KR900008743B1 - 안트라시클리논 글리코시드의 정제방법 - Google Patents

안트라시클리논 글리코시드의 정제방법 Download PDF

Info

Publication number
KR900008743B1
KR900008743B1 KR1019830006090A KR830006090A KR900008743B1 KR 900008743 B1 KR900008743 B1 KR 900008743B1 KR 1019830006090 A KR1019830006090 A KR 1019830006090A KR 830006090 A KR830006090 A KR 830006090A KR 900008743 B1 KR900008743 B1 KR 900008743B1
Authority
KR
South Korea
Prior art keywords
resin
water
purifying
resins
adsorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830006090A
Other languages
English (en)
Korean (ko)
Other versions
KR840007438A (ko
Inventor
오피치 에르네스토
바레시오 카를로
기아코마로사 오노리노
Original Assignee
파미탈리아 카를로 에바 에스피에이
기오르기오 오란도
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 파미탈리아 카를로 에바 에스피에이, 기오르기오 오란도 filed Critical 파미탈리아 카를로 에바 에스피에이
Publication of KR840007438A publication Critical patent/KR840007438A/ko
Application granted granted Critical
Publication of KR900008743B1 publication Critical patent/KR900008743B1/ko
Priority to KR1019910014922A priority Critical patent/KR920000102B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1019830006090A 1982-12-23 1983-12-22 안트라시클리논 글리코시드의 정제방법 Expired KR900008743B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910014922A KR920000102B1 (ko) 1982-12-23 1991-08-23 안트라시클리논 글리코시드의 정제방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT24939A/82 1982-12-23
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019910014922A Division KR920000102B1 (ko) 1982-12-23 1991-08-23 안트라시클리논 글리코시드의 정제방법

Publications (2)

Publication Number Publication Date
KR840007438A KR840007438A (ko) 1984-12-07
KR900008743B1 true KR900008743B1 (ko) 1990-11-29

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830006090A Expired KR900008743B1 (ko) 1982-12-23 1983-12-22 안트라시클리논 글리코시드의 정제방법

Country Status (30)

Country Link
US (1) US4861870A (enExample)
JP (2) JPS59118797A (enExample)
KR (1) KR900008743B1 (enExample)
AT (1) AT383601B (enExample)
AU (1) AU570935B2 (enExample)
BE (1) BE898506A (enExample)
CA (1) CA1204738A (enExample)
CH (1) CH657623A5 (enExample)
CS (1) CS258114B2 (enExample)
DE (1) DE3345445C2 (enExample)
DK (1) DK594083A (enExample)
ES (1) ES8504758A1 (enExample)
FI (1) FI834650A7 (enExample)
FR (1) FR2538394B1 (enExample)
GB (1) GB2133005B (enExample)
GR (1) GR79135B (enExample)
HK (1) HK74887A (enExample)
HU (1) HU197917B (enExample)
IE (1) IE56678B1 (enExample)
IL (1) IL70500A (enExample)
IT (1) IT1155446B (enExample)
NL (1) NL193108C (enExample)
NO (1) NO834765L (enExample)
NZ (1) NZ206605A (enExample)
PT (1) PT77883B (enExample)
SE (1) SE8307134L (enExample)
SG (1) SG34587G (enExample)
SU (6) SU1440350A3 (enExample)
YU (1) YU247183A (enExample)
ZA (1) ZA839564B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
US6388058B1 (en) 1997-08-28 2002-05-14 Mercian Corporation Method of purifying daunomycin
WO1999029708A1 (fr) * 1997-12-05 1999-06-17 Mercian Corporation Anthracycline cristalline antibiotique et son procede de production
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
ES2235518T3 (es) * 1998-10-16 2005-07-01 Mercian Corporation Cristalizacion de hidrocloruro de doxorubicina.
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
US7485707B2 (en) * 2003-07-02 2009-02-03 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
US20050059156A1 (en) * 2003-08-06 2005-03-17 Pharmacia Italia S.P.A. Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
CN101331147B (zh) * 2005-12-13 2011-11-30 苏洛克股份有限公司 用于制备4-脱甲基柔红霉素的方法
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
BRPI0923815A2 (pt) 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
AU2009329917B2 (en) 2008-12-23 2016-03-31 Gilead Pharmasset Llc Nucleoside analogs
CN102695513A (zh) 2008-12-23 2012-09-26 吉利德制药有限责任公司 核苷氨基磷酸酯
EP2301943B1 (en) 2009-09-08 2014-01-08 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCI
SMT201700412T1 (it) 2010-03-31 2017-11-15 Gilead Pharmasset Llc Procedimento per la cristallizzazione di (s)-isopropil 2-(((s)-(perfluorofenossi)(fenossi)fosforil)ammino)propanoato
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (en) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
CN108350015A (zh) * 2015-11-05 2018-07-31 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1003383A (enExample) *
US2960437A (en) * 1954-09-03 1960-11-15 Pfizer & Co C Ion exchange purification of basic antibiotics
US2827417A (en) * 1954-09-03 1958-03-18 Pfizer & Co C Ion exchange purification of basic antibiotics
US2793978A (en) * 1955-06-27 1957-05-28 Olin Mathieson Ion exchange purification of neomycin
US3221008A (en) * 1962-01-30 1965-11-30 Merck & Co Inc Ion exchange process for the recovery of ionic organic substances
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) * 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
FR1593235A (enExample) * 1968-11-18 1970-05-25
JPS4944347A (enExample) * 1972-09-01 1974-04-26
US3882195A (en) * 1973-05-16 1975-05-06 Air Prod & Chem Pre-emulsification-delayed initiation suspension pearl polymerization process
JPS5134915B2 (enExample) * 1974-07-27 1976-09-29
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
NL7602342A (nl) * 1975-03-13 1976-09-15 Rhone Poulenc Ind Naftaceenderivaat met antibiotische activiteit.
US4029548A (en) * 1976-05-07 1977-06-14 The Upjohn Company Process for producing antibiotics U-50,147 and U-51,738
IT1098212B (it) * 1978-05-09 1985-09-07 Farmaceutici Italia Antracioline antitumorali sostituite
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
KR840007438A (ko) 1984-12-07
NZ206605A (en) 1987-02-20
NL193108B (nl) 1998-07-01
SU1470197A3 (ru) 1989-03-30
HUT35270A (en) 1985-06-28
SE8307134L (sv) 1984-06-24
SU1575943A3 (ru) 1990-06-30
JPH0439476B2 (enExample) 1992-06-29
DK594083A (da) 1984-06-24
FI834650L (fi) 1984-06-24
CH657623A5 (it) 1986-09-15
JP2749272B2 (ja) 1998-05-13
GB2133005B (en) 1986-04-30
IE56678B1 (en) 1991-11-06
AT383601B (de) 1987-07-27
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
DE3345445A1 (de) 1984-06-28
CA1204738A (en) 1986-05-20
BE898506A (fr) 1984-04-16
FR2538394A1 (fr) 1984-06-29
SG34587G (en) 1988-03-04
NL193108C (nl) 1998-11-03
NO834765L (no) 1984-06-25
HK74887A (en) 1987-10-23
SU1447287A3 (ru) 1988-12-23
NL8304327A (nl) 1984-07-16
ZA839564B (en) 1984-08-29
SE8307134D0 (sv) 1983-12-22
ES528226A0 (es) 1985-05-01
GR79135B (enExample) 1984-10-02
DE3345445C2 (de) 1995-09-21
JPH07252291A (ja) 1995-10-03
AU2245583A (en) 1984-06-28
CS258114B2 (en) 1988-07-15
IE833060L (en) 1984-06-23
CS980283A2 (en) 1987-12-17
HU197917B (en) 1989-06-28
SU1440350A3 (ru) 1988-11-23
GB2133005A (en) 1984-07-18
YU247183A (en) 1985-10-31
GB8333511D0 (en) 1984-01-25
FI834650A7 (fi) 1984-06-24
IL70500A0 (en) 1984-03-30
SU1450747A3 (ru) 1989-01-07
IT1155446B (it) 1987-01-28
SU1450748A3 (ru) 1989-01-07
ATA440083A (de) 1986-12-15
FI834650A0 (fi) 1983-12-16
IT8224939A0 (it) 1982-12-23
ES8504758A1 (es) 1985-05-01
US4861870A (en) 1989-08-29
AU570935B2 (en) 1988-03-31
FR2538394B1 (fr) 1986-03-28
PT77883B (en) 1986-04-09
IL70500A (en) 1990-07-12
DK594083D0 (da) 1983-12-22

Similar Documents

Publication Publication Date Title
KR900008743B1 (ko) 안트라시클리논 글리코시드의 정제방법
Hrazdina Column chromatographic isolation of the anthocyanidin-3, 5-diglucosides from grapes
JPH0645626B2 (ja) セフタジジムの回収方法
KR920000102B1 (ko) 안트라시클리논 글리코시드의 정제방법
US6649755B1 (en) Process for preparing acarbose with high purity
JP3141029B2 (ja) ペントスタチンの精製方法
CN116854755A (zh) 一种高纯度京尼平苷的分离纯化方法及其应用
JPS628118B2 (enExample)
WO2003014135A1 (en) Method for purification of acarbose
JP2000351791A (ja) ドキソルビシンの精製方法
KR100351718B1 (ko) 4'-에피-독소루비신의 정제방법
WO1998026085A1 (fr) Procedes de fabrication de vancomycine
JPS6257637B2 (enExample)
CN116514927A (zh) 一种替考拉宁的纯化方法
JPS6149317B2 (enExample)
CN121159548A (zh) 一种纯化丝裂霉素c的方法
JPS6210511B2 (enExample)
JPH10225299A (ja) バンコマイシンの製造方法
CN120699072A (zh) 一种酒石酸泰万菌素纯化的方法
JPH0737434B2 (ja) ７−ジメチルアミノ−６−デメチル−６−デオキシテトラサイクリンの採取法
JPH0352448B2 (enExample)
JPS59144799A (ja) コエンザイムａの精製方法
WO1999011650A1 (fr) Procede de purification de daunomycine

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

O035 Opposition [patent]: request for opposition
PO0301 Opposition

St.27 status event code: A-2-3-E10-E11-opp-PO0301

Opposition date: 19910128

Opposition reference: 101991000838

Opposition grounds text: 01

Opposition date: 19910128

Opposition reference: 101991000837

Opposition grounds text: 01

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
O073 Decision to grant registration after opposition [patent]: decision to grant registration
PO0701 Decision to grant registration after opposition

St.27 status event code: A-3-4-F10-F13-opp-PO0701

PO1301 Decision on opposition

St.27 status event code: A-3-3-W10-W00-opp-PO1301

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

FPAY Annual fee payment

Payment date: 20021029

Year of fee payment: 13

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 13

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20031130

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20031130