GB1322149A - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- GB1322149A GB1322149A GB1135172A GB1135172A GB1322149A GB 1322149 A GB1322149 A GB 1322149A GB 1135172 A GB1135172 A GB 1135172A GB 1135172 A GB1135172 A GB 1135172A GB 1322149 A GB1322149 A GB 1322149A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- salts
- methyl
- benzyl
- penicilloyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1322149 Penicillin compositions F HOFFMANN-LA ROCHE & CO AG 10 March 1972 [11 March 1971] 11351/72 Heading A5B [Also in Division C2] Pharmaceutical compositions for penicillin treatment where a penicillin allergy exists or is suspected and for the prophylactic treatment of penicillin allergies contain a therapeutically active penicillin and a penicilloyl acid derivative of the formula: wherein X represents a hydrogen atom or a group of the formula R'-NH- in which R' represents a hydrogen atom or a C 1-7 acyl group, n represents a whole number from 1-4 and R represents 2-pentenyl, n-pentyl, nheptyl, allylthiomethyl, 5-amino-5-carboxypentyl, benzyl, carboxybenzyl, α-aminobenzyl, phenoxybenzyl, phenoxymethyl, α-phenoxyethyl, α-phenoxypropyl, 2, 6-dimethoxyphenyl, 2-ethoxy-1-naphthyl, 3-carboxy-2-quinoxalinyl, 5-methyl-3-phenyl - 4 - isoxazolyl, 3 - (2-chlorophenyl)-5-methyl-4-isoxazolyl, 3-(2, 6-dichlorophenyl)-5-methyl-4-isoxazolyl or 2-furoyloxyisobutyl or a pharmaceutically acceptable salt thereof. Preferably the therapeutically active penicillin is benzyl penicillin, α-phenoxyethylpenicillin, sodium 2, 6-dimethoxyphenylpenicillin monohydrate, sodium 3-(2-chlorophenyl)-5- methyl-4-isoxozolylpenicillin monohydrate or α-aminobenzylpenicillin or salts or hydrates thereof. Salts referred to include organic ammonium salts such as the procaine, bis benzylammonium or bisdicyclohexylammonium salts and mineral salts such as the sodium, potassium or calcium salts. R in the penicilloyl acid derivative is preferably the same as in the therapeutically active penicillin and a preferred composition comprises benzyl penicillin and N<SP>6</SP>-(benzyl-α-penicilloyl)aminocaproic acid. The compositions may be administered enterally or parenterally in the form of tablets, dragÚes, suppositories, capsules, salves, solutions, suspensions or emulsions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH355871 | 1971-03-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1322149A true GB1322149A (en) | 1973-07-04 |
Family
ID=4258572
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1135272A Expired GB1333524A (en) | 1971-03-11 | 1972-03-10 | Penicilloic acid derivatives |
GB1135172A Expired GB1322149A (en) | 1971-03-11 | 1972-03-10 | Pharmaceutical compositions |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1135272A Expired GB1333524A (en) | 1971-03-11 | 1972-03-10 | Penicilloic acid derivatives |
Country Status (21)
Country | Link |
---|---|
AT (2) | AT312802B (en) |
AU (1) | AU461136B2 (en) |
BE (2) | BE780471A (en) |
CA (1) | CA972759A (en) |
CH (1) | CH546783A (en) |
DE (2) | DE2211419A1 (en) |
DK (1) | DK136977B (en) |
ES (2) | ES400623A1 (en) |
FI (1) | FI52345C (en) |
FR (2) | FR2128823B1 (en) |
GB (2) | GB1333524A (en) |
HK (1) | HK14676A (en) |
HU (2) | HU165203B (en) |
IE (2) | IE36203B1 (en) |
IL (2) | IL38864A (en) |
NL (2) | NL7202771A (en) |
NO (1) | NO138142C (en) |
PH (2) | PH12264A (en) |
SE (3) | SE406198B (en) |
YU (1) | YU35011B (en) |
ZA (2) | ZA721364B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4316882A (en) * | 1978-04-20 | 1982-02-23 | Levine Bernard B | Compositions for testing to predict and/or diagnose allergy to penicillins |
CA1209477A (en) * | 1981-03-26 | 1986-08-12 | Bruce E. Haeger | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
-
1971
- 1971-03-11 CH CH355871A patent/CH546783A/en not_active IP Right Cessation
-
1972
- 1972-03-01 IL IL38864A patent/IL38864A/en unknown
- 1972-03-01 ZA ZA721364A patent/ZA721364B/en unknown
- 1972-03-01 IL IL38865A patent/IL38865A/en unknown
- 1972-03-01 ZA ZA721363A patent/ZA721363B/en unknown
- 1972-03-02 AU AU39571/72A patent/AU461136B2/en not_active Expired
- 1972-03-02 NL NL7202771A patent/NL7202771A/xx not_active Application Discontinuation
- 1972-03-02 PH PH13316A patent/PH12264A/en unknown
- 1972-03-02 NL NL7202772A patent/NL7202772A/xx unknown
- 1972-03-03 PH PH13315*UA patent/PH9295A/en unknown
- 1972-03-06 CA CA136,277A patent/CA972759A/en not_active Expired
- 1972-03-07 IE IE281/72A patent/IE36203B1/en unknown
- 1972-03-07 AT AT188772A patent/AT312802B/en not_active IP Right Cessation
- 1972-03-07 AT AT188672A patent/AT331389B/en not_active IP Right Cessation
- 1972-03-07 IE IE282/72A patent/IE36204B1/en unknown
- 1972-03-08 FI FI720618A patent/FI52345C/en active
- 1972-03-09 DE DE19722211419 patent/DE2211419A1/en active Pending
- 1972-03-09 DE DE19722211420 patent/DE2211420A1/en active Pending
- 1972-03-10 HU HUHO1460A patent/HU165203B/hu unknown
- 1972-03-10 FR FR7208434A patent/FR2128823B1/fr not_active Expired
- 1972-03-10 ES ES400623A patent/ES400623A1/en not_active Expired
- 1972-03-10 GB GB1135272A patent/GB1333524A/en not_active Expired
- 1972-03-10 DK DK112072AA patent/DK136977B/en unknown
- 1972-03-10 GB GB1135172A patent/GB1322149A/en not_active Expired
- 1972-03-10 FR FR7208435A patent/FR2128824B1/fr not_active Expired
- 1972-03-10 BE BE780471A patent/BE780471A/en unknown
- 1972-03-10 YU YU625/72A patent/YU35011B/en unknown
- 1972-03-10 HU HUHO1459A patent/HU166712B/hu unknown
- 1972-03-10 ES ES400624A patent/ES400624A1/en not_active Expired
- 1972-03-10 BE BE780472A patent/BE780472A/en unknown
- 1972-03-10 NO NO790/72A patent/NO138142C/en unknown
- 1972-03-10 SE SE7203125A patent/SE406198B/en unknown
-
1975
- 1975-12-08 SE SE7513807A patent/SE7513807L/en unknown
- 1975-12-11 SE SE7514031A patent/SE7514031L/en unknown
-
1976
- 1976-03-18 HK HK146/76*UA patent/HK14676A/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |