JPH10508284A - 超音波造影媒体、この媒体を含む造影剤及び方法 - Google Patents
超音波造影媒体、この媒体を含む造影剤及び方法Info
- Publication number
- JPH10508284A JPH10508284A JP7516634A JP51663495A JPH10508284A JP H10508284 A JPH10508284 A JP H10508284A JP 7516634 A JP7516634 A JP 7516634A JP 51663495 A JP51663495 A JP 51663495A JP H10508284 A JPH10508284 A JP H10508284A
- Authority
- JP
- Japan
- Prior art keywords
- gas
- mixture
- ultrasound
- contrast agent
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.通常の界面活性剤、添加剤及び安定化剤を含む水性担体液の中で懸濁物と なっているときに超音波エコグラフィーにとっての造影剤を供する、体温におい て気性である生体適合性物質を含んで成る注射用超音波造影媒体であって、その 媒体が気体(A)と(B)との混合物であり、ここで気体(B)の少なくとも一 種類が、0.5〜41容量%の量において存在しており、80ダルトンより大きい分子 量を有しており、そしてその水の中での溶解度が標準条件下で測定して水1ml当 り0.0283mlの気体未満であり、この混合物の残りが気体(A)であることを特徴 とする超音波造影媒体。 2.前記気体(B)がフッ素含有生体適合性気体である、請求項1記載の超音 波造影媒体。 3.前記フッ素含有気体が、SF6,CF4,C2F6,C2F8,C3F6,C3F8,C4F6,C4F8 ,C4F10,C5F10,C5F12及びそれらの混合物より成る群から選ばれる、請求項2 記載の超音波造影媒体。 4.前記フッ素含有気体が六フッ素化硫黄又はオクタフルオロシクロブタンで ある、請求項3記載の超音波造影媒体。 5.前記気体Aがエアー、酸素、窒素、二酸化炭素及びそれらの混合物より選 ばれる、請求項1記載の超音波造影媒体。 6.通常の界面活性剤、添加剤及び安定化剤を含んで成る生理学的に許容され る水性担体中の気体充填化マイクロバブル又はマイクロバルーンの懸濁物を含ん で成る注射用超音波造影剤であって、前記気体が少なくとも2種類の生体適合性 気体A及びBの気体混合物であり、ここで少なくとも一種類の気体(B)は0.5 〜41容量%の量において存在しており、80ダルトンより大きい分子量を有してお り、そして標準条件下において水1ml当り0.0283ml未満の水中での 溶解度を有しており、この混合物の残りが気体Aであることを特徴とする、注射 用超音波造影剤。 7.前記気体(B)がフッ素含有生体適合性気体である、請求項6記載の超音 波造影剤。 8.前記フッ素含有気体が、SF6,CF4,C2F6,C2F8,C3F6,C3F8,C4F6,C4F8 ,C4F10,C5F10,C5F12及びそれらの混合物より成る群から選ばれる、請求項7 記載の超音波造影剤。 9.前記気体Aがエアー、酸素、窒素、二酸化炭素又はそれらの混合物より成 る群から選ばれる請求項6又は7記載の超音波造影剤。 10.前記界面活性剤が積層及び/又は板状に存在している少なくとも一種のフ ィルム形成性界面活性剤並びに任意的に親水性安定化剤を含んで成る、請求項6 記載の超音波造影剤。 11.前記フィルム形成性界面活性剤がリン脂質である、請求項10記載の超音波 造影剤。 12.前記リン脂質が、ホスファチジン酸、ホスファチジルコリン、ホスファチ ジルエタノールアミン、ホスファチジルセリン、ホスファチジルグリセロール、 ホスファチジルイノシトール、カルジオリピン、スフィンゴミエリン及びそれら の混合物より成る群から選ばれる、請求項11記載の超音波造影剤。 13.前記リン脂質に加えて、前記水性担体がポリオキシエチレンとポリオキシ プロピレンとのコポリマー及びグリセロールを含んで成る、請求項11記載の超音 波造影剤。 14.前記界面活性剤がダイズ油、Tween(商標)20及び/又はソルビトールであ る、請求項6記載の超音波造影剤。 15.体温において生体適合性気体である物質の混合物のもとにある界面活性剤 、添加剤及び安定化剤を含んで成るドライ製剤であっ て、その少なくとも一種の物質が80ダルトンより大きい分子量であり、そしてそ の水の中での溶解度が標準条件において1mlの水当り0.0283ml未満である、ドラ イ製剤。 16.前記気体がフッ素含有生体適合性気体でる、請求項15記載のドライ製剤。 17.前記フッ素含有気体が前記混合物の中で0.5〜41容量%の量において存在 しており、残りが59〜99.5容量%のエアー、酸素、窒素、二酸化炭素又はそれら の混合物である、請求項16記載のドライ製剤。 18.二成分キットであって、第一成分としての、体温において気体である物質 の混合物のもとにある界面活性剤、添加剤及び安定化剤のドライ製剤、並びに第 二成分としての、生理学的に許容される担体液であって、この第一成分と混合し たときに、これら二成分の懸濁物として超音波造影剤を形成するような担体液を 含んで成り、ここでこの混合物中の少なくとも一種の気体は分子量が80ダルトン より大きく、且つ水の中での溶解度が標準条件下において水1ml当り0.0283ml未 満であることを特徴とするキット。 19.前記気体が前記混合物の中で0.5〜41容量%の量において存在するフッ素 含有生体適合性気体であり、残りがエアー、酸素、窒素、二酸化炭素又はそれら の混合物である、請求項18記載の二成分キット。 20.前記フッ素含有気体がSF6,CF4,C2F6,C2F8,C3F6,C3F8,C4F8,C4F10 ,C5F10,C5F12及びそれらの混合物より成る群から選ばれる、請求項18記載の二 成分キット。 21.請求項6記載の超音波造影剤を作る方法であって、少なくとも2種の生体 適合性成分(A及びB)の気体混合物を通常の界面活性剤、添加剤及び安定化剤 を含む生理学的に許容される水性担体液 の中に気体充填化マイクロバブル又はマイクロバルーンが形成されるように懸濁 する方法であり、ここで前記気体混合物の中での少なくとも一種の気体成分の最 少有効比率を次の基準 Bc%=K/ebMwt+C (式中、Bc%(容量)はこの混合物中の成分Bの全量であり、K,C及びbはそ れぞれ140,−10.8及び0.012の値を有する定数であり、Mwtは成分Bの分子量で あり>80である値を表わしている)に従って決定することを特徴とする方法。 22.前記界面活性剤が、ホスファチジン酸、ホスファチジルコリン、ホスファ チジルエタノールアミン、ホスファチジルセリン、ホスファチジルグリセロール 、ホスファチジルイノシトール、カルジオリピン、スフィンゴミエリン及びそれ らの混合物より成る群から選ばれる、請求項21記載の超音波造影剤を作る方法。 23.ヒト又は動物身体の超音波イメージ形成のための請求項1記載の超音波造 影剤の利用。 24.超音波造影剤の製造のための請求項1記載の超音波造影媒体の利用。
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EP93810885 | 1993-12-15 | ||
PCT/IB1994/000376 WO1995016467A1 (en) | 1993-12-15 | 1994-12-01 | Gas mixtures useful as ultrasound contrast media |
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US (3) | US5846518A (ja) |
EP (1) | EP0682530B1 (ja) |
JP (1) | JPH10508284A (ja) |
KR (1) | KR100295173B1 (ja) |
CN (1) | CN1068229C (ja) |
AT (1) | ATE234638T1 (ja) |
AU (1) | AU679295B2 (ja) |
CA (1) | CA2154867C (ja) |
CZ (1) | CZ208995A3 (ja) |
DE (1) | DE69432295T2 (ja) |
DK (1) | DK0682530T3 (ja) |
ES (1) | ES2192572T3 (ja) |
FI (1) | FI116365B (ja) |
HU (1) | HU225495B1 (ja) |
IL (1) | IL111977A (ja) |
IS (1) | IS1739B (ja) |
NO (2) | NO314019B1 (ja) |
NZ (1) | NZ276167A (ja) |
PL (1) | PL182223B1 (ja) |
PT (1) | PT682530E (ja) |
RU (1) | RU2138293C1 (ja) |
WO (1) | WO1995016467A1 (ja) |
ZA (1) | ZA949983B (ja) |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101419137B1 (ko) * | 2012-12-20 | 2014-07-14 | 가톨릭대학교 산학협력단 | 약물전달을 위한 기체생성 약물전달체 및 이의 제조방법 |
JP2021516684A (ja) * | 2018-03-07 | 2021-07-08 | ブラッコ・スイス・ソシエテ・アノニム | サイズが制御された微小胞の調製 |
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