EP0400695A3 - A process for the preparation of tauroursodesoxycholic acid dihydrate - Google Patents

A process for the preparation of tauroursodesoxycholic acid dihydrate Download PDF

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Publication number
EP0400695A3
EP0400695A3 EP19900200513 EP90200513A EP0400695A3 EP 0400695 A3 EP0400695 A3 EP 0400695A3 EP 19900200513 EP19900200513 EP 19900200513 EP 90200513 A EP90200513 A EP 90200513A EP 0400695 A3 EP0400695 A3 EP 0400695A3
Authority
EP
European Patent Office
Prior art keywords
preparation
acid dihydrate
tauroursodesoxycholic
tauroursodesoxycholic acid
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19900200513
Other languages
German (de)
French (fr)
Other versions
EP0400695A2 (en
EP0400695B1 (en
Inventor
Massimo Parenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prodotti Chimici e Alimentari SpA
Original Assignee
Prodotti Chimici e Alimentari SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodotti Chimici e Alimentari SpA filed Critical Prodotti Chimici e Alimentari SpA
Publication of EP0400695A2 publication Critical patent/EP0400695A2/en
Publication of EP0400695A3 publication Critical patent/EP0400695A3/en
Application granted granted Critical
Publication of EP0400695B1 publication Critical patent/EP0400695B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

For the purification of tauroursodesoxycolic acid prepared through reaction between taurine and mixed anhydride of ursodesoxycolic acid with an alkylchloroformiate the raw reaction product is purified by means of ion exchange resins.
EP90200513A 1989-05-30 1990-03-05 A process for the preparation of tauroursodesoxycholic acid dihydrate Expired - Lifetime EP0400695B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2069889 1989-05-30
IT8920698A IT1230796B (en) 1989-05-30 1989-05-30 PROCEDURE FOR THE PREPARATION OF TAUROURSODESOXICOLIC BIIDRATE ACID.

Publications (3)

Publication Number Publication Date
EP0400695A2 EP0400695A2 (en) 1990-12-05
EP0400695A3 true EP0400695A3 (en) 1991-07-24
EP0400695B1 EP0400695B1 (en) 1995-07-12

Family

ID=11170729

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90200513A Expired - Lifetime EP0400695B1 (en) 1989-05-30 1990-03-05 A process for the preparation of tauroursodesoxycholic acid dihydrate

Country Status (5)

Country Link
EP (1) EP0400695B1 (en)
JP (1) JPH0317096A (en)
AT (1) ATE124954T1 (en)
DE (1) DE69020804D1 (en)
IT (1) IT1230796B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1247489B (en) * 1991-04-17 1994-12-17 Prodotti Chimici Alimentari METHYLTAUROUROXODESOXICOLIC ACID AND ITS THERAPEUTICALLY ACTIVE DERIVATIVES PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
IT1255485B (en) * 1992-08-04 1995-11-06 Erregierre Ind Chim PROCESS TO PREPARE GLYCINE CONJUGATED BILIARY ACIDS AND RELATED THERAPEUTIC COMPOSITIONS FOR THE TREATMENT OF HEPATIC INSUFFICIENCY
US5616741A (en) * 1992-08-04 1997-04-01 Erregierre Industria Chimica S.P.A. Process for the preparation of glycine-conjugated bile acids
IT1255486B (en) * 1992-08-04 1995-11-06 Erregierre Ind Chim PROCESS FOR PREPARING BILIARY ACIDS CONJUGATED WITH TAURINE
IT1270853B (en) * 1993-05-20 1997-05-13 Sanofi Elf PROCEDURE FOR THE PREPARATION OF TAUROCOLANIC DERIVATIVES
KR100396113B1 (en) * 1996-10-14 2003-12-24 동아제약 주식회사 Method for purifying tauroursodeoxycholic acid
IT201900005906A1 (en) 2019-04-16 2020-10-16 Dipharma Francis Srl PROCEDURE FOR THE PREPARATION OF CONJUGATES OF A CHOLANIC ACID

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119040A1 (en) * 1983-03-04 1984-09-19 Kabushiki Kaisha Yakult Honsha Producing conjugated ursodeoxycholic acids
BE901069A (en) * 1983-11-30 1985-03-15 Prodotti Chimici Alimentari PROCESS FOR THE SYNTHESIS OF URSODESOXYCHOLIC ACID CONJUGATED WITH TAURINE AND PRODUCT THUS OBTAINED.
EP0272462A1 (en) * 1986-11-26 1988-06-29 Jago Research AG Process for preparing ursodeoxycholic acid derivates and their inorganic and organic salts having therpeutic activity.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119040A1 (en) * 1983-03-04 1984-09-19 Kabushiki Kaisha Yakult Honsha Producing conjugated ursodeoxycholic acids
BE901069A (en) * 1983-11-30 1985-03-15 Prodotti Chimici Alimentari PROCESS FOR THE SYNTHESIS OF URSODESOXYCHOLIC ACID CONJUGATED WITH TAURINE AND PRODUCT THUS OBTAINED.
EP0272462A1 (en) * 1986-11-26 1988-06-29 Jago Research AG Process for preparing ursodeoxycholic acid derivates and their inorganic and organic salts having therpeutic activity.

Also Published As

Publication number Publication date
ATE124954T1 (en) 1995-07-15
IT8920698A0 (en) 1989-05-30
DE69020804D1 (en) 1995-08-17
JPH0317096A (en) 1991-01-25
EP0400695A2 (en) 1990-12-05
EP0400695B1 (en) 1995-07-12
IT1230796B (en) 1991-10-29

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