ES8206534A1 - Un procedimiento para la preparacion de derivados acilicos de cefalosporina - Google Patents

Un procedimiento para la preparacion de derivados acilicos de cefalosporina

Info

Publication number
ES8206534A1
ES8206534A1 ES506022A ES506022A ES8206534A1 ES 8206534 A1 ES8206534 A1 ES 8206534A1 ES 506022 A ES506022 A ES 506022A ES 506022 A ES506022 A ES 506022A ES 8206534 A1 ES8206534 A1 ES 8206534A1
Authority
ES
Spain
Prior art keywords
preparation
intermediates
pharmaceutical compositions
compositions containing
cephalosporin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506022A
Other languages
English (en)
Other versions
ES506022A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES506022A0 publication Critical patent/ES506022A0/es
Publication of ES8206534A1 publication Critical patent/ES8206534A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS ACILICOS DE CEFALOSPORINA, ASI COMO DE SUS SALES,ETERES Y ESTERES FACILMENTE HIDROLIZABLES Y DE SUS HIDRATOS DE FORMULA (I), EN LA QUE X ES 1,2,5,6-TETRAHIDRO-2-METIL-5,6-DIOXO-AS-TRIACIN-3-ILO O2,5-DIHIDRO-6-HIDROXI-2-METIL-5-OXO-AS-TRIACIN-3-ILO. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE X TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y HAL ES CLORO O BROMO, CON TIOUREA EN UN DISOLVENTE ORGANICO INERTE, AGUA O SUS MEZCLAS, A UNA TEMPARATURA ENTRE 0 Y 60 C. SI EL GRUPO CARBOXI ESTA PROTEGIDO, SE DISOCIA U SE PUEDEN PREPARAR LAS SALES,ESTERES Y ETERES CORRESPONDIENTES POR METODOS CONVENCIANALES. ESTOS COMPUESTOS TIENEN APLICACIONES FAMACOLOGICAS POR SU ACTIVIDAD ANTIBIOTICA.
ES506022A 1980-10-06 1981-10-05 Un procedimiento para la preparacion de derivados acilicos de cefalosporina Expired ES8206534A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH745080 1980-10-06

Publications (2)

Publication Number Publication Date
ES506022A0 ES506022A0 (es) 1982-08-16
ES8206534A1 true ES8206534A1 (es) 1982-08-16

Family

ID=4325316

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506022A Expired ES8206534A1 (es) 1980-10-06 1981-10-05 Un procedimiento para la preparacion de derivados acilicos de cefalosporina

Country Status (21)

Country Link
US (3) US4412070A (es)
EP (1) EP0049499B1 (es)
JP (3) JPS5791989A (es)
KR (1) KR870000828B1 (es)
AT (1) ATE17729T1 (es)
AU (1) AU554552B2 (es)
CA (1) CA1168227A (es)
DE (1) DE3173642D1 (es)
DK (1) DK379581A (es)
ES (1) ES8206534A1 (es)
FI (1) FI73442C (es)
GR (1) GR75072B (es)
HU (1) HU185963B (es)
IE (1) IE51633B1 (es)
IL (1) IL63964A (es)
MC (1) MC1421A1 (es)
NO (2) NO813375L (es)
NZ (1) NZ198507A (es)
PH (1) PH20367A (es)
PT (1) PT73764B (es)
ZA (1) ZA816741B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695565A (en) * 1984-10-04 1987-09-22 Merck & Co., Inc. Antibacterial 7β-heterocyclic-cephem
EP0185220A3 (de) * 1984-12-19 1987-09-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Zwischenprodukte zur Herstellung von Cephalosporinen
JP2620743B2 (ja) * 1992-12-02 1997-06-18 株式会社山一屋 垣形成用支柱

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348518A (en) * 1974-05-05 1982-09-07 Hoffmann-La Roche Inc. Cephalosporins
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
CH641468A5 (de) * 1978-05-30 1984-02-29 Hoffmann La Roche Cephemderivate.
NL8100089A (nl) * 1980-01-17 1981-08-17 Rhone Poulenc Ind Nieuwe thiolen en de bereiding daarvan.

Also Published As

Publication number Publication date
JPH0333159B2 (es) 1991-05-16
IE812315L (en) 1982-04-06
NO813375L (no) 1982-04-07
PH20367A (en) 1986-12-04
IL63964A (en) 1984-12-31
EP0049499A2 (de) 1982-04-14
US4520195A (en) 1985-05-28
NO822876L (no) 1982-04-07
CA1168227A (en) 1984-05-29
MC1421A1 (fr) 1982-10-18
GR75072B (es) 1984-07-13
FI73442B (fi) 1987-06-30
FI73442C (fi) 1987-10-09
AU7574181A (en) 1982-04-22
ATE17729T1 (de) 1986-02-15
ES506022A0 (es) 1982-08-16
JPH0786112B2 (ja) 1995-09-20
US4412070A (en) 1983-10-25
ZA816741B (en) 1982-09-29
NZ198507A (en) 1985-02-28
US4774330A (en) 1988-09-27
AU554552B2 (en) 1986-08-28
KR830007691A (ko) 1983-11-04
FI813088L (fi) 1982-04-07
PT73764B (en) 1983-10-14
JPS61178993A (ja) 1986-08-11
IL63964A0 (en) 1981-12-31
JPS6146478B2 (es) 1986-10-14
EP0049499B1 (de) 1986-01-29
PT73764A (en) 1981-11-01
JPS5791989A (en) 1982-06-08
HU185963B (en) 1985-04-28
KR870000828B1 (ko) 1987-04-23
DK379581A (da) 1982-04-07
JPH03264591A (ja) 1991-11-25
DE3173642D1 (en) 1986-03-13
IE51633B1 (en) 1987-01-21
EP0049499A3 (en) 1983-09-07

Similar Documents

Publication Publication Date Title
EG14153A (en) Process for preparing of novel acyl derivatives
ES482675A1 (es) Un procedimiento para la preparacion de nuevos derivados de oxadiazolopirimidina.
ES478485A1 (es) Procedimiento para la preparacion de 1-oxo-1h-pirimido (6-1-b) benzotiazoles.
ES8400103A1 (es) "un procedimiento para la preparacion de nuevos acilderivados de cefalosporina".
IL61687A (en) (benzothiazole-2-yl-thio)-phenylpropionic acid derivatives,pharmaceutical formulations containing them and a process for their preparation
ES8206534A1 (es) Un procedimiento para la preparacion de derivados acilicos de cefalosporina
ES8401926A1 (es) Un procedimiento para la preparacion de un compuesto de hidroxibencilaminobenceno, dotado de propiedades antiinflamatorias.
JPS5227791A (en) Synthesis of cephalosporins