MXPA05007730A - Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos. - Google Patents
Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos.Info
- Publication number
- MXPA05007730A MXPA05007730A MXPA05007730A MXPA05007730A MXPA05007730A MX PA05007730 A MXPA05007730 A MX PA05007730A MX PA05007730 A MXPA05007730 A MX PA05007730A MX PA05007730 A MXPA05007730 A MX PA05007730A MX PA05007730 A MXPA05007730 A MX PA05007730A
- Authority
- MX
- Mexico
- Prior art keywords
- phospholipid
- emulsion
- preparation
- gas
- microbubbles
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002961 echo contrast media Substances 0.000 title 1
- 239000007900 aqueous suspension Substances 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Un metodo para preparar una matriz liofilizada y, al momento de la reconstitucion de la misma, un agente de contraste inyectable respectivo que comprende una suspension liquida acuosa de microburbujas llenas de gas estabilizadas predominantemente por un fosfolipido. El metodo comprende la preparacion de una emulsion de un medio acuoso, un fosfolipido y un solvente organico inmiscible en agua. La emulsion es entonces secada por congelacion y posteriormente reconstituida en una suspension acuosa de microburbujas llenas de gas. El metodo permite obtener suspensiones que comprenden microburbujas que tienen un diametro relativamente pequeno y una distribucion de tamano estrecha.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03002375 | 2003-02-04 | ||
PCT/IB2004/000243 WO2004069284A2 (en) | 2003-02-04 | 2004-02-03 | Ultrasound contrast agents and process for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05007730A true MXPA05007730A (es) | 2006-01-31 |
Family
ID=32842689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05007730A MXPA05007730A (es) | 2003-02-04 | 2004-02-03 | Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos. |
Country Status (16)
Country | Link |
---|---|
US (4) | US9364569B2 (es) |
EP (1) | EP1590006B1 (es) |
JP (1) | JP4670083B2 (es) |
KR (1) | KR101076053B1 (es) |
CN (1) | CN100374165C (es) |
AT (1) | ATE480263T1 (es) |
AU (1) | AU2004210221B2 (es) |
CA (1) | CA2512454C (es) |
DE (1) | DE602004029010D1 (es) |
DK (1) | DK1590006T3 (es) |
ES (1) | ES2352087T3 (es) |
IL (1) | IL169677A (es) |
MX (1) | MXPA05007730A (es) |
NO (1) | NO331966B1 (es) |
RU (1) | RU2345793C2 (es) |
WO (1) | WO2004069284A2 (es) |
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2004
- 2004-02-03 MX MXPA05007730A patent/MXPA05007730A/es active IP Right Grant
- 2004-02-03 DE DE602004029010T patent/DE602004029010D1/de not_active Expired - Lifetime
- 2004-02-03 US US10/544,123 patent/US9364569B2/en active Active
- 2004-02-03 KR KR1020057013951A patent/KR101076053B1/ko active IP Right Grant
- 2004-02-03 AU AU2004210221A patent/AU2004210221B2/en not_active Ceased
- 2004-02-03 EP EP04707586A patent/EP1590006B1/en not_active Expired - Lifetime
- 2004-02-03 ES ES04707586T patent/ES2352087T3/es not_active Expired - Lifetime
- 2004-02-03 CN CNB2004800029752A patent/CN100374165C/zh not_active Expired - Lifetime
- 2004-02-03 WO PCT/IB2004/000243 patent/WO2004069284A2/en active Application Filing
- 2004-02-03 DK DK04707586.6T patent/DK1590006T3/da active
- 2004-02-03 CA CA2512454A patent/CA2512454C/en not_active Expired - Lifetime
- 2004-02-03 RU RU2005127634/15A patent/RU2345793C2/ru active
- 2004-02-03 JP JP2006502384A patent/JP4670083B2/ja not_active Expired - Lifetime
- 2004-02-03 AT AT04707586T patent/ATE480263T1/de active
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2005
- 2005-07-14 IL IL169677A patent/IL169677A/en active IP Right Grant
- 2005-08-11 US US11/202,008 patent/US20060034770A1/en not_active Abandoned
- 2005-09-02 NO NO20054089A patent/NO331966B1/no not_active IP Right Cessation
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2011
- 2011-03-03 US US13/039,838 patent/US20110236320A1/en not_active Abandoned
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Also Published As
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---|---|
WO2004069284A3 (en) | 2004-11-25 |
IL169677A (en) | 2011-07-31 |
ATE480263T1 (de) | 2010-09-15 |
US20110236320A1 (en) | 2011-09-29 |
DK1590006T3 (da) | 2010-12-20 |
JP4670083B2 (ja) | 2011-04-13 |
RU2005127634A (ru) | 2006-01-20 |
RU2345793C2 (ru) | 2009-02-10 |
CN1744921A (zh) | 2006-03-08 |
KR101076053B1 (ko) | 2011-10-21 |
EP1590006B1 (en) | 2010-09-08 |
EP1590006A2 (en) | 2005-11-02 |
DE602004029010D1 (de) | 2010-10-21 |
JP2006520754A (ja) | 2006-09-14 |
AU2004210221B2 (en) | 2008-11-20 |
NO331966B1 (no) | 2012-05-14 |
CA2512454A1 (en) | 2004-08-19 |
KR20050096959A (ko) | 2005-10-06 |
AU2004210221A1 (en) | 2004-08-19 |
NO20054089L (no) | 2005-10-05 |
US9364569B2 (en) | 2016-06-14 |
CA2512454C (en) | 2012-10-30 |
US20130101522A1 (en) | 2013-04-25 |
NO20054089D0 (no) | 2005-09-02 |
CN100374165C (zh) | 2008-03-12 |
ES2352087T3 (es) | 2011-02-15 |
US20060051297A1 (en) | 2006-03-09 |
US20060034770A1 (en) | 2006-02-16 |
WO2004069284A2 (en) | 2004-08-19 |
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