ES8800244A1 - Un procedimiento para preparar naftiridinas antibacterianas - Google Patents

Un procedimiento para preparar naftiridinas antibacterianas

Info

Publication number
ES8800244A1
ES8800244A1 ES554375A ES554375A ES8800244A1 ES 8800244 A1 ES8800244 A1 ES 8800244A1 ES 554375 A ES554375 A ES 554375A ES 554375 A ES554375 A ES 554375A ES 8800244 A1 ES8800244 A1 ES 8800244A1
Authority
ES
Spain
Prior art keywords
compounds
processes
producing
quinoline
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554375A
Other languages
English (en)
Other versions
ES554375A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES554375A0 publication Critical patent/ES554375A0/es
Publication of ES8800244A1 publication Critical patent/ES8800244A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NAFTIRIDINAS, DE FORMULA (I), Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA (III) O (IV), PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE X REPRESENTA NITROGENO, L ES CLORO O FLUOR Y Z, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN ACEPTOR DE ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 20GC Y 150GC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA. *FORMULA* Z
ES554375A 1984-07-20 1986-04-25 Un procedimiento para preparar naftiridinas antibacterianas Expired ES8800244A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63315384A 1984-07-20 1984-07-20

Publications (2)

Publication Number Publication Date
ES554375A0 ES554375A0 (es) 1987-10-16
ES8800244A1 true ES8800244A1 (es) 1987-10-16

Family

ID=24538490

Family Applications (3)

Application Number Title Priority Date Filing Date
ES545390A Expired ES8704161A1 (es) 1984-07-20 1985-07-19 Un procedimiento para preparar dihidroquinoleinas antibacterianas.
ES554376A Expired ES8800245A1 (es) 1984-07-20 1986-04-25 Un procedimiento para preparar benzoxazinas antibacterianas
ES554375A Expired ES8800244A1 (es) 1984-07-20 1986-04-25 Un procedimiento para preparar naftiridinas antibacterianas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES545390A Expired ES8704161A1 (es) 1984-07-20 1985-07-19 Un procedimiento para preparar dihidroquinoleinas antibacterianas.
ES554376A Expired ES8800245A1 (es) 1984-07-20 1986-04-25 Un procedimiento para preparar benzoxazinas antibacterianas

Country Status (18)

Country Link
EP (1) EP0172651B1 (es)
JP (2) JPH0791288B2 (es)
KR (1) KR900003495B1 (es)
AR (1) AR241183A1 (es)
AT (1) ATE50255T1 (es)
AU (3) AU576252B2 (es)
CA (1) CA1331381C (es)
DE (1) DE3575924D1 (es)
DK (3) DK302885A (es)
ES (3) ES8704161A1 (es)
FI (1) FI83648C (es)
GR (1) GR851648B (es)
IE (1) IE58742B1 (es)
NO (1) NO171638C (es)
NZ (1) NZ212805A (es)
PH (3) PH22341A (es)
PT (1) PT80836B (es)
ZA (1) ZA855038B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
EP0207420B1 (en) * 1985-06-26 1992-05-06 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
AU594983B2 (en) 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
DE3635846C2 (de) * 1986-10-22 1995-08-03 Teves Gmbh Alfred Blockiergeschützte Bremsanlage mit Antriebsschlupfregelung
JPS63185607A (ja) * 1987-01-27 1988-08-01 Matsushita Electric Works Ltd シ−ト状成形材料の製法
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4839355A (en) * 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US5286723A (en) * 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
ES2147721T3 (es) 1990-04-18 2000-10-01 Procter & Gamble Pharma Quinolonil lactamas antimicrobianas.
DE4032560A1 (de) * 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
DE69132314T2 (de) * 1990-12-05 2000-12-14 Naeja Pharmaceutical Inc., Edmonton 7-substituierte-6-fluor-1,4-dihydro-4-oxo-chinolin-3-carbonsäurederivate als antibakterielle wirkstoffe
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
TW252107B (es) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
EP0806421A4 (en) * 1995-01-24 1998-04-15 Hokuriku Pharmaceutical DERIVATIVES OF CHINOLINE CARBONIC ACID
BRPI0413964B8 (pt) 2003-09-10 2021-05-25 Kyorin Seiyaku Kk ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
JP5322927B2 (ja) 2007-05-24 2013-10-23 杏林製薬株式会社 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
USD808799S1 (en) 2015-11-17 2018-01-30 Hunter Fan Company Carton with color striping

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS57149286A (en) * 1981-03-13 1982-09-14 Dai Ichi Seiyaku Co Ltd 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative
JPS58174367A (ja) * 1982-04-07 1983-10-13 Tanabe Seiyaku Co Ltd キノリン誘導体及びその製法
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester

Also Published As

Publication number Publication date
ZA855038B (en) 1986-02-26
DE3575924D1 (de) 1990-03-15
PT80836A (en) 1985-08-01
ES545390A0 (es) 1987-03-16
JPH0826003B2 (ja) 1996-03-13
PH22341A (en) 1988-08-12
PH23474A (en) 1989-08-07
AU613372B2 (en) 1991-08-01
JPS6143186A (ja) 1986-03-01
GR851648B (es) 1985-11-26
AU576252B2 (en) 1988-08-18
CA1331381C (en) 1994-08-09
ES554375A0 (es) 1987-10-16
DK28892A (da) 1992-03-04
JPH0791288B2 (ja) 1995-10-04
NO171638C (no) 1993-04-14
ES8704161A1 (es) 1987-03-16
ES8800245A1 (es) 1987-10-16
IE851666L (en) 1986-01-20
DK6193D0 (da) 1993-01-19
AU4458185A (en) 1986-01-23
ATE50255T1 (de) 1990-02-15
NO171638B (no) 1993-01-04
FI852624L (fi) 1986-01-21
PH24824A (en) 1990-10-30
AU1731388A (en) 1988-09-15
DK6193A (da) 1993-01-19
FI852624A0 (fi) 1985-07-03
EP0172651B1 (en) 1990-02-07
NO852885L (no) 1986-01-21
DK302885D0 (da) 1985-07-03
DK28892D0 (da) 1992-03-04
AU602585B2 (en) 1990-10-18
DK302885A (da) 1986-01-21
PT80836B (pt) 1987-09-30
AR241183A1 (es) 1992-01-31
JPH0748354A (ja) 1995-02-21
IE58742B1 (en) 1993-11-05
KR860001110A (ko) 1986-02-22
FI83648C (fi) 1991-08-12
NZ212805A (en) 1989-01-06
EP0172651A1 (en) 1986-02-26
DK171935B1 (da) 1997-08-18
FI83648B (fi) 1991-04-30
KR900003495B1 (ko) 1990-05-21
ES554376A0 (es) 1987-10-16
AU1731288A (en) 1988-08-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040903