ES2138971T3 - Regulador de la apoptosis. - Google Patents

Regulador de la apoptosis.

Info

Publication number
ES2138971T3
ES2138971T3 ES92914177T ES92914177T ES2138971T3 ES 2138971 T3 ES2138971 T3 ES 2138971T3 ES 92914177 T ES92914177 T ES 92914177T ES 92914177 T ES92914177 T ES 92914177T ES 2138971 T3 ES2138971 T3 ES 2138971T3
Authority
ES
Spain
Prior art keywords
apoptosis regulator
link
carboestiril
carbonocarbon
benzoil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92914177T
Other languages
English (en)
Inventor
Satoru Nakai
Koutoku Aihara
Hitomi Mori
Michiaki Tominaga
Masakazu Adachi
Hiroyuki Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2138971T3 publication Critical patent/ES2138971T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN REGULADOR DE LA APOPTOSIS QUE CONTIENE UN DERIVADO DE CARBOESTIRIL REPRESENTADO POR LA FORMULA GENERAL (1) Y SU SAL COMO EL INGREDIENTE ACTIVO, EN DONDE R REPRESENTA BENZOILO QUE PUEDE SER SUSTITUIDO POR ALCOXI INFERIOR Y EL ENLACE CARBONOCARBONO ENTRE LAS POSICIONES 3 Y 4 DEL ESQUELETO DE CARBOESTIRIL ES BIEN UN ENLACE SENCILLO O UN ENLACE DOBLE.
ES92914177T 1991-07-03 1992-07-02 Regulador de la apoptosis. Expired - Lifetime ES2138971T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP16258791 1991-07-03
JP3346992 1992-02-20
JP4571892 1992-03-03
JP10058592 1992-03-25

Publications (1)

Publication Number Publication Date
ES2138971T3 true ES2138971T3 (es) 2000-02-01

Family

ID=27459795

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92914177T Expired - Lifetime ES2138971T3 (es) 1991-07-03 1992-07-02 Regulador de la apoptosis.

Country Status (12)

Country Link
US (5) US5672603A (es)
EP (1) EP0552373B1 (es)
KR (1) KR100196368B1 (es)
AU (1) AU648690B2 (es)
CA (1) CA2090876A1 (es)
DE (1) DE69230131T2 (es)
DK (1) DK0552373T3 (es)
ES (1) ES2138971T3 (es)
HK (1) HK1004469A1 (es)
MX (1) MX9203950A (es)
TW (1) TW229157B (es)
WO (1) WO1993000902A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2121148A1 (en) * 1992-08-19 1994-03-03 Satoru Nakai Apoptosis regulator
AU672288B2 (en) * 1993-03-02 1996-09-26 Akira Matsumori Rejection inhibitor for transplants and IL-1 production inhibitor
GB9311132D0 (en) * 1993-05-28 1993-07-14 Eisai London Res Lab Ltd Control of cell death
KR100191191B1 (ko) * 1993-10-21 1999-06-15 오쓰까 아끼히꼬 인터루킨-8합성억제의 카르보스티릴 유도체
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
WO1996021449A1 (en) * 1995-01-11 1996-07-18 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical composition of indene derivatives for regulating apoptosis
WO1998046229A1 (fr) * 1995-06-21 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Inhibiteurs de la production d'il-8 et du mcaf
JPH0971532A (ja) * 1995-09-06 1997-03-18 Otsuka Pharmaceut Co Ltd 発癌抑制剤
US5700803A (en) * 1995-12-12 1997-12-23 Otsuka Pharmaceutical Co., Ltd. Method for reducing infarct size in subjects afflicted with ischemic heart disease
WO1998048807A1 (fr) * 1997-04-25 1998-11-05 Otsuka Pharmaceutical Co., Ltd. Inhibiteurs de la synthese de l'hyaluronate
US6008209A (en) * 1997-04-28 1999-12-28 Hoffmann-La Roche Inc. Method of using vitamin D3 analogs with bis C-20 side chains
US6544972B1 (en) 1997-09-25 2003-04-08 Regents Of The University Of Minnesota Methods of limiting apoptosis of cells
US6281191B1 (en) 1997-12-29 2001-08-28 Vladimir I. Slesarev Compositions and methods for treating hepatitis-C
FR2774289B1 (fr) * 1998-02-03 2002-05-24 Goemar Lab Sa Medicament pour le traitement des dereglements de l'apoptose
NZ508950A (en) 1998-07-13 2003-10-31 Univ Texas Cancer treatment methods using antibodies to aminophospholipids
EP1234585A3 (en) 1998-09-04 2004-01-21 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
US6277974B1 (en) 1999-12-14 2001-08-21 Cogent Neuroscience, Inc. Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death
US20030044413A1 (en) * 2000-08-15 2003-03-06 Regents Of The University Of Minnesota Methods of limiting apoptosis of cells
EP1467767A2 (en) * 2001-12-20 2004-10-20 Cogent Neuroscience, Inc. Methods for treating conditions,disorders,or diseases involving cell death
KR20120068769A (ko) 2002-07-15 2012-06-27 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
AU2003275495A1 (en) * 2002-11-07 2004-06-03 Walter C. Low Methods of treating injuries of the nervous system associated with hemorrhage
US8431396B2 (en) 2003-03-21 2013-04-30 The Cleveland Clinic Foundation Anti-angiogenic peptides
US20060204481A1 (en) * 2003-04-02 2006-09-14 Steer Clifford J Methods of promoting cell viability
CN110522717A (zh) 2004-01-22 2019-12-03 迈阿密大学 局部辅酶q10制剂及其使用方法
WO2006086452A1 (en) * 2005-02-10 2006-08-17 Regents Of The University Of Minnesota Methods for treating visual disorders
JP5809415B2 (ja) 2007-11-09 2015-11-10 ペレグリン ファーマシューティカルズ，インコーポレーテッド 抗ｖｅｇｆ抗体の組成物および方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430184A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
JPS6038384B2 (ja) * 1978-03-24 1985-08-31 大塚製薬株式会社 チオセミカルバゾン誘導体
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5793962A (en) * 1980-12-01 1982-06-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS62135423A (ja) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd 低酸素症改善剤

Also Published As

Publication number Publication date
US5872120A (en) 1999-02-16
US5916890A (en) 1999-06-29
DE69230131D1 (de) 1999-11-18
HK1004469A1 (en) 1998-11-27
AU648690B2 (en) 1994-04-28
EP0552373B1 (en) 1999-10-13
AU2231792A (en) 1993-02-11
US5798358A (en) 1998-08-25
DK0552373T3 (da) 1999-12-27
US5672603A (en) 1997-09-30
WO1993000902A1 (en) 1993-01-21
KR100196368B1 (ko) 1999-06-15
EP0552373A4 (en) 1993-09-22
KR930702002A (ko) 1993-09-08
EP0552373A1 (en) 1993-07-28
US5925640A (en) 1999-07-20
CA2090876A1 (en) 1993-01-04
DE69230131T2 (de) 2000-03-02
TW229157B (es) 1994-09-01
MX9203950A (es) 1993-05-01

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