MX348166B - Diacuerpos covalentes y sus usos. - Google Patents

Diacuerpos covalentes y sus usos.

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Publication number
MX348166B
MX348166B MX2013010955A MX2013010955A MX348166B MX 348166 B MX348166 B MX 348166B MX 2013010955 A MX2013010955 A MX 2013010955A MX 2013010955 A MX2013010955 A MX 2013010955A MX 348166 B MX348166 B MX 348166B
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MX
Mexico
Prior art keywords
same
diabody
molecules
molecule
antigens
Prior art date
Application number
MX2013010955A
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English (en)
Inventor
s johnson Leslie
Huang Ling
Original Assignee
Macrogenics Inc
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Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of MX348166B publication Critical patent/MX348166B/es

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Abstract

La presente invención se refiere a moléculas de diacuerpo y sus usos en el tratamiento de una variedad de enfermedades y trastornos, que incluyen trastornos inmunológicos, enfermedad infecciosa, intoxicación, y cánceres. Las moléculas de diacuerpo de la invención comprenden dos cadenas de polipéptido que se asocian para formar al menos dos sitios de unión de epítopo, que pueden reconocer el mismo o diferentes epítopos en el mismo o diferentes antígenos. Adicionalmente, los antígenos pueden formar la misma o diferentes moléculas. Las cadenas de polipéptido individuales de la molécula de diacuerpo pueden covalentemente unirse a través de enlaces covalente de unión no de péptido, tales como, pero no limitándose a el enlace de disulfuro de residuos de cisteína localizados dentro de cada cadena de polipéptido. En modalidades paricu1ares, las moléculas de diacuerpo de la presente invención además comprenden una región Fc, que permite la funcionalidad de tipo anticuerpo para modificarse dentro de la molécula.
MX2013010955A 2008-12-19 2009-12-17 Diacuerpos covalentes y sus usos. MX348166B (es)

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JP2012512894A (ja) 2012-06-07
ES2986435T3 (es) 2024-11-11
EP3482769B1 (en) 2024-05-29
WO2010080538A1 (en) 2010-07-15
IL269454B (en) 2021-05-31
IL213348A (en) 2017-08-31
ES2732191T3 (es) 2019-11-21
CY1122412T1 (el) 2021-01-27
EP2376109A1 (en) 2011-10-19
CN106432503B (zh) 2020-03-06
IL253751A0 (en) 2017-09-28
IL213348A0 (en) 2011-07-31
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CN106220734A (zh) 2016-12-14
KR101940059B1 (ko) 2019-01-18

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