NL194205B - Carbostyrilverbindingen met cardiotonische werking en preparaten die deze verbindingen bevatten. - Google Patents

Carbostyrilverbindingen met cardiotonische werking en preparaten die deze verbindingen bevatten.

Info

Publication number
NL194205B
NL194205B NL8104923A NL8104923A NL194205B NL 194205 B NL194205 B NL 194205B NL 8104923 A NL8104923 A NL 8104923A NL 8104923 A NL8104923 A NL 8104923A NL 194205 B NL194205 B NL 194205B
Authority
NL
Netherlands
Prior art keywords
compounds
cardiotonic
preparations containing
carbostyril
carbostyril compounds
Prior art date
Application number
NL8104923A
Other languages
English (en)
Other versions
NL8104923A (nl
NL194205C (nl
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NL8104923A publication Critical patent/NL8104923A/nl
Publication of NL194205B publication Critical patent/NL194205B/nl
Application granted granted Critical
Publication of NL194205C publication Critical patent/NL194205C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
NL8104923A 1980-10-31 1981-10-30 Carbostyrilverbindingen met cardiotonische werking en preparaten die deze verbindingen bevatten. NL194205C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15407180 1980-10-31
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (3)

Publication Number Publication Date
NL8104923A NL8104923A (nl) 1982-05-17
NL194205B true NL194205B (nl) 2001-05-01
NL194205C NL194205C (nl) 2001-09-04

Family

ID=15576252

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8104923A NL194205C (nl) 1980-10-31 1981-10-30 Carbostyrilverbindingen met cardiotonische werking en preparaten die deze verbindingen bevatten.
NL8403096A NL8403096A (nl) 1980-10-31 1984-10-11 Piperazinokaneelzuur- en piperazinofenylpropionzuurderivaten en werkwijze voor de bereiding daarvan.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL8403096A NL8403096A (nl) 1980-10-31 1984-10-11 Piperazinokaneelzuur- en piperazinofenylpropionzuurderivaten en werkwijze voor de bereiding daarvan.

Country Status (24)

Country Link
US (1) US4415572A (nl)
JP (1) JPS5777676A (nl)
KR (1) KR860001944B1 (nl)
AR (2) AR242563A1 (nl)
AT (1) AT381701B (nl)
AU (1) AU524419B2 (nl)
BE (1) BE890942A (nl)
CA (1) CA1209575A (nl)
CH (2) CH650782A5 (nl)
DE (2) DE3153260C2 (nl)
DK (1) DK155665C (nl)
ES (3) ES507198A0 (nl)
FI (1) FI77450C (nl)
FR (2) FR2493320B1 (nl)
GB (1) GB2086896B (nl)
IT (2) IT1210585B (nl)
MX (1) MX8481A (nl)
NL (2) NL194205C (nl)
NO (1) NO158099C (nl)
PH (1) PH17962A (nl)
PT (1) PT73910B (nl)
SE (2) SE448877B (nl)
SU (1) SU1426452A3 (nl)
ZA (1) ZA817515B (nl)

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US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
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JPS60126270A (ja) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
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US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
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US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
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US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
JPH0625123B2 (ja) * 1985-12-12 1994-04-06 大塚製薬株式会社 カルボスチリル誘導体−シクロデキストリン包接化合物
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
DK111387A (da) * 1986-03-05 1987-09-06 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
ES2138971T3 (es) * 1991-07-03 2000-02-01 Otsuka Pharma Co Ltd Regulador de la apoptosis.
US5750529A (en) * 1991-07-03 1998-05-12 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating compostion
WO1993011769A1 (en) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Carcinostatic
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
CA2121148A1 (en) * 1992-08-19 1994-03-03 Satoru Nakai Apoptosis regulator
JP2826790B2 (ja) * 1992-12-26 1998-11-18 キッセイ薬品工業株式会社 ３，４−ジヒドロカルボスチリル誘導体
US5521185A (en) * 1993-03-02 1996-05-28 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting graft rejection and IL-1 production
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
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BRPI9708389B8 (pt) * 1996-03-29 2015-12-08 Duphar Int Res compostos de piperazina e piperidina, composições farmacêuticas.
GB2312843A (en) * 1996-05-07 1997-11-12 Merck & Co Inc Method of treating rheumatoid arthritis
US5684007A (en) * 1996-09-05 1997-11-04 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
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WO2001016133A2 (en) 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
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Also Published As

Publication number Publication date
DK155665B (da) 1989-05-01
IT1210585B (it) 1989-09-14
PH17962A (en) 1985-02-20
NL8104923A (nl) 1982-05-17
ES520638A0 (es) 1984-04-16
DK480381A (da) 1982-05-01
AT381701B (de) 1986-11-25
FI77450B (fi) 1988-11-30
KR830007607A (ko) 1983-11-04
SE8106430L (sv) 1982-05-01
NO158099B (no) 1988-04-05
PT73910B (en) 1983-04-18
FI77450C (fi) 1989-03-10
ATA460281A (de) 1986-04-15
PT73910A (en) 1981-11-01
FR2493320A1 (fr) 1982-05-07
GB2086896A (en) 1982-05-19
IT8547867A0 (it) 1985-03-26
ES8403886A1 (es) 1984-04-16
SU1426452A3 (ru) 1988-09-23
IT8149588A0 (it) 1981-10-29
SE8406209D0 (sv) 1984-12-06
FR2552760A1 (fr) 1985-04-05
IT1226479B (it) 1991-01-16
ES8403885A1 (es) 1984-04-16
AR242375A1 (es) 1993-03-31
FR2552760B1 (fr) 1988-08-05
JPS5777676A (en) 1982-05-15
SE466655B (sv) 1992-03-16
CH650782A5 (de) 1985-08-15
ZA817515B (en) 1982-10-27
CA1209575A (en) 1986-08-12
JPH0143747B2 (nl) 1989-09-22
ES8306743A1 (es) 1983-06-16
ES507198A0 (es) 1983-06-16
GB2086896B (en) 1984-10-10
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
FR2493320B1 (fr) 1985-08-23
FI813408L (fi) 1982-05-01
NO158099C (no) 1988-07-13
DE3142982A1 (de) 1982-06-24
SE8406209L (sv) 1984-12-06
AU7699681A (en) 1982-05-06
CH656616A5 (de) 1986-07-15
DE3153260C2 (nl) 1989-05-24
DK155665C (da) 1989-09-04
ES520637A0 (es) 1984-04-16
DE3142982C2 (de) 1985-12-19
NL194205C (nl) 2001-09-04
US4415572A (en) 1983-11-15
DE3153260A1 (nl) 1985-05-15
SE448877B (sv) 1987-03-23
KR860001944B1 (ko) 1986-11-01
MX8481A (es) 1994-02-28
NO813678L (no) 1982-05-03
NL8403096A (nl) 1985-02-01
AR242563A1 (es) 1993-04-30

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