ES8200142A1 - Un procedimiento para la produccion de analogos de cefalosporina. - Google Patents

Un procedimiento para la produccion de analogos de cefalosporina.

Info

Publication number
ES8200142A1
ES8200142A1 ES495036A ES495036A ES8200142A1 ES 8200142 A1 ES8200142 A1 ES 8200142A1 ES 495036 A ES495036 A ES 495036A ES 495036 A ES495036 A ES 495036A ES 8200142 A1 ES8200142 A1 ES 8200142A1
Authority
ES
Spain
Prior art keywords
optically active
preparation
optically
hydrogen
cephalosporin analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495036A
Other languages
English (en)
Other versions
ES495036A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13698679A external-priority patent/JPS5661377A/ja
Priority claimed from JP5561880A external-priority patent/JPS56152478A/ja
Priority claimed from JP10242280A external-priority patent/JPS5729291A/ja
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of ES8200142A1 publication Critical patent/ES8200142A1/es
Publication of ES495036A0 publication Critical patent/ES495036A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE ANALOGOS DE CEFALOSPORINA OPTICAMENTE ACTIVOS RESPRESENTADOS POR LA FORMULA GENERAL (I). CONSISTENTE EN OBTENER (I) POR DESACILACION OPTICAMENTE SELECTIVA DE UN COMPUESTO REPRESENTADO POR LA FORMULA (II) EN PRESENCIA DE UNA ENZIMA, EN CUYAS FORMULAS R1 REPRESENTA HIDROGENO, UN GRUPO ALQUILO INFERIOR A UN GRUPO ACILO INFERIOR; R2 REPRESENTA HIDROGENO O UN GRUPO PROTECTOR DE ACIDO CARBOXILICO; R ES UN CARBOCICLO DE SEIS MIEMBROS, UN GRUPO FENOXI O UN HETEROCICLO; X REPRESENTA HIDROGENO, GRUPO AMINO, HIDROXI O ALQUILO INFERIOR, Y LOS HIDROGENOS EN LAS POSICIONES 6 Y 7 ESTAN EN CONFIGURACION CIS. DICHA ENZIMA SE OBTIENE DE UN MOCROORGANISMO QUE PUEDE PERTENECER A DIVERSOS GENEROS. LA REACCION SE LLEVA A CABO A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 50C Y A UN PH DE 4 A 10, EN UN DISOLVENTE INACTIVO QUE NO AFECTE A LA REACCION. UNA VEZ COMPLETA LA REACCION, EL AISLAMIENTO DEL PRODUCTO DESEADO SE REALIZA POR UN METODO CONVENCIONAL.
ES495036A 1979-10-25 1980-09-12 Un procedimiento para la produccion de analogos de cefalosporina. Granted ES495036A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13698679A JPS5661377A (en) 1979-10-25 1979-10-25 Optically active cephaloasporin analog
JP5561880A JPS56152478A (en) 1980-04-26 1980-04-26 Optically active cephalosporin analog
JP10242280A JPS5729291A (en) 1980-07-28 1980-07-28 Preparation of optically active cephalosporin analoge

Publications (2)

Publication Number Publication Date
ES8200142A1 true ES8200142A1 (es) 1981-10-16
ES495036A0 ES495036A0 (es) 1981-10-16

Family

ID=27295649

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495036A Granted ES495036A0 (es) 1979-10-25 1980-09-12 Un procedimiento para la produccion de analogos de cefalosporina.

Country Status (7)

Country Link
EP (1) EP0027882B1 (es)
AU (1) AU6235580A (es)
CA (1) CA1160584A (es)
DE (1) DE3069901D1 (es)
DK (1) DK389180A (es)
ES (1) ES495036A0 (es)
NO (1) NO802714L (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082501A1 (en) * 1981-12-18 1983-06-29 Kyowa Hakko Kogyo Co., Ltd Beta-lactam compound and a pharmaceutical composition containing the same
DE3803169A1 (de) 1988-02-03 1989-08-17 Bayer Ag Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln
US5099015A (en) * 1991-01-10 1992-03-24 Eli Lilly And Company Trifluoromethyl 1-carba(1-dethia)cephems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7902598L (sv) * 1978-03-25 1979-10-04 Kyowa Hakko Kogyo Kk Cephalosporinanaloger

Also Published As

Publication number Publication date
DE3069901D1 (en) 1985-02-14
DK389180A (da) 1981-04-26
ES495036A0 (es) 1981-10-16
NO802714L (no) 1981-04-27
AU6235580A (en) 1982-07-29
CA1160584A (en) 1984-01-17
EP0027882A1 (en) 1981-05-06
EP0027882B1 (en) 1985-01-02

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