ES8506264A1 - Un procedimiento para la preparacion de carboxialquil-dipeptidos - Google Patents

Un procedimiento para la preparacion de carboxialquil-dipeptidos

Info

Publication number
ES8506264A1
ES8506264A1 ES535853A ES535853A ES8506264A1 ES 8506264 A1 ES8506264 A1 ES 8506264A1 ES 535853 A ES535853 A ES 535853A ES 535853 A ES535853 A ES 535853A ES 8506264 A1 ES8506264 A1 ES 8506264A1
Authority
ES
Spain
Prior art keywords
carboxyalkyl dipeptides
preparing carboxyalkyl
preparing
dipeptides
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535853A
Other languages
English (en)
Other versions
ES535853A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27011123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8506264(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES535853A0 publication Critical patent/ES535853A0/es
Publication of ES8506264A1 publication Critical patent/ES8506264A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR CARBOXIALQUIL-DIPEPTIDOS.COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON EL HIDROCLORURO DEL ESTER BENCILICO DE UN DIPEPTIDO, PARA OBTENER UN (A); B) HIDROGENAR A (A), EN PRESENCIA DE PD/C COMO CATALIZADOR, PARA OBTENER UN (B); Y C) TRATAR A (B) CON ACETONITRILO Y ACIDO MALEICO, PARA OBTENER COMPUESTOS DE FORMULA (I), EN LA CONFIGURACION ESTEROISOMETRICA S,S,S Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO A UN ESTER DIPEPTIDO PROTEGIDO; B UN ESTER DIPEPTIDICO DIPROTEGIDO; R ARILO, ARILO SUSTITUIDO CON ALQUILO INFERIOR, ALCOXI INFERIOR Y HALOGENO Y OTROS; Y X E Y ALAMINA, GLICINA Y OTRAS.SE UTILIZAN COMO AGENTES ANTIHIPERTENSIVOS.
ES535853A 1982-06-07 1984-09-12 Un procedimiento para la preparacion de carboxialquil-dipeptidos Expired ES8506264A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38574582A 1982-06-07 1982-06-07
US06/462,727 US4442030A (en) 1982-06-07 1983-01-31 Process for preparing carboxyalkyl dipeptides

Publications (2)

Publication Number Publication Date
ES535853A0 ES535853A0 (es) 1985-07-01
ES8506264A1 true ES8506264A1 (es) 1985-07-01

Family

ID=27011123

Family Applications (2)

Application Number Title Priority Date Filing Date
ES522753A Expired ES8502082A1 (es) 1982-06-07 1983-05-27 "un procedimiento para la preparacion de carboxialquil-dipeptidos"
ES535853A Expired ES8506264A1 (es) 1982-06-07 1984-09-12 Un procedimiento para la preparacion de carboxialquil-dipeptidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522753A Expired ES8502082A1 (es) 1982-06-07 1983-05-27 "un procedimiento para la preparacion de carboxialquil-dipeptidos"

Country Status (7)

Country Link
US (1) US4442030A (es)
KR (1) KR910001720B1 (es)
AT (1) AT393508B (es)
ES (2) ES8502082A1 (es)
GR (1) GR78282B (es)
NO (1) NO166231C (es)
PT (2) PT76790B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746676A (en) * 1984-09-12 1988-05-24 Rorer Pharmaceutical Corporation Carboxyalkyl dipeptide compounds
TW533196B (en) * 1998-09-23 2003-05-21 Merck & Co Inc Improved stereoselective process for ENALAPRIL

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR910001720B1 (ko) 1991-03-22
PT76790A (en) 1983-07-01
ES535853A0 (es) 1985-07-01
NO166231C (no) 1991-06-19
PT76790B (en) 1986-04-09
NO832036L (no) 1983-12-08
AT393508B (de) 1991-11-11
ES522753A0 (es) 1984-12-16
KR840005079A (ko) 1984-11-03
ATA201283A (de) 1991-04-15
GR78282B (es) 1984-09-26
NO166231B (no) 1991-03-11
PT76790B1 (pt) 1996-09-30
ES8502082A1 (es) 1984-12-16
US4442030A (en) 1984-04-10

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