NO20060220L - Forbindelser med inhiberene aktivitet mot natriumavhengige transportorer - Google Patents

Forbindelser med inhiberene aktivitet mot natriumavhengige transportorer

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Publication number
NO20060220L
NO20060220L NO20060220A NO20060220A NO20060220L NO 20060220 L NO20060220 L NO 20060220L NO 20060220 A NO20060220 A NO 20060220A NO 20060220 A NO20060220 A NO 20060220A NO 20060220 L NO20060220 L NO 20060220L
Authority
NO
Norway
Prior art keywords
ring
optionally substituted
substituted unsaturated
monocyclic heterocyclic
compounds
Prior art date
Application number
NO20060220A
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English (en)
Other versions
NO333933B1 (no
Inventor
Sumihiro Nomura
Kiichiro Ueta
Eiji Kawanishi
Original Assignee
Tanabe Seiyaku Co
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Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of NO20060220L publication Critical patent/NO20060220L/no
Publication of NO333933B1 publication Critical patent/NO333933B1/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Biochemistry (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
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  • Endocrinology (AREA)
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  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det beskrives en forbindelse av formel (I) hvor Ring A og Ring B er: (1) Ring A er en valgfrit substituert umettet monocyklisk heterocyklisk ring, Ring B er en valgfritt substituert umettet monocyklisk heterocyklisk ring, en valgfritt substituert umettet fusjonert heterobicyklisk ring, eller en valgfritt substituert benzenring, (2) Ring A er en valgfritt substituert benzenring, og Ring B er en valgfritt substituert umettet monocyklisk heterocyklisk ring eller en valgfritt substituert umettet fusjonert heterobicyklisk ring, eller (3) Ring A er en valgfritt substituert umettet fusjonert heterobicyklisk ring, og Ring B er uavhengig en valgfritt substituert umettet monocyklisk heterocyklisk ring, en valgfritt substituert umettet fusjonert heterobicyklisk ring, eller en valgfritt substituert benzenring; X er et karbonatom eller et nitrogenatom; Y er-(CH2)n- (n er 1 eller 2); et farmasøytisk akseptabelt salt derav, eller et prodrug derav.
NO20060220A 2003-08-01 2006-01-16 Forbindelser, farmasøytiske sammensetninger og anvendelser derav, samt fremgangsmåte for å fremstille nevnte forbindelser NO333933B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49153403P 2003-08-01 2003-08-01
PCT/JP2004/011312 WO2005012326A1 (en) 2003-08-01 2004-07-30 Novel compounds having inhibitory activity against sodium-dependant transporter

Publications (2)

Publication Number Publication Date
NO20060220L true NO20060220L (no) 2006-05-02
NO333933B1 NO333933B1 (no) 2013-10-28

Family

ID=34115515

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20060220A NO333933B1 (no) 2003-08-01 2006-01-16 Forbindelser, farmasøytiske sammensetninger og anvendelser derav, samt fremgangsmåte for å fremstille nevnte forbindelser
NO20120585A NO334706B1 (no) 2003-08-01 2012-05-18 Forbindelser, farmasøytiske sammensetninger og anvendelser av slike forbindelser, samt fremgangsmåter for fremstilling av nevnte forbindelser
NO2014009C NO2014009I2 (no) 2003-08-01 2014-04-25 Forbindelser, farmasøytiske sammensetninger og anvendelser derav, samt fremgangsmåte for å fremstille nevnte forbindelser

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO20120585A NO334706B1 (no) 2003-08-01 2012-05-18 Forbindelser, farmasøytiske sammensetninger og anvendelser av slike forbindelser, samt fremgangsmåter for fremstilling av nevnte forbindelser
NO2014009C NO2014009I2 (no) 2003-08-01 2014-04-25 Forbindelser, farmasøytiske sammensetninger og anvendelser derav, samt fremgangsmåte for å fremstille nevnte forbindelser

Country Status (36)

Country Link
US (3) US7943788B2 (no)
EP (4) EP2896397B2 (no)
JP (2) JP4130466B2 (no)
KR (2) KR100778988B1 (no)
CN (4) CN1829729A (no)
AR (1) AR045173A1 (no)
AU (1) AU2004260761B2 (no)
BE (1) BE2014C027I2 (no)
BR (1) BRPI0413232B8 (no)
CA (1) CA2534024C (no)
CR (2) CR8188A (no)
CY (3) CY1113813T1 (no)
DK (2) DK1651658T4 (no)
EA (2) EA010299B1 (no)
ES (4) ES2844401T3 (no)
FR (1) FR14C0034I2 (no)
HR (2) HRP20130124T4 (no)
HU (2) HUE037320T2 (no)
IL (2) IL173050A (no)
LT (1) LT2896397T (no)
LU (1) LU92426I2 (no)
ME (1) ME00411B (no)
MX (1) MXPA06001274A (no)
MY (1) MY143203A (no)
NL (1) NL300670I2 (no)
NO (3) NO333933B1 (no)
NZ (2) NZ575711A (no)
PL (2) PL1651658T5 (no)
PT (2) PT1651658E (no)
RS (1) RS53365B (no)
SG (1) SG145694A1 (no)
SI (2) SI2896397T2 (no)
TW (2) TWI365190B (no)
UA (1) UA83243C2 (no)
WO (1) WO2005012326A1 (no)
ZA (5) ZA200601685B (no)

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LT2896397T (lt) † 2003-08-01 2017-11-27 Mitsubishi Tanabe Pharma Corporation Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį
JP4950657B2 (ja) * 2004-03-04 2012-06-13 キッセイ薬品工業株式会社 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
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WO2006010557A1 (de) * 2004-07-27 2006-02-02 Boehringer Ingelheim International Gmbh D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
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ES2314743T3 (es) 2004-12-16 2009-03-16 Boehringer Ingelheim International Gmbh Derivados de benceno sustituidos con glucopiranosilo, medicamentos que contienen a este tipo de compuestos, su uso y procedimiento para su fabricacion.
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JP4496174B2 (ja) * 2005-01-31 2010-07-07 田辺三菱製薬株式会社 医薬組成物
MY147375A (en) * 2005-01-31 2012-11-30 Mitsubishi Tanabe Pharma Corp Indole derivatives
AR053329A1 (es) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
EP1856082B1 (en) 2005-02-23 2009-10-14 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors
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