NO313142B1 - Endothelin-antagonister: N-[[2'-[[(4,5-dimetyl-3- isoksazolyl)amino]sulfonyl]-4-(2-oksazolyl[[1,1'-bifenyl]-2-yl]metyl]-N,3,3-trimetylbutanamid og N-(4,5-dimetyl-3-isoksazolyl)-2'-[(3,3-dimetyl-2-okso-1-pyrrolidinyl)metyl]-4'-(2-oksazolyl)[1,1'-b - Google Patents
Endothelin-antagonister: N-[[2'-[[(4,5-dimetyl-3- isoksazolyl)amino]sulfonyl]-4-(2-oksazolyl[[1,1'-bifenyl]-2-yl]metyl]-N,3,3-trimetylbutanamid og N-(4,5-dimetyl-3-isoksazolyl)-2'-[(3,3-dimetyl-2-okso-1-pyrrolidinyl)metyl]-4'-(2-oksazolyl)[1,1'-b Download PDFInfo
- Publication number
- NO313142B1 NO313142B1 NO19993691A NO993691A NO313142B1 NO 313142 B1 NO313142 B1 NO 313142B1 NO 19993691 A NO19993691 A NO 19993691A NO 993691 A NO993691 A NO 993691A NO 313142 B1 NO313142 B1 NO 313142B1
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- Prior art keywords
- treatment
- compound according
- dimethyl
- preparation
- isoxazolyl
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
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- Pain & Pain Management (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3583297P | 1997-01-30 | 1997-01-30 | |
PCT/US1998/001490 WO1998033780A1 (en) | 1997-01-30 | 1998-01-26 | Endothelin antagonists: n-[[2'-[ [(4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl]methyl] -n,3,3-trimethylbutanamide and n-(4,5-dimethyl-3-isoxazolyl) -2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl) methyl] -4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide and salts thereof |
Publications (3)
Publication Number | Publication Date |
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NO993691L NO993691L (no) | 1999-07-29 |
NO993691D0 NO993691D0 (no) | 1999-07-29 |
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- 1998-01-26 RU RU99118903/04A patent/RU2183632C2/ru not_active IP Right Cessation
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- 1998-01-26 IL IL13062298A patent/IL130622A/xx not_active IP Right Cessation
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- 1998-01-26 AT AT98906005T patent/ATE254115T1/de active
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1999
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RU2183632C2 (ru) | 2002-06-20 |
HUP0001310A3 (en) | 2001-07-30 |
CN1244862A (zh) | 2000-02-16 |
AR015358A1 (es) | 2001-05-02 |
NZ336380A (en) | 2001-04-27 |
JP2002513397A (ja) | 2002-05-08 |
EP0996618A4 (en) | 2000-05-03 |
WO1998033780A1 (en) | 1998-08-06 |
TW536540B (en) | 2003-06-11 |
DE69819729T2 (de) | 2004-09-23 |
IL130622A (en) | 2003-01-12 |
BR9807098A (pt) | 2000-04-18 |
DE69819729D1 (de) | 2003-12-18 |
NO993691L (no) | 1999-07-29 |
CZ236299A3 (cs) | 1999-11-17 |
ES2205451T3 (es) | 2004-05-01 |
AU730111B2 (en) | 2001-02-22 |
IL130622A0 (en) | 2000-06-01 |
NO993691D0 (no) | 1999-07-29 |
KR20000070584A (ko) | 2000-11-25 |
PL334773A1 (en) | 2000-03-13 |
EP0996618A1 (en) | 2000-05-03 |
ATE254115T1 (de) | 2003-11-15 |
CN1117738C (zh) | 2003-08-13 |
US6043265A (en) | 2000-03-28 |
ZA98759B (en) | 1999-07-29 |
HUP0001310A2 (hu) | 2001-06-28 |
AU6134998A (en) | 1998-08-25 |
CA2279178A1 (en) | 1998-08-06 |
EP0996618B1 (en) | 2003-11-12 |
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