PT682530E - Misturas de gases uteis como meios de contraste para ultrassons - Google Patents

Misturas de gases uteis como meios de contraste para ultrassons

Info

Publication number
PT682530E
PT682530E PT95900883T PT95900883T PT682530E PT 682530 E PT682530 E PT 682530E PT 95900883 T PT95900883 T PT 95900883T PT 95900883 T PT95900883 T PT 95900883T PT 682530 E PT682530 E PT 682530E
Authority
PT
Portugal
Prior art keywords
mixture
component
ultrasound
gas
ultrasound contrast
Prior art date
Application number
PT95900883T
Other languages
English (en)
Inventor
Michel Schneider
Jean Brochot
Feng Yan
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of PT682530E publication Critical patent/PT682530E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225Microparticles, microcapsules
PT95900883T 1993-12-15 1994-12-01 Misturas de gases uteis como meios de contraste para ultrassons PT682530E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810885 1993-12-15

Publications (1)

Publication Number Publication Date
PT682530E true PT682530E (pt) 2003-06-30

Family

ID=8215090

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95900883T PT682530E (pt) 1993-12-15 1994-12-01 Misturas de gases uteis como meios de contraste para ultrassons

Country Status (23)

Country Link
US (3) US5846518A (pt)
EP (1) EP0682530B1 (pt)
JP (1) JPH10508284A (pt)
KR (1) KR100295173B1 (pt)
CN (1) CN1068229C (pt)
AT (1) ATE234638T1 (pt)
AU (1) AU679295B2 (pt)
CA (1) CA2154867C (pt)
CZ (1) CZ208995A3 (pt)
DE (1) DE69432295T2 (pt)
DK (1) DK0682530T3 (pt)
ES (1) ES2192572T3 (pt)
FI (1) FI116365B (pt)
HU (1) HU225495B1 (pt)
IL (1) IL111977A (pt)
IS (1) IS1739B (pt)
NO (2) NO314019B1 (pt)
NZ (1) NZ276167A (pt)
PL (1) PL182223B1 (pt)
PT (1) PT682530E (pt)
RU (1) RU2138293C1 (pt)
WO (1) WO1995016467A1 (pt)
ZA (1) ZA949983B (pt)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
ATE281183T1 (de) 1993-07-30 2004-11-15 Alliance Pharma Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
JP2001515458A (ja) * 1995-06-07 2001-09-18 マリンクロッド・インコーポレイテッド 気体状超音波造影剤および造影方法
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5840276A (en) * 1996-01-11 1998-11-24 Apfel Enterprises, Inc. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
GB9708240D0 (en) 1997-04-23 1997-06-11 Nycomed Imaging As Improvements in or relating to contrast agents
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
KR20010088022A (ko) * 2000-03-10 2001-09-26 모리스 토파즈 초음파 에너지 보조된 수술용 생체적합성 주사제 수성 용액
EP2279757A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
AU2002253454A1 (en) 2001-04-06 2002-10-21 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
DE10119522A1 (de) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel
WO2004069153A2 (en) * 2003-01-27 2004-08-19 Medrad, Inc. Apparatus, system and method for generating bubbles on demand
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP2301587B1 (en) 2002-03-01 2014-06-25 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US20040037887A1 (en) 2002-06-12 2004-02-26 Scimed Life Systems, Inc. Bulking agent
WO2004006964A1 (en) * 2002-07-11 2004-01-22 Targeson, Llc Microbubble compositions, and methods for preparing and using same
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
JP4748564B2 (ja) 2002-11-29 2011-08-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ 超音波トリガ法
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
AU2004210221B2 (en) * 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
AU2004217894B2 (en) 2003-03-03 2010-07-15 Bracco International B.V. Peptides that specifically bind HGF receptor (cMet) and uses thereof
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
US8021303B2 (en) 2003-06-12 2011-09-20 Bracco Research Sa System for extracting morphological information through a perfusion assessment process
EP1635709B1 (en) 2003-06-12 2013-10-30 Bracco Suisse SA Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
ES2531732T3 (es) * 2003-12-22 2015-03-18 Bracco Suisse Sa Montaje de microvesícula rellena de gas para imagenología de contraste
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
CN1993147B (zh) * 2004-06-04 2013-03-06 阿库斯菲尔公司 超声对比剂剂量组合物
CN102600485B (zh) * 2004-06-04 2014-10-22 阿库斯菲尔公司 超声对比剂剂量配方
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
AU2005318077B2 (en) 2004-12-23 2011-11-03 Bracco Suisse S.A. A perfusion assessment method and system based on bolus administration
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
WO2006094951A1 (en) * 2005-03-03 2006-09-14 Bracco Research Sa Medical imaging system based on a targeted contrast agent
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
EP1951124B1 (en) 2005-11-10 2017-01-04 Bracco Suisse SA Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
WO2007054561A1 (en) 2005-11-10 2007-05-18 Bracco Research Sa Instantaneous visualization of contrast agent concentration in imaging applications
CN101374955B (zh) 2005-12-09 2013-03-27 布拉科瑞士有限公司 靶向载体-磷脂缀合物
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
JP2010506129A (ja) * 2006-10-03 2010-02-25 ワイス エルエルシー 凍結乾燥法および装置
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
AU2007336126B2 (en) 2006-12-21 2013-03-28 Bracco Suisse S.A. Detection of the detachment of immobilized contrast agent in medical imaging applications
WO2009043031A2 (en) 2007-09-27 2009-04-02 Children's Medical Center Corporation Microbubbles and methods for oxygen delivery
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
WO2009083557A1 (en) 2007-12-28 2009-07-09 Bracco Research S.A. Quantification analisys of immobilized contrast agent in medical imaging applications
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
EP2189112A1 (en) 2008-11-24 2010-05-26 Bracco Research S.A. Real-time perfusion imaging and quantification
US9307957B2 (en) 2009-06-08 2016-04-12 Bracco Suisse Sa Auto-scaling of parametric images
JP5628314B2 (ja) 2009-09-01 2014-11-19 ブラッコ・シュイス・ソシエテ・アノニムBracco Suisse SA 経時的な動的挙動に基づくパラメトリック画像
EP2544593B1 (en) 2010-03-09 2014-12-31 Bracco Suisse SA Initialization of fitting parameters for perfusion assessment based on bolus administration
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2013151682A1 (en) 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
KR101419137B1 (ko) * 2012-12-20 2014-07-14 가톨릭대학교 산학협력단 약물전달을 위한 기체생성 약물전달체 및 이의 제조방법
CN104885121B (zh) 2012-12-21 2018-08-31 博莱科瑞士股份有限公司 诊断成像应用中的基于随着时间的统计分析的分割
WO2014144364A1 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
CN103212094B (zh) * 2013-04-28 2014-10-22 重庆医科大学附属儿童医院 一种氧氟脂质微泡及其制备方法
JP6523326B2 (ja) 2014-04-07 2019-05-29 ブラッコ・シュイス・ソシエテ・アノニムBracco Suisse SA 非基本波分析による音響レベルのIn−Situ推定
TWI556837B (zh) * 2014-07-18 2016-11-11 國立清華大學 用於藥物傳遞之奈/微米氣泡
IL252705B2 (en) 2014-12-31 2023-03-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
KR20180091025A (ko) 2015-12-10 2018-08-14 브라코 스위스 에스.에이. 동적 역치화에 의한 고정된 조영제의 검출
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
MX2018013409A (es) 2016-05-04 2019-07-08 Lantheus Medical Imaging Inc Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido.
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
DK3506882T3 (da) 2016-08-30 2022-03-21 Bracco Suisse Sa Fremstilling af størrelseskontrollerede mikropartikler
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
JP7330163B2 (ja) 2017-07-07 2023-08-21 ドレクセル ユニバーシティ 電位活性化型の治療用構築物、診断用構築物、および/またはセラノスティック用構築物
CA3091952A1 (en) 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US3900420A (en) * 1970-05-18 1975-08-19 Felix Sebba Microgas emulsions and method of forming same
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (pt) 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (pt) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4256251A (en) * 1978-04-24 1981-03-17 Lawrence M. Smith Surgical staplers and staple
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4316391A (en) * 1979-11-13 1982-02-23 Ultra Med, Inc. Flow rate measurement
US4442843A (en) 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
DE3141641A1 (de) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
DE3324754A1 (de) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen Ultraschallkontrastmittel sowie dessen herstellung
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
GB8504916D0 (en) 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
EP0245019A3 (en) 1986-04-30 1989-05-10 Michael A. Davis Low density contrast medium for diagnosis of pathologic conditions
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5283067A (en) * 1987-01-30 1994-02-01 Ciba-Geigy Corporation Parenteral suspensions
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
CH672733A5 (pt) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
KR0133132B1 (ko) * 1988-02-05 1998-04-17 쉐링 아게, 베를린 운트 베르크카멘 초음파 조영제, 이의 제법 및 이의 진단제로서의 용도
US5171755A (en) 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5730954A (en) * 1988-08-23 1998-03-24 Schering Aktiengesellschaft Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
DE3934656A1 (de) * 1989-10-13 1991-04-18 Schering Ag Verfahren zur herstellung von waessrigen dispersionen
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5123414A (en) 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
IN172208B (pt) * 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5215680A (en) 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
JP3247374B2 (ja) * 1990-10-05 2002-01-15 ブラッコ インターナショナル ベスローテン フェンノートシャップ 超音波エコグラフィーに適切な中空気体封入微小球の安定懸濁物の製造のための方法
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
ES2103947T5 (es) 1991-06-03 2001-05-16 Nycomed Imaging As Mejoras introducidas en o relacionadas con agentes de contraste.
US5389519A (en) * 1991-08-01 1995-02-14 The Research Foundation Of The State University Of New York Method of screening for infertility
DE4127442C2 (de) * 1991-08-17 1996-08-22 Udo Dr Gros Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
AU679428C (en) * 1991-09-17 2006-07-13 Ge Healthcare As Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
AU2789192A (en) * 1991-10-04 1993-05-03 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
BE1006651A3 (fr) * 1992-01-24 1994-11-08 Raffinerie Tirlemontoise Sa Sucre perle, procede pour sa fabrication et son utilisation dans le secteur alimentaire.
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
CN1084410A (zh) 1992-03-06 1994-03-30 奈科姆成像有限公司 涉及造影剂的改进
EP0679066A4 (en) * 1992-11-02 1996-04-03 Univ Drexel TENSIDE-STABILIZED MICROBUBBLE MIXTURES, METHOD FOR THEIR PRODUCTION AND USE.
US5558853A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
AU683485B2 (en) * 1993-07-02 1997-11-13 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
ATE281183T1 (de) * 1993-07-30 2004-11-15 Alliance Pharma Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5601085A (en) * 1995-10-02 1997-02-11 Nycomed Imaging As Ultrasound imaging

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FI953843A (fi) 1995-08-14
JPH10508284A (ja) 1998-08-18
NO953195D0 (no) 1995-08-14
US5846518A (en) 1998-12-08
DK0682530T3 (da) 2003-07-14
IS1739B (is) 1999-12-30
NO953141D0 (no) 1995-08-10
PL182223B1 (pl) 2001-11-30
PL310172A1 (en) 1995-11-27
IS4239A (is) 1995-06-16
CZ208995A3 (en) 1996-01-17
CA2154867A1 (en) 1995-06-22
EP0682530A1 (en) 1995-11-22
AU1033095A (en) 1995-07-03
IL111977A0 (en) 1995-03-15
IL111977A (en) 2000-06-01
HU9502390D0 (en) 1995-10-30
HUT73251A (en) 1996-07-29
KR100295173B1 (ko) 2001-09-17
CN1068229C (zh) 2001-07-11
ES2192572T3 (es) 2003-10-16
NO953141L (no) 1995-08-10
FI116365B (fi) 2005-11-15
ZA949983B (en) 1995-08-22
AU679295B2 (en) 1997-06-26
ATE234638T1 (de) 2003-04-15
KR960700757A (ko) 1996-02-24
NO314019B1 (no) 2003-01-20
CA2154867C (en) 2007-05-29
DE69432295T2 (de) 2003-08-14
US6183725B1 (en) 2001-02-06
DE69432295D1 (de) 2003-04-24
EP0682530B1 (en) 2003-03-19
NZ276167A (en) 1996-11-26
US20040197269A1 (en) 2004-10-07
FI953843A0 (fi) 1995-08-14
HU225495B1 (en) 2007-01-29
CN1117713A (zh) 1996-02-28

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