AR241183A1 - Procedimiento para la preparacion de nuevos acidos naftiridin-, quinolin- y benzoxazin-carboxilicos. - Google Patents

Procedimiento para la preparacion de nuevos acidos naftiridin-, quinolin- y benzoxazin-carboxilicos.

Info

Publication number
AR241183A1
AR241183A1 AR85301059A AR30105985A AR241183A1 AR 241183 A1 AR241183 A1 AR 241183A1 AR 85301059 A AR85301059 A AR 85301059A AR 30105985 A AR30105985 A AR 30105985A AR 241183 A1 AR241183 A1 AR 241183A1
Authority
AR
Argentina
Prior art keywords
oxo
fluoro
substituted
dihydro
amino
Prior art date
Application number
AR85301059A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of AR241183A1 publication Critical patent/AR241183A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ACIDOS NAFTIRIDIN-, QUINOLIN Y BENZOXAZINCARBOXILICOS DE FORMULAS I O II, DONDE Z ES III O IV, N ES 1 A 3; O N'ES 1 A 3 DONDE N+N' = 4 Y N" ES 0 A2, R1 ES H, O UN CATION; R2 ES ALQUILO, R3 ES H, ALQUILO, CICLOALQUILO, R4 ES ALQUILO Y SUS SALES. SE HACE REACCIONAR UN COMPUESTO DE LAS FORMULA V O VI, DONDE L ES FLUORO O CLORO CON UNA AMINA CORRESPONDIENTE AL GRUPO Z TAL COMO SE HA DEFINIDO ANTERIORMENTE,Y SI SE DESEA, CONVERTIR EL PRODUCTO RESULTANTE A UNA SAL DE ADICION DE ACIDO O UNA SAL BASICA FARMACEUTICAMENTE ACEPTABLE.
AR85301059A 1984-07-20 1985-07-22 Procedimiento para la preparacion de nuevos acidos naftiridin-, quinolin- y benzoxazin-carboxilicos. AR241183A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63315384A 1984-07-20 1984-07-20

Publications (1)

Publication Number Publication Date
AR241183A1 true AR241183A1 (es) 1992-01-31

Family

ID=24538490

Family Applications (1)

Application Number Title Priority Date Filing Date
AR85301059A AR241183A1 (es) 1984-07-20 1985-07-22 Procedimiento para la preparacion de nuevos acidos naftiridin-, quinolin- y benzoxazin-carboxilicos.

Country Status (18)

Country Link
EP (1) EP0172651B1 (es)
JP (2) JPH0791288B2 (es)
KR (1) KR900003495B1 (es)
AR (1) AR241183A1 (es)
AT (1) ATE50255T1 (es)
AU (3) AU576252B2 (es)
CA (1) CA1331381C (es)
DE (1) DE3575924D1 (es)
DK (3) DK302885A (es)
ES (3) ES8704161A1 (es)
FI (1) FI83648C (es)
GR (1) GR851648B (es)
IE (1) IE58742B1 (es)
NO (1) NO171638C (es)
NZ (1) NZ212805A (es)
PH (3) PH22341A (es)
PT (1) PT80836B (es)
ZA (1) ZA855038B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
IL79189A (en) * 1985-06-26 1990-07-12 Daiichi Seiyaku Co Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them
AU594983B2 (en) 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
DE3635846C2 (de) * 1986-10-22 1995-08-03 Teves Gmbh Alfred Blockiergeschützte Bremsanlage mit Antriebsschlupfregelung
JPS63185607A (ja) * 1987-01-27 1988-08-01 Matsushita Electric Works Ltd シ−ト状成形材料の製法
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4839355A (en) * 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US5286723A (en) * 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
JPH05506033A (ja) 1990-04-18 1993-09-02 ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド 抗微生物性キノロニルラクタム類
DE4032560A1 (de) * 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
HU9301648D0 (en) * 1990-12-05 1993-09-28 Synphar Lab Inc Substituted oxaquinoline-3-carboxylic acids of bactericidal effect and method for producing them
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
TW252107B (es) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
AU697025B2 (en) * 1995-01-24 1998-09-24 Hokuriku Seiyaku Co. Ltd Quinoline carboxylic acid
US7514451B2 (en) 2003-09-10 2009-04-07 Kyorin Pharmaceutical Co., Ltd. 7-(4-Substituted-3-cyclopropylaminomethyl-1 pyrrolidinyl) quinolonecarboxylic acid derivative
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
CA2688008A1 (en) 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
USD808799S1 (en) 2015-11-17 2018-01-30 Hunter Fan Company Carton with color striping

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS57149286A (en) * 1981-03-13 1982-09-14 Dai Ichi Seiyaku Co Ltd 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative
JPS58174367A (ja) * 1982-04-07 1983-10-13 Tanabe Seiyaku Co Ltd キノリン誘導体及びその製法
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester

Also Published As

Publication number Publication date
KR860001110A (ko) 1986-02-22
EP0172651B1 (en) 1990-02-07
DK171935B1 (da) 1997-08-18
PH23474A (en) 1989-08-07
JPH0748354A (ja) 1995-02-21
EP0172651A1 (en) 1986-02-26
AU576252B2 (en) 1988-08-18
ES554375A0 (es) 1987-10-16
JPH0826003B2 (ja) 1996-03-13
AU1731288A (en) 1988-08-25
ES554376A0 (es) 1987-10-16
DK28892A (da) 1992-03-04
NO171638B (no) 1993-01-04
IE851666L (en) 1986-01-20
AU1731388A (en) 1988-09-15
PH24824A (en) 1990-10-30
JPS6143186A (ja) 1986-03-01
DK28892D0 (da) 1992-03-04
GR851648B (es) 1985-11-26
JPH0791288B2 (ja) 1995-10-04
NO852885L (no) 1986-01-21
DK6193A (da) 1993-01-19
AU613372B2 (en) 1991-08-01
PH22341A (en) 1988-08-12
ZA855038B (en) 1986-02-26
ATE50255T1 (de) 1990-02-15
NO171638C (no) 1993-04-14
KR900003495B1 (ko) 1990-05-21
FI852624A0 (fi) 1985-07-03
NZ212805A (en) 1989-01-06
ES8800245A1 (es) 1987-10-16
IE58742B1 (en) 1993-11-05
CA1331381C (en) 1994-08-09
AU602585B2 (en) 1990-10-18
PT80836B (pt) 1987-09-30
ES8704161A1 (es) 1987-03-16
DK302885D0 (da) 1985-07-03
FI852624L (fi) 1986-01-21
ES8800244A1 (es) 1987-10-16
DK302885A (da) 1986-01-21
AU4458185A (en) 1986-01-23
PT80836A (en) 1985-08-01
FI83648B (fi) 1991-04-30
DK6193D0 (da) 1993-01-19
FI83648C (fi) 1991-08-12
ES545390A0 (es) 1987-03-16
DE3575924D1 (de) 1990-03-15

Similar Documents

Publication Publication Date Title
AR241183A1 (es) Procedimiento para la preparacion de nuevos acidos naftiridin-, quinolin- y benzoxazin-carboxilicos.
DK543787A (da) Naphthyridin-, quinolin- og benzoxazincarboxylsyreforbindelser med antibakteriel aktivitet
NZ212750A (en) 3-acylamino-2-azetidinone derivatives useful as intermediates in the preparation of antibacterial agents
ES8607298A1 (es) Procedimiento para la preparacion de pirazolopiridinas.
AR240830A2 (es) Procedimiento para preparar derivados de acidos naftiridin quinolin-y benzoxazincarboxilicos.
AU575927B2 (en) Optically active alkyl-aryl ketals and the preparation of alpha-aryly alkanoic acids
ES2000185A6 (es) Procedimiento para preparar derivados de acidos piridoncaboxilicos
AR241593A1 (es) Procedimiento para preparar derivados de acido quinolin-3-carboxilico.
KR860005818A (ko) 6,7-이치환 1-시클로프로필-1,4-디히드로-4-옥소-1,8-나프티리딘-3-카르복실산의 제조방법
DK0594099T3 (da) Fremgangsmåde til rensning af rå clavulansyre
ES8706144A1 (es) Un procedimiento para preparar derivados de 1,8-naftiridina
SE8305917D0 (sv) Mellanprodukter for anvendning vid framstellning av hexahydro-gamma-karbolinforeningar
DE3578423D1 (de) Neue cephalosporine und verfahren zu ihrer herstellung.
ES541544A0 (es) Un metodo de preparar bestatinas
ES8101646A1 (es) Un procedimiento para producir un compuesto opticamente ac- tivo
FI103885B1 (fi) Menetelmä terapeuttisesti aktiivisten 1-bentsyyli-4-fenyylipiperatsiinijohdannaisten valmistamiseksi ja välituotteina käyttökelpoisia yhdisteitä
ES8200142A1 (es) Un procedimiento para la produccion de analogos de cefalosporina.
ATE33493T1 (de) Phenylethylaminopropiophenon-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
FI882667A (fi) Foerfarande foer framstaellning av antibakteriska vid 7-staellningen substituerade 1-cyklopropyl-6-fluor -1,4-dihydro-4-oxo-1,8-naftyridin-3-karboxylsyror.
ES8200366A1 (es) Procedimiento para preparar derivados de pirimidina
ES8307812A1 (es) Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.