HK74887A - Purification of anthracycline glycosides - Google Patents

Purification of anthracycline glycosides Download PDF

Info

Publication number
HK74887A
HK74887A HK748/87A HK74887A HK74887A HK 74887 A HK74887 A HK 74887A HK 748/87 A HK748/87 A HK 748/87A HK 74887 A HK74887 A HK 74887A HK 74887 A HK74887 A HK 74887A
Authority
HK
Hong Kong
Prior art keywords
glycoside
purification
impure
anthracycline glycosides
water
Prior art date
Application number
HK748/87A
Other languages
English (en)
Inventor
Oppici Ernesto
Varosio Carlo
Giacoma Rosa Onorino
Original Assignee
Farmitalia Carlo Erba S.R.L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S.R.L filed Critical Farmitalia Carlo Erba S.R.L
Publication of HK74887A publication Critical patent/HK74887A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HK748/87A 1982-12-23 1987-10-15 Purification of anthracycline glycosides HK74887A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Publications (1)

Publication Number Publication Date
HK74887A true HK74887A (en) 1987-10-23

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
HK748/87A HK74887A (en) 1982-12-23 1987-10-15 Purification of anthracycline glycosides

Country Status (30)

Country Link
US (1) US4861870A (enExample)
JP (2) JPS59118797A (enExample)
KR (1) KR900008743B1 (enExample)
AT (1) AT383601B (enExample)
AU (1) AU570935B2 (enExample)
BE (1) BE898506A (enExample)
CA (1) CA1204738A (enExample)
CH (1) CH657623A5 (enExample)
CS (1) CS258114B2 (enExample)
DE (1) DE3345445C2 (enExample)
DK (1) DK594083A (enExample)
ES (1) ES8504758A1 (enExample)
FI (1) FI834650A7 (enExample)
FR (1) FR2538394B1 (enExample)
GB (1) GB2133005B (enExample)
GR (1) GR79135B (enExample)
HK (1) HK74887A (enExample)
HU (1) HU197917B (enExample)
IE (1) IE56678B1 (enExample)
IL (1) IL70500A (enExample)
IT (1) IT1155446B (enExample)
NL (1) NL193108C (enExample)
NO (1) NO834765L (enExample)
NZ (1) NZ206605A (enExample)
PT (1) PT77883B (enExample)
SE (1) SE8307134L (enExample)
SG (1) SG34587G (enExample)
SU (6) SU1440350A3 (enExample)
YU (1) YU247183A (enExample)
ZA (1) ZA839564B (enExample)

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US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
EP1020475B1 (en) * 1997-08-28 2003-01-15 Mercian Corporation Method of purifying daunomycin
JP3900243B2 (ja) 1997-12-05 2007-04-04 メルシャン株式会社 結晶質アントラサイクリン抗生物質およびその製造方法
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
ATE284893T1 (de) * 1998-10-16 2005-01-15 Mercian Corp Kristallisation von doxorubicin-hydrochlorid
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
EP1638509B1 (en) * 2003-07-02 2015-12-30 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
US20050059156A1 (en) * 2003-08-06 2005-03-17 Pharmacia Italia S.P.A. Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CA2748034A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Purified 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate prodrugs for the treatment of viral infections
EA019295B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
MX2011006891A (es) 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
PL2301943T3 (pl) 2009-09-08 2014-06-30 Heraeus Precious Metals Gmbh Krystalizacja epidaunorubicyny x HCI
SG184323A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasett Llc Stereoselective synthesis of phosphorus containing actives
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (en) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
CN108350015A (zh) * 2015-11-05 2018-07-31 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1003383A (enExample) *
US2827417A (en) * 1954-09-03 1958-03-18 Pfizer & Co C Ion exchange purification of basic antibiotics
US2960437A (en) * 1954-09-03 1960-11-15 Pfizer & Co C Ion exchange purification of basic antibiotics
US2793978A (en) * 1955-06-27 1957-05-28 Olin Mathieson Ion exchange purification of neomycin
US3221008A (en) * 1962-01-30 1965-11-30 Merck & Co Inc Ion exchange process for the recovery of ionic organic substances
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) * 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
FR1593235A (enExample) * 1968-11-18 1970-05-25
JPS4944347A (enExample) * 1972-09-01 1974-04-26
US3882195A (en) * 1973-05-16 1975-05-06 Air Prod & Chem Pre-emulsification-delayed initiation suspension pearl polymerization process
JPS5134915B2 (enExample) * 1974-07-27 1976-09-29
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
NL7602342A (nl) * 1975-03-13 1976-09-15 Rhone Poulenc Ind Naftaceenderivaat met antibiotische activiteit.
US4029548A (en) * 1976-05-07 1977-06-14 The Upjohn Company Process for producing antibiotics U-50,147 and U-51,738
IT1098212B (it) * 1978-05-09 1985-09-07 Farmaceutici Italia Antracioline antitumorali sostituite
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
AU570935B2 (en) 1988-03-31
NO834765L (no) 1984-06-25
FR2538394B1 (fr) 1986-03-28
DK594083D0 (da) 1983-12-22
DE3345445A1 (de) 1984-06-28
SU1440350A3 (ru) 1988-11-23
PT77883B (en) 1986-04-09
BE898506A (fr) 1984-04-16
IL70500A (en) 1990-07-12
SG34587G (en) 1988-03-04
GB2133005A (en) 1984-07-18
HUT35270A (en) 1985-06-28
CH657623A5 (it) 1986-09-15
SU1447287A3 (ru) 1988-12-23
AU2245583A (en) 1984-06-28
NL193108C (nl) 1998-11-03
SE8307134D0 (sv) 1983-12-22
SU1450747A3 (ru) 1989-01-07
IE56678B1 (en) 1991-11-06
FI834650L (fi) 1984-06-24
DK594083A (da) 1984-06-24
US4861870A (en) 1989-08-29
IT8224939A0 (it) 1982-12-23
CS258114B2 (en) 1988-07-15
ATA440083A (de) 1986-12-15
GB8333511D0 (en) 1984-01-25
ZA839564B (en) 1984-08-29
JPH0439476B2 (enExample) 1992-06-29
SE8307134L (sv) 1984-06-24
FI834650A7 (fi) 1984-06-24
FR2538394A1 (fr) 1984-06-29
NZ206605A (en) 1987-02-20
DE3345445C2 (de) 1995-09-21
AT383601B (de) 1987-07-27
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
FI834650A0 (fi) 1983-12-16
YU247183A (en) 1985-10-31
ES528226A0 (es) 1985-05-01
IE833060L (en) 1984-06-23
GB2133005B (en) 1986-04-30
CS980283A2 (en) 1987-12-17
HU197917B (en) 1989-06-28
IT1155446B (it) 1987-01-28
JPH07252291A (ja) 1995-10-03
ES8504758A1 (es) 1985-05-01
CA1204738A (en) 1986-05-20
JP2749272B2 (ja) 1998-05-13
SU1450748A3 (ru) 1989-01-07
NL193108B (nl) 1998-07-01
IL70500A0 (en) 1984-03-30
KR840007438A (ko) 1984-12-07
KR900008743B1 (ko) 1990-11-29
SU1470197A3 (ru) 1989-03-30
GR79135B (enExample) 1984-10-02
NL8304327A (nl) 1984-07-16
SU1575943A3 (ru) 1990-06-30

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