FR2457293A1 - Nouveaux derives d'acide penicillanique substitues en 6-a et 6-b et leur procede de production - Google Patents

Nouveaux derives d'acide penicillanique substitues en 6-a et 6-b et leur procede de production

Info

Publication number
FR2457293A1
FR2457293A1 FR8011063A FR8011063A FR2457293A1 FR 2457293 A1 FR2457293 A1 FR 2457293A1 FR 8011063 A FR8011063 A FR 8011063A FR 8011063 A FR8011063 A FR 8011063A FR 2457293 A1 FR2457293 A1 FR 2457293A1
Authority
FR
France
Prior art keywords
penicillanic acid
novel
compounds
production method
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8011063A
Other languages
English (en)
Other versions
FR2457293B1 (fr
Inventor
John Edward Glyn Kemp
Edward Glyn Kemp John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Pfizer Inc
Original Assignee
Pfizer Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp, Pfizer Inc filed Critical Pfizer Corp
Publication of FR2457293A1 publication Critical patent/FR2457293A1/fr
Application granted granted Critical
Publication of FR2457293B1 publication Critical patent/FR2457293B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/10—Modification of an amino radical directly attached in position 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX DERIVES D'ACIDE PENICILLANIQUE SUBSTITUES EN 6-A ET 6-B ET LEUR PROCEDE DE PRODUCTION. LES COMPOSES DE L'INVENTION, DE FORMULE: (CF DESSIN DANS BOPI) (DANS LAQUELLE R REPRESENTE H OU UN GROUPE CLASSIQUE PROTEGEANT LA FONCTION CARBOXY D'UNE PENICILLINE OU UN RESIDU FORMANT UN ESTER, AISEMENT HYDROLYSABLE IN VIVO ET R EST UN GROUPE PERHALOGENALKYLE EN C-1 A C-4 DONT LES ATOMES D'HALOGENE SONT LES ATOMES DE F OU DE CL) SUBISSENT UN DEPLACEMENT NUCLEOPHILE DE TYPE SN AVEC INVERSION DE LA CONFIGURATION EN C-6 EN DONNANT LE PRODUIT A SUBSTITUTION 6-B OU 6-A CORRESPONDANT. LES COMPOSES DE L'INVENTION SONT PAR CONSEQUENT DES COMPOSES INTERMEDIAIRES INTERESSANTS A UTILISER NOTAMMENT POUR LA PREPARATION DE DERIVES 6-A-HALOGENES DE L'ACIDE PENICILLANIQUE.
FR8011063A 1979-05-19 1980-05-16 Nouveaux derives d'acide penicillanique substitues en 6-a et 6-b et leur procede de production Granted FR2457293A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7917505 1979-05-19

Publications (2)

Publication Number Publication Date
FR2457293A1 true FR2457293A1 (fr) 1980-12-19
FR2457293B1 FR2457293B1 (fr) 1983-05-20

Family

ID=10505288

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8011063A Granted FR2457293A1 (fr) 1979-05-19 1980-05-16 Nouveaux derives d'acide penicillanique substitues en 6-a et 6-b et leur procede de production

Country Status (28)

Country Link
US (1) US4356122A (fr)
JP (1) JPS5941994B2 (fr)
KR (1) KR840000079B1 (fr)
AR (1) AR225038A1 (fr)
AT (1) AT366694B (fr)
AU (1) AU517488B2 (fr)
BE (1) BE883319A (fr)
CA (1) CA1140916A (fr)
CH (1) CH650262A5 (fr)
CS (1) CS214756B2 (fr)
DD (1) DD151310A5 (fr)
DE (1) DE3018847C2 (fr)
DK (1) DK155180A (fr)
ES (1) ES491612A0 (fr)
FI (1) FI71562C (fr)
FR (1) FR2457293A1 (fr)
GR (1) GR68461B (fr)
IE (1) IE49804B1 (fr)
IL (1) IL60097A (fr)
IT (1) IT1140946B (fr)
LU (1) LU82458A1 (fr)
NL (1) NL180937C (fr)
NO (1) NO801473L (fr)
PH (1) PH15033A (fr)
PL (1) PL224188A1 (fr)
PT (1) PT71253A (fr)
SE (1) SE449995B (fr)
ZA (1) ZA802908B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA803742B (en) * 1979-07-02 1981-06-24 Beecham Group Ltd Penicillanic acid derivatives, their preparation and use
JPS6034969A (ja) * 1983-08-08 1985-02-22 Toyama Chem Co Ltd 新規なペニシラン酸誘導体およびその塩類

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2224131A1 (fr) * 1973-04-04 1974-10-31 Massachusetts Inst Technol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282149A (en) * 1977-03-21 1981-08-04 Massachusetts Institute Of Technology Carbon and oxygen analogs of penicillin
US4265882A (en) * 1977-10-03 1981-05-05 Massachusetts Institute Of Technology Sulphur analogs of penicillins having a nucleophile substituted in the 6 and 7 position, respectively

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2224131A1 (fr) * 1973-04-04 1974-10-31 Massachusetts Inst Technol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/62 *

Also Published As

Publication number Publication date
ES8105737A1 (es) 1981-05-16
AT366694B (de) 1982-04-26
CH650262A5 (de) 1985-07-15
ATA259780A (de) 1981-09-15
AR225038A1 (es) 1982-02-15
FR2457293B1 (fr) 1983-05-20
IE49804B1 (en) 1985-12-25
ZA802908B (en) 1981-05-27
US4356122A (en) 1982-10-26
CS214756B2 (en) 1982-05-28
NL180937B (nl) 1986-12-16
DE3018847C2 (de) 1982-09-30
JPS5941994B2 (ja) 1984-10-11
FI71562B (fi) 1986-10-10
GR68461B (fr) 1981-12-30
NL180937C (nl) 1987-05-18
PL224188A1 (fr) 1981-02-13
IL60097A0 (en) 1980-07-31
AU5846880A (en) 1980-11-27
CA1140916A (fr) 1983-02-08
NO801473L (no) 1980-11-20
IL60097A (en) 1983-02-23
FI71562C (fi) 1987-01-19
SE449995B (sv) 1987-06-01
NL8002843A (nl) 1980-11-21
SE8003676L (sv) 1980-11-20
PT71253A (en) 1980-06-01
KR830002769A (ko) 1983-05-30
DK155180A (da) 1980-11-20
KR840000079B1 (ko) 1984-02-08
DD151310A5 (de) 1981-10-14
IT1140946B (it) 1986-10-10
ES491612A0 (es) 1981-05-16
PH15033A (en) 1982-05-20
BE883319A (fr) 1980-11-14
DE3018847A1 (de) 1980-12-11
IT8022104A0 (it) 1980-05-16
IE801024L (en) 1980-11-19
JPS55157588A (en) 1980-12-08
AU517488B2 (en) 1981-08-06
FI801581A (fi) 1980-11-20
LU82458A1 (fr) 1980-10-08

Similar Documents

Publication Publication Date Title
FR2405946A1 (fr) Nouveaux derives de l'acide 3-methyl-crotonique et procede pour leur preparation
FR2384765A1 (fr) Derives amino-substitues du furanne et procede pour leur preparation
FR2438035A1 (fr) Procede et intermediaires pour la preparation de derives 1a-hydroxyles de vitamines du groupe d
FR2456745A1 (fr) Bis-esters de methanediol avec des penicillines et le 1,1-dioxyde d'acide penicillanique, leur procede de production et composition pharmaceutique les contenant
FR2357541A1 (fr) Composes polyeniques et leur procede de preparation
FR2397403A1 (fr) Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes
FR2375187A1 (fr) Cyclopentane-1-amines, procede pour leur preparation et produits contenant ces composes
FR2411839A1 (fr) Derives de l'acide cephalosporanique, procedes pour leur preparation et composition pharmaceutique les contenant
FR2443467A1 (fr) Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2405258A1 (fr) Procede de preparation et de purification du facteur citrovorum par ouverture de noyau d'imidazoline et nouveau produit ainsi obtenu
FR2401144A1 (fr) Derives de benzimidazole contenant du soufre, procede pour leur preparation et intermediaires utiles pour leur production
FR2362845A1 (fr) Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2457293A1 (fr) Nouveaux derives d'acide penicillanique substitues en 6-a et 6-b et leur procede de production
FR2418789A1 (fr) Nouveaux sels de guanidine, procede permettant leur production et preparations microbicides les contenant
FR2355849A1 (fr) Derives de l'acide 7 b-acylamidoceph-3-eme 4-carboxyliques, leur procede de preparation et application therapeutique
FR2383931A1 (fr) Derives d'oxadiazolopyrimidine
FR2400020A1 (fr) Procede pour la preparation de furannones
FR2356657A1 (fr) Nouveaux derives phospholipidiques de prostaglandines et leur procede de preparation
FR2396021A1 (fr) 3-((s)-1'-phenylethylamino)propylaminobleomycine, son procede de preparation et son application en therapeutique
FR2367079A1 (fr) Procede de preparation de nouveaux composes steroidiques ayant une fonction oxygene en position 19
FR2439785A1 (fr) Nouveau procede de preparation des produits derives de l'acide 7-amino-thiazolyl acetamido cephalosporanique
FR2385708A1 (fr) Nouveaux derives de l'alcool alpha-(6-carboxyhexyl)-furfurylique et leur procede d'obtention
FR2429211A1 (fr) Procede de production de derives de n-methylbenzothiazolone substitues en position 4
FR2385687A1 (fr) Nouveaux derives de l'aniline utiles comme agents microbicides
FR2416214A1 (fr) Derives d'acide naphtyl-1 acetique, leur procede de preparation et leur application therapeutique

Legal Events

Date Code Title Description
ST Notification of lapse