NO310177B1 - Fremgangsmåte for å innkapsle en aktiv substans samt vedvarende frigivelsesmikro- eller nanopartikler - Google Patents
Fremgangsmåte for å innkapsle en aktiv substans samt vedvarende frigivelsesmikro- eller nanopartikler Download PDFInfo
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- NO310177B1 NO310177B1 NO20002039A NO20002039A NO310177B1 NO 310177 B1 NO310177 B1 NO 310177B1 NO 20002039 A NO20002039 A NO 20002039A NO 20002039 A NO20002039 A NO 20002039A NO 310177 B1 NO310177 B1 NO 310177B1
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- Prior art keywords
- active substance
- agents
- aqueous
- polyethylene glycol
- biodegradable polymer
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
- B01J13/18—In situ polymerisation with all reactants being present in the same phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- Formation And Processing Of Food Products (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Surgical Instruments (AREA)
- Glass Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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SE9703874A SE512663C2 (sv) | 1997-10-23 | 1997-10-23 | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
PCT/SE1998/001717 WO1999020253A1 (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
Publications (3)
Publication Number | Publication Date |
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NO20002039D0 NO20002039D0 (no) | 2000-04-18 |
NO20002039L NO20002039L (no) | 2000-06-13 |
NO310177B1 true NO310177B1 (no) | 2001-06-05 |
Family
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Application Number | Title | Priority Date | Filing Date |
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NO20002039A NO310177B1 (no) | 1997-10-23 | 2000-04-18 | Fremgangsmåte for å innkapsle en aktiv substans samt vedvarende frigivelsesmikro- eller nanopartikler |
Country Status (19)
Country | Link |
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US (1) | US6861064B1 (ko) |
EP (1) | EP1033973B1 (ko) |
JP (1) | JP2001520186A (ko) |
KR (1) | KR100572711B1 (ko) |
AT (1) | ATE249813T1 (ko) |
AU (1) | AU732891B2 (ko) |
CA (1) | CA2306824C (ko) |
CZ (1) | CZ299100B6 (ko) |
DE (1) | DE69818295T2 (ko) |
DK (1) | DK1033973T3 (ko) |
ES (1) | ES2205551T3 (ko) |
HK (1) | HK1029931A1 (ko) |
HU (1) | HU224008B1 (ko) |
IL (1) | IL135733A (ko) |
NO (1) | NO310177B1 (ko) |
PT (1) | PT1033973E (ko) |
SE (1) | SE512663C2 (ko) |
WO (1) | WO1999020253A1 (ko) |
ZA (1) | ZA989199B (ko) |
Families Citing this family (310)
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SK282231B6 (sk) | 1993-11-19 | 2001-12-03 | Janssen Pharmaceutica N. V. | Farmaceutický prostriedok na liečenie psychotických porúch |
DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
KR20010002589A (ko) * | 1999-06-16 | 2001-01-15 | 김윤 | 생리활성물질 함유 생분해성 고분자 마이크로스피어의 제조방법 |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
WO2002043660A2 (en) | 2000-11-28 | 2002-06-06 | Mediummune, Inc | Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment |
US7229619B1 (en) | 2000-11-28 | 2007-06-12 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
IT1318539B1 (it) * | 2000-05-26 | 2003-08-27 | Italfarmaco Spa | Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente |
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US4166800A (en) | 1977-08-25 | 1979-09-04 | Sandoz, Inc. | Processes for preparation of microspheres |
US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
PH19942A (en) | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4568559A (en) * | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
CH660302A5 (fr) | 1984-10-17 | 1987-04-15 | Debiopharm Sa | Procede de micro-encapsulation en phase heterogene de substances medicamenteuses hydrosolubles. |
SE459005B (sv) * | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
US5000886A (en) | 1987-05-26 | 1991-03-19 | American Cyanamid Company | Silicone-hardened pharmaceutical microcapsules and process of making the same |
US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
CA2050911C (en) * | 1989-05-04 | 1997-07-15 | Thomas R. Tice | Encapsulation process and products therefrom |
SE9302777D0 (sv) * | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
DK0674506T3 (da) | 1992-12-02 | 2001-01-08 | Alkermes Inc | Væksthormonholdige mikrosfærer med styret frigivelse |
DK0686045T3 (da) | 1993-02-23 | 2001-03-05 | Genentech Inc | Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof |
EP0688429B1 (en) | 1993-03-09 | 1998-02-11 | Epic Therapeutics, Inc.. | Macromolecular microparticles and methods of production |
ES2151079T3 (es) | 1994-09-09 | 2000-12-16 | Takeda Chemical Industries Ltd | Preparacion de liberacion sostenida que contiene una sal metalica de un peptido. |
WO1996040074A2 (en) | 1995-06-07 | 1996-12-19 | Alkermes Controlled Therapeutics, Inc. | Device for releasing aggregation-stabilized, biologically active agent |
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1997
- 1997-10-23 SE SE9703874A patent/SE512663C2/sv not_active IP Right Cessation
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1998
- 1998-09-24 CA CA002306824A patent/CA2306824C/en not_active Expired - Fee Related
- 1998-09-24 KR KR1020007004276A patent/KR100572711B1/ko not_active IP Right Cessation
- 1998-09-24 DE DE69818295T patent/DE69818295T2/de not_active Expired - Fee Related
- 1998-09-24 HU HU0004732A patent/HU224008B1/hu active IP Right Grant
- 1998-09-24 JP JP2000516653A patent/JP2001520186A/ja active Pending
- 1998-09-24 PT PT98948005T patent/PT1033973E/pt unknown
- 1998-09-24 IL IL13573398A patent/IL135733A/xx not_active IP Right Cessation
- 1998-09-24 EP EP98948005A patent/EP1033973B1/en not_active Expired - Lifetime
- 1998-09-24 AU AU94670/98A patent/AU732891B2/en not_active Ceased
- 1998-09-24 US US09/529,442 patent/US6861064B1/en not_active Expired - Fee Related
- 1998-09-24 AT AT98948005T patent/ATE249813T1/de not_active IP Right Cessation
- 1998-09-24 WO PCT/SE1998/001717 patent/WO1999020253A1/en active IP Right Grant
- 1998-09-24 DK DK98948005T patent/DK1033973T3/da active
- 1998-09-24 CZ CZ20001352A patent/CZ299100B6/cs not_active IP Right Cessation
- 1998-09-24 ES ES98948005T patent/ES2205551T3/es not_active Expired - Lifetime
- 1998-10-08 ZA ZA989199A patent/ZA989199B/xx unknown
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2000
- 2000-04-18 NO NO20002039A patent/NO310177B1/no unknown
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CA2306824C (en) | 2008-01-08 |
AU732891B2 (en) | 2001-05-03 |
ES2205551T3 (es) | 2004-05-01 |
KR20010031289A (ko) | 2001-04-16 |
HK1029931A1 (en) | 2001-04-20 |
SE9703874L (sv) | 1999-04-24 |
IL135733A0 (en) | 2001-05-20 |
AU9467098A (en) | 1999-05-10 |
ZA989199B (en) | 1999-04-15 |
JP2001520186A (ja) | 2001-10-30 |
SE512663C2 (sv) | 2000-04-17 |
WO1999020253A1 (en) | 1999-04-29 |
HU224008B1 (hu) | 2005-04-28 |
SE9703874D0 (sv) | 1997-10-23 |
CA2306824A1 (en) | 1999-04-29 |
US6861064B1 (en) | 2005-03-01 |
ATE249813T1 (de) | 2003-10-15 |
DK1033973T3 (da) | 2004-02-02 |
IL135733A (en) | 2005-11-20 |
EP1033973B1 (en) | 2003-09-17 |
DE69818295D1 (de) | 2003-10-23 |
EP1033973A1 (en) | 2000-09-13 |
CZ299100B6 (cs) | 2008-04-23 |
DE69818295T2 (de) | 2004-07-08 |
KR100572711B1 (ko) | 2006-04-24 |
NO20002039L (no) | 2000-06-13 |
CZ20001352A3 (cs) | 2000-10-11 |
PT1033973E (pt) | 2004-02-27 |
HUP0004732A2 (hu) | 2001-05-28 |
HUP0004732A3 (en) | 2001-12-28 |
NO20002039D0 (no) | 2000-04-18 |
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