ES8602018A1 - Un procedimiento para la preparacion de derivados cefem - Google Patents

Un procedimiento para la preparacion de derivados cefem

Info

Publication number
ES8602018A1
ES8602018A1 ES540544A ES540544A ES8602018A1 ES 8602018 A1 ES8602018 A1 ES 8602018A1 ES 540544 A ES540544 A ES 540544A ES 540544 A ES540544 A ES 540544A ES 8602018 A1 ES8602018 A1 ES 8602018A1
Authority
ES
Spain
Prior art keywords
image
acylating agent
acid
preparation
cephem derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540544A
Other languages
English (en)
Other versions
ES540544A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Advanced Institute of Science and Technology KAIST
Original Assignee
Korea Advanced Institute of Science and Technology KAIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Advanced Institute of Science and Technology KAIST filed Critical Korea Advanced Institute of Science and Technology KAIST
Publication of ES8602018A1 publication Critical patent/ES8602018A1/es
Publication of ES540544A0 publication Critical patent/ES540544A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

METODO DE PREPARACION PARA DERVIADOS CEFEM DE FORMULA (I), EN DONDE R1 HIDROGENO O METAL ALCALINO Y R2 HIDROGENO, ACETOXIMETILO O UN RADICAL HETEROCICICLICO DE 5 O 6 MIEMBROS CON UNO O VARIOS ATOMOS DE HIDROGENO. SE ESTERIFICA UN ACIDO ORGANICO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R3-O-)(C)(N-O-R3, DONDE N 1 O 2 Y R3 ES BENZOTRIAZOILO, PIRIDILO, SUCCCINIMIDILO O FTALIMIDILO, EN PRESENCIA DE UNA AMINA ORGANICA PARA FORMAR EL ESTER REACTIVO CORRESPONDIENTE QUE SE ACILA CON UN COMPUESTO DE FORMULA (III) EN PRESENCIA DE UN DISOLVENTE ORGANICO DE REACCION PREFERENTEMENTE ACETONITRILO, TETRAHIDROFURANO, ACETATO DE ETILO, ACETONA, N,N-DIMETILFORMAMIDA, N-N-DIMETILACETAMIDA Y/O DOXANO Y EN PRESENCIA DE UNA BASE, PREFERENTEMENTE HIDROGENO-CARBONATO SODICO, HIDROGENO-CARBONATO POTASICO O TRIETILAMINA.
ES540544A 1984-04-27 1985-02-20 Un procedimiento para la preparacion de derivados cefem Granted ES540544A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840002267A KR850001206B1 (ko) 1984-04-27 1984-04-27 세펨 유도체의 제조 방법

Publications (2)

Publication Number Publication Date
ES8602018A1 true ES8602018A1 (es) 1985-11-16
ES540544A0 ES540544A0 (es) 1985-11-16

Family

ID=19233668

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540544A Granted ES540544A0 (es) 1984-04-27 1985-02-20 Un procedimiento para la preparacion de derivados cefem

Country Status (6)

Country Link
JP (1) JPS60233090A (es)
KR (1) KR850001206B1 (es)
CH (1) CH667458A5 (es)
ES (1) ES540544A0 (es)
GB (1) GB2158432B (es)
IT (1) IT1185509B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1259563B2 (en) 1999-12-22 2016-08-10 Nektar Therapeutics Method for the preparation of 1-benzotriazolyl carbonate esters of water soluble polymers.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1145744A (fr) * 1979-05-23 1983-05-03 Daniel Farge Thiovinyl-3 cephalosporines, leur preparation et les compositions qui les contiennent
NL8100089A (nl) * 1980-01-17 1981-08-17 Rhone Poulenc Ind Nieuwe thiolen en de bereiding daarvan.
US4346076A (en) * 1980-09-17 1982-08-24 Eli Lilly And Company Bis-tetrazoylmethyl substituted cephalosporin antibiotics
JPS591490A (ja) * 1982-06-29 1984-01-06 Dai Ichi Seiyaku Co Ltd ３−セフェム−４−カルボン酸誘導体

Also Published As

Publication number Publication date
GB2158432B (en) 1987-10-28
GB8423207D0 (en) 1984-10-17
IT8519547A0 (it) 1985-02-18
KR850001206B1 (ko) 1985-08-20
CH667458A5 (de) 1988-10-14
GB2158432A (en) 1985-11-13
ES540544A0 (es) 1985-11-16
JPS60233090A (ja) 1985-11-19
IT1185509B (it) 1987-11-12

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506