KR880003890A - 벤조산 유도체의 제조방법 - Google Patents

벤조산 유도체의 제조방법 Download PDF

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Publication number
KR880003890A
KR880003890A KR1019870010386A KR870010386A KR880003890A KR 880003890 A KR880003890 A KR 880003890A KR 1019870010386 A KR1019870010386 A KR 1019870010386A KR 870010386 A KR870010386 A KR 870010386A KR 880003890 A KR880003890 A KR 880003890A
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KR
South Korea
Prior art keywords
compound
formula
chlorine
fluorine
general formula
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KR1019870010386A
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English (en)
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KR950008083B1 (ko
Inventor
페터센 우베
패러센 우베
슈리버 미카엘
키젤라 에른스트
그로헤 클라우스
Original Assignee
바이엘 악티엔게젤샤프트
루디 마이어, 칼 루드비히슈미트
칼 루드비히슈미트
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Publication of KR880003890A publication Critical patent/KR880003890A/ko
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Publication of KR950008083B1 publication Critical patent/KR950008083B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/38—Acyl halides
    • C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

벤조산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(Ⅱ)의 화합물을 샌드마이어(Sandmeyer) 또는 발쯔-쉬만(Balz-Schiemann) 반응을 통해 하기 일반식(Ⅰa)의 화합물로 전환시키고, 필요에 따라서 이카르복실산을 하기 일반식(Ⅰb)의 염화 아실로 전환시키고, 기 X1또는 X2중 적어도 하나가 염소인 경우, 이것을 필요에 따라서 불소화 반응을 통해 하기 일반식(Ⅰc)의 화합물을 거쳐 하기 일반식(Ⅰd)의 화합물로 전환시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물의 제조방법.
    상기 식 중, X1및 X2는 서로 동일하거나 또는 상이한 것으로서 염소 또는 불소이고, Y는 염소, 브롬, 불소 또는 요오드이며, Z는 히드록실, 염소 또는 불소이다.
  2. 하기 일반식(Ⅲ)의 화합물을 하기 일반식(Ⅳ)의 2,4,5-트리플루오로-3-니트로-벤조일 플루오라이드로 전환시키고, 이것을 비누화시켜서 하기 일반식(Ⅴ)의 2,4,5-트리플루오로-3-니트로-벤조산을 생성하고, 이어서 니트로기를 환원시킨 후, 일반식(Ⅴ)를 샌드마이어 또는 발쯔-쉬만 반응을 통해 하기 일반식(Ⅰf)의 화합물로 전환시키고, 필요에 따라서 일반식(Ⅰf)의 이 카르복실산을 하기 일반식(Ⅰg)의 화합물로 전환시킴을 특징으로 하는 하기 일반식(Ⅰe)의 화합물의 제조방법
    상기 식 중, Y 및 Z는 제1항에서 정의한 바와 같으며, Z1는 불소 또는 염소일 수 있다
  3. 하기 일반식(Ⅱ)의 화합물
    상기 식 중, X1및 X2는 서로 동일하거나 또는 상이한 것으로서 염소 또는 불소이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870010386A 1986-09-19 1987-09-18 벤조산 유도체의 제조 방법 KR950008083B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19863631906 DE3631906A1 (de) 1986-09-19 1986-09-19 Verfahren zur herstellung von benzoesaeure-derivaten
DEP3631906.6 1986-09-19
DE3631906.6 1986-09-19

Publications (2)

Publication Number Publication Date
KR880003890A true KR880003890A (ko) 1988-06-01
KR950008083B1 KR950008083B1 (ko) 1995-07-25

Family

ID=6309936

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870010386A KR950008083B1 (ko) 1986-09-19 1987-09-18 벤조산 유도체의 제조 방법

Country Status (22)

Country Link
US (2) US4851160A (ko)
EP (1) EP0266512B1 (ko)
JP (2) JPS6388157A (ko)
KR (1) KR950008083B1 (ko)
CN (1) CN1024415C (ko)
AR (1) AR245438A1 (ko)
AT (1) ATE70045T1 (ko)
AU (1) AU600020B2 (ko)
CA (1) CA1325018C (ko)
DD (1) DD269146A5 (ko)
DE (2) DE3631906A1 (ko)
DK (2) DK168212B1 (ko)
ES (1) ES2044886T3 (ko)
FI (1) FI86843C (ko)
GR (1) GR3003383T3 (ko)
HU (1) HU197872B (ko)
IE (1) IE60032B1 (ko)
IL (1) IL83919A (ko)
NO (1) NO166785C (ko)
PH (2) PH25370A (ko)
PT (1) PT85743B (ko)
ZA (1) ZA877027B (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782180A (en) * 1985-09-09 1988-11-01 Warner-Lambert Company Process for tetrafluorobenzoic acid
US4791225A (en) * 1986-01-20 1988-12-13 Kyorin Pharmaceutical Co., Ltd. Halogenobenzoic acid derivatives and their preparation
JP2552319B2 (ja) * 1987-02-13 1996-11-13 株式会社日本触媒 ３−アミノ−２，４，５−トリフルオロ安息香酸
US4782179A (en) * 1987-02-13 1988-11-01 Nippon Shokubai Kagaku Kogyo Co., Ltd. 3-amino-2,4,5-trifluorobenzoic acid and a method for manufacture thereof
JPH02746A (ja) * 1987-12-29 1990-01-05 Nippon Carbide Ind Co Inc ３−アミノ−２，４，５−トリフルオロ安息香酸及びその製造方法
US4885386A (en) * 1988-10-28 1989-12-05 Warner-Lambert Company Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid
JPH02215744A (ja) * 1989-02-15 1990-08-28 Sds Biotech Kk 安息香酸誘導体およびその製造方法
US5237086A (en) * 1989-09-02 1993-08-17 Bayer Aktiengesellschaft Fungicidal derivatives of carbocyclic anilides
US4935541A (en) * 1989-11-20 1990-06-19 Occidental Chemical Corporation Preparation of 2,4,5-trifluorobenzoic acid by decarboxylation of 3,4,6-trifluorophthalic anhydride
US5233083A (en) * 1991-08-16 1993-08-03 Hoechst Aktiengesellschaft Process for the preparation of 2-amino-3-chlorobenzoic acid
DE4409578A1 (de) * 1994-03-21 1995-09-28 Bayer Ag Verfahren zur Herstellung von 2-Halogen-4,5-difluorbenzoylfluoriden
WO1998007682A1 (fr) * 1996-08-19 1998-02-26 Ube Industries, Ltd. Acides trifluorobenzoiques substitues, esters de ces acides et procede de production
DE19733243A1 (de) 1997-08-01 1999-02-04 Bayer Ag Verfahren zur Herstellung von 3-Cyano-2,4-dihalogen-5-fluor-benzoesäure
US6187931B1 (en) 1999-04-06 2001-02-13 Albemarle Corporation Process for making fluorophthalimides
US6677479B2 (en) * 2001-11-13 2004-01-13 Clariant Finance Lbvi Limited Substituted fluoroaromatics, process for preparing them and their use
CN1328238C (zh) * 2004-09-06 2007-07-25 大连绿源药业有限责任公司 2，4，5－三氟苯甲酸的制备方法
CN103102262A (zh) * 2013-01-18 2013-05-15 浙江华基生物技术有限公司 2,3,4,5,6-五氟苯甲酸的合成方法
CN103980113B (zh) * 2014-06-04 2016-05-25 国药集团化学试剂有限公司 一种4-溴代邻苯二甲酸的制备方法
CN105777548A (zh) * 2016-03-31 2016-07-20 常州大学 一种2，4，6-三氯-3-硝基苯甲酸的合成方法
CN106748721B (zh) * 2016-11-17 2019-06-21 山东铂源药业有限公司 一种2-氯-5-碘苯甲酸的制备方法
CN113912487B (zh) * 2021-11-23 2024-05-28 山东研峰新材料科技有限公司 一种2,5-双卤代苯甲酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB991537A (en) * 1963-02-18 1965-05-12 Bayer Ag Plant growth influencing compositions containing chlorobenzoic acid derivatives
CA1157884A (en) * 1980-04-16 1983-11-29 Byron R. Cotter Process for the preparation of trifluoromethylbenzoyl halides
DE3142856A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid
DE3409244A1 (de) * 1984-03-14 1985-09-19 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von halogenanthranilsaeuren
DE3420796A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 2,4,5-trihalogen- bzw. 2,3,4,5-tetrahalogenbenzolderivate und verfahren zu ihrer herstellung
AU576272B2 (en) * 1984-11-13 1988-08-18 Kyorin Pharmaceutical Co. Ltd. Quinolone carboxylic acid derivates
IT1201443B (it) * 1985-07-31 1989-02-02 Zambon Spa Intermedi per la sintesi di acidi carbossilici
US4791225A (en) * 1986-01-20 1988-12-13 Kyorin Pharmaceutical Co., Ltd. Halogenobenzoic acid derivatives and their preparation
JP2637399B2 (ja) * 1986-04-03 1997-08-06 キヤノン株式会社 消去装置
JP2552319B2 (ja) * 1987-02-13 1996-11-13 株式会社日本触媒 ３−アミノ−２，４，５−トリフルオロ安息香酸
US4885386A (en) * 1988-10-28 1989-12-05 Warner-Lambert Company Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid

Also Published As

Publication number Publication date
DK168212B1 (da) 1994-02-28
AU7829087A (en) 1988-03-24
EP0266512A2 (de) 1988-05-11
DK86193A (da) 1993-07-21
IE60032B1 (en) 1994-05-18
AU600020B2 (en) 1990-08-02
DK490287A (da) 1988-03-20
NO166785C (no) 1991-09-04
PT85743A (en) 1987-10-01
DD269146A5 (de) 1989-06-21
IE872533L (en) 1988-03-19
JPS6388157A (ja) 1988-04-19
JPH0694446B2 (ja) 1994-11-24
US4851160A (en) 1989-07-25
AR245438A1 (es) 1994-01-31
ES2044886T3 (es) 1994-01-16
HUT45001A (en) 1988-05-30
HU197872B (en) 1989-06-28
US4990661A (en) 1991-02-05
NO166785B (no) 1991-05-27
IL83919A0 (en) 1988-02-29
CN1024415C (zh) 1994-05-04
DK490287D0 (da) 1987-09-18
DK86193D0 (da) 1993-07-21
PH26462A (en) 1992-07-27
JPH0576934B2 (ko) 1993-10-25
DE3775003D1 (de) 1992-01-16
JPH0625125A (ja) 1994-02-01
NO873689L (no) 1988-03-21
IL83919A (en) 1991-06-30
FI874063A0 (fi) 1987-09-17
DK170253B1 (da) 1995-07-17
GR3003383T3 (en) 1993-02-17
CN87106482A (zh) 1988-03-30
PH25370A (en) 1991-05-13
CA1325018C (en) 1993-12-07
ZA877027B (en) 1988-03-23
DE3631906A1 (de) 1988-03-31
PT85743B (pt) 1990-06-29
FI874063A (fi) 1988-03-20
EP0266512B1 (de) 1991-12-04
EP0266512A3 (en) 1989-05-03
KR950008083B1 (ko) 1995-07-25
NO873689D0 (no) 1987-09-03
FI86843B (fi) 1992-07-15
FI86843C (fi) 1992-10-26
ATE70045T1 (de) 1991-12-15

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