FR2552760B1 - Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese - Google Patents

Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Info

Publication number
FR2552760B1
FR2552760B1 FR848416085A FR8416085A FR2552760B1 FR 2552760 B1 FR2552760 B1 FR 2552760B1 FR 848416085 A FR848416085 A FR 848416085A FR 8416085 A FR8416085 A FR 8416085A FR 2552760 B1 FR2552760 B1 FR 2552760B1
Authority
FR
France
Prior art keywords
obtaining
synthesis intermediates
carbostyrile
derivatives
carbostyrile derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR848416085A
Other languages
English (en)
Other versions
FR2552760A1 (fr
Inventor
Michiaki Tominaga
Yung-Hsiung Yang
Hidenori Ogawa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2552760A1 publication Critical patent/FR2552760A1/fr
Application granted granted Critical
Publication of FR2552760B1 publication Critical patent/FR2552760B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
FR848416085A 1980-10-31 1984-10-19 Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese Expired FR2552760B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (2)

Publication Number Publication Date
FR2552760A1 FR2552760A1 (fr) 1985-04-05
FR2552760B1 true FR2552760B1 (fr) 1988-08-05

Family

ID=15576252

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8120470A Expired FR2493320B1 (fr) 1980-10-31 1981-10-30 Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant
FR848416085A Expired FR2552760B1 (fr) 1980-10-31 1984-10-19 Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR8120470A Expired FR2493320B1 (fr) 1980-10-31 1981-10-30 Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant

Country Status (24)

Country Link
US (1) US4415572A (fr)
JP (1) JPS5777676A (fr)
KR (1) KR860001944B1 (fr)
AR (2) AR242563A1 (fr)
AT (1) AT381701B (fr)
AU (1) AU524419B2 (fr)
BE (1) BE890942A (fr)
CA (1) CA1209575A (fr)
CH (2) CH650782A5 (fr)
DE (2) DE3142982C2 (fr)
DK (1) DK155665C (fr)
ES (3) ES8306743A1 (fr)
FI (1) FI77450C (fr)
FR (2) FR2493320B1 (fr)
GB (1) GB2086896B (fr)
IT (2) IT1210585B (fr)
MX (1) MX8481A (fr)
NL (2) NL194205C (fr)
NO (1) NO158099C (fr)
PH (1) PH17962A (fr)
PT (1) PT73910B (fr)
SE (2) SE448877B (fr)
SU (1) SU1426452A3 (fr)
ZA (1) ZA817515B (fr)

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US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
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US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
DK111387A (da) * 1986-03-05 1987-09-06 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
US5750529A (en) * 1991-07-03 1998-05-12 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating compostion
CA2090876A1 (fr) * 1991-07-03 1993-01-04 Satoru Nakai Composition regulatrice d'apoptose
WO1993011769A1 (fr) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Agent anticancereux
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
US5464833A (en) * 1992-08-19 1995-11-07 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating composition
JP2826790B2 (ja) * 1992-12-26 1998-11-18 キッセイ薬品工業株式会社 ３，４−ジヒドロカルボスチリル誘導体
WO1994020107A1 (fr) * 1993-03-02 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Inhibiteur de rejet pour transplantations et inhibiteur de production d'interleukine 1
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
GB9326373D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
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US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
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US5684007A (en) * 1996-09-05 1997-11-04 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
US6667313B1 (en) 1999-08-27 2003-12-23 Ligand Pharmaceuticals Inc. 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
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CA2688161C (fr) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
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ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
WO2014131024A2 (fr) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et applications associées
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Also Published As

Publication number Publication date
NL194205C (nl) 2001-09-04
FI77450B (fi) 1988-11-30
SU1426452A3 (ru) 1988-09-23
CH656616A5 (de) 1986-07-15
AR242375A1 (es) 1993-03-31
US4415572A (en) 1983-11-15
CH650782A5 (de) 1985-08-15
ES8403885A1 (es) 1984-04-16
SE8406209L (sv) 1984-12-06
JPS5777676A (en) 1982-05-15
NL8403096A (nl) 1985-02-01
FR2493320B1 (fr) 1985-08-23
NO158099B (no) 1988-04-05
SE8406209D0 (sv) 1984-12-06
NO158099C (no) 1988-07-13
AR242563A1 (es) 1993-04-30
FI77450C (fi) 1989-03-10
AT381701B (de) 1986-11-25
FR2493320A1 (fr) 1982-05-07
KR830007607A (ko) 1983-11-04
ES507198A0 (es) 1983-06-16
DE3153260A1 (fr) 1985-05-15
DK480381A (da) 1982-05-01
FI813408L (fi) 1982-05-01
NL8104923A (nl) 1982-05-17
IT8149588A0 (it) 1981-10-29
ZA817515B (en) 1982-10-27
GB2086896B (en) 1984-10-10
SE448877B (sv) 1987-03-23
NL194205B (nl) 2001-05-01
DE3142982C2 (de) 1985-12-19
PT73910B (en) 1983-04-18
CA1209575A (fr) 1986-08-12
DE3142982A1 (de) 1982-06-24
MX8481A (es) 1994-02-28
PT73910A (en) 1981-11-01
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
SE8106430L (sv) 1982-05-01
DE3153260C2 (fr) 1989-05-24
DK155665B (da) 1989-05-01
IT1210585B (it) 1989-09-14
ES8403886A1 (es) 1984-04-16
FR2552760A1 (fr) 1985-04-05
ATA460281A (de) 1986-04-15
KR860001944B1 (ko) 1986-11-01
DK155665C (da) 1989-09-04
SE466655B (sv) 1992-03-16
GB2086896A (en) 1982-05-19
ES520637A0 (es) 1984-04-16
IT8547867A0 (it) 1985-03-26
ES8306743A1 (es) 1983-06-16
IT1226479B (it) 1991-01-16
NO813678L (no) 1982-05-03
AU7699681A (en) 1982-05-06
JPH0143747B2 (fr) 1989-09-22
PH17962A (en) 1985-02-20
ES520638A0 (es) 1984-04-16

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