BR112017013787A2 - Composições de microesfera de gás lipídio- encapsulado e métodos relacionados - Google Patents

Composições de microesfera de gás lipídio- encapsulado e métodos relacionados

Info

Publication number
BR112017013787A2
BR112017013787A2 BR112017013787-9A BR112017013787A BR112017013787A2 BR 112017013787 A2 BR112017013787 A2 BR 112017013787A2 BR 112017013787 A BR112017013787 A BR 112017013787A BR 112017013787 A2 BR112017013787 A2 BR 112017013787A2
Authority
BR
Brazil
Prior art keywords
lipid
compositions
related methods
encapsulated gas
gas microsphere
Prior art date
Application number
BR112017013787-9A
Other languages
English (en)
Inventor
P. Robinson Simon
W. SIEGLER Robert
C. Onthank David
Tuyet NGUYEN Nhung
Original Assignee
Lantheus Medical Imaging, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantheus Medical Imaging, Inc. filed Critical Lantheus Medical Imaging, Inc.
Publication of BR112017013787A2 publication Critical patent/BR112017013787A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

a invenção fornece, entre outros, formulações de lipídio melhoradas usadas para gerar microesferas de gás encapsuladas por lipídio, e métodos de seu uso.
BR112017013787-9A 2014-12-31 2015-12-28 Composições de microesfera de gás lipídio- encapsulado e métodos relacionados BR112017013787A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098453P 2014-12-31 2014-12-31
US62/098,453 2014-12-31
PCT/US2015/067615 WO2016109400A2 (en) 2014-12-31 2015-12-28 Lipid-encapsulated gas microsphere compositions and related methods

Publications (1)

Publication Number Publication Date
BR112017013787A2 true BR112017013787A2 (pt) 2018-03-13

Family

ID=56285147

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017013787-9A BR112017013787A2 (pt) 2014-12-31 2015-12-28 Composições de microesfera de gás lipídio- encapsulado e métodos relacionados

Country Status (17)

Country Link
US (4) US10583207B2 (pt)
EP (2) EP3240579B1 (pt)
JP (3) JP6728186B2 (pt)
KR (2) KR102618877B1 (pt)
CN (2) CN107206111B (pt)
AU (2) AU2015374286B2 (pt)
BR (1) BR112017013787A2 (pt)
CA (1) CA2972423A1 (pt)
EA (1) EA201791437A1 (pt)
ES (1) ES2928401T3 (pt)
HK (2) HK1244677A1 (pt)
IL (2) IL252705B2 (pt)
MX (3) MX2017008721A (pt)
NZ (1) NZ733010A (pt)
TW (2) TWI821755B (pt)
WO (1) WO2016109400A2 (pt)
ZA (1) ZA201704426B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017008721A (es) 2014-12-31 2017-11-17 Lantheus Medical Imaging Inc Composiciones de microesferas de gas encapsulado en lipidos y metodos relacionados.
TWI832081B (zh) * 2016-05-04 2024-02-11 美商藍瑟斯醫學影像公司 用於形成充氣微球體及成像個體之方法、震盪裝置及電腦可讀軟體
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

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