MX342959B - Derivados de quinolina como inhibidores de la p13 quinasa. - Google Patents

Derivados de quinolina como inhibidores de la p13 quinasa.

Info

Publication number
MX342959B
MX342959B MX2012009210A MX2012009210A MX342959B MX 342959 B MX342959 B MX 342959B MX 2012009210 A MX2012009210 A MX 2012009210A MX 2012009210 A MX2012009210 A MX 2012009210A MX 342959 B MX342959 B MX 342959B
Authority
MX
Mexico
Prior art keywords
quinoline derivatives
diseases
kinase inhibitors
invented
pancreatitis
Prior art date
Application number
MX2012009210A
Other languages
English (en)
Spanish (es)
Inventor
Joelle Lorraine Burgess
Kenneth Allen Newlander
Michael Gerard Darcy
Steven David Knight
Nicholas D Adams
Stanley J Schmidt
Carla A Donatelli
Lance Ridgers
Martha Sarpong
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MX342959B publication Critical patent/MX342959B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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MX2012009210A 2007-05-18 2008-05-16 Derivados de quinolina como inhibidores de la p13 quinasa. MX342959B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93876107P 2007-05-18 2007-05-18
PCT/US2008/063819 WO2008144463A1 (en) 2007-05-18 2008-05-16 Quinoline derivatives as pi3 kinase inhibitors

Publications (1)

Publication Number Publication Date
MX342959B true MX342959B (es) 2016-10-18

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012009210A MX342959B (es) 2007-05-18 2008-05-16 Derivados de quinolina como inhibidores de la p13 quinasa.
MX2009012479A MX2009012479A (es) 2007-05-18 2008-05-16 Derivados de quinolina como inhibidores de la pi3 quinasa.

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