp | Genherstellung zur produktion von transgenfisch |
IT1256575B (it) * | 1992-12-10 | 1995-12-11 | Cesalpino Andrea Fond | Procedimento per la preparazione di immunogeni costituiti da antigeni esogeni capaci di generare non solo la risposta immune dei linfociti t helper,ma anche una efficace risposta dei linfociti t citotossici; e immunogeni cosi' ottenibili. |
EP0702516A4 (fr) * | 1993-06-01 | 1998-04-22 | Life Technologies Inc | Immunisation genetique a l'aide de lipides cationiques |
FR2719316B1 (fr) * | 1994-04-28 | 1996-05-31 | Idm | Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules. |
-
1996
- 1996-11-04 US US08/740,805 patent/US5780448A/en not_active Expired - Lifetime
- 1996-11-07 EP EP96117859A patent/EP0773295B1/fr not_active Expired - Lifetime
- 1996-11-07 EP EP05001566A patent/EP1538210A3/fr not_active Withdrawn
- 1996-11-07 NO NO19964713A patent/NO325343B1/no not_active IP Right Cessation
- 1996-11-07 JP JP8295565A patent/JPH09285291A/ja active Pending
- 1996-11-07 DK DK96117859T patent/DK0773295T3/da active
- 1996-11-07 CA CA002189831A patent/CA2189831C/fr not_active Expired - Lifetime
-
1998
- 1998-07-14 US US09/115,423 patent/US6180614B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0773295B1 (fr) | 2006-06-21 |
NO964713D0 (no) | 1996-11-07 |
CA2189831A1 (fr) | 1997-05-08 |
DK0773295T3 (da) | 2006-12-27 |
EP0773295A2 (fr) | 1997-05-14 |
EP1538210A3 (fr) | 2006-02-01 |
JPH09285291A (ja) | 1997-11-04 |
EP0773295A3 (fr) | 1999-06-16 |
CA2189831C (fr) | 2006-01-10 |
NO964713L (no) | 1997-05-09 |
US6180614B1 (en) | 2001-01-30 |
EP1538210A2 (fr) | 2005-06-08 |
US5780448A (en) | 1998-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5780448A (en) | DNA-based vaccination of fish | |
EP0821583B1 (fr) | Vaccins adn contre les infections causees par le rotavirus | |
AU692152B2 (en) | Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments | |
Kanellos et al. | DNA vaccination can protect Cyprinus Carpio against spring viraemia of carp virus | |
EP0914440B1 (fr) | Vaccination avec des acides nucleiques contre les infections parvovirales | |
HU222369B1 (hu) | Polinukleotidot tartalmazó tuberkulózis elleni oltóanyag | |
JP2004510440A (ja) | 高発現可能遺伝子 | |
JP2004528012A (ja) | 改善された免疫応答を誘導し得る発現ベクターおよびこのベクターの使用方法 | |
US20040147721A1 (en) | Antigens and vectors for vaccination | |
US6462027B2 (en) | Delivery of nucleic acid into aquatic animals | |
EP0839913B1 (fr) | Möthode d'expression de polypeptides dans des poissons par immersion dans une solution contenant des plasmides d'ADN . | |
Alonso et al. | A fish specific expression vector containing the interferon regulatory factor 1A (IRF1A) promoter for genetic immunization of fish | |
ES2247942B1 (es) | Construccion genica, vector y vacuna adn para la vacunacion de animales acuaticos. | |
NO337372B1 (no) | DNA-ekspresjonsvektor som koder for en del av den infeksiøse hematopoietiske nekrosevirus IHNV G-proteinkodende sekvensen og fusjonsprotein omfattende en del av IHNV G-proteinet, samt nukleinsyrevaksine omfattende disse og anvendelse av en DNA-ekspresjonsvektor for fremstilling av et medikament for forebyggelse eller behandling av patogen infeksjon hos fisk. | |
WO2009138752A2 (fr) | Vaccin pour poisson | |
CA2499302A1 (fr) | Immunisation de poissons a l'aide d'adn, par des techniques d'immersion | |
JP2002531135A (ja) | クラミジア感染に対する2段階免疫感作法 | |
JP2001151698A (ja) | インフルエンザワクチン | |
ES2358733T3 (es) | Vacuna derivada de levadura contra ipnv. | |
EP3037539A1 (fr) | Vaccin recombinant dirigé contre le virus de la septicémie hémorragique virale |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |