IT1226479B - Composti di acido carbossilico utili come prodotti intermedi per la preparazione di composti carbostirilici - Google Patents

Composti di acido carbossilico utili come prodotti intermedi per la preparazione di composti carbostirilici

Info

Publication number
IT1226479B
IT1226479B IT8547867A IT4786785A IT1226479B IT 1226479 B IT1226479 B IT 1226479B IT 8547867 A IT8547867 A IT 8547867A IT 4786785 A IT4786785 A IT 4786785A IT 1226479 B IT1226479 B IT 1226479B
Authority
IT
Italy
Prior art keywords
preparation
carboxylic acid
intermediate products
compounds
carbostyryl
Prior art date
Application number
IT8547867A
Other languages
English (en)
Other versions
IT8547867A0 (it
Inventor
Tominaga Michiaki
Yang Yung-Hsiung
Ogawa Hidenori
Nakagawa Kazuyuki
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of IT8547867A0 publication Critical patent/IT8547867A0/it
Application granted granted Critical
Publication of IT1226479B publication Critical patent/IT1226479B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
IT8547867A 1980-10-31 1985-03-26 Composti di acido carbossilico utili come prodotti intermedi per la preparazione di composti carbostirilici IT1226479B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (2)

Publication Number Publication Date
IT8547867A0 IT8547867A0 (it) 1985-03-26
IT1226479B true IT1226479B (it) 1991-01-16

Family

ID=15576252

Family Applications (2)

Application Number Title Priority Date Filing Date
IT8149588A IT1210585B (it) 1980-10-31 1981-10-29 Composti carbostirilici composizioni che li contengono e procedimenti per la loro preparazione
IT8547867A IT1226479B (it) 1980-10-31 1985-03-26 Composti di acido carbossilico utili come prodotti intermedi per la preparazione di composti carbostirilici

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IT8149588A IT1210585B (it) 1980-10-31 1981-10-29 Composti carbostirilici composizioni che li contengono e procedimenti per la loro preparazione

Country Status (24)

Country Link
US (1) US4415572A (it)
JP (1) JPS5777676A (it)
KR (1) KR860001944B1 (it)
AR (2) AR242563A1 (it)
AT (1) AT381701B (it)
AU (1) AU524419B2 (it)
BE (1) BE890942A (it)
CA (1) CA1209575A (it)
CH (2) CH656616A5 (it)
DE (2) DE3142982C2 (it)
DK (1) DK155665C (it)
ES (3) ES507198A0 (it)
FI (1) FI77450C (it)
FR (2) FR2493320B1 (it)
GB (1) GB2086896B (it)
IT (2) IT1210585B (it)
MX (1) MX8481A (it)
NL (2) NL194205C (it)
NO (1) NO158099C (it)
PH (1) PH17962A (it)
PT (1) PT73910B (it)
SE (2) SE448877B (it)
SU (1) SU1426452A3 (it)
ZA (1) ZA817515B (it)

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JPS60126270A (ja) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
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US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
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JPS61145162A (ja) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
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US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
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US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
WO1993000902A1 (en) * 1991-07-03 1993-01-21 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
US5543412A (en) * 1991-07-03 1996-08-06 Otsuka Pharmaceutical Co., Ltd. Hepatitis treatment with carbostyril compounds
JP2597953B2 (ja) * 1991-12-10 1997-04-09 大塚製薬株式会社 制癌剤
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
CA2121148A1 (en) * 1992-08-19 1994-03-03 Satoru Nakai Apoptosis regulator
JP2826790B2 (ja) * 1992-12-26 1998-11-18 キッセイ薬品工業株式会社 ３，４−ジヒドロカルボスチリル誘導体
CA2134880A1 (en) * 1993-03-02 1994-09-03 Akira Matsumori Graft rejection inhibitor and il-1 production inhibitor
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
GB9326232D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
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US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
PL189256B1 (pl) 1996-03-29 2005-07-29 Duphar Int Res Związki piperazyny i piperydyny, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca te związki, zastosowanie tych związków do wytwarzania leków
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Also Published As

Publication number Publication date
FR2552760B1 (fr) 1988-08-05
NL8403096A (nl) 1985-02-01
SE8106430L (sv) 1982-05-01
DE3142982A1 (de) 1982-06-24
AU7699681A (en) 1982-05-06
JPH0143747B2 (it) 1989-09-22
ES520637A0 (es) 1984-04-16
DK155665B (da) 1989-05-01
NO813678L (no) 1982-05-03
FR2552760A1 (fr) 1985-04-05
IT8547867A0 (it) 1985-03-26
CH656616A5 (de) 1986-07-15
PT73910A (en) 1981-11-01
GB2086896A (en) 1982-05-19
JPS5777676A (en) 1982-05-15
IT8149588A0 (it) 1981-10-29
KR830007607A (ko) 1983-11-04
ES8306743A1 (es) 1983-06-16
DE3142982C2 (de) 1985-12-19
FI77450C (fi) 1989-03-10
SE8406209L (sv) 1984-12-06
DE3153260C2 (it) 1989-05-24
ES507198A0 (es) 1983-06-16
DE3153260A1 (it) 1985-05-15
AR242563A1 (es) 1993-04-30
ATA460281A (de) 1986-04-15
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
FR2493320A1 (fr) 1982-05-07
CH650782A5 (de) 1985-08-15
FI77450B (fi) 1988-11-30
ES520638A0 (es) 1984-04-16
IT1210585B (it) 1989-09-14
DK155665C (da) 1989-09-04
PH17962A (en) 1985-02-20
ES8403885A1 (es) 1984-04-16
NO158099B (no) 1988-04-05
ES8403886A1 (es) 1984-04-16
GB2086896B (en) 1984-10-10
ZA817515B (en) 1982-10-27
FR2493320B1 (fr) 1985-08-23
CA1209575A (en) 1986-08-12
AR242375A1 (es) 1993-03-31
NL194205B (nl) 2001-05-01
NO158099C (no) 1988-07-13
SE448877B (sv) 1987-03-23
DK480381A (da) 1982-05-01
FI813408L (fi) 1982-05-01
SU1426452A3 (ru) 1988-09-23
US4415572A (en) 1983-11-15
SE8406209D0 (sv) 1984-12-06
NL194205C (nl) 2001-09-04
KR860001944B1 (ko) 1986-11-01
PT73910B (en) 1983-04-18
SE466655B (sv) 1992-03-16
AT381701B (de) 1986-11-25
MX8481A (es) 1994-02-28
NL8104923A (nl) 1982-05-17

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