DE602004029010D1 - Ultraschall kontrastmittel und verfahren zur erstellung - Google Patents

Ultraschall kontrastmittel und verfahren zur erstellung

Info

Publication number
DE602004029010D1
DE602004029010D1 DE602004029010T DE602004029010T DE602004029010D1 DE 602004029010 D1 DE602004029010 D1 DE 602004029010D1 DE 602004029010 T DE602004029010 T DE 602004029010T DE 602004029010 T DE602004029010 T DE 602004029010T DE 602004029010 D1 DE602004029010 D1 DE 602004029010D1
Authority
DE
Germany
Prior art keywords
phospholipid
emulsion
creation
gas
microbubbles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004029010T
Other languages
English (en)
Inventor
Michel Schneider
Philippe Bussat
Feng Yan
Christian Guillot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of DE602004029010D1 publication Critical patent/DE602004029010D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
DE602004029010T 2003-02-04 2004-02-03 Ultraschall kontrastmittel und verfahren zur erstellung Expired - Lifetime DE602004029010D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002375 2003-02-04
PCT/IB2004/000243 WO2004069284A2 (en) 2003-02-04 2004-02-03 Ultrasound contrast agents and process for the preparation thereof

Publications (1)

Publication Number Publication Date
DE602004029010D1 true DE602004029010D1 (de) 2010-10-21

Family

ID=32842689

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004029010T Expired - Lifetime DE602004029010D1 (de) 2003-02-04 2004-02-03 Ultraschall kontrastmittel und verfahren zur erstellung

Country Status (16)

Country Link
US (4) US9364569B2 (de)
EP (1) EP1590006B1 (de)
JP (1) JP4670083B2 (de)
KR (1) KR101076053B1 (de)
CN (1) CN100374165C (de)
AT (1) ATE480263T1 (de)
AU (1) AU2004210221B2 (de)
CA (1) CA2512454C (de)
DE (1) DE602004029010D1 (de)
DK (1) DK1590006T3 (de)
ES (1) ES2352087T3 (de)
IL (1) IL169677A (de)
MX (1) MXPA05007730A (de)
NO (1) NO331966B1 (de)
RU (1) RU2345793C2 (de)
WO (1) WO2004069284A2 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
KR101076053B1 (ko) 2003-02-04 2011-10-21 브라코 인터내셔날 비.브이. 초음파 조영제 및 그것의 제조방법
WO2005063305A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US8708909B2 (en) † 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents
CN101005858A (zh) * 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
EP1714642A1 (de) 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
DK1966388T3 (da) 2005-12-09 2013-10-28 Bracco Suisse Sa Tilsigte vektor-fosfolipidkonjugater
EP1797919A1 (de) 2005-12-16 2007-06-20 Bracco Research S.A. Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten
WO2007136554A1 (en) * 2006-05-15 2007-11-29 Mayo Foundation For Medical Education And Research Method for imaging intracavitary blood flow patterns
JP2010503421A (ja) * 2006-07-13 2010-02-04 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド エコー粒子画像速度（ｅｐｉｖ）およびエコー粒子追跡速度測定（ｅｐｔｖ）システムおよび方法
EP2076179B1 (de) 2006-08-01 2018-07-04 Stichting voor de Technische Wetenschappen Impulsumkehrungssequenzen für nichtlineare bildgebung
CA2662087C (en) 2006-09-05 2015-01-06 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
WO2008042841A2 (en) * 2006-10-02 2008-04-10 Dr. Reddy's Laboratories Limited Docetaxel compositions
WO2008075192A2 (en) 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
US20090191244A1 (en) * 2007-09-27 2009-07-30 Children's Medical Center Corporation Microbubbles and methods for oxygen delivery
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
JP5491511B2 (ja) 2008-10-07 2014-05-14 ブラッコ・シュイス・ソシエテ・アノニム 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物
US20110045095A1 (en) * 2008-10-08 2011-02-24 The Regents Of The University Of California Polymer-phospholipid shelled microbubbles
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
AU2009327219B9 (en) 2008-12-16 2014-08-07 Bracco Suisse S.A. Device for bolus administration of contrast agent
RU2444296C2 (ru) * 2010-03-24 2012-03-10 Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО УГМА Росздрава) Способ использования суспензий наночастиц оксидов металлов в качестве контрастных веществ для ультразвуковой визуализации сердца и сосудов
BR112012027634A2 (pt) * 2010-04-30 2016-08-09 H R D Corp método e sistema
WO2012020030A1 (en) 2010-08-09 2012-02-16 Bracco Suisse Sa Targeted gas-filled microvesicles
WO2012065060A2 (en) * 2010-11-12 2012-05-18 Children's Medical Center Corporation Gas-filled microbubbles and systems for gas delivery
EP2668961A4 (de) 2010-11-19 2016-07-06 Univ Sapporo Medical Pharmazeutisches kombinationspräparat
WO2012085072A1 (en) 2010-12-24 2012-06-28 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
RU2485976C2 (ru) * 2011-05-17 2013-06-27 Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГОУ ВПО СибГМУ Минздравсоцразвития России) Контрастное средство для ультразвуковой визуализации
IN2014MN01571A (de) 2012-02-10 2015-05-15 Taiwan Liposome Co Ltd
WO2013151682A1 (en) * 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
US11045748B2 (en) * 2012-04-30 2021-06-29 Ge Healthcare As Method for filling a container with a foamable composition
EP2858554A4 (de) * 2012-06-11 2016-02-24 Univ California Verfahren und system für in-vivo-wasserstoffperoxidnachweis mit ultraschall
CN103099780B (zh) * 2012-12-11 2015-11-25 中国科学院深圳先进技术研究院 制备含氢气微泡水溶液的方法，其产品及应用
EP2934740B1 (de) 2012-12-21 2019-12-11 Bracco Suisse SA Gasgefüllte mikrovesikel
WO2014144364A1 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
WO2015000953A1 (en) 2013-07-03 2015-01-08 Bracco Suisse S.A. Devices and methods for the ultrasound treatment of ischemic stroke
KR101520443B1 (ko) 2013-11-06 2015-05-14 서울대학교산학협력단 유기 마이크로 버블 복합 입자의 제조 방법, 유기 마이크로 버블 복합 입자 및 조영제
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
CA2944417A1 (en) 2014-04-02 2015-10-08 Nitto Denko Corporation A targeting molecule and a use thereof
CN113209316A (zh) 2014-12-18 2021-08-06 博莱科瑞士股份有限公司 靶向的充气微囊制剂
BR112017011881A2 (pt) 2014-12-22 2018-01-02 Bracco Suisse Sa microvesículas cheias com gás para uso como vacina
CN104622848A (zh) * 2015-02-13 2015-05-20 西安交通大学 一种等离子体活化包膜微气泡
US10688199B2 (en) * 2015-06-10 2020-06-23 Teikyo University Theranostic bubble preparation (TB), and method for using same
JP2018538056A (ja) 2015-12-09 2018-12-27 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 超音波血栓溶解用及び血管音響共振器を介した他の治療用のインターリーブビームパターン
WO2017136475A1 (en) * 2016-02-01 2017-08-10 Trust Biosonics Inc. Lipid microbubbles and process of making thereof
CA3011248A1 (en) 2016-02-09 2017-08-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
WO2017214468A1 (en) * 2016-06-09 2017-12-14 Tien Yang Der Nanodroplet compositions for the efficient delivery of anti-cancer agents
CA3032062A1 (en) 2016-08-30 2018-03-08 Bracco Suisse Sa Preparation of size-controlled microparticles
KR102052945B1 (ko) 2016-09-29 2019-12-11 연세대학교 산학협력단 나노 조영제의 재분산 방법
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
WO2018198008A1 (en) 2017-04-24 2018-11-01 Abdolahad Mohammad In-situ microbubbles generation for ultrasonic biomedical applications
WO2019170606A1 (en) 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
FR3082422B1 (fr) * 2018-06-14 2021-01-22 Univ D'avignon Et Des Pays De Vaucluse Emulsion pour la chirurgie d'ablation ultrasonore
US20210389320A1 (en) 2018-12-21 2021-12-16 Bracco Suisse Sa Gas-filled microvesicles with ligand
KR102180629B1 (ko) * 2018-12-24 2020-11-20 서강대학교 산학협력단 세포외 소포 기반의 초음파 조영제용 마이크로버블 및 이의 제조방법
CN110051630A (zh) * 2019-02-03 2019-07-26 彭盛 一种载氧聚合物微泡及其制备方法
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) * 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
EP3980016A4 (de) * 2019-06-05 2023-11-15 Microvascular Therapeutics LLC Zusammensetzungen und verfahren zur detektion und behandlung von thrombose und vaskulären plaques
CN114007656A (zh) * 2019-06-25 2022-02-01 博莱科瑞士股份有限公司 用于制备标准化充气微泡的冻干组合物
ES2967186T3 (es) * 2019-06-25 2024-04-29 Bracco Suisse Sa Composición liofilizada para preparar microvesículas llenas de gas calibradas
JP7321015B2 (ja) 2019-07-12 2023-08-04 株式会社コーセー バイセル構造体を含有する組成物
WO2021086806A1 (en) * 2019-10-29 2021-05-06 The Chemist's Cabinet, Llc Cannabinoid products with high bioavailability
US20230057224A1 (en) 2020-02-11 2023-02-23 Bracco Suisse Sa Gas-filled microvesicles for therapeutic use
CN111939122B (zh) * 2020-08-06 2022-04-05 温州医科大学 肺动脉高压靶向治疗的速效制剂
CN113041365B (zh) * 2021-03-25 2022-04-08 黑龙江中医药大学 一种增强颈动脉硬化超声诊断的靶向超声造影剂及其制备方法
WO2024033540A1 (en) * 2022-08-12 2024-02-15 Bracco Suisse Sa Freeze-dried nanodroplets with fluorinated compound

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
JPS60501759A (ja) * 1983-07-01 1985-10-17 バテル　メモリアル　インステイチユ−ト 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
EP0179023B1 (de) * 1984-10-19 1991-01-23 Battelle Memorial Institute Durch Mikroorganismen abbaubares Polypeptid und seine Verwendung für die fortschreitende Abgabe von Medikamenten
CH667874A5 (fr) 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6088613A (en) * 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5487390A (en) * 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
JP2974083B2 (ja) 1990-11-26 1999-11-08 株式会社 小松製作所 静油圧―機械式伝動機の制御装置
AU2317592A (en) * 1991-07-05 1993-02-11 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
DE4208527A1 (de) 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
WO1994001140A1 (de) * 1992-07-03 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Echokontrastmittelzubereitung
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
JP3559849B2 (ja) * 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー 超音波技術のための安定化された微小気泡組成物
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
ATE234638T1 (de) * 1993-12-15 2003-04-15 Bracco Research Sa Gas-mischungen verwendbar als ultraschallkontrastmittel
NO940711D0 (no) 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5876697A (en) * 1994-08-04 1999-03-02 Gakko Houjin Toin Gakuen Method for the production of microbubble-type ultrasonic contrast agent using fatty acid surfactants
GB9417941D0 (en) 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
EP0783295A1 (de) * 1994-09-23 1997-07-16 The Liposome Company, Inc. Verfahren zur herstellung eines lyophilisierten liposomenprodukts
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) * 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US6165442A (en) * 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
PL328406A1 (en) 1996-02-19 1999-01-18 Nycomed Imaging As Improved contrast media
ES2197331T3 (es) * 1996-02-19 2004-01-01 Amersham Health As Medio de contraste estabilizado termicamente.
KR100442182B1 (ko) 1996-07-22 2004-07-30 시게이트 테크놀로지 엘엘씨 위상 검출 추정기
CZ28999A3 (cs) * 1996-08-02 1999-07-14 Nycomed Imaging As Použití kontrastního prostředku
KR20000052652A (ko) * 1996-10-21 2000-08-25 조오지 디빈센조, 토브 아스 헬지, 에바 요한손 조영제 또는 그와 관련된 개선
NZ335799A (en) 1996-10-28 2000-11-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
ES2264159T3 (es) 1996-10-28 2006-12-16 Amersham Health As Mejoras en/o relacionadas con agentes de diagnostico/terapeuticos.
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
GB9701237D0 (en) 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) * 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9717589D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
JP2001520207A (ja) 1997-10-21 2001-10-30 ニユコメド・イメージング・アクシエセルカペト 微小血管に標的設定された造影剤および血管拡張剤による超音波造影
US20020169138A1 (en) * 1997-10-24 2002-11-14 Southern Research Institute Delivery vehicles for bioactive agents and uses thereof
US20010003580A1 (en) * 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
WO1999039738A1 (en) 1998-02-09 1999-08-12 Bracco Research S.A. Targeted delivery of biologically active media
GB9808599D0 (en) 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000143550A (ja) 1998-11-10 2000-05-23 Toin Gakuen 超音波造影剤
DE10013850A1 (de) 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
AU2002248222B2 (en) 2000-12-23 2006-04-27 Dyax Corp. Fibrin binding polypeptides useful inter alia in medical imaging processes
US6793626B2 (en) * 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
JP2002212108A (ja) 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
US7179449B2 (en) * 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
ATE299378T1 (de) * 2001-01-31 2005-07-15 Bracco Research Sa Lyophilisierbares kontrastmittel, gasgefüllte mikrobläschen enthaltend
WO2003005029A2 (en) 2001-07-03 2003-01-16 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
CA2456988A1 (en) 2001-08-16 2003-02-27 Alan P. Carpenter, Jr. Gas microsphere liposome composites
EP2014310B8 (de) 2002-03-01 2012-12-26 Dyax Corp. KDR- und VEGF/KDR-bindende Peptide sowie ihre Verwendung bei der Diagnose und Therapie
EP1482987B1 (de) 2002-03-01 2014-08-13 Bracco Suisse SA Multivalente konstrukte für therapeutische und diagnostische anwendungen
EP1518028B1 (de) 2002-06-19 2011-11-09 Dimitrios Patsalaridis Schraubbarer erdanker
AU2003303954A1 (en) * 2002-10-25 2004-10-11 Emory University Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
KR101076053B1 (ko) 2003-02-04 2011-10-21 브라코 인터내셔날 비.브이. 초음파 조영제 및 그것의 제조방법
EP1696965B1 (de) 2003-12-22 2014-12-10 Bracco Suisse SA Anordnung aus gasgefüllten mikrovesikeln mit wirkstoff für die kontrastdarstellung
WO2005063305A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US8708909B2 (en) 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents
CN101005858A (zh) 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物

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AU2004210221A1 (en) 2004-08-19
WO2004069284A2 (en) 2004-08-19
RU2005127634A (ru) 2006-01-20
ATE480263T1 (de) 2010-09-15
KR20050096959A (ko) 2005-10-06
AU2004210221B2 (en) 2008-11-20
NO20054089D0 (no) 2005-09-02
ES2352087T3 (es) 2011-02-15
MXPA05007730A (es) 2006-01-31
CN100374165C (zh) 2008-03-12
CA2512454C (en) 2012-10-30
WO2004069284A3 (en) 2004-11-25
NO331966B1 (no) 2012-05-14
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US9364569B2 (en) 2016-06-14
CN1744921A (zh) 2006-03-08
US20130101522A1 (en) 2013-04-25
JP4670083B2 (ja) 2011-04-13
JP2006520754A (ja) 2006-09-14
US20060051297A1 (en) 2006-03-09
CA2512454A1 (en) 2004-08-19
EP1590006A2 (de) 2005-11-02
US20060034770A1 (en) 2006-02-16
DK1590006T3 (da) 2010-12-20
EP1590006B1 (de) 2010-09-08
US20110236320A1 (en) 2011-09-29

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