ES8602018A1 - Un procedimiento para la preparacion de derivados cefem - Google Patents
Un procedimiento para la preparacion de derivados cefemInfo
- Publication number
- ES8602018A1 ES8602018A1 ES540544A ES540544A ES8602018A1 ES 8602018 A1 ES8602018 A1 ES 8602018A1 ES 540544 A ES540544 A ES 540544A ES 540544 A ES540544 A ES 540544A ES 8602018 A1 ES8602018 A1 ES 8602018A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- acylating agent
- acid
- preparation
- cephem derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001782 cephems Chemical class 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- -1 succinimidyl Chemical group 0.000 abstract 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 125000005545 phthalimidyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
METODO DE PREPARACION PARA DERVIADOS CEFEM DE FORMULA (I), EN DONDE R1 HIDROGENO O METAL ALCALINO Y R2 HIDROGENO, ACETOXIMETILO O UN RADICAL HETEROCICICLICO DE 5 O 6 MIEMBROS CON UNO O VARIOS ATOMOS DE HIDROGENO. SE ESTERIFICA UN ACIDO ORGANICO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R3-O-)(C)(N-O-R3, DONDE N 1 O 2 Y R3 ES BENZOTRIAZOILO, PIRIDILO, SUCCCINIMIDILO O FTALIMIDILO, EN PRESENCIA DE UNA AMINA ORGANICA PARA FORMAR EL ESTER REACTIVO CORRESPONDIENTE QUE SE ACILA CON UN COMPUESTO DE FORMULA (III) EN PRESENCIA DE UN DISOLVENTE ORGANICO DE REACCION PREFERENTEMENTE ACETONITRILO, TETRAHIDROFURANO, ACETATO DE ETILO, ACETONA, N,N-DIMETILFORMAMIDA, N-N-DIMETILACETAMIDA Y/O DOXANO Y EN PRESENCIA DE UNA BASE, PREFERENTEMENTE HIDROGENO-CARBONATO SODICO, HIDROGENO-CARBONATO POTASICO O TRIETILAMINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019840002267A KR850001206B1 (ko) | 1984-04-27 | 1984-04-27 | 세펨 유도체의 제조 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8602018A1 true ES8602018A1 (es) | 1985-11-16 |
ES540544A0 ES540544A0 (es) | 1985-11-16 |
Family
ID=19233668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES540544A Granted ES540544A0 (es) | 1984-04-27 | 1985-02-20 | Un procedimiento para la preparacion de derivados cefem |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS60233090A (es) |
KR (1) | KR850001206B1 (es) |
CH (1) | CH667458A5 (es) |
ES (1) | ES540544A0 (es) |
GB (1) | GB2158432B (es) |
IT (1) | IT1185509B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1259563B2 (en) | 1999-12-22 | 2016-08-10 | Nektar Therapeutics | Method for the preparation of 1-benzotriazolyl carbonate esters of water soluble polymers. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1145744A (fr) * | 1979-05-23 | 1983-05-03 | Daniel Farge | Thiovinyl-3 cephalosporines, leur preparation et les compositions qui les contiennent |
NL8100089A (nl) * | 1980-01-17 | 1981-08-17 | Rhone Poulenc Ind | Nieuwe thiolen en de bereiding daarvan. |
US4346076A (en) * | 1980-09-17 | 1982-08-24 | Eli Lilly And Company | Bis-tetrazoylmethyl substituted cephalosporin antibiotics |
JPS591490A (ja) * | 1982-06-29 | 1984-01-06 | Dai Ichi Seiyaku Co Ltd | 3−セフェム−4−カルボン酸誘導体 |
-
1984
- 1984-04-27 KR KR1019840002267A patent/KR850001206B1/ko not_active IP Right Cessation
- 1984-09-14 GB GB08423207A patent/GB2158432B/en not_active Expired
- 1984-12-25 JP JP59272168A patent/JPS60233090A/ja active Pending
-
1985
- 1985-02-18 IT IT19547/85A patent/IT1185509B/it active
- 1985-02-20 ES ES540544A patent/ES540544A0/es active Granted
- 1985-04-16 CH CH1615/85A patent/CH667458A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB2158432B (en) | 1987-10-28 |
GB8423207D0 (en) | 1984-10-17 |
IT8519547A0 (it) | 1985-02-18 |
KR850001206B1 (ko) | 1985-08-20 |
CH667458A5 (de) | 1988-10-14 |
GB2158432A (en) | 1985-11-13 |
ES540544A0 (es) | 1985-11-16 |
JPS60233090A (ja) | 1985-11-19 |
IT1185509B (it) | 1987-11-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |