WO1998020856A3 - Wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung - Google Patents

Wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung Download PDF

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Publication number
WO1998020856A3
WO1998020856A3 PCT/EP1997/006257 EP9706257W WO9820856A3 WO 1998020856 A3 WO1998020856 A3 WO 1998020856A3 EP 9706257 W EP9706257 W EP 9706257W WO 9820856 A3 WO9820856 A3 WO 9820856A3
Authority
WO
WIPO (PCT)
Prior art keywords
active substances
well
ultrasound
production
same
Prior art date
Application number
PCT/EP1997/006257
Other languages
English (en)
French (fr)
Other versions
WO1998020856A2 (de
Inventor
Werner Weitschies
Martina Bergmann
Volkmar Uhlendorf
Dieter Heldmann
Original Assignee
Schering Ag
Werner Weitschies
Martina Bergmann
Volkmar Uhlendorf
Dieter Heldmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Werner Weitschies, Martina Bergmann, Volkmar Uhlendorf, Dieter Heldmann filed Critical Schering Ag
Priority to JP52216498A priority Critical patent/JP2001506590A/ja
Priority to EP97950159A priority patent/EP0955998A2/de
Priority to AU53209/98A priority patent/AU5320998A/en
Publication of WO1998020856A2 publication Critical patent/WO1998020856A2/de
Publication of WO1998020856A3 publication Critical patent/WO1998020856A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Abstract

Die Erfindung betrifft wirkstoffhaltige Mikropartikel, deren Wirkstoff in einer niedrig siedenen flüssigen Phase gelöst, suspendiert oder emulgiert ist, diese Partikel enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten in vivo Wirkstofffreisetzung, sowie Verfahren zur Herstellung der Partikel und Mittel.
PCT/EP1997/006257 1996-11-14 1997-11-04 Wirkstoffhaltige mikropartikel, diese enthaltende mittel, deren verwendung zur ultraschallgesteuerten freisetzung von wirkstoffen sowie verfahren zu deren herstellung WO1998020856A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP52216498A JP2001506590A (ja) 1996-11-14 1997-11-04 有効成分を含むミクロ粒子、該粒子を含む薬剤、有効成分の超音波制御放出のためのその使用ならびにその製造方法
EP97950159A EP0955998A2 (de) 1996-11-14 1997-11-04 Wirkstoffhaltige mikropartikel, diese enthaltende mittel, deren verwendung zur ultraschallgesteuerten freisetzung von wirkstoffen sowie verfahren zu deren herstellung
AU53209/98A AU5320998A (en) 1996-11-14 1997-11-04 Microparticles containing active substances, agents containing the same, their use in ultrasound-controlled releasing of active substances as well as the method for their production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996148664 DE19648664A1 (de) 1996-11-14 1996-11-14 Wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung
DE19648664.5 1996-11-14

Publications (2)

Publication Number Publication Date
WO1998020856A2 WO1998020856A2 (de) 1998-05-22
WO1998020856A3 true WO1998020856A3 (de) 1998-08-06

Family

ID=7812647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/006257 WO1998020856A2 (de) 1996-11-14 1997-11-04 Wirkstoffhaltige mikropartikel, diese enthaltende mittel, deren verwendung zur ultraschallgesteuerten freisetzung von wirkstoffen sowie verfahren zu deren herstellung

Country Status (5)

Country Link
EP (1) EP0955998A2 (de)
JP (1) JP2001506590A (de)
AU (1) AU5320998A (de)
DE (1) DE19648664A1 (de)
WO (1) WO1998020856A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261537B1 (en) 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US6264917B1 (en) 1996-10-28 2001-07-24 Nycomed Imaging As Targeted ultrasound contrast agents
DE10119522A1 (de) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel
JP4678591B2 (ja) * 2005-08-31 2011-04-27 カシオ電子工業株式会社 超音波破壊用マイクロカプセル
US20100221190A1 (en) * 2006-01-24 2010-09-02 Koninklijke Philips Electronics N.V. Method for producing a particle comprising a gas core and a shell and particles thus obtained
WO2011046443A1 (en) * 2009-10-15 2011-04-21 Vivid As Ultrasound triggered controlled release drug delivery
JP2014518201A (ja) * 2011-06-03 2014-07-28 ダウ グローバル テクノロジーズ エルエルシー カプセル化された極性材料および製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028780A2 (en) * 1993-06-11 1994-12-22 Unger Evan C Methods of preparing gas and gaseous precursor-filled microspheres
WO1994028874A1 (en) * 1993-06-11 1994-12-22 Unger Evan C Novel therapeutic delivery systems
WO1995007072A2 (de) * 1993-09-09 1995-03-16 Schering Aktiengesellschaft Wirkstoffe und gas enthaltende mikropartikel
WO1995015118A1 (en) * 1993-11-30 1995-06-08 Imarx Pharmaceutical Corp. Gas microspheres for topical and subcutaneous application
WO1995022963A1 (en) * 1994-02-28 1995-08-31 Medinova Medical Consulting Gmbh Drug targeting system, method for preparing same and its use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028780A2 (en) * 1993-06-11 1994-12-22 Unger Evan C Methods of preparing gas and gaseous precursor-filled microspheres
WO1994028874A1 (en) * 1993-06-11 1994-12-22 Unger Evan C Novel therapeutic delivery systems
WO1995007072A2 (de) * 1993-09-09 1995-03-16 Schering Aktiengesellschaft Wirkstoffe und gas enthaltende mikropartikel
WO1995015118A1 (en) * 1993-11-30 1995-06-08 Imarx Pharmaceutical Corp. Gas microspheres for topical and subcutaneous application
WO1995022963A1 (en) * 1994-02-28 1995-08-31 Medinova Medical Consulting Gmbh Drug targeting system, method for preparing same and its use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BECK P: "INFLUENCE OF POLYBUTYLCYANOACRYLATE NANOPARTICLES AND LIPOSOMES ON THE EFFICACY AND TOXICITY OF THE ANTICANCER DRUG MITOXANTRONE IN MURINE TUMOUR MODELS", JOURNAL OF MICROENCAPSULATION, vol. 10, no. 1, 1 January 1993 (1993-01-01), pages 101 - 114, XP000334997 *
GASPAR, ROGERIO: "Vectorização de medicamentos com nano-partículas de poli-alquilcianoacrilato (PACA)", REV. PORT. FARM., VOL. 41, NO. 3, PAGE(S) 36-8, 40-2, 44-5, 1991, XP002065277 *
HARRIS G R: "Are current hydrophone low frequency response standards acceptable for measuring mechanical/cavitation indices?", ULTRASONICS, vol. 6, no. 34, August 1996 (1996-08-01), pages 649-654, XP004035705 *
PORTER T R ET AL: "INTERACTION OF DIAGNOSTIC ULTRASOUND WITH SYNTHETIC OLIGONUCLEOTIDE-LABELED PERFLUOROCARBON-EXPOSED SONICATED DEXTROSE ALBUMIN MICROBUBBLES", JOURNAL OF ULTRASOUND IN MEDICINE, vol. 15, no. 8, August 1996 (1996-08-01), pages 577 - 584, XP002054859 *

Also Published As

Publication number Publication date
WO1998020856A2 (de) 1998-05-22
JP2001506590A (ja) 2001-05-22
DE19648664A1 (de) 1998-05-28
AU5320998A (en) 1998-06-03
EP0955998A2 (de) 1999-11-17

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