ES2192572T3 - Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo. - Google Patents
Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo.Info
- Publication number
- ES2192572T3 ES2192572T3 ES95900883T ES95900883T ES2192572T3 ES 2192572 T3 ES2192572 T3 ES 2192572T3 ES 95900883 T ES95900883 T ES 95900883T ES 95900883 T ES95900883 T ES 95900883T ES 2192572 T3 ES2192572 T3 ES 2192572T3
- Authority
- ES
- Spain
- Prior art keywords
- ultrasound
- contrast
- ultrasound contrast
- mixture
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002872 contrast media Substances 0.000 title abstract 3
- 238000002604 ultrasonography Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- 239000002961 echo contrast media Substances 0.000 abstract 4
- 239000007789 gas Substances 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 229960003853 ultrasound contrast media Drugs 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 239000003570 air Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Editing Of Facsimile Originals (AREA)
- Soundproofing, Sound Blocking, And Sound Damping (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Glass Compositions (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Materials For Medical Uses (AREA)
Abstract
LA INVENCION SE REFIERE A UN MEDIO INYECTABLE PARA LA ECOGRAFIA ULTRASONICA EN FORMA DE MICROBURBUJAS O MICROBALONES QUE COMPRENDAN AL MENOS DOS SUBSTANCIAS BIOCOMPATIBLES A Y B (GASEOSAS A LA TEMPERATURA CORPORAL) QUE FORMAN UNA MEZCLA QUE CUANDO SE ENCUENTRA EN SUSPENSION CON SURFACTANTES, ADITIVOS Y ESTABILIZADORES HABITUALES SUMINISTRA AGENTES DE CONTRASTE ULTRASONICO MUY UTILES. AL MENOS UNO DE LOS COMPONENTES (B) EN LA MEZCLA ES UN GAS CUYO PESO MOLECULAR ES MAYOR DE 80 DALTONS Y CUYA SOLUBILIDAD EN AGUA ESTA POR DEBAJO DE 0.0283 ML POR ML DE AGUA EN CONDICIONES ESTANDAR. LA PRESENCIA DEL PRIMER COMPONENTE (B) EN EL MEDIO DE CONTRASTE PUEDE VARIAR ENTRE UN 0.5 Y UN 41% DEL VOLUMEN. EL OTRO COMPONENTE (A) DEL MEDIO DE CONTRASTE DE ULTRASONIDOS ES UN GAS O UNA MEZCLA DE GASES CUYO PESO MOLECULAR ESTA POR DEBAJO DE 80 DALTONS. EL SEGUNDO COMPONENTE ESTA PRESENTE EN UNA PROPORCION DE ENTRE UN 59 Y UN 99.5% POR VOLUMEN, Y SE ESCOGE PREFERIBLEMENTE ENTRE OXIGENO, AIRE, NITROGENO, DIOXIDO DECARBONO O MEZCLAS DE LOS MISMOS. LAS MEZCLAS DE GASES DESCRITAS SON MUY EFECTIVAS COMO MEDIOS DE CONTRASTE DE ULTRASONIDOS. LA INVENCION TAMBIEN COMPRENDE UN METODO PARA FABRICAR EL MEDIO DE CONTRASTE DE ULTRASONIDOS, EL AGENTE DE CONTRASTE Y EL EQUIPO DE AGENTE DE ULTRASONIDOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93810885 | 1993-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2192572T3 true ES2192572T3 (es) | 2003-10-16 |
Family
ID=8215090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95900883T Expired - Lifetime ES2192572T3 (es) | 1993-12-15 | 1994-12-01 | Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo. |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US5846518A (es) |
| EP (1) | EP0682530B1 (es) |
| JP (1) | JPH10508284A (es) |
| KR (1) | KR100295173B1 (es) |
| CN (1) | CN1068229C (es) |
| AT (1) | ATE234638T1 (es) |
| AU (1) | AU679295B2 (es) |
| CA (1) | CA2154867C (es) |
| CZ (1) | CZ208995A3 (es) |
| DE (1) | DE69432295T2 (es) |
| DK (1) | DK0682530T3 (es) |
| ES (1) | ES2192572T3 (es) |
| FI (1) | FI116365B (es) |
| HU (1) | HU225495B1 (es) |
| IL (1) | IL111977A (es) |
| IS (1) | IS1739B (es) |
| NO (2) | NO314019B1 (es) |
| NZ (1) | NZ276167A (es) |
| PL (1) | PL182223B1 (es) |
| PT (1) | PT682530E (es) |
| RU (1) | RU2138293C1 (es) |
| WO (1) | WO1995016467A1 (es) |
| ZA (1) | ZA949983B (es) |
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| AU694135B2 (en) | 1993-07-30 | 1998-07-16 | Imcor Pharmaceutical Company | Stabilized microbubble compositions for ultrasound |
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| JP2001515458A (ja) * | 1995-06-07 | 2001-09-18 | マリンクロッド・インコーポレイテッド | 気体状超音波造影剤および造影方法 |
| US5840276A (en) * | 1996-01-11 | 1998-11-24 | Apfel Enterprises, Inc. | Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis |
| DE19602930A1 (de) * | 1996-01-18 | 1997-07-24 | Schering Ag | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
| GB9617811D0 (en) | 1996-08-27 | 1996-10-09 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5846517A (en) † | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| GB9708240D0 (en) | 1997-04-23 | 1997-06-11 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| KR20010088022A (ko) * | 2000-03-10 | 2001-09-26 | 모리스 토파즈 | 초음파 에너지 보조된 수술용 생체적합성 주사제 수성 용액 |
| EP1289565B1 (en) | 2000-06-02 | 2015-04-22 | Bracco Suisse SA | Compounds for targeting endothelial cells |
| US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
| US6962071B2 (en) | 2001-04-06 | 2005-11-08 | Bracco Research S.A. | Method for improved measurement of local physical parameters in a fluid-filled cavity |
| DE10119522A1 (de) * | 2001-04-20 | 2002-12-05 | Innovacell Biotechnologie Gmbh | Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel |
| WO2004069153A2 (en) * | 2003-01-27 | 2004-08-19 | Medrad, Inc. | Apparatus, system and method for generating bubbles on demand |
| US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| EP1587944A4 (en) | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| WO2003074005A2 (en) | 2002-03-01 | 2003-09-12 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| CA2492339A1 (en) | 2002-06-12 | 2003-12-24 | Boston Scientific Limited | Bulking agents |
| JP2006510579A (ja) * | 2002-07-11 | 2006-03-30 | ターゲソン・エルエルシー | マイクロバブル組成物およびその製法ならびに使用法 |
| US7842377B2 (en) | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7883490B2 (en) | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
| WO2004049950A1 (en) | 2002-11-29 | 2004-06-17 | Amersham Health As | Ultrasound triggering method |
| US9364569B2 (en) * | 2003-02-04 | 2016-06-14 | Bracco Suisse S.A. | Ultrasound contrast agents and process for the preparation thereof |
| US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| EP2284180B1 (en) | 2003-03-03 | 2015-09-09 | Dyax Corp. | Uses of peptides that specifically bind HGF receptor (cMET) |
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| CN102600485B (zh) * | 2004-06-04 | 2014-10-22 | 阿库斯菲尔公司 | 超声对比剂剂量配方 |
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-
1994
- 1994-12-01 JP JP7516634A patent/JPH10508284A/ja not_active Withdrawn
- 1994-12-01 ES ES95900883T patent/ES2192572T3/es not_active Expired - Lifetime
- 1994-12-01 DE DE69432295T patent/DE69432295T2/de not_active Expired - Lifetime
- 1994-12-01 PT PT95900883T patent/PT682530E/pt unknown
- 1994-12-01 WO PCT/IB1994/000376 patent/WO1995016467A1/en active IP Right Grant
- 1994-12-01 AT AT95900883T patent/ATE234638T1/de active
- 1994-12-01 EP EP95900883A patent/EP0682530B1/en not_active Expired - Lifetime
- 1994-12-01 HU HU9502390A patent/HU225495B1/hu not_active IP Right Cessation
- 1994-12-01 DK DK95900883T patent/DK0682530T3/da active
- 1994-12-01 AU AU10330/95A patent/AU679295B2/en not_active Ceased
- 1994-12-01 KR KR1019950703422A patent/KR100295173B1/ko not_active IP Right Cessation
- 1994-12-01 PL PL94310172A patent/PL182223B1/pl not_active IP Right Cessation
- 1994-12-01 CZ CZ952089A patent/CZ208995A3/cs unknown
- 1994-12-01 CN CN94191154A patent/CN1068229C/zh not_active Expired - Fee Related
- 1994-12-01 RU RU95120360A patent/RU2138293C1/ru not_active IP Right Cessation
- 1994-12-01 NZ NZ276167A patent/NZ276167A/en unknown
- 1994-12-01 CA CA002154867A patent/CA2154867C/en not_active Expired - Fee Related
- 1994-12-12 IS IS4239A patent/IS1739B/is unknown
- 1994-12-14 IL IL11197794A patent/IL111977A/xx not_active IP Right Cessation
- 1994-12-14 ZA ZA949983A patent/ZA949983B/xx unknown
-
1995
- 1995-08-10 NO NO19953141A patent/NO314019B1/no not_active IP Right Cessation
- 1995-08-14 NO NO953195A patent/NO953195D0/no unknown
- 1995-08-14 FI FI953843A patent/FI116365B/fi not_active IP Right Cessation
-
1997
- 1997-05-01 US US08/848,912 patent/US5846518A/en not_active Expired - Lifetime
-
1998
- 1998-02-10 US US09/021,367 patent/US6183725B1/en not_active Expired - Fee Related
-
2004
- 2004-04-26 US US10/831,165 patent/US20040197269A1/en not_active Abandoned
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