ES8502082A1 - "un procedimiento para la preparacion de carboxialquil-dipeptidos" - Google Patents

"un procedimiento para la preparacion de carboxialquil-dipeptidos"

Info

Publication number
ES8502082A1
ES8502082A1 ES522753A ES522753A ES8502082A1 ES 8502082 A1 ES8502082 A1 ES 8502082A1 ES 522753 A ES522753 A ES 522753A ES 522753 A ES522753 A ES 522753A ES 8502082 A1 ES8502082 A1 ES 8502082A1
Authority
ES
Spain
Prior art keywords
carboxyalkyl dipeptides
preparing carboxyalkyl
preparing
dipeptides
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522753A
Other languages
English (en)
Other versions
ES522753A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27011123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8502082(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES522753A0 publication Critical patent/ES522753A0/es
Publication of ES8502082A1 publication Critical patent/ES8502082A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE CARBOXIALQUILDIPEPTIDOS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN PEPTIDO, PARA OBTENER UN D-CARBOXI-DIPEPTIDO EL CUAL SE HIDROGENA EN UN MEDIO ACIDO, EN UN DISOLVENTE ALCOHOLICO, PARA PRODUCIR DESPUES DE LA ESTERIFICACION SIMULTANEA, UN DICARBOALCOXI-DIPEPTIDO COMO MEZCLA DE DIASTEREOMEROS Y SEPARAR LA MEZCLA DIASTEREOMERICA PARA PRODUCIR COMPUESTOS DE CARBOXIALQUIL-DIPEPTIDOS DE FORMULA (I). EL TRATAMIENTO DEL DICARBOXI-DIPEPTIDO SE REALIZA EN PRESENCIA DE UN CATALIZADOR DE PD/C, DONDE R ES ARILO; R1 ES ALQUILO INFERIOR DE C 1 A 4; X ES ALAMINA, GLICINA Y OTROS; E Y ES PROLINA O VALINA.
ES522753A 1982-06-07 1983-05-27 "un procedimiento para la preparacion de carboxialquil-dipeptidos" Expired ES8502082A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38574582A 1982-06-07 1982-06-07
US06/462,727 US4442030A (en) 1982-06-07 1983-01-31 Process for preparing carboxyalkyl dipeptides

Publications (2)

Publication Number Publication Date
ES522753A0 ES522753A0 (es) 1984-12-16
ES8502082A1 true ES8502082A1 (es) 1984-12-16

Family

ID=27011123

Family Applications (2)

Application Number Title Priority Date Filing Date
ES522753A Expired ES8502082A1 (es) 1982-06-07 1983-05-27 "un procedimiento para la preparacion de carboxialquil-dipeptidos"
ES535853A Expired ES8506264A1 (es) 1982-06-07 1984-09-12 Un procedimiento para la preparacion de carboxialquil-dipeptidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES535853A Expired ES8506264A1 (es) 1982-06-07 1984-09-12 Un procedimiento para la preparacion de carboxialquil-dipeptidos

Country Status (7)

Country Link
US (1) US4442030A (es)
KR (1) KR910001720B1 (es)
AT (1) AT393508B (es)
ES (2) ES8502082A1 (es)
GR (1) GR78282B (es)
NO (1) NO166231C (es)
PT (2) PT76790B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746676A (en) * 1984-09-12 1988-05-24 Rorer Pharmaceutical Corporation Carboxyalkyl dipeptide compounds
TW533196B (en) * 1998-09-23 2003-05-21 Merck & Co Inc Improved stereoselective process for ENALAPRIL

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT76790B1 (pt) 1996-09-30
ES535853A0 (es) 1985-07-01
ES522753A0 (es) 1984-12-16
GR78282B (es) 1984-09-26
PT76790B (en) 1986-04-09
US4442030A (en) 1984-04-10
KR910001720B1 (ko) 1991-03-22
NO832036L (no) 1983-12-08
ES8506264A1 (es) 1985-07-01
PT76790A (en) 1983-07-01
KR840005079A (ko) 1984-11-03
ATA201283A (de) 1991-04-15
AT393508B (de) 1991-11-11
NO166231B (no) 1991-03-11
NO166231C (no) 1991-06-19

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