MX369329B - Metodo para la produccion de peces infertiles y animales acuaticos productores de huevos y para la administracion de compuestos en huevos y embriones. - Google Patents
Metodo para la produccion de peces infertiles y animales acuaticos productores de huevos y para la administracion de compuestos en huevos y embriones.Info
- Publication number
- MX369329B MX369329B MX2016006315A MX2016006315A MX369329B MX 369329 B MX369329 B MX 369329B MX 2016006315 A MX2016006315 A MX 2016006315A MX 2016006315 A MX2016006315 A MX 2016006315A MX 369329 B MX369329 B MX 369329B
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- producing
- eggs
- aquatic animals
- egg
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 235000013601 eggs Nutrition 0.000 title abstract 6
- 241000251468 Actinopterygii Species 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 210000002257 embryonic structure Anatomy 0.000 title 1
- 208000021267 infertility disease Diseases 0.000 title 1
- 230000004913 activation Effects 0.000 abstract 2
- 230000018109 developmental process Effects 0.000 abstract 2
- 230000002710 gonadal effect Effects 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 108700039887 Essential Genes Proteins 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 238000009360 aquaculture Methods 0.000 abstract 1
- 244000144974 aquaculture Species 0.000 abstract 1
- 230000011712 cell development Effects 0.000 abstract 1
- 101150100366 end gene Proteins 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 210000004602 germ cell Anatomy 0.000 abstract 1
- 238000007654 immersion Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 230000000270 postfertilization Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/40—Monitoring or fighting invasive species
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Marine Sciences & Fisheries (AREA)
- Farming Of Fish And Shellfish (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
La presente invención se refiere a métodos para la producción de peces y animales acuáticos reproductivamente estériles para la acuicultura, el comercio de acuarios y el control de especies invasoras. Los métodos incluyen la alteración del desarrollo gonadal mediante la administración de compuestos que conducen a la falla en el desarrollo gonadal fértil. Los compuestos pueden ser administrados a los huevos antes de la fertilización o la activación en agua o después de la fertilización y la activación en agua contactando a los huevos no fertilizados o los huevos fertilizados previamente activados en agua o los huevos fertilizados con un medio de inmersión que incluye el compuesto de interés. Los compuestos pueden ser conjugados con un compuesto transportador molecular eficaz para el transporte coriónico del conjugado. Los compuestos pueden ser oligómeros de morfolino anti-sentidos que son capaces de suprimir con eficacia la expresión del gen dead end u otros genes esenciales para el desarrollo de la célula germinal en peces y otros animales acuáticos productores de huevo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361904652P | 2013-11-15 | 2013-11-15 | |
US201461968458P | 2014-03-21 | 2014-03-21 | |
US201462050815P | 2014-09-16 | 2014-09-16 | |
PCT/US2014/065698 WO2015073819A1 (en) | 2013-11-15 | 2014-11-14 | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016006315A MX2016006315A (es) | 2017-01-19 |
MX369329B true MX369329B (es) | 2019-11-05 |
Family
ID=53058068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016006315A MX369329B (es) | 2013-11-15 | 2014-11-14 | Metodo para la produccion de peces infertiles y animales acuaticos productores de huevos y para la administracion de compuestos en huevos y embriones. |
Country Status (18)
Country | Link |
---|---|
US (3) | US9999208B2 (es) |
EP (1) | EP3068216B1 (es) |
JP (1) | JP6669650B2 (es) |
CN (1) | CN105764333B (es) |
AU (1) | AU2014348473B2 (es) |
CA (1) | CA2929496C (es) |
CL (1) | CL2016001113A1 (es) |
DK (1) | DK180609B1 (es) |
ES (1) | ES2981867T3 (es) |
FI (1) | FI3068216T3 (es) |
HR (1) | HRP20240918T1 (es) |
IL (1) | IL245293B (es) |
MX (1) | MX369329B (es) |
NZ (1) | NZ719421A (es) |
PL (1) | PL3068216T3 (es) |
PT (1) | PT3068216T (es) |
RU (1) | RU2723037C2 (es) |
WO (1) | WO2015073819A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2723037C2 (ru) | 2013-11-15 | 2020-06-08 | Юниверсити Оф Мэриленд Балтимор Каунти | Способ получения бесплодной рыбы и бесплодных производящих икру водных животных и способ доставки соединений в икру и эмбрионы |
MX2017000555A (es) * | 2014-07-14 | 2017-08-10 | Univ Washington State | Desactivacion de nanos que produce ablacion de celulas de linea germinal. |
DK180094B1 (en) | 2015-05-19 | 2020-04-27 | University Of Maryland At Baltimore County | METHODS OF ADMINISTRATION IN FISH EGGS AND EMBRYOS FOR PHARMACEUTICAL CREATION, MEDICINE TOXICITY ASSAY AND MANUFACTURE OF INFERTILE FISH. |
CN106614142B (zh) * | 2016-12-28 | 2019-12-03 | 浙江省海洋水产研究所 | 一种杂交不育黄姑鱼的生产方法 |
CN109864017A (zh) * | 2017-12-05 | 2019-06-11 | 柳州市渔业技术推广站 | 山塘水库高产高效渔业养殖方法 |
FI3723479T3 (fi) | 2017-12-15 | 2024-08-21 | Acd Pharmaceuticals As | Steriilien kalojen tuotantomenetelmät |
CN108668984B (zh) * | 2018-04-15 | 2021-02-12 | 广西壮族自治区水产科学研究院 | 一种罗非鱼苗种高密度运输方法 |
CN108739537B (zh) * | 2018-06-06 | 2021-02-09 | 江苏省淡水水产研究所 | 一种粉白体色斑点叉尾鮰家系制种方法 |
CN112553205B (zh) * | 2020-12-29 | 2022-09-13 | 中国水产科学研究院淡水渔业研究中心 | 一种抑制黄颡鱼性腺发育的反义rna序列组合和方法及应用 |
CN114982678B (zh) * | 2022-07-21 | 2024-02-23 | 新疆额河生态养殖科技有限公司 | 一种北极茴鱼人工繁殖操作方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5780448A (en) * | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
WO2005001028A2 (en) | 2003-05-19 | 2005-01-06 | University Of Hawaii | Method for direct nucleic acid uptake |
US7194978B2 (en) | 2003-08-22 | 2007-03-27 | University Of Maryland Biotechnology Institute | Inducing sterility in fish by disrupting the development of the GnRH system |
CN1294808C (zh) * | 2003-09-26 | 2007-01-17 | 中国科学院水生生物研究所 | 不育转基因鱼的制备方法 |
CN1274822C (zh) * | 2004-02-19 | 2006-09-13 | 武汉康祥科技发展有限公司 | 活体化学诱导鱼类雌核发育方法 |
NZ578390A (en) * | 2007-01-26 | 2012-01-12 | Synageva Biopharma Corp | Transgene expression in avians using oviduct specific promoters and SIN vectors |
US7935816B2 (en) | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
US8383880B2 (en) * | 2009-02-18 | 2013-02-26 | Academia Sinica | Infertility control of genetically modified fish |
WO2011099528A1 (ja) * | 2010-02-09 | 2011-08-18 | 国立大学法人北海道大学 | 生殖系列キメラを介して致死的魚類半数体に由来する生殖細胞から遺伝的に同一な配偶子を得る方法 |
RU2422529C1 (ru) * | 2010-02-12 | 2011-06-27 | Учреждение Российской академии наук Институт цитологии и генетики Сибирского отделения РАН (ИЦиГ СО РАН) | ГЕННО-ИНЖЕНЕРНАЯ КОНСТРУКЦИЯ pGoatcasGCSF, ОБЕСПЕЧИВАЮЩАЯ ПРОДУКЦИЮ ГРАНУЛОЦИТ-КОЛОНИЕСТИМУЛИРУЮЩЕГО ФАКТОРА ЧЕЛОВЕКА В МОЛОКО ТРАНСГЕННЫХ ЖИВОТНЫХ |
CA2825994A1 (en) * | 2011-02-01 | 2012-08-09 | Ten-Tsao WONG | Efficient sterilization of fish by disruption of germ cell development |
GB201117538D0 (en) | 2011-10-11 | 2011-11-23 | Royal Veterinary College The | Methods |
US9538734B2 (en) | 2013-03-12 | 2017-01-10 | The General Hospital Corporation | Germ cell ablation compounds and uses thereof |
RU2723037C2 (ru) | 2013-11-15 | 2020-06-08 | Юниверсити Оф Мэриленд Балтимор Каунти | Способ получения бесплодной рыбы и бесплодных производящих икру водных животных и способ доставки соединений в икру и эмбрионы |
DK180094B1 (en) | 2015-05-19 | 2020-04-27 | University Of Maryland At Baltimore County | METHODS OF ADMINISTRATION IN FISH EGGS AND EMBRYOS FOR PHARMACEUTICAL CREATION, MEDICINE TOXICITY ASSAY AND MANUFACTURE OF INFERTILE FISH. |
-
2014
- 2014-11-14 RU RU2016123427A patent/RU2723037C2/ru active
- 2014-11-14 WO PCT/US2014/065698 patent/WO2015073819A1/en active Application Filing
- 2014-11-14 JP JP2016530195A patent/JP6669650B2/ja active Active
- 2014-11-14 HR HRP20240918TT patent/HRP20240918T1/hr unknown
- 2014-11-14 US US15/035,342 patent/US9999208B2/en active Active
- 2014-11-14 EP EP14862081.8A patent/EP3068216B1/en active Active
- 2014-11-14 PT PT148620818T patent/PT3068216T/pt unknown
- 2014-11-14 NZ NZ719421A patent/NZ719421A/en unknown
- 2014-11-14 CN CN201480062691.6A patent/CN105764333B/zh active Active
- 2014-11-14 FI FIEP14862081.8T patent/FI3068216T3/fi active
- 2014-11-14 CA CA2929496A patent/CA2929496C/en active Active
- 2014-11-14 MX MX2016006315A patent/MX369329B/es active IP Right Grant
- 2014-11-14 AU AU2014348473A patent/AU2014348473B2/en active Active
- 2014-11-14 PL PL14862081.8T patent/PL3068216T3/pl unknown
- 2014-11-14 ES ES14862081T patent/ES2981867T3/es active Active
-
2016
- 2016-04-24 IL IL245293A patent/IL245293B/en active IP Right Grant
- 2016-05-10 CL CL2016001113A patent/CL2016001113A1/es unknown
- 2016-06-06 DK DKPA201670401A patent/DK180609B1/en active IP Right Grant
-
2018
- 2018-06-18 US US16/011,631 patent/US10136621B2/en active Active
- 2018-10-22 US US16/166,387 patent/US20190104710A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK180609B1 (en) | 2021-10-14 |
US10136621B2 (en) | 2018-11-27 |
CA2929496C (en) | 2022-08-23 |
MX2016006315A (es) | 2017-01-19 |
PL3068216T3 (pl) | 2024-10-14 |
FI3068216T3 (fi) | 2024-07-10 |
CN105764333B (zh) | 2021-09-03 |
US20190104710A1 (en) | 2019-04-11 |
AU2014348473A1 (en) | 2016-05-19 |
US9999208B2 (en) | 2018-06-19 |
AU2014348473B2 (en) | 2018-06-14 |
JP6669650B2 (ja) | 2020-03-18 |
US20160286768A1 (en) | 2016-10-06 |
EP3068216A1 (en) | 2016-09-21 |
US20180288984A1 (en) | 2018-10-11 |
CN105764333A (zh) | 2016-07-13 |
HRP20240918T1 (hr) | 2024-10-11 |
EP3068216B1 (en) | 2024-04-10 |
CA2929496A1 (en) | 2015-05-21 |
NZ719421A (en) | 2022-09-30 |
ES2981867T3 (es) | 2024-10-10 |
WO2015073819A1 (en) | 2015-05-21 |
EP3068216A4 (en) | 2017-10-11 |
JP2017502651A (ja) | 2017-01-26 |
DK201670401A1 (en) | 2016-07-04 |
RU2723037C2 (ru) | 2020-06-08 |
IL245293A0 (en) | 2016-06-30 |
CL2016001113A1 (es) | 2017-01-06 |
PT3068216T (pt) | 2024-07-12 |
IL245293B (en) | 2020-04-30 |
RU2016123427A (ru) | 2017-12-20 |
BR112016011080A2 (pt) | 2017-12-05 |
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