MD663G2 - Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente - Google Patents

Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
carbon atoms
hydrogen atom
heteroatoms
formula
saturated
Prior art date
Application number
MD95-0431A
Other languages
English (en)
Romanian (ro)
Russian (ru)
Other versions
MD663F1 (ro
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/xx
Publication of MD663G2 publication Critical patent/MD663G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MD95-0431A 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente MD663G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (ro) 1997-01-31
MD663G2 true MD663G2 (ro) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (ro) 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Country Status (49)

Country Link
US (2) US5656607A (sh)
EP (1) EP0676409B1 (sh)
JP (1) JP3000023B2 (sh)
KR (1) KR100317148B1 (sh)
CN (1) CN1059445C (sh)
AP (1) AP587A (sh)
AT (1) ATE234853T1 (sh)
AU (1) AU684939B2 (sh)
BG (1) BG61916B1 (sh)
BR (1) BR9506147A (sh)
CA (1) CA2164638C (sh)
CO (1) CO4370097A1 (sh)
CZ (1) CZ296005B6 (sh)
DE (1) DE69529934T2 (sh)
DK (1) DK0676409T3 (sh)
DZ (1) DZ1869A1 (sh)
EE (1) EE04498B1 (sh)
ES (1) ES2189820T3 (sh)
FI (1) FI111264B (sh)
FR (1) FR2718450B1 (sh)
GB (1) GB2288174A (sh)
GE (1) GEP19991836B (sh)
HR (1) HRP950217B1 (sh)
HU (1) HU215396B (sh)
IL (1) IL112954A (sh)
IS (1) IS1865B (sh)
JO (1) JO1850B1 (sh)
LV (1) LV11182B (sh)
MA (1) MA23501A1 (sh)
MD (1) MD663G2 (sh)
MY (1) MY114672A (sh)
NO (1) NO308361B1 (sh)
NZ (1) NZ284498A (sh)
OA (1) OA10200A (sh)
PE (1) PE2896A1 (sh)
PL (1) PL180837B1 (sh)
PT (1) PT676409E (sh)
RO (1) RO115634B1 (sh)
RU (1) RU2141965C1 (sh)
SA (1) SA97170757A (sh)
SI (1) SI0676409T1 (sh)
SK (1) SK284079B6 (sh)
SV (1) SV1995000018A (sh)
TN (1) TNSN95026A1 (sh)
TW (1) TW316908B (sh)
UA (1) UA44705C2 (sh)
WO (1) WO1995027720A1 (sh)
YU (1) YU49221B (sh)
ZA (1) ZA952059B (sh)

Families Citing this family (49)

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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
BR9708930A (pt) * 1996-05-07 1999-08-03 Abbott Lab Composto derivado de 3-descladinose-2,3-anidro-eritromicina ou um seu sal ou éster farmaceuticamente aceitável processo para a preparação do composto composição farmacêutica e processo de tratamento de infecções bacterianas
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
WO1998009978A1 (en) * 1996-09-04 1998-03-12 Abbott Laboratories 6-o-substituted ketolides having antibacterial activity
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
JP2000513026A (ja) * 1997-06-11 2000-10-03 ファイザー・プロダクツ・インク ９−オキシム エリスロマイシン誘導体
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
WO2000017218A1 (en) 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TR200102129T2 (tr) 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
KR100710605B1 (ko) * 1999-04-16 2007-04-24 코산 바이오사이언시즈, 인코포레이티드 매크롤라이드 항감염제
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
JP2003500414A (ja) * 1999-05-24 2003-01-07 ファイザー・プロダクツ・インク １３−メチルエリスロマイシン誘導体
US6756359B2 (en) 2001-07-03 2004-06-29 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
CN105039464A (zh) 2002-07-01 2015-11-11 阿基昂生命科学公司,以生物技术资源部的名义经营 用于生产葡糖胺和n-乙酰氨基葡糖的方法和物质
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
EP1618119A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Pyridyl substituted ketolide antibiotics
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
WO2011119604A1 (en) 2010-03-22 2011-09-29 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
CA2868262A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN105163785A (zh) 2013-03-14 2015-12-16 森普拉制药公司 用于治疗呼吸道疾病的方法及其制剂
CA2907085A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
KR102363621B1 (ko) 2013-04-04 2022-02-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 매크롤라이드 그리고 그의 제조방법 및 용도
WO2016057798A1 (en) * 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
US10640528B2 (en) 2015-03-25 2020-05-05 President And Fellows Of Havard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

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US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Also Published As

Publication number Publication date
US5656607A (en) 1997-08-12
JO1850B1 (en) 1995-12-27
PT676409E (pt) 2003-08-29
FR2718450B1 (fr) 1997-01-10
NZ284498A (en) 1997-07-27
RO115634B1 (ro) 2000-04-28
CN1059445C (zh) 2000-12-13
FI955913A (fi) 1995-12-08
ATE234853T1 (de) 2003-04-15
YU49221B (sh) 2004-11-25
AU2310795A (en) 1995-10-30
JPH07278177A (ja) 1995-10-24
RU2141965C1 (ru) 1999-11-27
CA2164638A1 (fr) 1995-10-19
JP3000023B2 (ja) 2000-01-17
YU21695A (sh) 1997-12-05
LV11182A (lv) 1996-04-20
ES2189820T3 (es) 2003-07-16
FI111264B (fi) 2003-06-30
SA97170757A (ar) 2005-12-03
FI955913A0 (fi) 1995-12-08
GB2288174A (en) 1995-10-11
WO1995027720A1 (fr) 1995-10-19
CZ322395A3 (en) 1996-08-14
NO308361B1 (no) 2000-09-04
TW316908B (sh) 1997-10-01
BG100150A (bg) 1996-06-28
MA23501A1 (fr) 1995-12-31
MY114672A (en) 2002-12-31
LV11182B (en) 1997-04-20
EP0676409A1 (fr) 1995-10-11
EE04498B1 (et) 2005-06-15
HRP950217B1 (en) 2004-06-30
KR100317148B1 (ko) 2002-06-22
AP587A (en) 1997-04-29
SK154695A3 (en) 1996-10-02
HU215396B (hu) 1998-12-28
PE2896A1 (es) 1996-02-12
GB9506856D0 (en) 1995-05-24
DZ1869A1 (fr) 2002-02-17
MD663F1 (ro) 1997-01-31
SV1995000018A (es) 1997-10-24
IL112954A0 (en) 1995-06-29
CZ296005B6 (cs) 2005-12-14
DE69529934D1 (de) 2003-04-24
AU684939B2 (en) 1998-01-08
CA2164638C (fr) 2003-12-30
SI0676409T1 (en) 2003-06-30
AP9500743A0 (en) 1995-07-31
DK0676409T3 (da) 2003-06-23
IS1865B (is) 2003-05-02
NO954942L (no) 1996-02-07
PL180837B1 (pl) 2001-04-30
EE9500080A (et) 1996-12-16
ZA952059B (en) 1996-03-13
UA44705C2 (uk) 2002-03-15
CN1126997A (zh) 1996-07-17
IL112954A (en) 2000-07-16
OA10200A (fr) 1996-12-18
PL311871A1 (en) 1996-03-18
IS4309A (is) 1995-11-17
HRP950217A2 (en) 1997-08-31
GEP19991836B (en) 1999-11-05
DE69529934T2 (de) 2003-09-04
CO4370097A1 (es) 1996-10-07
HUT73772A (en) 1996-09-30
EP0676409B1 (fr) 2003-03-19
HU9503505D0 (en) 1996-02-28
BR9506147A (pt) 1996-04-16
SK284079B6 (sk) 2004-09-08
TNSN95026A1 (fr) 1996-02-06
NO954942D0 (no) 1995-12-06
US5760233A (en) 1998-06-02
BG61916B1 (bg) 1998-09-30
FR2718450A1 (fr) 1995-10-13

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees