DK0605477T4 - Gasformige ultralydskontrastmidler - Google Patents

Gasformige ultralydskontrastmidler

Info

Publication number
DK0605477T4
DK0605477T4 DK92919150T DK92919150T DK0605477T4 DK 0605477 T4 DK0605477 T4 DK 0605477T4 DK 92919150 T DK92919150 T DK 92919150T DK 92919150 T DK92919150 T DK 92919150T DK 0605477 T4 DK0605477 T4 DK 0605477T4
Authority
DK
Denmark
Prior art keywords
agents
microbubbles
gases
contrast agents
comprised
Prior art date
Application number
DK92919150T
Other languages
English (en)
Other versions
DK0605477T3 (da
Inventor
Steven C Quay
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27116965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0605477(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/893,657 external-priority patent/US5409688A/en
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of DK0605477T3 publication Critical patent/DK0605477T3/da
Application granted granted Critical
Publication of DK0605477T4 publication Critical patent/DK0605477T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Hydrogen, Water And Hydrids (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Electron Sources, Ion Sources (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK92919150T 1991-09-17 1992-09-02 Gasformige ultralydskontrastmidler DK0605477T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76131191A 1991-09-17 1991-09-17
US07/893,657 US5409688A (en) 1991-09-17 1992-06-05 Gaseous ultrasound contrast media
PCT/US1992/007250 WO1993005819A1 (en) 1991-09-17 1992-09-02 Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media

Publications (2)

Publication Number Publication Date
DK0605477T3 DK0605477T3 (da) 2000-08-14
DK0605477T4 true DK0605477T4 (da) 2007-10-01

Family

ID=27116965

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92919150T DK0605477T4 (da) 1991-09-17 1992-09-02 Gasformige ultralydskontrastmidler

Country Status (19)

Country Link
US (1) US5558094B1 (da)
EP (1) EP0605477B2 (da)
JP (2) JP3231768B2 (da)
KR (1) KR100191303B1 (da)
AT (1) ATE191346T1 (da)
AU (2) AU679428C (da)
CA (1) CA2119129C (da)
CZ (1) CZ286149B6 (da)
DE (2) DE605477T1 (da)
DK (1) DK0605477T4 (da)
ES (1) ES2145011T5 (da)
FI (1) FI119466B (da)
GR (1) GR3033908T3 (da)
HK (1) HK1012564A1 (da)
HU (1) HU218018B (da)
NO (1) NO313577B1 (da)
RU (1) RU2114637C1 (da)
SG (1) SG54121A1 (da)
WO (1) WO1993005819A1 (da)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (da) * 1990-04-02 1993-05-01 Sint Sa
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
DE605477T1 (de) * 1991-09-17 1998-09-24 Sonus Pharma Inc Gasförmige ultraschallkontrastmittel und verfahren zur auswahl von gasen für die verwendung als ultraschallkontrastmittel.
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
DE69427185T2 (de) * 1993-01-25 2001-12-06 Sonus Pharma Inc Phase-Stift Kolloide zur Verwendung als Ultraschallkontrastmittel
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
GB9305349D0 (en) * 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
KR100218642B1 (ko) * 1993-07-02 1999-09-01 스티븐 로손 열변성된 단백질로부터 캡슐화된 마이크로스피어의 제조방법
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US5605673A (en) * 1993-07-30 1997-02-25 Alliance Pharmaceutical Corp. Stabilized microbubble compositions for ultrasound
CN1068229C (zh) 1993-12-15 2001-07-11 勃勒柯研究有限公司 超声对比介质、含该介质的对比剂及方法
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
WO1998053855A1 (en) 1997-05-30 1998-12-03 Alliance Pharmaceutical Corp. Methods and apparatus for monitoring and quantifying the movement of fluid
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5560364A (en) * 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5674469A (en) * 1995-06-07 1997-10-07 Molecular Biosystems, Inc. Gas-exchange method of making gas-filled microspheres
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5840276A (en) * 1996-01-11 1998-11-24 Apfel Enterprises, Inc. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
CZ281298A3 (cs) * 1996-03-05 1999-01-13 Acusphere, Inc. Fluorované plyny v mikrokapslích jako zobrazující činidla pro ultrazvukové vyšetření
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
JP2001507207A (ja) 1996-05-01 2001-06-05 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 化合物を細胞に送達する方法
US5728315A (en) * 1996-05-01 1998-03-17 Alliedsignal Inc. Azeotrope-like compositions of trifluoromethane, carbon dioxide, ethane and hexafluoroethane
US5849727A (en) * 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
WO1998003205A2 (en) * 1996-07-19 1998-01-29 Sonus Pharmaceuticals, Inc. Enhanced ultrasound contrast imaging using inhaled gases
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
WO1998010798A1 (en) 1996-09-11 1998-03-19 Imarx Pharmaceutical Corp. Improved methods for diagnostic imaging using a contrast agent and a vasodilator
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6439236B1 (en) 1999-10-25 2002-08-27 The Board Of Regents Of The University Of Nebraska Methods for inducing atrial and ventricular rhythms using ultrasound and microbubbles
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US7358226B2 (en) * 2003-08-27 2008-04-15 The Regents Of The University Of California Ultrasonic concentration of drug delivery capsules
PT1694292E (pt) 2003-11-17 2009-10-26 Btg Int Ltd Espuma terapêutica
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
WO2005070472A2 (en) 2004-01-20 2005-08-04 Sunnybrook And Women's College Health Sciences Centre, High frequency ultrasound imaging using contrast agents
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
WO2009043031A2 (en) 2007-09-27 2009-04-02 Children's Medical Center Corporation Microbubbles and methods for oxygen delivery
RU2492812C2 (ru) * 2008-01-23 2013-09-20 Михалакис АВЕРКИУ Оценка лечения с использованием ультразвуковых контрастных веществ
US8846063B2 (en) 2008-12-16 2014-09-30 Kimberly-Clark Worldwide, Inc. Personal care composition containing a volatile and a terpene alcohol
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
EP2858554A4 (en) 2012-06-11 2016-02-24 Univ California METHOD AND SYSTEM FOR IN VIVO HYDROGEN PEROXIDE DETECTION WITH ULTRASOUND
KR102139393B1 (ko) 2012-06-26 2020-07-29 지이 헬스케어 에이에스 기체 미세기포를 포함하는 조성물의 제조
US10577554B2 (en) 2013-03-15 2020-03-03 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
AU2015374286B2 (en) 2014-12-31 2021-11-18 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
JP2019515936A (ja) 2016-05-04 2019-06-13 ランセウス メディカル イメージング, インコーポレイテッド 超音波造影剤を調製するための方法およびデバイス
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
TW202313536A (zh) * 2019-02-08 2023-04-01 日商大金工業股份有限公司 含有含氟烯烴之組成物

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
JPS57150542A (en) * 1981-03-13 1982-09-17 Katashi Aoki Injection, stretching, and blow molding machine
US4361979A (en) * 1981-04-07 1982-12-07 Brio Toy Ab Connection element for making assemblies of toy units
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
JPS5967229A (ja) * 1982-10-08 1984-04-16 Green Cross Corp:The 超音波診断造影剤
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3834705A1 (de) * 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
JPS6073621A (ja) * 1983-09-30 1985-04-25 Fuji Photo Film Co Ltd 折畳み式カメラ
US4767610A (en) * 1984-10-19 1988-08-30 The Regents Of The University Of California Method for detecting abnormal cell masses in animals
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
WO1987002893A1 (en) * 1985-11-18 1987-05-21 Board Of Regents, The University Of Texas System Polychelating agents for image and spectral enhancement (and spectral shift)
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
US5284645A (en) * 1987-08-05 1994-02-08 Alliance Pharmaceutical Corp. Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems
ES2054658T3 (es) * 1986-01-24 1994-08-16 Childrens Hosp Medical Center Metodo para la preparacion de una emulsion fisiologicamente aceptable.
EP0245019A3 (en) * 1986-04-30 1989-05-10 Michael A. Davis Low density contrast medium for diagnosis of pathologic conditions
JPS6360943A (ja) * 1986-09-01 1988-03-17 Green Cross Corp:The 超音波診断造影剤
US5219538A (en) * 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US5354549A (en) * 1987-07-24 1994-10-11 Nycomed Imaging As Iodinated esters
CN1013830B (zh) * 1987-08-26 1991-09-11 宋振才 B超胃肠造影剂的制造工艺
IE61591B1 (en) * 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
EP0586875A1 (de) * 1988-02-05 1994-03-16 Schering Aktiengesellschaft Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US4993415A (en) * 1988-08-19 1991-02-19 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
GB8900376D0 (en) * 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
DK0489773T3 (da) * 1989-08-30 1993-11-29 Kali Chemie Ag Fremgangsmåde til adskillelse af blandinger af delvist fluorerede eller perflourerede carbonhydridforbindelser
JPH062134B2 (ja) * 1989-09-08 1994-01-12 株式会社東芝 超音波診断装置
JPH02196730A (ja) * 1989-12-15 1990-08-03 Green Cross Corp:The 超音波診断造影剤
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
IN172208B (da) * 1990-04-02 1993-05-01 Sint Sa
DK0454044T3 (da) * 1990-04-25 1996-04-22 Hoechst Ag Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
WO1991018612A1 (en) * 1990-06-01 1991-12-12 Unger Evan C Contrast media for ultrasonic imaging
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
FR2665705B1 (fr) * 1990-08-09 1993-07-30 Atta Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.
US5310540A (en) * 1990-10-05 1994-05-10 Sintetica Sa Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5236693A (en) * 1990-11-14 1993-08-17 Brigham And Women's Hospital Medical ultrasound contrast agent and method of using same
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US5107842A (en) * 1991-02-22 1992-04-28 Molecular Biosystems, Inc. Method of ultrasound imaging of the gastrointestinal tract
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5496535A (en) * 1991-04-12 1996-03-05 Alliance Pharmaceutical Corp. Fluorocarbon contrast media for use with MRI and radiographic imaging
SE470086B (sv) * 1991-04-23 1993-11-08 Kabi Pharmacia Ab Organspecifik emulsion
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
EP0586524B2 (en) * 1991-06-03 2000-11-02 Nycomed Imaging As Improvements in or relating to contrast agents
WO1992022298A1 (en) * 1991-06-18 1992-12-23 Unger Evan C Novel liposomal drug delivery systems
DK0593624T3 (da) * 1991-07-05 1997-05-20 Nycomed Imaging As Forbedringer af eller i relation til kontrastmidler
JPH06511481A (ja) * 1991-07-05 1994-12-22 ユニバーシティ オブ ロチェスター 気泡を取り込む超微小非凝集多孔質粒子
FR2679150A1 (fr) * 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
DE4127442C2 (de) * 1991-08-17 1996-08-22 Udo Dr Gros Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
DE605477T1 (de) * 1991-09-17 1998-09-24 Sonus Pharma Inc Gasförmige ultraschallkontrastmittel und verfahren zur auswahl von gasen für die verwendung als ultraschallkontrastmittel.
AU2789192A (en) * 1991-10-04 1993-05-03 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
US5344640A (en) * 1991-10-22 1994-09-06 Mallinckrodt Medical, Inc. Preparation of apatite particles for medical diagnostic imaging
EP0614527A4 (en) * 1991-11-19 1998-06-03 Evan C Unger CONTRAST AGENTS BASED ON GEL-SHAPED PARTICLES FOR IMPROVED IMAGE GENERATION.
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5344393A (en) * 1992-02-28 1994-09-06 Alliance Pharmaceutical Corp. Use of synthetic oxygen carriers to facilitate oxygen delivery
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent

Also Published As

Publication number Publication date
AU679428B2 (en) 1997-07-03
NO313577B1 (no) 2002-10-28
JPH07501319A (ja) 1995-02-09
FI941242A (fi) 1994-05-16
AU3995997A (en) 1998-02-05
RU2114637C1 (ru) 1998-07-10
CA2119129A1 (en) 1993-04-01
DK0605477T3 (da) 2000-08-14
AU679428C (en) 2006-07-13
AU2550392A (en) 1993-04-27
CZ61294A3 (en) 1994-10-19
HU9400786D0 (en) 1994-08-29
HU218018B (hu) 2000-05-28
DE69230885T2 (de) 2001-06-07
NO940956D0 (no) 1994-03-16
ES2145011T3 (es) 2000-07-01
CA2119129C (en) 1999-11-09
EP0605477B1 (en) 2000-04-05
NO940956L (no) 1994-03-16
FI119466B (fi) 2008-11-28
JP3231768B2 (ja) 2001-11-26
ES2145011T5 (es) 2008-02-01
GR3033908T3 (en) 2000-11-30
CZ286149B6 (cs) 2000-01-12
DE69230885T3 (de) 2008-01-24
ATE191346T1 (de) 2000-04-15
EP0605477B2 (en) 2007-06-20
DE69230885D1 (de) 2000-05-11
HUT68083A (en) 1995-05-29
HK1012564A1 (en) 1999-08-06
FI941242A0 (fi) 1994-03-16
US5558094B1 (en) 1999-01-19
US5558094A (en) 1996-09-24
WO1993005819A1 (en) 1993-04-01
EP0605477A1 (en) 1994-07-13
KR100191303B1 (ko) 1999-06-15
JP2001026554A (ja) 2001-01-30
EP0605477A4 (en) 1994-09-07
SG54121A1 (en) 1998-11-16
DE605477T1 (de) 1998-09-24

Similar Documents

Publication Publication Date Title
US5558094B1 (en) Methods for using persistent gases as ultrasound contrast media
CA2273140A1 (en) Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
PT100867A (pt) Meios de contraste gasoso para ultrsons e metodo para seleccionar gases para utilizacao como meios de contraste para ultrasons
RU94030382A (ru) Биосовместимая контрастная среда и способ получения ультразвукового изображения
DK0788348T3 (da) Beholder med multifasesammensætning til brug i diagnostiske og terapeutiske anvendelser
NO981044L (no) Sirkulært DNA-molekyl med kondisjonell replikasjonsopprinnelse, dets fremstilling og anvendelse derav i genterapi
NO305385B1 (no) Kontrastmidler for ultralyd-ekkografi, fremgangsmÕte for fremstilling av disse, kontrastmiddelforl°pere og anvendelse derav
ATE371834T1 (de) Sauerstoffanreichungsapparat
MX9200902A (es) Metodo de anestesia.
ITRM920590A1 (it) Sistema per la realizzazione distrutture in fibra di carbonio, e procedimento per detto, particolarmente idoneo per applicazioni aeronautiche.
ATE393650T1 (de) Photolytische oxygenationseinheit mit kohlendioxidfixierung und -trennung
HUP0104176A2 (hu) Párologtató- és öntözőberendezés
MY111060A (en) Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
ATE116007T1 (de) Gasspülstein.
FR2710544B1 (fr) Rétro tuba.
DE69421665T2 (de) Anomere Fluorribosylamine
EP0868921A3 (en) Medical gas mixtures
DE69426912D1 (de) Gerät zur lokale Hydromassage
ITSA930012A0 (it) Sistema, per strumenti musicali e simili, in grado di interagire con l'utente segnalandogli, mediante illuminazioni, la corretta procedura di esecuzione di un brano.
ITRM920224A1 (it) Sistema ottico per la combinazione di due cammini ottici, in particolare i cammini ottici di uno strumento di diagnostica oculare e di un altro strumento.
ITPN910075A1 (it) Procedimento di costruzione di telai in fibra di carbonio.
IT8635859V0 (it) Sordina metallica per contrabbassi, violoncelli e simili
UA15359A (uk) Спосіб формуваhhя активhого середовища ваhhи або басейhа та система для його здійсhеhhя
KR910009523A (ko) 선박구상선수 표면류 분산기
KR950005709U (ko) 유희용 훌라후프(Hula-Hoop)에 설치된 음발생장치의 결착구조