JO2891B1 - Quinoline derivatives used as inhibitors of PI3 kinase - Google Patents

Quinoline derivatives used as inhibitors of PI3 kinase

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Publication number
JO2891B1
JO2891B1 JO2008222A JOP20080222A JO2891B1 JO 2891 B1 JO2891 B1 JO 2891B1 JO 2008222 A JO2008222 A JO 2008222A JO P20080222 A JOP20080222 A JO P20080222A JO 2891 B1 JO2891 B1 JO 2891B1
Authority
JO
Jordan
Prior art keywords
quinoline derivatives
diseases
kinase inhibitors
invented
pancreatitis
Prior art date
Application number
JO2008222A
Other languages
Arabic (ar)
English (en)
Inventor
لورين بيرجس جويل
جيرارد دارسي مايكل
آ دوناتيلي كارلا
ديفيد نايت ستيفن
الين نيولاندر كينيث
ريدجرز لانس
أ. ساربونج مارثا
جي شميدت ستانلي
دي ادامز نيكولاس
Original Assignee
سميثكلاين بيشام كوربوريشن
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by سميثكلاين بيشام كوربوريشن filed Critical سميثكلاين بيشام كوربوريشن
Application granted granted Critical
Publication of JO2891B1 publication Critical patent/JO2891B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JO2008222A 2007-05-18 2008-05-15 Quinoline derivatives used as inhibitors of PI3 kinase JO2891B1 (en)

Applications Claiming Priority (1)

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US93876107P 2007-05-18 2007-05-18

Publications (1)

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JO2891B1 true JO2891B1 (en) 2015-09-15

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JO2008222A JO2891B1 (en) 2007-05-18 2008-05-15 Quinoline derivatives used as inhibitors of PI3 kinase

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US (6) US20100168100A1 (enExample)
EP (3) EP2596793B1 (enExample)
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