KR830002769A - 6-β-치환된 페니실란산 유도체의 제조방법 - Google Patents
6-β-치환된 페니실란산 유도체의 제조방법Info
- Publication number
- KR830002769A KR830002769A KR1019800001920A KR800001920A KR830002769A KR 830002769 A KR830002769 A KR 830002769A KR 1019800001920 A KR1019800001920 A KR 1019800001920A KR 800001920 A KR800001920 A KR 800001920A KR 830002769 A KR830002769 A KR 830002769A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- structural formula
- hydrogen
- formula
- protecting group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
- C07D499/32—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/10—Modification of an amino radical directly attached in position 6
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 다음 구조식(Ⅱ)의 6-α-하이드록시페니실란산 또는 에스테르를 퍼할로알킬 설포닐할라이드 또는 무수물과 반응시킨 후, 필요한 경우 카복시 보호그룹을 제거하여 R이 수소인 다음 구조식(Ⅰ) 화합물을 수득하고 임의로는 R이 수소인 구조식(Ⅰ) 화합물을 통상의 페니실린 카복시-보호그룹으로 보호시켜 구조식(Ⅰ) 화합물을 얻은후 이 구조식(Ⅰ)의 6-α-치환된 화합물을 금속 브로마이드, 요오다이드 또는 아지드와 반응시키고, R이 카복시보호그룹인 경우에는 보호그룹을 제고한 후 구조식(Ⅲ) 화합물을 분리시킴을 특징으로 하여 구조식(Ⅲ)의 6-β-치환된 페니실란산 유도체를 제조하는 방법.
-
- 상기 구조식에서
- X는 브롬, 염소, 요오드 또는 아지드이고,
- R2는 수소 또는 생체내에서 쉽게 가수분해될 수 있는 에스테르 형성잔기이고,
- R은 수소이거나 통상의 페니실린 카복시 보호그룹 또는 생체내에서 쉽게 가수분해될 수 있는 에스테르형성 잔기이고,
- R1은 탄소수 1 내지 4의 퍼할로알킬그룹이고, 여기서 할로겐원자는 불소 또는 염소이다.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7917505 | 1979-05-19 | ||
GB7917505 | 1979-05-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830002769A true KR830002769A (ko) | 1983-05-30 |
KR840000079B1 KR840000079B1 (ko) | 1984-02-08 |
Family
ID=10505288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800001920A KR840000079B1 (ko) | 1979-05-19 | 1980-05-15 | 6-β-치환된 페니실란산 유도체의 제조방법 |
Country Status (28)
Country | Link |
---|---|
US (1) | US4356122A (ko) |
JP (1) | JPS5941994B2 (ko) |
KR (1) | KR840000079B1 (ko) |
AR (1) | AR225038A1 (ko) |
AT (1) | AT366694B (ko) |
AU (1) | AU517488B2 (ko) |
BE (1) | BE883319A (ko) |
CA (1) | CA1140916A (ko) |
CH (1) | CH650262A5 (ko) |
CS (1) | CS214756B2 (ko) |
DD (1) | DD151310A5 (ko) |
DE (1) | DE3018847C2 (ko) |
DK (1) | DK155180A (ko) |
ES (1) | ES491612A0 (ko) |
FI (1) | FI71562C (ko) |
FR (1) | FR2457293A1 (ko) |
GR (1) | GR68461B (ko) |
IE (1) | IE49804B1 (ko) |
IL (1) | IL60097A (ko) |
IT (1) | IT1140946B (ko) |
LU (1) | LU82458A1 (ko) |
NL (1) | NL180937C (ko) |
NO (1) | NO801473L (ko) |
PH (1) | PH15033A (ko) |
PL (1) | PL224188A1 (ko) |
PT (1) | PT71253A (ko) |
SE (1) | SE449995B (ko) |
ZA (1) | ZA802908B (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA803742B (en) * | 1979-07-02 | 1981-06-24 | Beecham Group Ltd | Penicillanic acid derivatives, their preparation and use |
JPS6034969A (ja) * | 1983-08-08 | 1985-02-22 | Toyama Chem Co Ltd | 新規なペニシラン酸誘導体およびその塩類 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5749555B2 (ko) * | 1973-04-04 | 1982-10-22 | ||
US4282149A (en) * | 1977-03-21 | 1981-08-04 | Massachusetts Institute Of Technology | Carbon and oxygen analogs of penicillin |
US4265882A (en) * | 1977-10-03 | 1981-05-05 | Massachusetts Institute Of Technology | Sulphur analogs of penicillins having a nucleophile substituted in the 6 and 7 position, respectively |
-
1980
- 1980-04-10 DK DK155180A patent/DK155180A/da not_active IP Right Cessation
- 1980-05-13 PL PL22418880A patent/PL224188A1/xx unknown
- 1980-05-14 CS CS803351A patent/CS214756B2/cs unknown
- 1980-05-14 BE BE0/200635A patent/BE883319A/fr unknown
- 1980-05-14 AT AT0259780A patent/AT366694B/de not_active IP Right Cessation
- 1980-05-15 GR GR61960A patent/GR68461B/el unknown
- 1980-05-15 KR KR1019800001920A patent/KR840000079B1/ko active
- 1980-05-15 CA CA000352042A patent/CA1140916A/en not_active Expired
- 1980-05-15 FI FI801581A patent/FI71562C/fi not_active IP Right Cessation
- 1980-05-16 AU AU58468/80A patent/AU517488B2/en not_active Ceased
- 1980-05-16 IT IT22104/80A patent/IT1140946B/it active
- 1980-05-16 DD DD80221165A patent/DD151310A5/de unknown
- 1980-05-16 CH CH3844/80A patent/CH650262A5/de not_active IP Right Cessation
- 1980-05-16 AR AR281078A patent/AR225038A1/es active
- 1980-05-16 IL IL60097A patent/IL60097A/xx unknown
- 1980-05-16 NO NO801473A patent/NO801473L/no unknown
- 1980-05-16 FR FR8011063A patent/FR2457293A1/fr active Granted
- 1980-05-16 NL NLAANVRAGE8002843,A patent/NL180937C/xx not_active IP Right Cessation
- 1980-05-16 PT PT71253A patent/PT71253A/pt unknown
- 1980-05-16 DE DE3018847A patent/DE3018847C2/de not_active Expired
- 1980-05-16 ZA ZA00802908A patent/ZA802908B/xx unknown
- 1980-05-16 PH PH24036A patent/PH15033A/en unknown
- 1980-05-16 IE IE1024/80A patent/IE49804B1/en unknown
- 1980-05-16 SE SE8003676A patent/SE449995B/sv not_active IP Right Cessation
- 1980-05-17 JP JP55065859A patent/JPS5941994B2/ja not_active Expired
- 1980-05-19 LU LU82458A patent/LU82458A1/fr unknown
- 1980-05-19 ES ES491612A patent/ES491612A0/es active Granted
- 1980-12-10 US US06/214,846 patent/US4356122A/en not_active Expired - Lifetime
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