ES2155134T3 - Derivados de imidazolidina y su utilizacion. - Google Patents
Derivados de imidazolidina y su utilizacion.Info
- Publication number
- ES2155134T3 ES2155134T3 ES95926500T ES95926500T ES2155134T3 ES 2155134 T3 ES2155134 T3 ES 2155134T3 ES 95926500 T ES95926500 T ES 95926500T ES 95926500 T ES95926500 T ES 95926500T ES 2155134 T3 ES2155134 T3 ES 2155134T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- alquilpiperazinil
- sterified
- ceno
- oalquenilo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002461 imidazolidines Chemical class 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical group [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical class O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
DERIVADO DE IMIDAZOLIDINA REPRESENTADO POR LA FORMULA GENERAL (I) Y MEDICINAS QUE LO CONTIENEN COMO EL INGREDIENTE ACTIVO, EJEMPLOS REPRESENTATIVOS QUE INCLUYEN UN INHIBIDOR DE QUIMASA Y UN PREVENTIVO O REMEDIO PARA ENFERMEDADES CIRCULATORIAS O CARDIACAS CAUSADAS POR PALPITACIONES ANORMALES INDUCIDAS POR LA ANGIOTENSINA II, DONDE A Y B REPRESENTAN CADA UNO UN GRUPO DE HIDROCARBURO AROMATICO QUE PUEDE SER SUSTITUIDO POR UNO O MAS SUSTITUYENTES SELECCIONADOS DE ENTRE HALOGENO, C ALQUILO, ALCOXI, ALQUILENODIOXI, FENOXI, NITRO,CIANO, FENILO, ALCANOILAMINO, CARBOXILO QUE PUEDE SER ESTERIFICADO CON ALQUILO O ALQUENILO, CARBOXIALQUILO QUE PUEDE SER ESTERIFICADO CON ALQUILO O ALQUENILO, CARBOXIALQUILOXI QUE SER ESTERIFICADO CON ALQUILO OALQUENILO, N-ALQUILPIPERAZINIL CARBONILO, N-ALQUILPIPERAZINIL-CARBONIALQUILO, N-ALQUILOPIPERAZINIL-CARBONILALQUILOXI Y MORFOLINOCARBONILO; X REPRESENTA OXIGENO O SULFURO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20786794 | 1994-07-29 | ||
JP33370694 | 1994-12-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2155134T3 true ES2155134T3 (es) | 2001-05-01 |
Family
ID=26516513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95926500T Expired - Lifetime ES2155134T3 (es) | 1994-07-29 | 1995-07-26 | Derivados de imidazolidina y su utilizacion. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5691335A (es) |
EP (1) | EP0721944B1 (es) |
AT (1) | ATE198743T1 (es) |
AU (1) | AU3086095A (es) |
DE (1) | DE69519921T2 (es) |
ES (1) | ES2155134T3 (es) |
WO (1) | WO1996004248A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5912261A (en) * | 1994-12-20 | 1999-06-15 | Nippon Zoki Pharmaceutical Co., Ltd. | Carboxyalkyl heterocyclic derivatives |
US6197806B1 (en) | 1995-12-20 | 2001-03-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Eliminating agent for activated oxygen and free radicals |
JPH10182460A (ja) * | 1996-12-27 | 1998-07-07 | Nippon Zoki Pharmaceut Co Ltd | 3−デオキシグルコソン生成阻害剤 |
US20050267148A1 (en) * | 1998-07-15 | 2005-12-01 | Teijin Limited | Benzimidazole derivative |
TR200100047T2 (tr) | 1998-07-15 | 2001-10-22 | Teijin Limited | Tiyobenzimidazol türevleri |
KR100381214B1 (ko) * | 1998-08-10 | 2003-09-22 | 주식회사 엘지생명과학 | 항암제로유용한이미다졸리딘-2,4-디온유도체및그의제조방법 |
CA2341195A1 (en) * | 1998-08-20 | 2000-03-02 | Mitsunori Waki | Prophylactic or therapeutic composition for ocular circulation disorders |
US6867214B1 (en) * | 1998-08-21 | 2005-03-15 | Daiichi Suntory Pharma Co., Ltd. | Quinazoline derivatives and pharmaceutical applications thereof |
AU754989B2 (en) | 1998-11-16 | 2002-11-28 | Nippon Zoki Pharmaceutical Co., Ltd. | A therapeutic agent for intractable vasculitis |
US6432978B1 (en) * | 1998-12-01 | 2002-08-13 | Meiji Seika Kaisha, Ltd. | SF2809-I,II,III,IV,V and VI substances exhibiting chymase-inhibiting activities |
EP1224945A4 (en) * | 1999-10-25 | 2004-08-18 | Senju Pharma Co | MEANS TO RELEASE THE CELLARIAN TENSION |
DE60034545T2 (de) | 1999-11-01 | 2007-10-25 | Asubio Pharma Co., Ltd. | Verwendung von chymase hemmern gegen vaskuläre lipidablagerung |
US6300503B1 (en) * | 1999-12-17 | 2001-10-09 | Dixie Chemical Company | Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same |
KR20010108519A (ko) | 2000-02-22 | 2001-12-07 | 도리이 신이치로 | 키마제 억제제를 유효성분으로 하는 선유증의 예방 또는치료약 |
CA2365606A1 (en) | 2000-02-22 | 2001-08-30 | Suntory Limited | Medicament for prevention or treatment of various diseases involving an increase in eosinophils chymase inhibitor as effective ingredient |
CN1245979C (zh) * | 2000-02-22 | 2006-03-22 | 第一阿斯比奥制药株式会社 | 含有胃促胰酶抑制剂作为有效成分的预防和治疗皮炎的药物 |
JP4711523B2 (ja) | 2001-02-13 | 2011-06-29 | 日本臓器製薬株式会社 | 低アルブミン血症改善剤 |
JPWO2002083649A1 (ja) * | 2001-04-11 | 2004-08-05 | 千寿製薬株式会社 | 新規イミダゾリジンジオン誘導体およびその医薬用途 |
EP1539171A4 (en) * | 2002-07-30 | 2007-12-19 | Sod Conseils Rech Applic | USE OF CHYMASE INHIBITORS IN THE PREVENTION AND / OR TREATMENT OF ARTERIOVINOUS GRAFT REJECTION |
FR2845384B1 (fr) * | 2002-10-04 | 2004-12-31 | Fournier Lab Sa | Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique |
US20060025589A1 (en) * | 2002-10-01 | 2006-02-02 | Jean Binet | 2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes |
FR2845383B1 (fr) * | 2002-10-04 | 2004-12-31 | Fournier Lab Sa | Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique |
US20060217421A1 (en) | 2003-05-09 | 2006-09-28 | Hajimu Kurumatani | Fortifier |
US7361767B2 (en) * | 2003-11-14 | 2008-04-22 | 3M Innovative Properties Company | N-sulfonyldicarboximide containing tethering compounds |
US7423155B2 (en) | 2003-11-14 | 2008-09-09 | 3M Innovative Properties Company | N-sulfonyldicarboximide containing tethering compounds |
NZ548209A (en) | 2003-12-19 | 2009-07-31 | Univ California | Methods and materials for assessing prostate cancer thearapies |
NZ550102A (en) | 2004-02-24 | 2010-10-29 | Univ California | Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives) |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
US7544756B2 (en) | 2005-09-30 | 2009-06-09 | 3M Innovative Properties Company | Crosslinked polymers with amine binding groups |
DK2656842T3 (en) | 2006-03-27 | 2016-11-07 | Univ California | Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES |
CA2648139A1 (en) | 2006-03-29 | 2007-11-08 | The Regents Of The University Of California | Diaryl thiohydantoin compounds and their use in the treatment of hyperproliferative disorders |
EP2620432A3 (en) | 2007-10-26 | 2013-12-18 | The Regents Of the University of California | Diarylhydantoin compounds |
JP5587914B2 (ja) | 2009-01-30 | 2014-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キマーゼ阻害剤として有用なアザキナゾリンジオン |
KR101972719B1 (ko) | 2010-02-16 | 2019-04-25 | 아라곤 파마슈티컬스, 인코포레이티드 | 안드로겐 수용체 조절제 및 이의 용도 |
NZ744456A (en) | 2012-09-26 | 2019-09-27 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
JP2016535769A (ja) * | 2013-11-08 | 2016-11-17 | バイエル ファーマ アクチエンゲゼルシャフト | キマーゼ阻害薬としての置換されているウラシル類 |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
CN109311821B (zh) * | 2016-06-14 | 2022-10-14 | 百时美施贵宝公司 | 作为apj激动剂的6-羟基-5-(苯基/杂芳基磺酰基)嘧啶-4(1h)-酮 |
CN109641843B (zh) * | 2016-06-14 | 2022-07-19 | 百时美施贵宝公司 | 作为apj激动剂的4-羟基-3-磺酰基吡啶-2(1h)-酮 |
WO2019023448A1 (en) * | 2017-07-26 | 2019-01-31 | Emory University | INHIBITORS OF NADPH OXIDASE AND THEIR USE |
SG11202003402QA (en) | 2017-10-16 | 2020-05-28 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1207391B (de) * | 1962-05-30 | 1965-12-23 | Degussa | Verfahren zur Herstellung von 3-Benzoyl-5, 5-dimethylhydantoinen |
US4166124A (en) * | 1970-05-15 | 1979-08-28 | U.S. Philips Corporation | Insecticidal 2,6-dihalobenzoyl urea derivatives |
JPS5371073A (en) * | 1976-12-03 | 1978-06-24 | Sumitomo Chem Co Ltd | 1-cyclic alkyl carbonyl-3(3,5-dihalogenophenyl)hydantoin derivs., process fo r their preparation and fungicides for agriculture and horti culture contg. the same as active constituents |
JPS5855468A (ja) * | 1981-09-25 | 1983-04-01 | Sumitomo Chem Co Ltd | 5−クロロヒダントイン誘導体、その製造法およびそれを有効成分として含有する殺虫剤 |
US4474796A (en) * | 1983-02-04 | 1984-10-02 | Sumitomo Chemical Company, Limited | Insecticidal substituted hydantoins |
JPH068281B2 (ja) * | 1985-09-19 | 1994-02-02 | 持田製薬株式会社 | ヒダントイン誘導体及びそれを有効成分とするアルド−スレダクタ−ゼ阻害剤 |
-
1995
- 1995-07-26 ES ES95926500T patent/ES2155134T3/es not_active Expired - Lifetime
- 1995-07-26 DE DE69519921T patent/DE69519921T2/de not_active Expired - Fee Related
- 1995-07-26 AT AT95926500T patent/ATE198743T1/de not_active IP Right Cessation
- 1995-07-26 WO PCT/JP1995/001485 patent/WO1996004248A1/ja active IP Right Grant
- 1995-07-26 AU AU30860/95A patent/AU3086095A/en not_active Abandoned
- 1995-07-26 US US08/615,277 patent/US5691335A/en not_active Expired - Fee Related
- 1995-07-26 EP EP95926500A patent/EP0721944B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1996004248A1 (fr) | 1996-02-15 |
ATE198743T1 (de) | 2001-02-15 |
EP0721944A1 (en) | 1996-07-17 |
US5691335A (en) | 1997-11-25 |
AU3086095A (en) | 1996-03-04 |
EP0721944A4 (en) | 1997-01-02 |
DE69519921D1 (de) | 2001-02-22 |
DE69519921T2 (de) | 2001-06-13 |
EP0721944B1 (en) | 2001-01-17 |
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Legal Events
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---|---|---|---|
FG2A | Definitive protection |
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