CN101754759B - 用作pi3激酶抑制剂的喹啉衍生物 - Google Patents
用作pi3激酶抑制剂的喹啉衍生物 Download PDFInfo
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- CN101754759B CN101754759B CN2008800249784A CN200880024978A CN101754759B CN 101754759 B CN101754759 B CN 101754759B CN 2008800249784 A CN2008800249784 A CN 2008800249784A CN 200880024978 A CN200880024978 A CN 200880024978A CN 101754759 B CN101754759 B CN 101754759B
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- Prior art keywords
- pyridyl
- quinolyl
- substituted
- amino
- quinoline
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- 0 CC(C)c1****2*1***2 Chemical compound CC(C)c1****2*1***2 0.000 description 8
- KJILYZMXTLCPDQ-UHFFFAOYSA-N Clc1ccnc(cc2)c1cc2Br Chemical compound Clc1ccnc(cc2)c1cc2Br KJILYZMXTLCPDQ-UHFFFAOYSA-N 0.000 description 2
- MWWLMHIMIVZWQG-UHFFFAOYSA-N O=Cc1ccc2nccc(-c3ccncc3)c2c1 Chemical compound O=Cc1ccc2nccc(-c3ccncc3)c2c1 MWWLMHIMIVZWQG-UHFFFAOYSA-N 0.000 description 2
- HCYNYTFWABXHAC-UHFFFAOYSA-N C(CC1)CCN1c(c1c2)ccnc1ccc2-c1cc(cn[nH]2)c2nc1 Chemical compound C(CC1)CCN1c(c1c2)ccnc1ccc2-c1cc(cn[nH]2)c2nc1 HCYNYTFWABXHAC-UHFFFAOYSA-N 0.000 description 1
- USHUYFAJDWRMFL-UHFFFAOYSA-N C=Cc(cc1)cc2c1nccc2Cl Chemical compound C=Cc(cc1)cc2c1nccc2Cl USHUYFAJDWRMFL-UHFFFAOYSA-N 0.000 description 1
- RAUVFJKLKMJWGN-UHFFFAOYSA-N CCCCCCCNc(c1c2)ccnc1ccc2Br Chemical compound CCCCCCCNc(c1c2)ccnc1ccc2Br RAUVFJKLKMJWGN-UHFFFAOYSA-N 0.000 description 1
- GUTGEMORYRGQDD-UHFFFAOYSA-N CN(C)S(c1c(N)ncc(-c(ccc2ncc3)cc2c3-c2cccc(S(N)(=O)=O)c2)c1)(=O)=O Chemical compound CN(C)S(c1c(N)ncc(-c(ccc2ncc3)cc2c3-c2cccc(S(N)(=O)=O)c2)c1)(=O)=O GUTGEMORYRGQDD-UHFFFAOYSA-N 0.000 description 1
- AHMLZYGNJYLNJQ-UHFFFAOYSA-N COc(ncc([Br]=C)c1)c1NS(c(ccc(F)c1)c1F)(=O)=O Chemical compound COc(ncc([Br]=C)c1)c1NS(c(ccc(F)c1)c1F)(=O)=O AHMLZYGNJYLNJQ-UHFFFAOYSA-N 0.000 description 1
- FLRGXIDFVYOCLP-UHFFFAOYSA-N N#Cc(ccc1ncc2)cc1c2Cl Chemical compound N#Cc(ccc1ncc2)cc1c2Cl FLRGXIDFVYOCLP-UHFFFAOYSA-N 0.000 description 1
- INLPDPKYJXJJMT-UHFFFAOYSA-N O=Cc(cc1)cc2c1nccc2Cl Chemical compound O=Cc(cc1)cc2c1nccc2Cl INLPDPKYJXJJMT-UHFFFAOYSA-N 0.000 description 1
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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