MX8481A - Procedimiento para preparar compuestos de carboestirilo. - Google Patents

Procedimiento para preparar compuestos de carboestirilo.

Info

Publication number
MX8481A
MX8481A MX848185A MX848185A MX8481A MX 8481 A MX8481 A MX 8481A MX 848185 A MX848185 A MX 848185A MX 848185 A MX848185 A MX 848185A MX 8481 A MX8481 A MX 8481A
Authority
MX
Mexico
Prior art keywords
carboestyral
preparing
compounds
procedure
preparing carboestyral
Prior art date
Application number
MX848185A
Other languages
English (en)
Inventor
Michiaki Tominaga
Original Assignee
Otsuka Pharmaceutical Col Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Col Ltd filed Critical Otsuka Pharmaceutical Col Ltd
Publication of MX8481A publication Critical patent/MX8481A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
MX848185A 1980-10-31 1985-08-09 Procedimiento para preparar compuestos de carboestirilo. MX8481A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (1)

Publication Number Publication Date
MX8481A true MX8481A (es) 1994-02-28

Family

ID=15576252

Family Applications (1)

Application Number Title Priority Date Filing Date
MX848185A MX8481A (es) 1980-10-31 1985-08-09 Procedimiento para preparar compuestos de carboestirilo.

Country Status (24)

Country Link
US (1) US4415572A (es)
JP (1) JPS5777676A (es)
KR (1) KR860001944B1 (es)
AR (2) AR242563A1 (es)
AT (1) AT381701B (es)
AU (1) AU524419B2 (es)
BE (1) BE890942A (es)
CA (1) CA1209575A (es)
CH (2) CH650782A5 (es)
DE (2) DE3153260C2 (es)
DK (1) DK155665C (es)
ES (3) ES8306743A1 (es)
FI (1) FI77450C (es)
FR (2) FR2493320B1 (es)
GB (1) GB2086896B (es)
IT (2) IT1210585B (es)
MX (1) MX8481A (es)
NL (2) NL194205C (es)
NO (1) NO158099C (es)
PH (1) PH17962A (es)
PT (1) PT73910B (es)
SE (2) SE448877B (es)
SU (1) SU1426452A3 (es)
ZA (1) ZA817515B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5929667A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体および強心剤
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
ZA848005B (en) * 1983-10-17 1985-05-29 Duphar Int Res Blood-pressure lowering piperazine derivatives
JPS60126270A (ja) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
PT80533B (en) * 1984-05-29 1987-04-06 Pfizer Process for preparing quinolone inotropic agents
JPS60256133A (ja) * 1984-06-01 1985-12-17 Fuji Photo Film Co Ltd 放射線画像情報記録読取装置
US4737501A (en) * 1984-07-06 1988-04-12 Otsuka Pharmaceutical Co., Ltd. Substituted piperazinyl oxindol compounds and cardiotonic compositions containing the same
US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
JPH07100696B2 (ja) * 1984-12-18 1995-11-01 大塚製薬株式会社 カルボスチリル誘導体
JPS61145162A (ja) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
EP0189612B1 (en) * 1984-12-21 1992-11-04 Duphar International Research B.V New pharmaceutical compositions having a psychotropic activity
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US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
DE3524067A1 (de) * 1985-07-05 1987-01-08 Boehringer Mannheim Gmbh Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
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US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
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US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
WO1993000902A1 (fr) * 1991-07-03 1993-01-21 Otsuka Pharmaceutical Co., Ltd. Regulateur d'apoptose
US5543412A (en) * 1991-07-03 1996-08-06 Otsuka Pharmaceutical Co., Ltd. Hepatitis treatment with carbostyril compounds
WO1993011769A1 (fr) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Agent anticancereux
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
AU666577B2 (en) * 1992-08-19 1996-02-15 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
JP2826790B2 (ja) * 1992-12-26 1998-11-18 キッセイ薬品工業株式会社 ３，４−ジヒドロカルボスチリル誘導体
KR0185226B1 (ko) * 1993-03-02 1999-05-01 오오쓰까 아끼히꼬 이식 조직의 거부반응 억제제 및 il-1 생산 억제제
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
GB9326373D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
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US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
UA52656C2 (uk) 1996-03-29 2003-01-15 Дюфар Інтернешнл Рісьоч Б.В. Похідні піперазину та піперидину, спосіб їх отримання, фармацевтична композиція, спосіб отримання фармацевтичної композиції і спосіб лікування розладів цнс
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US5684007A (en) * 1996-09-05 1997-11-04 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
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JPS54138585A (en) * 1978-04-18 1979-10-27 Yoshitomi Pharmaceut Ind Ltd Pyridazine derivative and its preparation
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JPS6017072B2 (ja) * 1978-09-05 1985-04-30 三菱電機株式会社 赤熱金属検出器
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JPS5583781A (en) * 1978-12-19 1980-06-24 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative

Also Published As

Publication number Publication date
SE8106430L (sv) 1982-05-01
PT73910A (en) 1981-11-01
NL8104923A (nl) 1982-05-17
PT73910B (en) 1983-04-18
DE3142982A1 (de) 1982-06-24
SU1426452A3 (ru) 1988-09-23
AR242375A1 (es) 1993-03-31
NL8403096A (nl) 1985-02-01
DK480381A (da) 1982-05-01
DE3142982C2 (de) 1985-12-19
IT1210585B (it) 1989-09-14
ES8403885A1 (es) 1984-04-16
FR2552760A1 (fr) 1985-04-05
ES8403886A1 (es) 1984-04-16
ES507198A0 (es) 1983-06-16
NO813678L (no) 1982-05-03
ZA817515B (en) 1982-10-27
AU7699681A (en) 1982-05-06
AT381701B (de) 1986-11-25
ES520638A0 (es) 1984-04-16
ATA460281A (de) 1986-04-15
KR830007607A (ko) 1983-11-04
DE3153260A1 (es) 1985-05-15
PH17962A (en) 1985-02-20
IT8149588A0 (it) 1981-10-29
FR2493320B1 (fr) 1985-08-23
JPS5777676A (en) 1982-05-15
KR860001944B1 (ko) 1986-11-01
IT1226479B (it) 1991-01-16
CA1209575A (en) 1986-08-12
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
GB2086896A (en) 1982-05-19
NO158099C (no) 1988-07-13
SE466655B (sv) 1992-03-16
NL194205B (nl) 2001-05-01
FI77450B (fi) 1988-11-30
CH650782A5 (de) 1985-08-15
AR242563A1 (es) 1993-04-30
JPH0143747B2 (es) 1989-09-22
US4415572A (en) 1983-11-15
SE8406209D0 (sv) 1984-12-06
FR2552760B1 (fr) 1988-08-05
ES8306743A1 (es) 1983-06-16
DK155665B (da) 1989-05-01
CH656616A5 (de) 1986-07-15
IT8547867A0 (it) 1985-03-26
NL194205C (nl) 2001-09-04
FI813408L (fi) 1982-05-01
DK155665C (da) 1989-09-04
ES520637A0 (es) 1984-04-16
FI77450C (fi) 1989-03-10
FR2493320A1 (fr) 1982-05-07
NO158099B (no) 1988-04-05
SE448877B (sv) 1987-03-23
DE3153260C2 (es) 1989-05-24
SE8406209L (sv) 1984-12-06
GB2086896B (en) 1984-10-10

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