FR2665705B1 - Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical. - Google Patents

Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.

Info

Publication number
FR2665705B1
FR2665705B1 FR9010206A FR9010206A FR2665705B1 FR 2665705 B1 FR2665705 B1 FR 2665705B1 FR 9010206 A FR9010206 A FR 9010206A FR 9010206 A FR9010206 A FR 9010206A FR 2665705 B1 FR2665705 B1 FR 2665705B1
Authority
FR
France
Prior art keywords
preparations
derivatives
carriers
preparation
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9010206A
Other languages
English (en)
Other versions
FR2665705A1 (fr
Inventor
Pavia Andre
Pucci Bernard
Jean G Riess
Zarif Leila
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATTA
Original Assignee
ATTA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9010206A priority Critical patent/FR2665705B1/fr
Application filed by ATTA filed Critical ATTA
Priority to EP91914689A priority patent/EP0548096B1/fr
Priority to CA002088923A priority patent/CA2088923A1/fr
Priority to PCT/EP1991/001521 priority patent/WO1992002560A1/fr
Priority to ES91914689T priority patent/ES2082222T3/es
Priority to AT91914689T priority patent/ATE130012T1/de
Priority to AU83947/91A priority patent/AU647176B2/en
Priority to DK91914689.4T priority patent/DK0548096T3/da
Priority to JP51419791A priority patent/JP3267292B2/ja
Priority to DE69114508T priority patent/DE69114508T2/de
Publication of FR2665705A1 publication Critical patent/FR2665705A1/fr
Application granted granted Critical
Publication of FR2665705B1 publication Critical patent/FR2665705B1/fr
Priority to US08/238,970 priority patent/US5527962A/en
Priority to US08/465,412 priority patent/US5703126A/en
Priority to US08/483,289 priority patent/US5847206A/en
Priority to GR960400176T priority patent/GR3018777T3/el
Priority to US09/344,850 priority patent/US6359006B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A61K8/70—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F20/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-acryloylmorpholine
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/28—Aminocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/38—Alcohols, e.g. oxidation products of paraffins
FR9010206A 1990-08-09 1990-08-09 Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical. Expired - Fee Related FR2665705B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR9010206A FR2665705B1 (fr) 1990-08-09 1990-08-09 Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.
DE69114508T DE69114508T2 (de) 1990-08-09 1991-08-08 Amphiphile fluorderivate mit telomerer struktur und biomedizinische anwendungen.
PCT/EP1991/001521 WO1992002560A1 (fr) 1990-08-09 1991-08-08 Derives amphiphiliques de fluor a structures telomeres, leur preparation et leurs applications biomedicales
ES91914689T ES2082222T3 (es) 1990-08-09 1991-08-08 Derivados fluoroanfifilicos con estructuras telomericas, preparacion y aplicaciones biomedicas.
AT91914689T ATE130012T1 (de) 1990-08-09 1991-08-08 Amphiphile fluorderivate mit telomerer struktur und biomedizinische anwendungen.
AU83947/91A AU647176B2 (en) 1990-08-09 1991-08-08 Amphiphilic fluorine derivatives with telomeric structures; preparation and biomedical applications
DK91914689.4T DK0548096T3 (da) 1990-08-09 1991-08-08 Amphifile fluorderivater med telomerisk struktur, deres fremstilling og biomedicinske anvendelser
JP51419791A JP3267292B2 (ja) 1990-08-09 1991-08-08 テロマー構造を有する両親媒性フッ素誘導体；調整および生物医学的適用
EP91914689A EP0548096B1 (fr) 1990-08-09 1991-08-08 Derives amphiphiliques de fluor a structures telomeres, leur preparation et leurs applications biomedicales
CA002088923A CA2088923A1 (fr) 1990-08-09 1991-08-08 Derives fluores amphiphiles a structures telomeriques; preparation et applications biomedicales
US08/238,970 US5527962A (en) 1990-08-09 1994-05-05 Amphiphilic fluorine derivatives with telomeric structures
US08/465,412 US5703126A (en) 1990-08-09 1995-06-05 Amphiphilic fluorine derivatives with telomeric structures
US08/483,289 US5847206A (en) 1990-08-09 1995-06-07 Amphiphilic fluorine derivatives with telomeric structures; preparation procedure and biomedical applications
GR960400176T GR3018777T3 (en) 1990-08-09 1996-01-24 Amphiphilic fluorine derivatives with telomeric structures; preparation and biomedical applications.
US09/344,850 US6359006B2 (en) 1990-08-09 1999-06-28 Amphiphilic fluorine derivatives with telomeric structures; preparation procedure and biomedical applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9010206A FR2665705B1 (fr) 1990-08-09 1990-08-09 Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.

Publications (2)

Publication Number Publication Date
FR2665705A1 FR2665705A1 (fr) 1992-02-14
FR2665705B1 true FR2665705B1 (fr) 1993-07-30

Family

ID=9399581

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9010206A Expired - Fee Related FR2665705B1 (fr) 1990-08-09 1990-08-09 Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.

Country Status (12)

Country Link
US (4) US5527962A (fr)
EP (1) EP0548096B1 (fr)
JP (1) JP3267292B2 (fr)
AT (1) ATE130012T1 (fr)
AU (1) AU647176B2 (fr)
CA (1) CA2088923A1 (fr)
DE (1) DE69114508T2 (fr)
DK (1) DK0548096T3 (fr)
ES (1) ES2082222T3 (fr)
FR (1) FR2665705B1 (fr)
GR (1) GR3018777T3 (fr)
WO (1) WO1992002560A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665705B1 (fr) * 1990-08-09 1993-07-30 Atta Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.
US6344489B1 (en) 1991-02-14 2002-02-05 Wayne State University Stabilized gas-enriched and gas-supersaturated liquids
DK0605477T4 (da) * 1991-09-17 2007-10-01 Ge Healthcare As Gasformige ultralydskontrastmidler
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
NZ262237A (en) * 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5658962A (en) * 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
FR2720943B1 (fr) * 1994-06-09 1996-08-23 Applic Transferts Technolo Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples.
US5874481A (en) * 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
US5667809A (en) * 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
JPH0924269A (ja) * 1995-07-10 1997-01-28 M Technic Kk リン脂質を使ったマイクロカプセルの製造方法
US5834519A (en) * 1996-10-11 1998-11-10 Wayne State University Stabilized gas-supersaturated emulsions and suspensions
US5980936A (en) * 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
EP0900786A1 (fr) * 1997-09-03 1999-03-10 Monsanto Europe S.A./N.V. Nouveaux composés tensio-actifs, méthode pour leur préparation et leur emploi
JP2002530364A (ja) * 1998-11-25 2002-09-17 ジーン セラピイ システムズ、インコーポレイテッド 両親媒性ポリアミン化合物
US6258275B1 (en) * 1999-10-01 2001-07-10 Ecole Polytechnique Federale De Lausanne Affinity macroligands
US6975896B2 (en) 2002-05-23 2005-12-13 Koninklijke Philips Electronics N.V. Fiducial markers for MRI
US7435774B2 (en) * 2002-09-11 2008-10-14 Peach State Labs, Inc. Fluoromonomers, fluoropolymers, methods of preparing them, and their application to various surfaces and substrates
FR2870236B1 (fr) * 2004-05-14 2008-08-01 Ts Pharma Sarl Nouveaux tensio-actifs telomeres et leurs applications
JP2007526912A (ja) 2004-01-30 2007-09-20 グレート・レークス・ケミカル・コーポレーション 製造方法並びにシステム、組成物、界面活性剤、モノマー単位、金属錯体、燐酸エステル、グリコール、水性皮膜形成フォーム、及びフォーム安定剤
WO2006113666A2 (fr) * 2005-04-19 2006-10-26 Massachusetts Institute Of Technology Polymeres amphiphiles et leurs procedes d'utilisation
JP2009523130A (ja) * 2006-01-10 2009-06-18 イノバフォーム テクノロジーズ エルエルシー 殺虫剤伝達システム
US8318656B2 (en) 2007-07-03 2012-11-27 E. I. Du Pont De Nemours And Company Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams, and foam stabilizers
EP2844377B1 (fr) 2012-05-01 2016-12-14 TherOx, Inc. Système visant à enrichir un écoulement de liquide à l'intérieur d'un conduit en un gaz sans bulles
EP3246353B1 (fr) * 2016-05-19 2021-03-17 Centre National De La Recherche Scientifique Utilisation de tensioactifs pour extraire de l'or ou un métal du groupe platine à partir de compositions organiques
WO2017198846A1 (fr) * 2016-05-19 2017-11-23 Centre National De La Recherche Scientifique Utilisation d'agents tensio-actifs pour extraire un métal du groupe platine ou de l'or de compositions organiques
KR102342324B1 (ko) * 2020-12-11 2021-12-23 애경케미칼주식회사 불소계 계면활성제 조성물

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US4089804A (en) * 1976-12-30 1978-05-16 Ciba-Geigy Corporation Method of improving fluorinated surfactants
EP0019584B1 (fr) * 1979-05-03 1984-11-14 Ciba-Geigy Ag Oligomères à groupes terminaux perfluoroalkyles contenant des groupes mercaptans, procédé pour leur préparation et leur utilisation comme matières tensio-actives et comme additifs dans les produits extincteurs
US4460480A (en) * 1980-03-13 1984-07-17 Ciba-Geigy Corporation Protein hydrolyzate compositions for fire fighting containing perfluoroalkyl sulfide terminated oligomers
US4460804A (en) * 1982-08-02 1984-07-17 Svejkovsky Roger L Flexible electrically conductive adhesive tape
FR2602774B1 (fr) * 1986-07-29 1990-10-19 Atta Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives
JPH0354610A (ja) * 1989-07-21 1991-03-08 Fanuc Ltd インボリュート補間誤差補正方式
US5562608A (en) 1989-08-28 1996-10-08 Biopulmonics, Inc. Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5464634A (en) * 1990-06-22 1995-11-07 The Regents Of The University Of California Red blood cell surrogate
FR2665705B1 (fr) 1990-08-09 1993-07-30 Atta Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.

Also Published As

Publication number Publication date
JP3267292B2 (ja) 2002-03-18
AU8394791A (en) 1992-03-02
WO1992002560A1 (fr) 1992-02-20
DE69114508D1 (de) 1995-12-14
US5847206A (en) 1998-12-08
DK0548096T3 (da) 1996-02-26
GR3018777T3 (en) 1996-04-30
EP0548096B1 (fr) 1995-11-08
FR2665705A1 (fr) 1992-02-14
EP0548096A1 (fr) 1993-06-30
ES2082222T3 (es) 1996-03-16
CA2088923A1 (fr) 1992-02-10
JPH06504985A (ja) 1994-06-09
DE69114508T2 (de) 1996-06-13
AU647176B2 (en) 1994-03-17
ATE130012T1 (de) 1995-11-15
US5527962A (en) 1996-06-18
US5703126A (en) 1997-12-30
US20020019442A1 (en) 2002-02-14
US6359006B2 (en) 2002-03-19

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