NO325100B1 - 2,4-di(hetero-)arylamino(-oksy)-5-substituerte pyrimidinderivater, anvendelse og fremstilling derav samt farmasoytisk sammensetning - Google Patents
2,4-di(hetero-)arylamino(-oksy)-5-substituerte pyrimidinderivater, anvendelse og fremstilling derav samt farmasoytisk sammensetning Download PDFInfo
- Publication number
- NO325100B1 NO325100B1 NO20024153A NO20024153A NO325100B1 NO 325100 B1 NO325100 B1 NO 325100B1 NO 20024153 A NO20024153 A NO 20024153A NO 20024153 A NO20024153 A NO 20024153A NO 325100 B1 NO325100 B1 NO 325100B1
- Authority
- NO
- Norway
- Prior art keywords
- carbamoyl
- formula
- pharmaceutically acceptable
- acceptable salt
- anilino
- Prior art date
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- 150000003230 pyrimidines Chemical class 0.000 title claims description 40
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 6
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title description 6
- 125000001769 aryl amino group Chemical group 0.000 title description 2
- 238000000034 method Methods 0.000 claims description 130
- -1 N-(2-di-n-butylaminoethyl)carbamoyl Chemical group 0.000 claims description 119
- 150000001875 compounds Chemical class 0.000 claims description 84
- 150000002148 esters Chemical class 0.000 claims description 44
- 238000001727 in vivo Methods 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 43
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 42
- 238000006243 chemical reaction Methods 0.000 claims description 27
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 25
- 150000001412 amines Chemical class 0.000 claims description 24
- 239000002253 acid Substances 0.000 claims description 22
- 230000000694 effects Effects 0.000 claims description 20
- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- 229910052799 carbon Inorganic materials 0.000 claims description 15
- 229910052717 sulfur Inorganic materials 0.000 claims description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 13
- 125000004429 atom Chemical group 0.000 claims description 13
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- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 10
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 10
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
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- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 6
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Classifications
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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GBGB0004890.0A GB0004890D0 (en) | 2000-03-01 | 2000-03-01 | Chemical compounds |
PCT/GB2001/000824 WO2001064655A1 (en) | 2000-03-01 | 2001-02-26 | 2, 4-di(hetero-)arylamino (-oxy)-5-substituted pyrimidines as antineoplastic agents |
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NO20024153A NO325100B1 (no) | 2000-03-01 | 2002-08-30 | 2,4-di(hetero-)arylamino(-oksy)-5-substituerte pyrimidinderivater, anvendelse og fremstilling derav samt farmasoytisk sammensetning |
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US (1) | US6649608B2 (es) |
EP (1) | EP1268444B1 (es) |
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-
2000
- 2000-03-01 GB GBGB0004890.0A patent/GB0004890D0/en not_active Ceased
-
2001
- 2001-02-26 NZ NZ520414A patent/NZ520414A/en unknown
- 2001-02-26 IL IL15092101A patent/IL150921A0/xx unknown
- 2001-02-26 BR BR0108834-3A patent/BR0108834A/pt not_active Application Discontinuation
- 2001-02-26 ES ES01906018T patent/ES2278720T3/es not_active Expired - Lifetime
- 2001-02-26 DE DE60126071T patent/DE60126071T2/de not_active Expired - Fee Related
- 2001-02-26 AU AU33976/01A patent/AU771144B2/en not_active Ceased
- 2001-02-26 CA CA002398685A patent/CA2398685A1/en not_active Abandoned
- 2001-02-26 EP EP01906018A patent/EP1268444B1/en not_active Expired - Lifetime
- 2001-02-26 PT PT01906018T patent/PT1268444E/pt unknown
- 2001-02-26 WO PCT/GB2001/000824 patent/WO2001064655A1/en active IP Right Grant
- 2001-02-26 MX MXPA02007302A patent/MXPA02007302A/es active IP Right Grant
- 2001-02-26 US US10/203,154 patent/US6649608B2/en not_active Expired - Fee Related
- 2001-02-26 CN CNB018057519A patent/CN1211373C/zh not_active Expired - Fee Related
- 2001-02-26 KR KR1020027011399A patent/KR100771455B1/ko not_active IP Right Cessation
- 2001-02-26 DK DK01906018T patent/DK1268444T3/da active
- 2001-02-26 JP JP2001563497A patent/JP2003525278A/ja active Pending
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2002
- 2002-07-25 IL IL150921A patent/IL150921A/en not_active IP Right Cessation
- 2002-08-02 ZA ZA200206195A patent/ZA200206195B/en unknown
- 2002-08-30 NO NO20024153A patent/NO325100B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6649608B2 (en) | 2003-11-18 |
CA2398685A1 (en) | 2001-09-07 |
NO20024153D0 (no) | 2002-08-30 |
ES2278720T3 (es) | 2007-08-16 |
IL150921A (en) | 2008-11-03 |
GB0004890D0 (en) | 2000-04-19 |
EP1268444B1 (en) | 2007-01-17 |
KR100771455B1 (ko) | 2007-10-31 |
CN1211373C (zh) | 2005-07-20 |
ZA200206195B (en) | 2003-11-26 |
US20030149266A1 (en) | 2003-08-07 |
NZ520414A (en) | 2004-06-25 |
JP2003525278A (ja) | 2003-08-26 |
WO2001064655A1 (en) | 2001-09-07 |
EP1268444A1 (en) | 2003-01-02 |
PT1268444E (pt) | 2007-03-30 |
MXPA02007302A (es) | 2002-11-29 |
AU771144B2 (en) | 2004-03-11 |
DE60126071T2 (de) | 2007-07-12 |
DE60126071D1 (de) | 2007-03-08 |
NO20024153L (no) | 2002-10-29 |
BR0108834A (pt) | 2002-12-10 |
DK1268444T3 (da) | 2007-04-10 |
CN1406230A (zh) | 2003-03-26 |
KR20020075461A (ko) | 2002-10-04 |
AU3397601A (en) | 2001-09-12 |
IL150921A0 (en) | 2003-02-12 |
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