ES8105737A1 - Un procedimiento para la preparacion de un derivado de un acido penicilanico 6b-sustituido - Google Patents

Un procedimiento para la preparacion de un derivado de un acido penicilanico 6b-sustituido

Info

Publication number
ES8105737A1
ES8105737A1 ES491612A ES491612A ES8105737A1 ES 8105737 A1 ES8105737 A1 ES 8105737A1 ES 491612 A ES491612 A ES 491612A ES 491612 A ES491612 A ES 491612A ES 8105737 A1 ES8105737 A1 ES 8105737A1
Authority
ES
Spain
Prior art keywords
beta
alpha
derivatives
perhaloalkylsulfonyloxy
penicillanic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491612A
Other languages
English (en)
Other versions
ES491612A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES8105737A1 publication Critical patent/ES8105737A1/es
Publication of ES491612A0 publication Critical patent/ES491612A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/10—Modification of an amino radical directly attached in position 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ACIDO PENICILANICO 6BETA-SUSTITUIDOS, DE FORMULA (I), DONDE X ES BROMO, CLORO, YODO O AZIDA Y R AL CUADRADO ES HIDROGENO O UN RESTO FORMADO DE UN ESTER FACILMENTE HIDROLIZABLE. CONSISTE EN HACER REACCIONAR UN COMPUESTO 6ALFA-SUSTITUIDO DE FORMULA (II), DONDE R ES R AL CUADRADO O UN GRUPO PROTECTOR DEL CARBOXI PENICILINICO, CON UN BROMURO, CLORURO, YODURO O AZIDA METALICOS. LA REACCION TIENE LUGAR CON EL COMPUESTO DE FORMULA (II) DISUELTO EN UN DISOLVENTE ORGANCIO INERTE, AÑADIENDO EL HALURO O AZIDA METALICO EN EXCESO Y AGITANDO LA MEZCLA A TEMPERATURA AMBIENTE. POSTERIORMENTE SE EXTRAE EL COMPUESTO POR EVAPORACION DEL DISOLVENTE. CUANDO R ES UN GRUPO PROTECTOR HAY QUE SEPARARLO Y AISLAR EL COMPUESTO (I). LOS DERIVADOS ASI OBTENIDOS TIENEN APLICACION PARA LA PREPARACION DE ANTIBIOTICOS. *FORMULA*
ES491612A 1979-05-19 1980-05-19 Un procedimiento para la preparacion de un derivado de un acido penicilanico 6b-sustituido Granted ES491612A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7917505 1979-05-19

Publications (2)

Publication Number Publication Date
ES8105737A1 true ES8105737A1 (es) 1981-05-16
ES491612A0 ES491612A0 (es) 1981-05-16

Family

ID=10505288

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491612A Granted ES491612A0 (es) 1979-05-19 1980-05-19 Un procedimiento para la preparacion de un derivado de un acido penicilanico 6b-sustituido

Country Status (28)

Country Link
US (1) US4356122A (es)
JP (1) JPS5941994B2 (es)
KR (1) KR840000079B1 (es)
AR (1) AR225038A1 (es)
AT (1) AT366694B (es)
AU (1) AU517488B2 (es)
BE (1) BE883319A (es)
CA (1) CA1140916A (es)
CH (1) CH650262A5 (es)
CS (1) CS214756B2 (es)
DD (1) DD151310A5 (es)
DE (1) DE3018847C2 (es)
DK (1) DK155180A (es)
ES (1) ES491612A0 (es)
FI (1) FI71562C (es)
FR (1) FR2457293A1 (es)
GR (1) GR68461B (es)
IE (1) IE49804B1 (es)
IL (1) IL60097A (es)
IT (1) IT1140946B (es)
LU (1) LU82458A1 (es)
NL (1) NL180937C (es)
NO (1) NO801473L (es)
PH (1) PH15033A (es)
PL (1) PL224188A1 (es)
PT (1) PT71253A (es)
SE (1) SE449995B (es)
ZA (1) ZA802908B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA803742B (en) * 1979-07-02 1981-06-24 Beecham Group Ltd Penicillanic acid derivatives, their preparation and use
JPS6034969A (ja) * 1983-08-08 1985-02-22 Toyama Chem Co Ltd 新規なペニシラン酸誘導体およびその塩類

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5749555B2 (es) * 1973-04-04 1982-10-22
US4282149A (en) * 1977-03-21 1981-08-04 Massachusetts Institute Of Technology Carbon and oxygen analogs of penicillin
US4265882A (en) * 1977-10-03 1981-05-05 Massachusetts Institute Of Technology Sulphur analogs of penicillins having a nucleophile substituted in the 6 and 7 position, respectively

Also Published As

Publication number Publication date
AT366694B (de) 1982-04-26
CH650262A5 (de) 1985-07-15
ATA259780A (de) 1981-09-15
AR225038A1 (es) 1982-02-15
FR2457293B1 (es) 1983-05-20
IE49804B1 (en) 1985-12-25
ZA802908B (en) 1981-05-27
US4356122A (en) 1982-10-26
CS214756B2 (en) 1982-05-28
NL180937B (nl) 1986-12-16
DE3018847C2 (de) 1982-09-30
JPS5941994B2 (ja) 1984-10-11
FI71562B (fi) 1986-10-10
GR68461B (es) 1981-12-30
NL180937C (nl) 1987-05-18
PL224188A1 (es) 1981-02-13
IL60097A0 (en) 1980-07-31
AU5846880A (en) 1980-11-27
CA1140916A (en) 1983-02-08
NO801473L (no) 1980-11-20
IL60097A (en) 1983-02-23
FI71562C (fi) 1987-01-19
SE449995B (sv) 1987-06-01
NL8002843A (nl) 1980-11-21
SE8003676L (sv) 1980-11-20
PT71253A (en) 1980-06-01
KR830002769A (ko) 1983-05-30
FR2457293A1 (fr) 1980-12-19
DK155180A (da) 1980-11-20
KR840000079B1 (ko) 1984-02-08
DD151310A5 (de) 1981-10-14
IT1140946B (it) 1986-10-10
ES491612A0 (es) 1981-05-16
PH15033A (en) 1982-05-20
BE883319A (fr) 1980-11-14
DE3018847A1 (de) 1980-12-11
IT8022104A0 (it) 1980-05-16
IE801024L (en) 1980-11-19
JPS55157588A (en) 1980-12-08
AU517488B2 (en) 1981-08-06
FI801581A (fi) 1980-11-20
LU82458A1 (fr) 1980-10-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202