ZA817515B - Carbostyril compounds,compositions containing same and processes for preparing same - Google Patents

Carbostyril compounds,compositions containing same and processes for preparing same

Info

Publication number
ZA817515B
ZA817515B ZA817515A ZA817515A ZA817515B ZA 817515 B ZA817515 B ZA 817515B ZA 817515 A ZA817515 A ZA 817515A ZA 817515 A ZA817515 A ZA 817515A ZA 817515 B ZA817515 B ZA 817515B
Authority
ZA
South Africa
Prior art keywords
same
processes
compositions containing
carbostyril compounds
preparing
Prior art date
Application number
ZA817515A
Other languages
English (en)
Inventor
Tominaga Michiaki
Hsiung Yang Yung
Ogawa Hidenori
Nakagawa Kazuyuki
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of ZA817515B publication Critical patent/ZA817515B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
ZA817515A 1980-10-31 1981-10-29 Carbostyril compounds,compositions containing same and processes for preparing same ZA817515B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (1)

Publication Number Publication Date
ZA817515B true ZA817515B (en) 1982-10-27

Family

ID=15576252

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA817515A ZA817515B (en) 1980-10-31 1981-10-29 Carbostyril compounds,compositions containing same and processes for preparing same

Country Status (24)

Country Link
US (1) US4415572A (fr)
JP (1) JPS5777676A (fr)
KR (1) KR860001944B1 (fr)
AR (2) AR242563A1 (fr)
AT (1) AT381701B (fr)
AU (1) AU524419B2 (fr)
BE (1) BE890942A (fr)
CA (1) CA1209575A (fr)
CH (2) CH650782A5 (fr)
DE (2) DE3142982C2 (fr)
DK (1) DK155665C (fr)
ES (3) ES507198A0 (fr)
FI (1) FI77450C (fr)
FR (2) FR2493320B1 (fr)
GB (1) GB2086896B (fr)
IT (2) IT1210585B (fr)
MX (1) MX8481A (fr)
NL (2) NL194205C (fr)
NO (1) NO158099C (fr)
PH (1) PH17962A (fr)
PT (1) PT73910B (fr)
SE (2) SE448877B (fr)
SU (1) SU1426452A3 (fr)
ZA (1) ZA817515B (fr)

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JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5929667A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体および強心剤
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
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JPS60126270A (ja) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
CA1292234C (fr) * 1984-05-29 1991-11-19 Simon Fraser Campbell Agents ionotropes a base de derives de substitution heterocycliques de la quinolone
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US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
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US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
EP0552373B1 (fr) 1991-07-03 1999-10-13 Otsuka Pharmaceutical Co., Ltd. Regulateur d'apoptose
US5543412A (en) * 1991-07-03 1996-08-06 Otsuka Pharmaceutical Co., Ltd. Hepatitis treatment with carbostyril compounds
JP2597953B2 (ja) * 1991-12-10 1997-04-09 大塚製薬株式会社 制癌剤
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
EP0623598A4 (fr) * 1992-08-19 1997-05-02 Otsuka Pharma Co Ltd Regulateur d'apoptose.
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AU672288B2 (en) * 1993-03-02 1996-09-26 Akira Matsumori Rejection inhibitor for transplants and IL-1 production inhibitor
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
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EP1865951A1 (fr) * 2005-03-14 2007-12-19 Nycomed GmbH Methode de prevention des maladies cardiovasculaires
CA2621310C (fr) * 2005-09-27 2014-08-12 Shionogi & Co., Ltd. Derive sulfonamide ayant une activite antagoniste de recepteur pgd2
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2930674A1 (fr) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
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Also Published As

Publication number Publication date
AR242375A1 (es) 1993-03-31
IT8547867A0 (it) 1985-03-26
GB2086896B (en) 1984-10-10
NO158099B (no) 1988-04-05
DE3153260C2 (fr) 1989-05-24
FR2493320B1 (fr) 1985-08-23
IT1226479B (it) 1991-01-16
DE3142982A1 (de) 1982-06-24
NL8403096A (nl) 1985-02-01
US4415572A (en) 1983-11-15
ATA460281A (de) 1986-04-15
DK155665B (da) 1989-05-01
ES520638A0 (es) 1984-04-16
KR860001944B1 (ko) 1986-11-01
ES520637A0 (es) 1984-04-16
DE3142982C2 (de) 1985-12-19
PH17962A (en) 1985-02-20
JPS5777676A (en) 1982-05-15
SE448877B (sv) 1987-03-23
AR242563A1 (es) 1993-04-30
SE8406209D0 (sv) 1984-12-06
DE3153260A1 (fr) 1985-05-15
FI77450B (fi) 1988-11-30
AT381701B (de) 1986-11-25
DK480381A (da) 1982-05-01
NO813678L (no) 1982-05-03
PT73910A (en) 1981-11-01
FR2552760A1 (fr) 1985-04-05
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
IT1210585B (it) 1989-09-14
JPH0143747B2 (fr) 1989-09-22
MX8481A (es) 1994-02-28
NL194205C (nl) 2001-09-04
IT8149588A0 (it) 1981-10-29
SE8106430L (sv) 1982-05-01
PT73910B (en) 1983-04-18
CA1209575A (fr) 1986-08-12
CH650782A5 (de) 1985-08-15
FR2552760B1 (fr) 1988-08-05
ES8306743A1 (es) 1983-06-16
FR2493320A1 (fr) 1982-05-07
ES8403885A1 (es) 1984-04-16
KR830007607A (ko) 1983-11-04
SE8406209L (sv) 1984-12-06
FI77450C (fi) 1989-03-10
GB2086896A (en) 1982-05-19
NO158099C (no) 1988-07-13
DK155665C (da) 1989-09-04
ES8403886A1 (es) 1984-04-16
NL8104923A (nl) 1982-05-17
AU7699681A (en) 1982-05-06
SE466655B (sv) 1992-03-16
ES507198A0 (es) 1983-06-16
NL194205B (nl) 2001-05-01
SU1426452A3 (ru) 1988-09-23
FI813408L (fi) 1982-05-01
CH656616A5 (de) 1986-07-15

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