ES8603476A1 - Procedimiento para preparar 2-imino-3, 4, 6, 7-tetrahidro-4h-pirimido (6, 1-a) isoquinolin-4-onas sustituidas - Google Patents

Procedimiento para preparar 2-imino-3, 4, 6, 7-tetrahidro-4h-pirimido (6, 1-a) isoquinolin-4-onas sustituidas

Info

Publication number
ES8603476A1
ES8603476A1 ES537511A ES537511A ES8603476A1 ES 8603476 A1 ES8603476 A1 ES 8603476A1 ES 537511 A ES537511 A ES 537511A ES 537511 A ES537511 A ES 537511A ES 8603476 A1 ES8603476 A1 ES 8603476A1
Authority
ES
Spain
Prior art keywords
preparation
pyrimido
isoquinolin
imino
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537511A
Other languages
English (en)
Other versions
ES537511A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES537511A0 publication Critical patent/ES537511A0/es
Publication of ES8603476A1 publication Critical patent/ES8603476A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1836—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from derivatives of carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 2-IMINO-3,4,6,7-TETRAHIDRO-4H-PIRIMIDO 6,1-A ISOQUINOLIN-4-ONAS SUSTITUIDAS. COMPRENDE: A) TRATAR UN COMPUESTO DE FORMULA (II) CON UN ISOCIANATO DE FORMULA (III), EN DISOLVENTES INERTES, A TEMPERARTURAS DE C10 A 100JC PARA DAR UN DERIVADO DE UREA DE FORMULA (IV); B) TRATAR EL COMPUESTO (IV) CON UN COMPUESTO (V) EN PRESENCIA DE CATALIZADORES BASICOS, EN UN DISOLVENTE ORGANICO PARA DAR UN COMPUESTO DE FORMULA (VI); Y C) TRATAR EL COMPUESTO (VI) CON UN HALOGENO DE FOSFORO PARA DAR UNA SAL DE IMINO, Y ESTA SE TRATA CON UNA AMINA DE FORMULA R3-NH2 PARA DAR UN COMPUESTO DE FORMULA (I). SIENDO: R1 RADICAL ALQUILO CON C 1 A 6; R2 UN RADICAL HIDROCARBURADO ALIFATICO CON C 1 A 6, Y OTROS; R3 UN RADICAL HIDROCARBURADO ALIFATICO CON C 1 A 7 Y OTROS; R5 UN RADICAL ALQUILO CON C 1 A 4. SE UTILIZANPOR SU EFECTO HIPOTENSOR.
ES537511A 1983-11-11 1984-11-08 Procedimiento para preparar 2-imino-3, 4, 6, 7-tetrahidro-4h-pirimido (6, 1-a) isoquinolin-4-onas sustituidas Expired ES8603476A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833340773 DE3340773A1 (de) 1983-11-11 1983-11-11 Verfahren zur herstellung von substituierten 2-imino-3,4,6,7-tetrahydro-4h-pyrimido(6,1-a)isochinolin-4-onen

Publications (2)

Publication Number Publication Date
ES537511A0 ES537511A0 (es) 1985-12-16
ES8603476A1 true ES8603476A1 (es) 1985-12-16

Family

ID=6214032

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537511A Expired ES8603476A1 (es) 1983-11-11 1984-11-08 Procedimiento para preparar 2-imino-3, 4, 6, 7-tetrahidro-4h-pirimido (6, 1-a) isoquinolin-4-onas sustituidas

Country Status (9)

Country Link
KR (1) KR850003537A (es)
DE (1) DE3340773A1 (es)
DK (1) DK534084A (es)
ES (1) ES8603476A1 (es)
FI (1) FI844392L (es)
GR (1) GR80900B (es)
HU (1) HU189946B (es)
NO (1) NO844491L (es)
PT (1) PT79481B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203944A1 (en) * 2000-08-21 2003-10-30 Suh Young Ger Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same
US6720421B2 (en) * 2001-02-20 2004-04-13 Fuji Photo Film Co., Ltd. Phenylurethane compounds and methods for producing same, asymmetric urea compounds and methods for producing same, barbituric acid derivative, and diazo thermal recording material containing the derivative

Also Published As

Publication number Publication date
FI844392L (fi) 1985-05-12
DE3340773A1 (de) 1985-05-30
DK534084A (da) 1985-05-12
HU189946B (en) 1986-08-28
KR850003537A (ko) 1985-06-20
ES537511A0 (es) 1985-12-16
FI844392A0 (fi) 1984-11-08
PT79481A (de) 1984-12-01
HUT35675A (en) 1985-07-29
NO844491L (no) 1985-05-13
GR80900B (en) 1985-02-26
PT79481B (de) 1987-01-13
DK534084D0 (da) 1984-11-09

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