JOP20210159A1 - أجسام مضادة لـ pmel17 ومترافقات منها - Google Patents
أجسام مضادة لـ pmel17 ومترافقات منهاInfo
- Publication number
- JOP20210159A1 JOP20210159A1 JOP/2021/0159A JOP20210159A JOP20210159A1 JO P20210159 A1 JOP20210159 A1 JO P20210159A1 JO P20210159 A JOP20210159 A JO P20210159A JO P20210159 A1 JOP20210159 A1 JO P20210159A1
- Authority
- JO
- Jordan
- Prior art keywords
- antibodies
- antigen binding
- binding fragments
- methods
- pmel17
- Prior art date
Links
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 239000012634 fragment Substances 0.000 abstract 5
- 239000000611 antibody drug conjugate Substances 0.000 abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 102100025334 Guanine nucleotide-binding protein G(q) subunit alpha Human genes 0.000 abstract 1
- 102100036738 Guanine nucleotide-binding protein subunit alpha-11 Human genes 0.000 abstract 1
- 101000857888 Homo sapiens Guanine nucleotide-binding protein G(q) subunit alpha Proteins 0.000 abstract 1
- 101001072407 Homo sapiens Guanine nucleotide-binding protein subunit alpha-11 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
يتعلق الأختراع الحالي بأجسام مضادة لـ PMEL17، شظايا ربط مستضد منها، ومترافقات جسم مضاد عقار من الأجسام المضادة المذكورة أو شظايا ربط المستضد المترافقة بمثبط GNAQ/GNA11. يتعلق الاختراع أيضاً بطرق لمعالجة أو الوقاية من السرطان باستخدام الأجسام المضادة، شظايا ربط المستضد، ومترافقات جسم مضاد عقار. يتم في هذه الوثيقة الكشف أيضاً عن طرق لتحضير الأجسام المضادة، شظايا ربط المستضد، ومترافقات جسم مضاد عقار، وطرق لاستخدام الأجسام المضادة وشظايا ربط المستضد على هيئة كواشف تشخيصية.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862783565P | 2018-12-21 | 2018-12-21 | |
US201962803110P | 2019-02-08 | 2019-02-08 | |
PCT/IB2019/001333 WO2020128612A2 (en) | 2018-12-21 | 2019-12-18 | Antibodies to pmel17 and conjugates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20210159A1 true JOP20210159A1 (ar) | 2023-01-30 |
Family
ID=69723993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2021/0159A JOP20210159A1 (ar) | 2018-12-21 | 2019-12-18 | أجسام مضادة لـ pmel17 ومترافقات منها |
Country Status (21)
Country | Link |
---|---|
US (2) | US11779649B2 (ar) |
EP (2) | EP3898697A2 (ar) |
JP (2) | JP2022515760A (ar) |
KR (2) | KR20210107731A (ar) |
CN (1) | CN113195541A (ar) |
AU (2) | AU2019409132A1 (ar) |
BR (1) | BR112021011900A2 (ar) |
CA (2) | CA3234463A1 (ar) |
CL (1) | CL2021001607A1 (ar) |
CO (1) | CO2021007968A2 (ar) |
CR (1) | CR20210324A (ar) |
CU (1) | CU20210047A7 (ar) |
EC (1) | ECSP21044421A (ar) |
IL (1) | IL284027A (ar) |
JO (1) | JOP20210159A1 (ar) |
MX (1) | MX2021007593A (ar) |
PE (1) | PE20211296A1 (ar) |
SG (1) | SG11202106629PA (ar) |
TW (1) | TW202039569A (ar) |
UY (1) | UY38520A (ar) |
WO (1) | WO2020128612A2 (ar) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111686085B (zh) * | 2020-06-30 | 2022-09-06 | 贵州益佰女子大药厂有限责任公司 | 一种咽喉清喉制剂的制备方法 |
EP4297786A1 (en) * | 2021-02-23 | 2024-01-03 | Pandion Operations, Inc. | Pd-1 antibodies, polypeptides and uses thereof |
WO2022221720A1 (en) | 2021-04-16 | 2022-10-20 | Novartis Ag | Antibody drug conjugates and methods for making thereof |
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AU2015229103C9 (en) | 2014-03-14 | 2020-11-26 | Immutep S.A.S | Antibody molecules to LAG-3 and uses thereof |
EP3125943A4 (en) | 2014-04-04 | 2017-12-06 | Merck Sharp & Dohme Corp. | Phosphate based linkers for intracellular delivery of drug conjugates |
TW202408592A (zh) * | 2016-03-02 | 2024-03-01 | 日商衛材R&D企管股份有限公司 | 基於艾日布林之抗體-藥物結合物及使用方法 |
EP4273551A3 (en) | 2016-03-25 | 2024-01-17 | F. Hoffmann-La Roche AG | Multiplexed total antibody and antibody-conjugated drug quantification assay |
JP7022080B2 (ja) | 2016-05-27 | 2022-02-17 | ジェネンテック, インコーポレイテッド | 部位特異的抗体-薬物複合体の特徴付けのための生化学分析的方法 |
AR113224A1 (es) * | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
US20200191789A1 (en) | 2017-06-14 | 2020-06-18 | Servizo Galego De Saúde | In vitro method for detecting tumor growth and diagnosing or prognosticating the risk of metastasis in a human subject that has been diagnosed with uveal melanoma |
US20200282015A1 (en) | 2017-09-22 | 2020-09-10 | Washington University | Targeted pharmacological therapeutics in uveal melanoma |
WO2022221720A1 (en) | 2021-04-16 | 2022-10-20 | Novartis Ag | Antibody drug conjugates and methods for making thereof |
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2019
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KR20210107731A (ko) | 2021-09-01 |
AU2019409132A1 (en) | 2021-07-15 |
EP4406555A2 (en) | 2024-07-31 |
SG11202106629PA (en) | 2021-07-29 |
CA3123996A1 (en) | 2019-12-18 |
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CA3234463A1 (en) | 2019-12-18 |
CU20210047A7 (es) | 2022-01-13 |
UY38520A (es) | 2020-07-31 |
IL284027A (en) | 2021-08-31 |
US11779649B2 (en) | 2023-10-10 |
CO2021007968A2 (es) | 2021-07-19 |
US20240189439A1 (en) | 2024-06-13 |
ECSP21044421A (es) | 2021-07-30 |
CL2021001607A1 (es) | 2022-02-11 |
CN113195541A (zh) | 2021-07-30 |
WO2020128612A2 (en) | 2020-06-25 |
US20200197528A1 (en) | 2020-06-25 |
TW202039569A (zh) | 2020-11-01 |
BR112021011900A2 (pt) | 2021-09-08 |
CR20210324A (es) | 2021-07-14 |
PE20211296A1 (es) | 2021-07-20 |
JP2022515760A (ja) | 2022-02-22 |
AU2024202263A1 (en) | 2024-05-02 |
EP3898697A2 (en) | 2021-10-27 |
WO2020128612A3 (en) | 2020-08-27 |
JP2024088757A (ja) | 2024-07-02 |
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