FR2552760B1 - Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese - Google Patents

Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Info

Publication number
FR2552760B1
FR2552760B1 FR848416085A FR8416085A FR2552760B1 FR 2552760 B1 FR2552760 B1 FR 2552760B1 FR 848416085 A FR848416085 A FR 848416085A FR 8416085 A FR8416085 A FR 8416085A FR 2552760 B1 FR2552760 B1 FR 2552760B1
Authority
FR
France
Prior art keywords
obtaining
synthesis intermediates
carbostyrile
derivatives
carbostyrile derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR848416085A
Other languages
English (en)
Other versions
FR2552760A1 (fr
Inventor
Michiaki Tominaga
Yung-Hsiung Yang
Hidenori Ogawa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2552760A1 publication Critical patent/FR2552760A1/fr
Application granted granted Critical
Publication of FR2552760B1 publication Critical patent/FR2552760B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
FR848416085A 1980-10-31 1984-10-19 Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese Expired FR2552760B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (2)

Publication Number Publication Date
FR2552760A1 FR2552760A1 (fr) 1985-04-05
FR2552760B1 true FR2552760B1 (fr) 1988-08-05

Family

ID=15576252

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8120470A Expired FR2493320B1 (fr) 1980-10-31 1981-10-30 Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant
FR848416085A Expired FR2552760B1 (fr) 1980-10-31 1984-10-19 Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR8120470A Expired FR2493320B1 (fr) 1980-10-31 1981-10-30 Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant

Country Status (24)

Country Link
US (1) US4415572A (fr)
JP (1) JPS5777676A (fr)
KR (1) KR860001944B1 (fr)
AR (2) AR242563A1 (fr)
AT (1) AT381701B (fr)
AU (1) AU524419B2 (fr)
BE (1) BE890942A (fr)
CA (1) CA1209575A (fr)
CH (2) CH650782A5 (fr)
DE (2) DE3153260C2 (fr)
DK (1) DK155665C (fr)
ES (3) ES507198A0 (fr)
FI (1) FI77450C (fr)
FR (2) FR2493320B1 (fr)
GB (1) GB2086896B (fr)
IT (2) IT1210585B (fr)
MX (1) MX8481A (fr)
NL (2) NL194205C (fr)
NO (1) NO158099C (fr)
PH (1) PH17962A (fr)
PT (1) PT73910B (fr)
SE (2) SE448877B (fr)
SU (1) SU1426452A3 (fr)
ZA (1) ZA817515B (fr)

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JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
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CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
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JPH0625123B2 (ja) * 1985-12-12 1994-04-06 大塚製薬株式会社 カルボスチリル誘導体−シクロデキストリン包接化合物
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US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
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US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
DE69230131T2 (de) * 1991-07-03 2000-03-02 Otsuka Pharmaceutical Co., Ltd. Apoptoseregulator
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WO1993011769A1 (fr) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Agent anticancereux
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
CA2121148A1 (fr) * 1992-08-19 1994-03-03 Otsuka Pharmaceutical Co., Ltd. Regulateur de l'apoptose
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US5521185A (en) * 1993-03-02 1996-05-28 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting graft rejection and IL-1 production
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
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Also Published As

Publication number Publication date
IT1210585B (it) 1989-09-14
PH17962A (en) 1985-02-20
SE8106430L (sv) 1982-05-01
DE3142982A1 (de) 1982-06-24
SE8406209L (sv) 1984-12-06
SE466655B (sv) 1992-03-16
DE3142982C2 (de) 1985-12-19
FI77450B (fi) 1988-11-30
FR2493320B1 (fr) 1985-08-23
IT8149588A0 (it) 1981-10-29
SE448877B (sv) 1987-03-23
KR860001944B1 (ko) 1986-11-01
MX8481A (es) 1994-02-28
NO158099C (no) 1988-07-13
US4415572A (en) 1983-11-15
ATA460281A (de) 1986-04-15
DK480381A (da) 1982-05-01
SU1426452A3 (ru) 1988-09-23
KR830007607A (ko) 1983-11-04
DE3153260A1 (fr) 1985-05-15
SE8406209D0 (sv) 1984-12-06
JPS5777676A (en) 1982-05-15
ES520638A0 (es) 1984-04-16
ES8403885A1 (es) 1984-04-16
IT8547867A0 (it) 1985-03-26
CH656616A5 (de) 1986-07-15
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
CH650782A5 (de) 1985-08-15
AR242375A1 (es) 1993-03-31
ES520637A0 (es) 1984-04-16
FR2552760A1 (fr) 1985-04-05
DE3153260C2 (fr) 1989-05-24
AR242563A1 (es) 1993-04-30
ZA817515B (en) 1982-10-27
NL194205C (nl) 2001-09-04
AT381701B (de) 1986-11-25
GB2086896A (en) 1982-05-19
FI813408L (fi) 1982-05-01
ES8306743A1 (es) 1983-06-16
AU7699681A (en) 1982-05-06
NO158099B (no) 1988-04-05
NL8403096A (nl) 1985-02-01
JPH0143747B2 (fr) 1989-09-22
PT73910B (en) 1983-04-18
DK155665C (da) 1989-09-04
NL194205B (nl) 2001-05-01
FI77450C (fi) 1989-03-10
ES8403886A1 (es) 1984-04-16
PT73910A (en) 1981-11-01
CA1209575A (fr) 1986-08-12
DK155665B (da) 1989-05-01
IT1226479B (it) 1991-01-16
FR2493320A1 (fr) 1982-05-07
NO813678L (no) 1982-05-03
ES507198A0 (es) 1983-06-16
NL8104923A (nl) 1982-05-17
GB2086896B (en) 1984-10-10

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