DK1590006T3 - Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf - Google Patents
Ultralydskontrastmidler og fremgangsmåde til frembringelse derafInfo
- Publication number
- DK1590006T3 DK1590006T3 DK04707586.6T DK04707586T DK1590006T3 DK 1590006 T3 DK1590006 T3 DK 1590006T3 DK 04707586 T DK04707586 T DK 04707586T DK 1590006 T3 DK1590006 T3 DK 1590006T3
- Authority
- DK
- Denmark
- Prior art keywords
- producing
- methods
- phospholipid
- emulsion
- gas
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002961 echo contrast media Substances 0.000 title 1
- 239000007900 aqueous suspension Substances 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03002375 | 2003-02-04 | ||
PCT/IB2004/000243 WO2004069284A2 (en) | 2003-02-04 | 2004-02-03 | Ultrasound contrast agents and process for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1590006T3 true DK1590006T3 (da) | 2010-12-20 |
Family
ID=32842689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04707586.6T DK1590006T3 (da) | 2003-02-04 | 2004-02-03 | Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf |
Country Status (16)
Country | Link |
---|---|
US (4) | US9364569B2 (da) |
EP (1) | EP1590006B1 (da) |
JP (1) | JP4670083B2 (da) |
KR (1) | KR101076053B1 (da) |
CN (1) | CN100374165C (da) |
AT (1) | ATE480263T1 (da) |
AU (1) | AU2004210221B2 (da) |
CA (1) | CA2512454C (da) |
DE (1) | DE602004029010D1 (da) |
DK (1) | DK1590006T3 (da) |
ES (1) | ES2352087T3 (da) |
IL (1) | IL169677A (da) |
MX (1) | MXPA05007730A (da) |
NO (1) | NO331966B1 (da) |
RU (1) | RU2345793C2 (da) |
WO (1) | WO2004069284A2 (da) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
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CA2513044A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
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WO2005063305A1 (en) | 2003-12-22 | 2005-07-14 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
DE602005021057D1 (de) † | 2004-01-20 | 2010-06-17 | Toronto E | Hochfrequenz-ultraschall-darstellung mit kontrastmitteln |
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EP1714642A1 (en) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
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EP1797919A1 (en) | 2005-12-16 | 2007-06-20 | Bracco Research S.A. | Liquid transfer device for medical dispensing containers |
WO2007136554A1 (en) * | 2006-05-15 | 2007-11-29 | Mayo Foundation For Medical Education And Research | Method for imaging intracavitary blood flow patterns |
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WO2008016992A1 (en) | 2006-08-01 | 2008-02-07 | Scimed Life Systems, Inc. | Pulse inversion sequences for nonlinear imaging |
ATE469660T1 (de) | 2006-09-05 | 2010-06-15 | Bracco Research Sa | Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden |
WO2008042841A2 (en) * | 2006-10-02 | 2008-04-10 | Dr. Reddy's Laboratories Limited | Docetaxel compositions |
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WO2009043031A2 (en) * | 2007-09-27 | 2009-04-02 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
EP2090322A1 (en) | 2008-02-18 | 2009-08-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of fsh receptor ligands for diagnosis and therapy of cancer |
JP2010005512A (ja) * | 2008-06-25 | 2010-01-14 | Kao Corp | 微細気泡前駆体組成物 |
GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
AU2009301141B2 (en) | 2008-10-07 | 2015-08-27 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same |
US20110045095A1 (en) * | 2008-10-08 | 2011-02-24 | The Regents Of The University Of California | Polymer-phospholipid shelled microbubbles |
CN101745126B (zh) * | 2008-12-10 | 2012-04-25 | 温州医学院 | 一种包载水溶性药物超声造影剂的制备方法 |
WO2010069943A1 (en) | 2008-12-16 | 2010-06-24 | Bracco Research Sa | Device for bolus administration of contrast agent |
RU2444296C2 (ru) * | 2010-03-24 | 2012-03-10 | Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО УГМА Росздрава) | Способ использования суспензий наночастиц оксидов металлов в качестве контрастных веществ для ультразвуковой визуализации сердца и сосудов |
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EP2603242B1 (en) | 2010-08-09 | 2018-03-14 | Bracco Suisse SA | Targeted gas-filled microvesicles |
WO2012065060A2 (en) * | 2010-11-12 | 2012-05-18 | Children's Medical Center Corporation | Gas-filled microbubbles and systems for gas delivery |
US9757462B2 (en) | 2010-11-19 | 2017-09-12 | Sapporo Medical University | Combined pharmaceutical preparation |
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JP6313329B2 (ja) * | 2012-12-21 | 2018-04-18 | ブラッコ・スイス・ソシエテ・アノニムBracco Suisse SA | ガス封入マイクロベシクル |
EP2968825A4 (en) | 2013-03-15 | 2016-09-07 | Childrens Medical Center | GAS STABILIZED PARTICLES AND METHODS OF USE |
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US10688199B2 (en) * | 2015-06-10 | 2020-06-23 | Teikyo University | Theranostic bubble preparation (TB), and method for using same |
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US20190046667A1 (en) * | 2016-02-01 | 2019-02-14 | Trust Biosonics Inc. | Lipid microbubbles and process of making thereof |
CA3011248A1 (en) | 2016-02-09 | 2017-08-17 | Bracco Suisse Sa | A recombinant chimeric protein for selectins targeting |
CN107233583B (zh) * | 2016-03-29 | 2020-04-24 | 北京飞锐达医疗科技有限公司 | 一种具有超长持续时间的超声造影剂及其制备方法 |
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US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
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WO2020260420A1 (en) * | 2019-06-25 | 2020-12-30 | Bracco Suisse Sa | Freeze-dried composition for preparing calibrated gas-filled microvesicles |
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WO2021086806A1 (en) * | 2019-10-29 | 2021-05-06 | The Chemist's Cabinet, Llc | Cannabinoid products with high bioavailability |
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WO2024033540A1 (en) * | 2022-08-12 | 2024-02-15 | Bracco Suisse Sa | Freeze-dried nanodroplets with fluorinated compound |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4276885A (en) | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
JPS60501759A (ja) | 1983-07-01 | 1985-10-17 | バテル メモリアル インステイチユ−ト | 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用 |
SE463651B (sv) | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
EP0179023B1 (fr) | 1984-10-19 | 1991-01-23 | Battelle Memorial Institute | Polypeptide biodégradable et son utilisation pour le relargage progressif de médicaments |
CH667874A5 (fr) | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US5776429A (en) * | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
IN172208B (da) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
US5562099A (en) | 1990-10-05 | 1996-10-08 | Massachusetts Institute Of Technology | Polymeric microparticles containing agents for imaging |
US5487390A (en) | 1990-10-05 | 1996-01-30 | Massachusetts Institute Of Technology | Gas-filled polymeric microbubbles for ultrasound imaging |
JP2974083B2 (ja) | 1990-11-26 | 1999-11-08 | 株式会社 小松製作所 | 静油圧―機械式伝動機の制御装置 |
JPH06511481A (ja) | 1991-07-05 | 1994-12-22 | ユニバーシティ オブ ロチェスター | 気泡を取り込む超微小非凝集多孔質粒子 |
IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
DE4208527A1 (de) | 1992-03-17 | 1993-09-23 | Max Planck Gesellschaft | Liposomen mit negativer ueberschussladung |
WO1994001140A1 (de) * | 1992-07-03 | 1994-01-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echokontrastmittelzubereitung |
US5464696A (en) | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
EP0711179B2 (en) * | 1993-07-30 | 2010-09-01 | IMCOR Pharmaceutical Co. | Stabilized microbubble compositions for ultrasound |
US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
PT682530E (pt) | 1993-12-15 | 2003-06-30 | Bracco Research Sa | Misturas de gases uteis como meios de contraste para ultrassons |
NO940711D0 (no) | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging |
US5876697A (en) | 1994-08-04 | 1999-03-02 | Gakko Houjin Toin Gakuen | Method for the production of microbubble-type ultrasonic contrast agent using fatty acid surfactants |
GB9417941D0 (en) | 1994-09-06 | 1994-10-26 | Nycomed Imaging As | Improvements in or relating to contrast agents |
JPH10508578A (ja) * | 1994-09-23 | 1998-08-25 | ザ リポソーム カンパニー、インコーポレーテッド | 凍結乾燥リポソーム生成物の製造方法 |
US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US5833948A (en) | 1995-06-15 | 1998-11-10 | Bracco Research S.A. | Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant |
DE69720979T2 (de) | 1996-02-19 | 2004-02-26 | Amersham Health As | Thermostabilisiertes kontrastmittel |
US6165442A (en) | 1996-02-19 | 2000-12-26 | Nycomed Imaging As | Thermally stabilized ultrasound contrast agent |
SK284200B6 (sk) | 1996-02-19 | 2004-10-05 | Amersham Health As | Vodná disperzia plynových mikrobublín, kontrastná látka s jej obsahom, spôsob prípravy kontrastnej látky a jej použitie |
US6263032B1 (en) | 1996-07-22 | 2001-07-17 | Seagate Technology Llc | Phase detector estimator |
CA2262908A1 (en) * | 1996-08-02 | 1998-02-12 | David Johnson | Contrast agents for ultrasound imaging of the liver |
RU2204415C2 (ru) | 1996-10-21 | 2003-05-20 | Амершем Хелт АС | Комбинированный препарат для использования в качестве контрастного агента и способ получения изображения |
ES2264159T3 (es) | 1996-10-28 | 2006-12-16 | Amersham Health As | Mejoras en/o relacionadas con agentes de diagnostico/terapeuticos. |
IL129445A0 (en) | 1996-10-28 | 2000-02-29 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
GB9701237D0 (en) | 1997-01-22 | 1997-03-12 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6245318B1 (en) | 1997-05-27 | 2001-06-12 | Mallinckrodt Inc. | Selectively binding ultrasound contrast agents |
GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
EP1024837A1 (en) | 1997-10-21 | 2000-08-09 | Nycomed Imaging As | Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug |
US20020169138A1 (en) | 1997-10-24 | 2002-11-14 | Southern Research Institute | Delivery vehicles for bioactive agents and uses thereof |
US20010003580A1 (en) * | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
AU753196B2 (en) | 1998-02-09 | 2002-10-10 | Bracco Research S.A. | Targeted delivery of biologically active media |
GB9808599D0 (en) | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or realting to contrast agents |
GB9809084D0 (en) | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
FR2782006B1 (fr) | 1998-08-07 | 2002-04-19 | Gattefosse Ets Sa | Composition a liberation prolongee apte a former une micro-emulsion |
JP2000143550A (ja) | 1998-11-10 | 2000-05-23 | Toin Gakuen | 超音波造影剤 |
DE10013850A1 (de) | 2000-03-15 | 2001-09-20 | Schering Ag | Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung |
JP3991086B2 (ja) | 2000-12-23 | 2007-10-17 | ダイアックス、コープ | 造影剤として有用なフィブリン結合部分 |
JP2002212108A (ja) | 2001-01-17 | 2002-07-31 | Fuji Photo Film Co Ltd | 超音波散乱体 |
US6793626B2 (en) | 2001-01-17 | 2004-09-21 | Fuji Photo Film Co., Ltd. | Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus |
US7179449B2 (en) | 2001-01-30 | 2007-02-20 | Barnes-Jewish Hospital | Enhanced ultrasound detection with temperature-dependent contrast agents |
DE60111917T2 (de) * | 2001-01-31 | 2006-04-20 | Bracco International B.V. | Lyophilisierbares Kontrastmittel, gasgefüllte Mikrobläschen enthaltend |
WO2003005029A2 (en) | 2001-07-03 | 2003-01-16 | Governors Of The University Of Alberta | Magnetic nanoparticles for bioseparation application and methods for producing same |
EP1416974A1 (en) | 2001-08-16 | 2004-05-12 | Bristol-Myers Squibb Pharma Company | Gas microsphere liposome composites |
AU2003228276B8 (en) | 2002-03-01 | 2010-02-18 | Bracco Suisse S.A. | Multivalent constructs for therapeutic and diagnostic applications |
ES2398393T3 (es) | 2002-03-01 | 2013-03-15 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia |
WO2004001140A1 (fr) | 2002-06-19 | 2003-12-31 | Dimitrios Patsalaridis | Dispositif de support ancrable dans le sol |
WO2004083902A2 (en) | 2002-10-25 | 2004-09-30 | Georgia Tech Research Corporation | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring |
DE602004029010D1 (de) | 2003-02-04 | 2010-10-21 | Bracco Suisse Sa | Ultraschall kontrastmittel und verfahren zur erstellung |
CN1897978B (zh) | 2003-12-22 | 2011-11-23 | 博莱科瑞士股份有限公司 | 具有用于反差成像的活性组分的充气微囊组件 |
WO2005063305A1 (en) | 2003-12-22 | 2005-07-14 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
DE602005021057D1 (de) | 2004-01-20 | 2010-06-17 | Toronto E | Hochfrequenz-ultraschall-darstellung mit kontrastmitteln |
EP1784228B1 (en) | 2004-08-18 | 2016-10-05 | Bracco Suisse SA | Gas-filled microvesicles composition for contrast imaging |
-
2004
- 2004-02-03 DE DE602004029010T patent/DE602004029010D1/de not_active Expired - Lifetime
- 2004-02-03 AU AU2004210221A patent/AU2004210221B2/en not_active Ceased
- 2004-02-03 AT AT04707586T patent/ATE480263T1/de active
- 2004-02-03 KR KR1020057013951A patent/KR101076053B1/ko active IP Right Grant
- 2004-02-03 MX MXPA05007730A patent/MXPA05007730A/es active IP Right Grant
- 2004-02-03 WO PCT/IB2004/000243 patent/WO2004069284A2/en active Application Filing
- 2004-02-03 DK DK04707586.6T patent/DK1590006T3/da active
- 2004-02-03 EP EP04707586A patent/EP1590006B1/en not_active Expired - Lifetime
- 2004-02-03 JP JP2006502384A patent/JP4670083B2/ja not_active Expired - Lifetime
- 2004-02-03 RU RU2005127634/15A patent/RU2345793C2/ru active
- 2004-02-03 CN CNB2004800029752A patent/CN100374165C/zh not_active Expired - Lifetime
- 2004-02-03 US US10/544,123 patent/US9364569B2/en active Active
- 2004-02-03 CA CA2512454A patent/CA2512454C/en not_active Expired - Lifetime
- 2004-02-03 ES ES04707586T patent/ES2352087T3/es not_active Expired - Lifetime
-
2005
- 2005-07-14 IL IL169677A patent/IL169677A/en active IP Right Grant
- 2005-08-11 US US11/202,008 patent/US20060034770A1/en not_active Abandoned
- 2005-09-02 NO NO20054089A patent/NO331966B1/no not_active IP Right Cessation
-
2011
- 2011-03-03 US US13/039,838 patent/US20110236320A1/en not_active Abandoned
-
2012
- 2012-12-10 US US13/710,189 patent/US20130101522A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE480263T1 (de) | 2010-09-15 |
AU2004210221B2 (en) | 2008-11-20 |
US20060034770A1 (en) | 2006-02-16 |
CA2512454C (en) | 2012-10-30 |
WO2004069284A2 (en) | 2004-08-19 |
CN100374165C (zh) | 2008-03-12 |
US20130101522A1 (en) | 2013-04-25 |
US9364569B2 (en) | 2016-06-14 |
EP1590006B1 (en) | 2010-09-08 |
EP1590006A2 (en) | 2005-11-02 |
DE602004029010D1 (de) | 2010-10-21 |
WO2004069284A3 (en) | 2004-11-25 |
RU2005127634A (ru) | 2006-01-20 |
US20110236320A1 (en) | 2011-09-29 |
NO331966B1 (no) | 2012-05-14 |
IL169677A (en) | 2011-07-31 |
JP2006520754A (ja) | 2006-09-14 |
US20060051297A1 (en) | 2006-03-09 |
NO20054089L (no) | 2005-10-05 |
KR101076053B1 (ko) | 2011-10-21 |
ES2352087T3 (es) | 2011-02-15 |
CA2512454A1 (en) | 2004-08-19 |
KR20050096959A (ko) | 2005-10-06 |
NO20054089D0 (no) | 2005-09-02 |
CN1744921A (zh) | 2006-03-08 |
JP4670083B2 (ja) | 2011-04-13 |
RU2345793C2 (ru) | 2009-02-10 |
AU2004210221A1 (en) | 2004-08-19 |
MXPA05007730A (es) | 2006-01-31 |
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