ES8603819A1 - Procedimiento para la fabricacion de derivados de pirrolidi-na - Google Patents
Procedimiento para la fabricacion de derivados de pirrolidi-naInfo
- Publication number
- ES8603819A1 ES8603819A1 ES545451A ES545451A ES8603819A1 ES 8603819 A1 ES8603819 A1 ES 8603819A1 ES 545451 A ES545451 A ES 545451A ES 545451 A ES545451 A ES 545451A ES 8603819 A1 ES8603819 A1 ES 8603819A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- image
- following formula
- pyrrolidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE DERIVADOS DE PIRROLIDINA. CONSISTENTE EN: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON CL-CO-RK PARA OBTENER EL ANHIDRIDO DE ACIDO DE FORMULA (III), EN PRESENCIA DE UNA BASE ORGANICA, A UNA TEMPERATURA ENTRE 5-30JC, Y EN UN DISOLVENTE SELECCIONADO ENTRE CLORURO DE METILENO, CLOROFORMO, TETRACLORURO DE CARBONO Y OTROS; B) ACILAR A (III) CON UN COMPUESTO (IV) A UNA TEMPERATURA ENTRE 10 Y 30JC; AÑADIR AGUA PARA ELIMINAR EL COMPUESTO SILICICO Y AJUSTAR EL PH ENTRE 4 Y 6 CON HIDROXIDO SODICO, CARBONATO SODICO U OTROS; SE SEPARAN LAS FASES ACUOSAS Y SE AJUSTA EL PH A 2 CON LO QUE OBTENEMOS UN COMPUESTO (V); C) HACER REACCIONAR A (V) CON TIOUREA PARA DAR (VI); Y D) HIDROLIZAR A (VI) CON UN HIDROXIDO DE METAL ALCALINO, Y AÑADIR CLH HASTA PH 0,5-2,5 PARA OBTENER (I). SE UTILIZAN PARA REDUCIR LA PRESION SANGUINEA Y PREVENIR LA HIPERTENSION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019840004361A KR860001391B1 (ko) | 1984-07-23 | 1984-07-23 | 피롤리딘 유도체의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8603819A1 true ES8603819A1 (es) | 1986-01-01 |
ES545451A0 ES545451A0 (es) | 1986-01-01 |
Family
ID=19234716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545451A Granted ES545451A0 (es) | 1984-07-23 | 1985-07-22 | Procedimiento para la fabricacion de derivados de pirrolidi-na |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS6193157A (es) |
KR (1) | KR860001391B1 (es) |
DE (1) | DE3526023A1 (es) |
ES (1) | ES545451A0 (es) |
FR (1) | FR2567881B1 (es) |
GB (1) | GB2162181B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU208954B (en) * | 1990-09-21 | 1994-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn |
AT395012B (de) * | 1986-06-27 | 1992-08-25 | Richter Gedeon Vegyeszet | Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4192945A (en) * | 1978-12-07 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Process for preparing proline and homoproline derivatives |
GB2065643B (en) * | 1979-12-13 | 1983-08-24 | Kanegafuchi Chemical Ind | Optically active n-mercaptoalkanoylamino acids |
HU184082B (en) * | 1979-12-29 | 1984-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid |
JPS58124764A (ja) * | 1982-01-20 | 1983-07-25 | Kanegafuchi Chem Ind Co Ltd | 光学活性チオ−ル化合物の製造法 |
-
1984
- 1984-07-23 KR KR1019840004361A patent/KR860001391B1/ko not_active IP Right Cessation
-
1985
- 1985-07-20 DE DE19853526023 patent/DE3526023A1/de active Granted
- 1985-07-22 FR FR8511194A patent/FR2567881B1/fr not_active Expired
- 1985-07-22 JP JP60160393A patent/JPS6193157A/ja active Granted
- 1985-07-22 ES ES545451A patent/ES545451A0/es active Granted
- 1985-07-23 GB GB08518550A patent/GB2162181B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6193157A (ja) | 1986-05-12 |
FR2567881B1 (fr) | 1987-12-24 |
JPS6137263B2 (es) | 1986-08-22 |
GB2162181A (en) | 1986-01-29 |
ES545451A0 (es) | 1986-01-01 |
DE3526023A1 (de) | 1986-01-23 |
DE3526023C2 (es) | 1988-10-20 |
KR860001391B1 (ko) | 1986-09-22 |
GB2162181B (en) | 1988-04-20 |
GB8518550D0 (en) | 1985-08-29 |
FR2567881A1 (fr) | 1986-01-24 |
KR860001066A (ko) | 1986-02-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000601 |